• Title/Summary/Keyword: Burst pressure

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Synthesis of Hyaluronic Acid Scaffold for Tissue Engineering and Evaluation of Its Drug Release Behaviors (히아루론산을 이용한 조직공학용 Scaffold의 제조와 약물 방출 거동에 관한 연구)

  • Nam, Hye-Sung;Kim, Ji-Heng;An, Jeong-Ho;Chung, Dong-June
    • Polymer(Korea)
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    • v.25 no.4
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    • pp.476-485
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    • 2001
  • In this study, we tried to design and synthesize using natural polymers (hyaluronic acid and sodium alginate) and also to make some kinds of scaffolds as sponge type for reducing the burst effect of loaded drug from them. Photo-dimerizable group was incorporated to hyaluronic acid and degradable hydrogel was prepared by the UV radiation of the polymer. The pore size and its distribution of scaffold were controlled by changing microsphere production conditions such as solution concentration and spraying pressure. It was found that drug release behavior from synthesized scaffolds was affected by hybridization of two naturally originated polymers (cinnamoylated tetrabutylammonium hyaluronate: CHT and cinnamolylated sodium alginate: CSA) and the obtained scaffolds were degraded in fairly long time (about 2 months) under in vitro environment. Therefore, we expect that obtained scaffolds can be applicable for the tissue regeneration scaffolds in the fields of orthopaedic surgery.

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Long-Term Thermal Conductivity Prediction of Polyurethane Foam Applying Precision Mass Spectrometer for Cell Gas Analysis (정밀질량분석기를 활용한 우레탄폼의 장기열전도도 예측을 위한 분석기법)

  • Kim, Jin-Seok;Chun, Jong-Han;Lee, Jin-Bok;Lee, Hyo-Jin
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.22 no.10
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    • pp.679-686
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    • 2010
  • A proprietary device is adopted to break out the membrane of cell in the rigid polyurethane foam. As it is known, the membrane of cell is hardly tearing-off thoroughly in a mechanical way due to both its elastic characteristic and micro sized pores. In this study, a novel experimental approach is introduced to burst out all gases inside the cells of the rigid polyurethane foam by abrasively grinding micro-cells completely into fine powder. The biggest advantage of this approach is to be capable of releasing all gases out from the cell even in the micro pores. As clearly reflected from the repeatability, the accuracy of the result is highly improved and high confidence in the data sets as well. For the measurements of not only gas composition but partial pressure for each gas simultaneously as well, a precision gas mass spectrometer is used in-line directly to the abrasive grinding device. To control the starting point of the polyurethane foam, all samples were prepared on site in the laboratory. Manufactured time is one of the most critical factors in characterization of cell gas composition because it is known that one of gas composition, especially, carbon dioxide, is diffused out dramatically in a short period of time as soon as it is foamed.

THE STUDY ON THE CHARACTERISTICS OF NOCICEPTIVE NEURONS IN TRIGEMINAL SUBNUCLEUS ORALIS (삼차신경 척수감각핵 문측소핵내 유해성 뉴론의 특성에 관한 연구)

