• Journal of fish pathology
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• v.25 no.1
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• pp.1-10
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• 2012

It has been reported that various anti-oxidant substances stimulate non-specific immune responses in fishes. In this study it was examined whether N-acetylcysteine (NAC), an anti-oxidant glutathione (GSH) precursor, can modulate non-specific immune parameters in 8 different fishes. NAC was intraperitoneally administered at 10 mg/kg to catfish (Silurus asotus), loach (Misgurnus mizolepis), common carp (Cyprinus carpio), crucian carp (Carassius carassius), eel (Anguilla japonica), snakehead (Channa argus), tilapia (Oreochromis niloticus) and mullet (Mugil cephalus). Forty-eight hours later, chemiluminescence (CL) response of head-kidney leukocytes and serum lysozyme activity were assessed. In all fishes except crusian carp and loach, CL responses were amplified by NAC. Lysozyme activity was increased by NAC in all fish species but not in tilapia. This result suggests that NAC stimulates non-specific immune responses in various species, and that such effects may have beneficial significance in aquaculture for practical utilization.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.8A
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• pp.820-829
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• 2006

IP-based design methodology has been popularly employed for SoC design to reduce design complexity and to cope with time-to-market pressure. Due to the request for high performance of current mobile systems, embedded SoC design needs a multi-processor to manage problems of high complexity and the data processing such as multimedia, DMB and image processing in real time. Interface module for communication between system buses and processors are required, since many IPs employ different protocols. High performance processors require interface module to minimize the latency of data transmission during read-write operation and to enhance the performance of a top level system. This paper proposes an automatic interface generation system based on FSM generated from the common protocol description sequence of a bus and an IP. The proposed interface does not use a buffer which stores data temporally causing the data transmission latency. Experimental results show that the area of the interface circuits generated by the proposed system is reduced by 48.5% on the average, when comparing to buffer-based interface circuits. Data transmission latency is reduced by 59.1% for single data transfer and by 13.3% for burst mode data transfer. By using the proposed system, it becomes possible to generate a high performance interface circuit automatically.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.2B
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• pp.279-288
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• 2004

Rapidly emerging P2P(Peer to Peer) applications generate very bursty traffic, which gives a lot of burden to network, and the amount of such traffic is increasing rapidly. Thus it is becoming more important to understand the characteristics of such traffic and reflect it when we design and analyze the network. To do that we measured the traffic in a campus network and present flow statistics and traffic models of the measured traffic, and compare them with those of the web traffic. The results indicate that P2P traffic is much burstier than web traffic and as a result it negatively affects network performance. We modeled P2P traffic using self-similar traffic model to predict packet delay and loss occurred in network which are very important to evaluate network performance. We also predict queue length distribution and loss probability in SSQ(Single Sewer Queue). To assess accuracy of traffic model, we compare the SSQ statistics of traffic models with that of the traffic trace. The results show that self-similar traffic models we use can predict P2P traffic behavior in network precisely. It is expected that the traffic models we derived can be used when we design network capacity and predict network performance and QoS of the P2P applications.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.41 no.1
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• pp.23-34
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• 2004

This paper presents architecture and control method of packet scheduler to guarantee QoS of high quality streaming services in high-speed packet-switched networks. Since streaming services need far more stringent QoS requirements than the typical sort of burst data applications, they should be guaranteed minimum bandwidth and end-to-end delay bound to each flow, regardless of the behavior of other flows. To meet these requirements, a packet scheduler isolate a flow from the undesirable effects of other flows and provides end-to-end delay guarantees for individual flow and divides stringently the available link bandwidth among flows sharing the link. Until now, many vendors are developing traffic management chips running at 10Gbps, but most of chips have drawbacks to support high quality streaming services. In this paper, we investigate the drawbacks of commercial TM chips and traffic characteristic of streaming services and present implementation frameworks of the proposed packet scheduler. Finally, we analyze the simulation results of the proposed scheduler.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.9
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• pp.1027-1031
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• 2014

Free cooling system is used to reduce energy consumption of cooling system. Free cooling system is consisted of cooling group and dry-cooler in which heat exchange of chilled water and out air is conducted. Although this system has an excellent energy saving effect in place having cooling load regularly, data or material of design for free cooling system is lacked. In this study, characteristics analysis of free cooling system is conducted through software HYSYS with changing some facts. The main result is following as : Dry-cooler capacity is influenced by out air temperature, required chilled water temperature and LMTD(Logarithmic Mean Temperature Difference) of heat exchanger. As out air temperature is more low, dry-cooler capacity become increased. in addition, as required chilled water temperature is more high and LMTD is more low, the out air temperature range is widened for using dry-cooler. If out air temperature is below $0^{\circ}C$, antifreeze need to be used because freeze and burst can be occurred. In case of South Korea, antifreeze of 34% of ethylene glycol concentration is proper. When compressor load of R22, R134a and R407C is compared, considering environmental regulation and energy consumption, R134a is best working fluid.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.39 no.6
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• pp.460-465
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• 2006

An 8-week feeding trial was conducted to investigate the effects of dietary supplementation with probiotics as a feed additive for Juvenile olive flounder (Paralichthys olivaceus). Three experimental diets supplemented with Bacillus polyfermenticus (BP), Bacillus licheniformis (BL), or Bacillus polyfermenticus plus Saccharomyces cerevisiae, (BP+SC) at $1.0{\times}10^7CFU/kg$ diet on a dry-matter basis were prepared. The basal diet was used as a control. After the 8-week feeding trial, the respiratory burst activity (NBT assay) of fish fed the BP + SC diet was significantly higher than that of fish fed the control diet. Fish fed the BP, BL and BP + SC diets had significantly lower cumulative mortality than did fish fed the control diet after the third day of the challenge test (P<0.05). However, there were no significant differences among fish fed the experimental diets in weight gain, feed efficiency, protein efficiency ratio, hematosomatic index, condition factor, survival rate, or Iysozyme activity. Results could suggest that dietary B. polyfermenticus, B. licheniformis, and B. polyfermenticus +S. cerevisiae enhance nonspecific immunity and disease resistance in juvenile olive flounder.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.2 no.4
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• pp.19-41
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• 2007

