• The Korean Journal of Pain
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• v.18 no.2
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• pp.99-106
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• 2005

Background: Cyclic guanosine monophosphate (cGMP) and opioid receptors are involved in the modulation of nociception. Although the opioid receptors agonists are active in pain, the effect of an phospodiesterase inhibitor (zaprinast) for increasing the level of cGMP has not been thoroughly investigated at the spinal level. This study examined the effects of intrathecal zaprinast and morphine in a nociceptive test and we also examined the nature of the pharmacological interaction after the coadministration of zaprinast with morphine. The role of the nitric oxide (NO)-cGMP-potassium channel pathway on the effect of zaprinast was further clarified. Methods: Catheters were inserted into the intrathecal space of male SD rats. For the induction of pain, $50{\mu}l$ of 5% formalin solution was applied to the hindpaw. Isobolographic analysis was used for the evaluation of the drug interaction between zaprinast and morphine. Furthermore, NO synthase inhibitor ($_L-NMMA$), guanylyl cyclase inhibitor (ODQ) or a potassium channel blocker (glibenclamide) were intrathecally administered to verify the involvement of the NO-cGMP- potassium channel pathway on the antinociception effect of zaprinast. Results: Both zaprinast and morphine produced an antinociceptive effect during phase 1 and phase 2 in the formalin test. Isobolographic analysis revealed a synergistic interaction after the intrathecal administration of the zaprinast-morphine mixture in both phases. Intrathecal $_L-NMMA$, ODQ and glibenclamide did not reverse the antinociception of zaprinast in either phase. Conclusions: These results suggest that zaprinast, morphine and the mixture of the two drugs are effective against acute pain and they facilitated pain state at the spinal level. Thus, the spinal combination of zaprinast with morphine may be useful for the management of pain. However, the NO-sensitive cGMP-potassium channel pathway did not contribute to the antinocieptive mechanism of zaprinast in the spinal cord.

• Nuclear Engineering and Technology
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• v.45 no.7
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• pp.941-950
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• 2013

The Korean Nuclear-Hydrogen Technology Development (NHTD) Plan will be performing irradiation testing of coated particle fuel at HANARO to support the development of VHTR in Korea. This testing will be carried out to demonstrate and qualify TRISO-coated particle fuel for use in VHTR. The testing will be irradiated in an inert gas atmosphere without on-line temperature monitoring and control combined with on-line fission product monitoring of the sweep gas. The irradiation device contains two test rods, one has nine fuel compacts and the other five compacts and eight graphite specimens. Each compact contains about 260 TRISO-coated particles. The irradiation device is being loaded and irradiated into the OR5 hole of the in HANARO core from August 2013. The device will be operated for about 150 effective full-power days at a peak temperature of about $1030^{\circ}C$ in BOC (Beginning of Cycle) during irradiation testing. After a peak burn-up of about 4 atomic percentage and a peak fast neutron fluence of about $1.7{\times}10^{21}\;n/cm^2$, PIE (Post-Irradiation Examination) of the irradiated coated particle fuel will be performed at IMEF (Irradiated Material Examination Facility). This paper reviews the design of test rod and irradiation device for coated particle fuel, and discusses the technical results for irradiation testing at HANARO.

• The Journal of Korean Academic Society of Nursing Education
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• v.9 no.2
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• pp.234-243
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• 2003