  • Ohn, Yeong-Suck;Park, Soo-Joung
    • Restorative Dentistry and Endodontics
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    • v.24 no.4
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    • pp.614-622
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    • 1999
  • Recent studies have implicated that more rostral components of the trigeminal spinal nucleus including subnucleus oralis (Vo) in orofacial nociceptive mechanisms. Since there is only limited electrophysiological evidence, the present study was initiated to characterize the receptive field and response properties of malls nociceptive neurons in chloralose/urethan-anesthetized rats. Single neuronal activity was recorded in right subnucleus oralis, and types of nociceptive neurons classified wide dynamic range (WDR), NS (nociceptive specific) and deep nociceptive (D) and the mechanoreceptive field (RF) and response properties were determined. A total of 34 nociceptive neurons could be subdivided into 17WDR neurons, 12NS neurons and 5D neurons. Vo nociceptive neurons had RF involving maxillary and/or mandibular divisions mainly located in the intraoral and/or perioral regions. Majority of Vo nociceptive neurons showed spontaneous activity less than 1Hz. The NS and D neurons activated only by heavy pressure and/or pinch stimuli had high mechanical thresholds compared to WDR neurons activated also by tactile stimuli. Vo nociceptive neurons showed a progressive increase of response to the graded mechanical stimuli. 39% of Vo nociceptive neurons received C-fiber electrical input as well as A-fiber electrical input from their RF, and 45% of them responded to electrical stimulation of the right maxillary first molar. 41% of Vo nociceptive neurons responded to noxious heat applied to their RF, and 18% of them showed an immediate burst of discharges following MO application to the right maxillary first molar pulp. These results indicate that Vo is involved in the transmission of nociceptive information mainly coming from intraoral or perioral region including tooth pulp.

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A Case of Severe Asthma Complicated with Pneumoperitoneum and Pneumomediastinum During AMBU Ventilation (AMBU(Air Mask Bag Unit) 환기로 복강기종과 종격동기흉이 합병된 중증 천식 1예)

  • Cho, Hoon;Choi, Byoung-Moon;Jung, Ho-Kyoung;Park, Ja-Young;Jang, Byoung-II;SunWoo, Mi-Ok;Seo, Chan-Hee;Sung, Han-Dong;Sin, Mi-Jeong;Hwang, Soon-Chul
    • Tuberculosis and Respiratory Diseases
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    • v.51 no.6
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    • pp.585-589
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    • 2001
  • Pneumoperitoneum, Pneumomediastinum, subcutaneous emphysema and a pneumothorax are some of the mechanical complications of bronchial asthma. The incidence of pneumoperitoneum during an attack of acute asthma is rare. The pathogenesis is free gas track from the overdistended alveoli, through the bronchovascular sheaths to the mediastinum. If the high pressure is maintained, air can escape retroperitoneally into the abdomen and burst into the peritoneal cavity. A 43-year-old woman was admitted due to a severe asthma attack. She was required endotracheal intubation and AMBU(air mask bag unit) ventilation. Immediately after these procedures, pneumoperitonewn, pnewnomediastinwn, and subcutaneous emphysema developed. She was treated with mechanical ventilation and medical therapy. The pneumoperitonewn was resolved after 27days. Here, we report this case with the review of the relevant literature.

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Serviceability Assessment of Corroded Subsea Crude Oil Pipelines (부식된 해저 원유 파이프라인의 사용적합성 평가)

  • Cui, Yushi;Kim, Dong Woo;Seo, Jung Kwan;Ha, Yeon Chul;Kim, Bong Ju;Paik, Jeom Kee
    • Journal of the Society of Naval Architects of Korea
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    • v.52 no.2
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    • pp.153-160
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    • 2015
  • Pipelines are one of the most important structures in subsea equipment. It is the main equipment for transportation of crude oil and natural gas to the downstream facilities. Crude oil and natural gas leak will be carry out not only political and financial issues but also pollution to the environment. Inaccurate predictions of corrosion behavior will make hazardous consequences. The serviceability assessment of corroded structures is essential especially for subsea pipelines. As corrosion is concerned, the effects of failure due to significant reduction will make it hard to the pipeline operator to maintain the serviceability of pipelines. In this paper, the serviceability assessment of corroded crude oil pipeline is performed using the industry design code (Shell92, DNV RP F101, ASME B31G, BS 7910, PCORRC) and FEA depending on corrosion area. In last step, the future integrity of the subsea crude oil pipeline is assessed to predict the remaining year in service of crude oil pipelines.

