• 약학회지
• /
• 제55권2호
• /
• pp.98-105
• /
• 2011

To search the minimum structural requirement of tricyclic isoxazole analogues (1~30) as new class potent antidepressant, thee-dimensional quanti- tative-structure relationship (3D-QSAR) models between substituents ($R_1{\sim}R_5$) of tricyclic isoxazoles and their antidepressant activity against medetomidine-induced loss of righting were performed and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indies analysis (CoMSIA) methods. The correlativity and predictability ($r^2$=0.484 and $q^2$=0.947) of CoMSIA-2 model were higher than those of the rest models. The inhibitory activity against medetomidine-induced loss of righting was dependent on electrostatic field (43.4%), hydrophobic field (35.3%), and steric field (21.2%) of tricyclic isoxazoles. From the CoMSIA-2 contour maps, it is predicted that the antidepressant activity of potent antidepressants against medetomidine-induced loss of righting will be able to increase by the substituents ($R_1{\sim}R_5$) which were in accord with CoMSIA field.

• 약학회지
• /
• 제55권2호
• /
• pp.91-97
• /
• 2011

To search a new anti-depressant agents against para-chloroamphetamine-induced excitation, three dimensional quantitative-structure relationships (3D-QSAR) models between structure of 3a,4-dihydro-3H-[1]-benzopyronao[4,3]isoxazoles (1-30) and thieir inhibitory activity against para-chloroamphetamine-induced excitation were performed and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. From these basis on the findings, the optimized CoMSIA-2F model ($q^2$=0.793 and $r^2$=0.952) showed the best statistical results. And also, it is found that the para-chloroamphetamine inhibitory activity from the optimized CoMSIA-2F model was dependent on steric field (35.2%) and electrostatic field (64.8%) of tricyclic isoxazoles. Particularly, it is predicted that the inhibitory activity against para-chloroamphetamine-induced excitation will be able to increase by the designed compounds from the CoMSIA-2F model.

• 벤처창업연구
• /
• 제10권1호
• /
• pp.175-185
• /
• 2015

본고는 미국의 창업 교육 프로그램의 주요한 구성적 특징을 파악하기 위하여 미국 주요대학들의 창업 프로그램에 대한 분석을 수행하였다. 분석에 포함된 프로그램은 MIT의 Martin Trust Center for MIT Entrepreneurship, 하버드 대학의 Harvard Innovation Lab에서 수행하는 Venture Incubation program(VIP), 시카고 대학의 Polsky Center for Entrepreneurship & Innovation, 스탠포드 대학의 Center for Entrepreneurial Studies(CES)이다. 이 프로그램들의 대학 내 주요 역할, 커리큘럼, 특징을 파악하고, 관련 선행 분석을 참고하여 미국 대학의 창업 지원 프로그램이 지닌 세 가지 유형의 구성적 특징을 파악하였다. 첫 번째는 역동적 교육중심형으로, 창업 경진 대회를 통해 학생들이 기업가정신 교육에서 배운 내용을 실제적으로 적용할 수 있는 기회를 제공하는 프로그램들이 이 분류에 포함되었다. 두 번째는 지역밀착형으로 대학이 위치한 지역의 산업 기반과 형태를 고려하여 지역의 창업 열풍을 주도하는 대학들이 포함되었다. 마지막은 창업 지원 유도형으로 교육과 실제 창업이 연결과는 선순환 구조를 구축하고 학생들의 창업에 대학이 직접적인 자본을 투자하는 프로그램들이다. 이러한 분류에 의거하여 학생들의 창업을 장려하고 성공적인 창업을 돕기 위한 주요 요인들을 제안하였다.

• 산업경영시스템학회지
• /
• 제37권3호
• /
• pp.75-81
• /
• 2014

To establish a new creative economy, the worldwide efforts have been made to wriggle out the old economic paradigm after the financial crisis of 2008. When it comes to the limitation of the viability. the start up companies have a high risk of failure. Therefore business incubator (BI) should carry out the role to improve their viability. As for the maximization of the effect on the business incubating services as move in companies, it is important for BI to increase the level of business incubating services by the systemic and scientific measurement. This study showed that the quality of the BI center services was measured by Kano analysis and the previous research as follows. First, BI quality attribute by Timko's customer satisfaction came out into the attractive qualities on the 14 items that amount to the 70% of 20 business incubating services items. It is desirable to perform the strategy for the satisfaction. Secondly, basic business incubating services were interpreted as the one-dimensional quality like incubating spaces, parking facilities, security facilities, industry technology development funds, and incubating managers. Finally, training and educational service was recognized as indifferent quality. Futhermore, the improvement and the limitation of this study as well as the interpretation of analysis results are also provided.