The researcher has studied the types of accidents and injuries that most often occur to infants, toddlers and preschool children. Using this knowledge, a first aid program was developed for mothers. This researcher used a Quasi experimental study which consisted of a nonequivalent control group pretest - posttest design for injury first-aid knowle. The experimental group consisted of 32 mothers, and the control group consisted of 29. The education program consisted of the types of injury, the structure and function of skin, the methods of obsevation, first-aid awareness, and the standard of professional support in case of contusion, abrasion, laceration, fracture and burn. The education program was developed and based on 'the systemetic design of instruction' by Dick & Carey(1996) and utilized multimedia text book, pictures, examples, practice and discussions to increase understanding and effectiveness of learning. The data for this study was collected from September to early November, 2001. There were two fomative evauations, pretest and posttest with an intervention of education program. The analysis of the collected data was analyzed by descriptive analysis, ANOVA, t-test and paired t-test using the SPSS 10.0 program. The results as follows; 1. The experimental group, who was given an education program before the test, got higher marks on the injury first-aid knowledge than the control group. There was a significant difference in knowledge between experimental group and control group(t=6.578, p=.000). 2. The experimental group got higher marks on the action evaluation than the control group. There were significant differences in the certainity of action (t=8.546, p=.000) and the accuracy of action (t=7.654, p=.000) between experimental group and control group. This study examined how a first aid education program increased effectiveness in the knowledge and action of injury first-aid.

• International Journal of Automotive Technology
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• v.8 no.6
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• pp.667-674
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• 2007

Various types of NOx storage catalysts for NGV's were designed, manufactured, and tested in this work on a model gas test bench. As in most of other studies on NOx storage catalyst, alkaline earth metal barium(Ba) was used as the NOx adsorbing substance. The barium-based experimental catalysts were designed to contain different amounts of Ba and precious metals at various ratios. Reaction tests were performed to investigate the NOx storage capacity and the NOx conversion efficiency of the experimental catalysts. From the results, it was found that when Ba loading of a catalyst was increased, the quantity of NOx stored in the catalyst increased in the high temperature range over 350. With more Ba deposition, the NOx conversion efficiency as well as its peak value increased in the high temperature range, but decreased in the low temperature range. The best of de-NOx catalyst tested in this study was catalyst B, which was loaded with 42.8 g/L of Ba in addition to Pt, Pd and Rh in the ratio of 7:7:1. In the low temperature range under $450^{\circ}C$, the NOx conversion efficiencies of the catalysts were lower when $CH_4$, instead of either $C_3H_6$ or $C_3H_8$, was used as the reductant.

• Journal of Pharmaceutical Investigation
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• v.27 no.2
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• pp.139-143
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• 1997

Epidermal growth factor (EGF) is a mitogen which activate the proliferation of basal cells in skin, which implicate the wound healing in severe skin damage such as burn. To carry out the preclinical test for the pharmacological action of EGF, EGF in transdermal delivery system must be stable. Since EGF is a protein susceptible to proteolysis and unstable in aqueous solution, in vitro stabilization of EGF is prerequisite for the formulation. In this study, effect of additives on the stability of EGF is investigated in vitro. The stability of EGF in aqueous solution was enhanced with the various water-soluble polysaccharides such as HPMC, sorbitol, mannitol and dextrin. EGF was successfully extracted from the ointment with 5% HPMC solution, and EGF in aqueous solution and ointment was also successfully stabilized with 5% HPMC. The ointments prepared with different amount of EGF were applied on the damaged dorsal skin of rats for the determination of optimal concentration of EGF. The ointment with EGF $(10\;{\mu}g/g)$ showed good wound healing action on the damaged skin of rats.

• Research in Community and Public Health Nursing
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• v.18 no.4
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• pp.643-650
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• 2007

Purpose: This study was to obtain information regarding to agricultural accidents in farm workers in the Kyungpook area. Methods: A questionnaire survey was carried out for 528 workers from the 1st to 31st of March, 2007. Frequency, percentage, mean and chi-square test with the SPSS program were used to analyze the data. Results: The causes of agricultural accidents include falling(29.0%), overseeing(18.9%), traffic accident(17.4%), putting between machinery(11.7%), crashing(5.3%), fire (0.6%) in the order of frequency. Injuries from agricultural accidents include fracture(44.7%) cerebral bleeding (10.4%), amputation(7.0%), airway obstruction (2.3%) burn(1.9%), drug addiction(1.9%) in the order of frequency. The largest proportion of the subjects of hospital treatment were in their 50s and belonged to the group of high-level economic state. Agricultural machinery collision was the most frequent cause among the subjects of hospital treatment. Conclusion: These results suggest that carelessness can be a potential risk factor for agricultural accidents in farm workers. These findings may give useful information for developing agricultural accident prevention programs for farm workers.