Thermal Hazards of Polystyrene Polymerization Process by Bulk Polymerization (벌크 중합법에 의한 폴리스티렌 중합공정의 열적위험성)

  • Han, In-Soo;Lee, Jung-Suk;Lee, Keun-Won
    • Journal of the Korean Institute of Gas
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    • v.17 no.4
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    • pp.1-8
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    • 2013
  • The aim of this study is to assess thermal hazards of polystyrene polymerization process by bulk polymerization with accelerating rate calorimeter(ARC) and Multimax reactor system(MM). From this study, we found out that the polymerization process should be operated at reaction temperature of $120^{\circ}C{\sim}130^{\circ}C$. At reaction temperature over $130^{\circ}C$, there was a runaway reaction hazard due to the temperature control failure following a viscosity increase of reaction products. With a cooling failure of a reactor in the early stage of process operation at the reaction temperature ($120^{\circ}C{\sim}130^{\circ}C$), there was a high thermal hazard of burst of a reactor's rupture disk or explosion of a reactor caused by the rapid rise of temperature and pressure to $340^{\circ}C$, 5.3 bar respectively within 30 - 50 minutes.

Evaluation of Risk Factors to Detect Anomaly in Water Supply Networks Based on the PROMETHEE and ANP (상수도관망의 이상징후 판정을 위한 위험요소 평가 - PROMETHEE와 ANP 기법 중심으로)

  • Hong, Sung-Jun;Lee, Yong-Dae;Kim, Sheung-Kown;Kim, Joong-Hoon
    • Journal of Korea Water Resources Association
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    • v.39 no.1 s.162
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    • pp.35-46
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    • 2006
  • In this study, we proposed a layout of the integrated decision support system in order to prevent the contamination and to manage risk in water supply networks for safe and smooth water supply. We evaluated the priority of risk factors to detect anomaly in water supply networks using PROMETHEE and ANP techniques, which are applied to various Multi-Criteria Decision Making area in Europe and America. To develop the model, we selected pH, residual chlorine concentration, discharge, hydraulic pressure, electrical conductivity, turbidity, block leakage and water temperature as the key data item. We also chose pipe corrosion, pipe burst and water pollution in pipe as the criteria and then we present the results of PROMETHEE and ANP analysis. The evaluation results of the priority of risk factors in water supply networks will provide basic data to establish a contingency plan for accidents so that we can establish the specific emergency response procedures.

Preparation and Characterization of Gelatin-immobilized Bacterial Cellulose Scaffold for Tissue Engineering Using Gamma-ray Irradiation (감마선을 이용한 조직공학용 젤라틴이 개질된 미생물 셀룰로오스 지지체의 제작 및 특성)

  • Choi, Jong-Bae;Jeong, Sung In;Gwon, Hui-Jeong;Park, Jong-Seok;Nho, Young-Chang;Choi, Young-Hun;Park, Kyung Jin;Park, Man Yong;Shin, Heungsoo;Lim, Youn-Mook
    • Journal of Radiation Industry
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    • v.6 no.2
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    • pp.159-164
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    • 2012
  • Bacterial cellulose (BC) is generated from citrus gel by Gluconacetobacter hansenii TL-2C. BC has good properties such as high-burst pressure, high-water contact and the ultrafine highly nanofibrous structure of mimic natural extracellular matrix (ECM) for tissue engineering. In this study, acrylic acid (AAc) was grafted onto BC surfaces under aqueous conditions using gamma-ray irradiation, and then immobilized gelatin onto AAc-g-BC. The characterization of scaffolds was performed by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), toluidine blue O (TBO) assay. Morphology of gelatin and AAc incorporation onto BC nanofibers did not changed. Our study suggests that gelatin-immobilized BC nanofibers scaffold has a potentiality to fabricate 3D nanofibrous scaffolds for tissue engineering.