• 한국산학기술학회논문지
• /
• 제16권6호
• /
• pp.3858-3869
• /
• 2015

산업사회에 있어 시대의 화두는 창업인바 창업의 활성화는 새로운 직업을 창출함으로써 고용극대화와 경제전반에 걸친 활성화에 중요한 역할을 담당하고 있으며 그 유인책중 하나가 창업보육시스템이고 그 중심에 창업보육센터가 있다. 이에 본 연구는 창업보육센터 지원서비스의 질적 수준 도움정도가 만족도에 미치는 영향을 실증적으로 분석함으로써 창업보육센터의 효율적 운영방향과 정책방향을 수립하는데 기여하고 하나의 논의의 단초를 제공하고자 한다. 이를 위해 선행연구를 바탕으로 설문지를 개발하고 총500부의 유효 표본을 대상으로 연구를 진행하였다. 연구결과 창업보육센터가 입주기업이나 창업 준비자에게 제공하는 서비스 중 질적 수준과 도움정도는 센터 및 지원서비스에 대한 만족도에 유의한 영향을 주었으며 매니저의 역량과 관련기술특성은 만족도에 유의한 영향을 주는 것으로 나타났다.

• 한국주조공학회지
• /
• 제26권1호
• /
• pp.27-33
• /
• 2006

Phase evolutions involving nucleation stages together with diffusional growth have been examined in order to provide a guideline for determining rate limiting stages during phase evolutions. In multiphase materials systems in coatings, composites or multilayered structures, diffusion treatments often result in the development of metastable/intermediate phases at the reaction interfaces. The development of metastable phases during solid state interdiffusion demonstrates that the nucleation reaction can be one controlling factor. Also, the concentration gradient and the relative magnitudes of the component diffusivities provide a basis for a phase selection and the application of a kinetic bias strategy in the phase selection. For multicomponent alloy systems, the identification of the operative diffusion pathway is central to control phase formation. Experimental access to the nucleation and growth stage is discussed in thin film multi layers and bulk samples.

• 한국발생생물학회지:발생과생식
• /
• 제19권1호
• /
• pp.25-31
• /
• 2015

We have launched an investigation for Embryonic Development, Larvae and Juvenile Morphology, of Buenos aires tetra in order to build basic data of Characidae and fish seeding production. We brought 50 couples of Characidae from Bizidduck aquarium in Yeosu-si, Jeollanamdo, from Korea on March of 2015. We put them in the tetragonal glass aquarium ($50{\times}50{\times}30cm$). Breeding water temperature was $27.5{\sim}28.5^{\circ}C$ (mean $28.0{\pm}0.05^{\circ}C$) and being maintained. The shape of fertilized egg was round shape, and it was adhesive demersal egg. The egg size was 0.63~0.91 mm (mean $0.74{\pm}0.07mm$, n=20). After getting fertilized egg, the developmental stage was gastrula stage, and embryo covered almost two-thirds of Yolk. Incubation was happened after 16 hours 13 minutes from gastrula stage, and the tail of juvenile came out first with tearing egg capsule. Immediately after the incubation, prelarvae had 3.78~3.88 mm length (mean $3.84{\pm}0.04mm$, n=5), and it had no mouth and anus yet. 34 days after hatching from the incubation, juvenile had 8.63~13.1 mm (mean $10.9{\pm}1.66mm$), and it had similar silver-colored body shape with its mother.

• 산업경영시스템학회지
• /
• 제46권spc호
• /
• pp.54-60
• /
• 2023

The government focuses on promoting start-ups, fostering ventures, and creating an ecosystem of start-ups through the formation of a strong growth environment for small businesses. This study provides academic and practical implications about ways of improving our business incubator's support service across stages of growth through IPA. To this end, an Importance-Performance Analysis (IPA) was conducted to analyze relationship and differences in importance and satisfaction of business incubator's support service support at business incubation center. These results present to provide the following academic and practical implications. The academic implications are the need for differences in support services for each phase of start-up growth. As factors that could increase the likelihood of successful start-up were identified in each phase of the start-up growth, important information needed for policy and strategy was provided. As a practical suggestion, the managers and expert groups are presented with sections to be opened for each start-up growth stage, minimum effort input, and areas to be maintained continuously. A systematic support plan is established and a foundation is provided for improvement measures in efficient start-up business incubator's support service.

• Biotechnology and Bioprocess Engineering:BBE
• /
• 제9권6호
• /
• pp.476-481
• /
• 2004

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

• 산업경영시스템학회지
• /
• 제46권4호
• /
• pp.124-132
• /
• 2023

In order to support start-ups effectively with limited resources, it is necessary to provide support tailored to start-up companies. Businesses that are operating in local incubation centers may have different demands for the support depending on the region characteristics. This study was worked on companies that have entered into the incubation center 'Youth Cube', which is operated by Ansan City. We investigated the perception of importance in the field of support to identify support policy priorities, and the satisfaction level of each field of support currently supported. Then We conducted an IPA analysis to derive the direction of support. The Ansan area has regional characteristics that it is located in the metropolitan area with well-equipped start-up infrastructure and many innovative institutions, As a result of the importance survey, technology commercialization was recognized as the most important, and education/mentoring was recognized as the least important. Satisfaction with the space and facilities that can be used free of charge was the highest, and the satisfaction was the lowest for entrepreneurship education/mentoring, as was the degree of importance. In addition, according to each quadrant, we derived support that should be maintained, support that should be intensively improved, support that should be given a low policy priority, and support directions that should be kept in mind to avoid excessive support.