This research has a goal which is suggesting the way of constructing 'Cluster' which mean scheming the commencement of an enterprise in an early stage. Now it is reorganized into a IT industry structure 'Time-to market growth' is burst as a big issue. in that point, this research analyze the core success factor which is drawing from the existing IT industrial complex, and then it will be used to draw up to the 'Idealistic growth-support Cluster' on the basis of it, we pulled out various issues about the Corporate in the early stage of its growth. Therefore, this research is focused on presenting the ideal network(net) by considering the Network that organizations and business in Cluster or the network including the factors linked organizations and business in Cluster. therefore, this research carried out three big analysis. from the case investigation we pulled out the core growth factor, and then we approached the analysis of net structure for making application to Network Analysis. and then we analyzed that the characteristics of the Network after measuring by on the basis of analyzing core growth factor. and especailly, this research carried out the Core analysis for recognition of Core- support-frame by base Centrality Test on the net which is composed of growth support organizations at each Business. Judging from this, we can help to make full use of resources for the network analysis in Cluster and establish the Network Strategy by Structure comparison between the structure of industry-Cluster and ideal Business-support networks on the basis of the analysis from the Core-success-factor

• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.452-459
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• 2017

In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as particle composition and drug loading efficiency and amount were similarly controlled to mainly evaluate the effect of different particle sizes of the solid lipid particulate systems on drug dissolution behavior and oral bioavailability. The results showed that genistein-loaded solid lipid microparticles and nanoparticles exhibited a considerably increased drug dissolution rate compared to that of genistein bulk powder and suspension. The microparticles gradually released genistein as a function of time while the nanoparticles exhibited a biphasic drug release pattern, showing an initial burst drug release, followed by a sustained release. The oral bioavailability of genistein loaded in solid lipid microparticles and nanoparticles in rats was also significantly enhanced compared to that in bulk powders and the suspension. However, the bioavailability from the microparticles increased more than that from the nanoparticles mainly because the rapid drug dissolution rate and rapid absorption of genistein because of the large surface area of the genistein-solid lipid nanoparticles cleared the drug to a greater extent than the genistein-solid lipid microparticles did. Therefore, the findings of this study suggest that controlling the particle size of solid-lipid particulate systems at a micro-scale would be a promising strategy to increase the oral bioavailability of genistein.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.17 no.2
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• pp.98-102
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• 2006

Background and Objectives : Voice onset time(VOT) is defined as the time interval from oral release of a stop consonant to the onset of glottal pulsing in the following vowel. VOT is a temporal characteristics of stop consonants that reflects the complex timing of glottal articulation relative to supraglottal articulation. Stop consonants are characterized by creation of a pressure difference across a complete occlusion in the vocal tract, followed by a sudden release 'burst' due to opening that occlusion. The objects of this study is to evaluate a usefulness of voice onset time in the assessment of voice disorderd patients. Subjects : Subjects were 20 adults with normal voice and with benign laryngeal disorders. Subjects with voice disorders represented the following vocal pathologies : vocal polyp, vocal nodule, Reinke's edema and unilateral vocal fold paralysis(UVFP). Control subjects were matched for age (21-40 yews old) and sex(male) with the voice disorders subjects and had normal vocal qualities with no history of voice disorders. Methods : Each voice-disordered and matched control subject read the test passages containing three types of Korean bilabial consonants. VOT measures were made for the initial $/p/p^h/\;and\;/p'/$. VOT was measured using acoustic waveform or wide band spectrogram. Results : For each voiceless stop consonants, there was a significant difference in VOT between the voice disordered and normal subjects. The mean VOTs of the lax stops in UVFP was significantly shorter than those of control subjects in the UVFP. The mean VOTs of the aspirated stops in the vocal polyp and nodule were longer than those of control subjects, but not significant. The mean VOTs of the glottalized in voice disordered groups were longer than those of control subjects, and significant statistically in the UVFP. Conclusions : VOT may be a clinically useful acoustic parameter in the assessment of voice disordered patients, especially in the unilateral vocal fold paralysis.

• Applied Microscopy
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• v.31 no.3
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• pp.275-285
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• 2001

The pulmonary alveolar macrophage is thought to play an important role in the mediation of acute inflammatory lung injury by secretory products including degraded enzymes, cytokines, and reactive oxygen metabolites . This study was conceived to understand the role of alveolar macrophage in oxidative stress induced acute lung injury. To examine the alveolar macrophages and xanthine oxidase (XO) activity in bronchoalveolar lavage fluid (BALF), time-dependent changes of numbers of alveolar macrophages, monocytes and neutrophils in alveolar cavity were counted in association with ultrastructural and cytochemical observations of lung tissue and alveolar cells. The number of monocytes was increased (p<0.001) at 1h after IL-1 treatment compared with that of sham. At 2h after instillation of IL-1, the number of alveolar macrophages was the highest, XO activity in BALF was elevated at 2h after IL-1 instillation and the activity was markedly elevated(p<0.05) at 3h after IL-1 treatment. On the basis of these experimental results, it is suggested that, during early phase of acute lung injury induced by IL-1, alveolar macrophage-derived XO contributes to lung injury earlier than the neutrophilic respiratory burst.