Edge Computing-based Differential Positioning Method for BeiDou Navigation Satellite System

  • Wang, Lina;Li, Linlin;Qiu, Rui
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.13 no.1
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    • pp.69-85
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    • 2019
  • BeiDou navigation satellite system (BDS) is one of the four main types of global navigation satellite systems. The current system has been widely used by the military and by the aerospace, transportation, and marine fields, among others. However, challenges still remain in the BeiDou system, which requires rapid responses for delay-sensitive devices. A differential positioning algorithm called the data center-based differential positioning (DCDP) method is widely used to avoid the influence of errors. In this method, the positioning information of multiple base stations is uploaded to the data center, and the positioning errors are calculated uniformly by the data center based on the minimum variance or a weighted average algorithm. However, the DCDP method has high delay and overload risk. To solve these problems, this paper introduces edge computing to relieve pressure on the data center. Instead of transmitting the positioning information to the data center, a novel method called edge computing-based differential positioning (ECDP) chooses the nearest reference station to perform edge computing and transmits the difference value to the mobile receiver directly. Simulation results and experiments demonstrate that the performance of the ECDP outperforms that of the DCDP method. The delay of the ECDP method is about 500ms less than that of the DCDP method. Moreover, in the range of allowable burst error, the median of the positioning accuracy of the ECDP method is 0.7923m while that of the DCDP method is 0.8028m.

Development of a pipe burst detection model using large consumer's smart water meter and pressure data (대수용가 스마트미터와 수압 데이터를 이용한 소블록 내 관 파손사고 감지모델 개발)

  • Kyoung Pil Kim;Wan Sik Yu;Shin Uk Kang;Doo Yong Choi
    • Proceedings of the Korea Water Resources Association Conference
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    • 2023.05a
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    • pp.521-521
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    • 2023
  • 지방상수도의 관 파손사고 감지 및 누수관리 방법에는 블록시스템 구축을 통한 소블록별 야간최소유량 감시방법이 가장 대표적이다. 야간최소유량은 새벽 2시와 4시 사이의 인구 활동 비율이 가장 낮은 새벽 시간대에 소블록에 공급된 유량을 의미하며, 대부분 유량 성분은 누수량일 것이라는 가정에서 출발한다. 그러나 아파트 중심의 주거 형태를 보이는 도심지의 경우, 새벽 시간대에도 다량의 물수요가 비정기적으로 발생하고 있어 관망의 이상 여부를 감시하기 위한 관리기준으로서 야간최소유량을 이용하기에는 높은 일간 변동성에 따른 한계가 있다고 할 수 있다. 즉, 야간최소유량은 관 파손사고 발생의 감시보다는 관로 연결 또는 급수전 분기 부위에서 발생하는 미량의 누수가 수개월에 걸쳐 누적되는 장기추세를 분석하여 누수탐사반의 투입 시점을 결정하기 위한 근거를 제시하기 위한 목적으로 사용되며, 아직까지 관 파손사고의 발생은 자체적인 감지보다는 민원에 의해 인지되는 경우가 많다. 최근, 스마트관망 구축사업(SWM) 등을 통해 관 파손 및 누수 감지를 위한 청음식 누수감지센서가 소블록 내 도입되고 있으나, 초기 시설투자에 큰 비용이 수반되며 주변 소음과 배터리 전원방식의 한계로 인하여 새벽 시간대에만 분석이 제한적으로 적용되는 경우가 많아 이 역시도 상시적인 관 파손사고의 감시기술이라 보기는 어렵다. 본 연구에서는 소블록 유입점에서의 유량·압력과 소블록 내에 설치된 대수용가 스마트미터, 그리고 사고감지를 위한 수압계 사이의 평상시 수리적 균형을 학습한 DNN(Deep Neural Network) 모델을 이용하여 관 파손사고를 실시간 감지하는 모델 개발연구를 수행하였다. 모델은 관 파손사고 감지를 위한 수압계의 최적 위치와 대수를 결정하기 위한 모듈과 관 파손사고 감지모듈로 구성되며, 1개 소블록 Test-Bed를 구축하여 모델을 생성하고 PDD 관망해석 모델을 통해 생성된 가상의 사고에 대한 감지 여부로서 개발 모델의 감지성능을 평가하였다.

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