• Advances in nano research
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• v.16 no.2
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• pp.127-140
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• 2024

Upon direct/indirect exposure to flame or heat, composite structures may burn or thermally buckle. This issue becomes more important in the natural fiber-based composite structures with higher flammability and lower mechanical properties. The main goal of the present study was to obtain an optimal eco-friendly composite system with low flammability and high thermal buckling resistance. The studied composite consisted of polypropylene (PP) and short abaca fiber (AF) with eggshell powder (ESP) and halloysite clay nanotubes (HNTs) additives. An optimal base composite, consisting of 30 wt.% AF and 70 wt.% PP, abbreviated as OAP, was initially introduced based on burning rate (BR) and the Young's modulus determined by horizontal burning test (HBT) and tensile test, respectively. The effects of adding ESP to the base composite were then investigated with the same experimental tests. The results indicated that though the BR significantly decreased with the increase of ESP content up to 6 wt.%, it had a very destructive influence on the stiffness of the composite. To compensate for the damaging effect of ESP, small amount of HNT was used. The performance of OAP composite with 6 wt.% ESP and 3 wt.% HNT (OAPEH) was explored by conducting HBT, cone calorimeter test (CCT) and tensile test. The experimental results indicated a 9~23 % reduction in almost all flammability parameters such as heat release rate (HRR), total heat released (THR), maximum average rate of heat emission (MARHE), total smoke released (TSR), total smoke production (TSP), and mass loss (ML) during combustion. Furthermore, the combination of 6 wt.% ESP and 3 wt.% HNT reduced the stiffness of OAP to an insignificant amount by maximum 3%. Moreover, the char residue analysis revealed the distinct differences in the formation of char between AF/PP and AF/PP/ESP/HNT composites. Afterward, dilatometry test was carried out to examine the coefficient of thermal expansion (CTE) of OAP and OAPEH samples. The obtained results showed that the CTE of OAPEH composite was about 18% less than that of OAP. Finally, a theoretical model was used based on first-order shear deformation theory (FSDT) to predict the critical bucking temperatures of the OAP and OAPEH composite plates. It was shown that in the absence of mechanical load, the critical buckling temperatures of OAPEH composite plates were higher than those of OAP composites, such that the difference between the buckling temperatures increased with the increase of thickness. On the contrary, the positive effect of CTE reduction on the buckling temperature decreased by raising the axial compressive mechanical load on the composite plates which can be assigned to the reduction of stiffness after the incorporation of ESP. The results of present study generally stated that a suitable combination of AF, PP, ESP, and HNT can result in a relatively optimal and environmentally friendly composite with proper flame and thermal buckling resistance with no significant decline in the stiffness.

• Journal of the Korean Society of Safety
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• v.22 no.4
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• pp.20-25
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• 2007

Instrument transformers are a safe measurement device designed to measure high voltage and large current. A current transformer(CT) is a type of instrument transformer designed to provide a current in its secondary winding proportional to the current flowing in its primary. It is commonly used in metering and protective relaying in the electrical power industry where it facilitates the safe measurement of large current. But, care must be taken that the secondary of a current transformer is not disconnected from its load while current is flowing in the primary, as this will produce a dangerously high voltage across the open secondary, and may permanently affect the accuracy of the transformer. Especially, industrial disaster such as an electric shock and/or a burn accident occurs occasionally by disregard of warning or attention. In this paper, we developed the detector for open of current transformer secondary terminal, and which was tested by the Korea Electrotechnology Research Institute. Test results show that Current Transformer secondary Open Detector(CTOD) interrupted within one second electronically when the 2nd terminal of current transformer opened.

• Journal of the Microelectronics and Packaging Society
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• v.19 no.4
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• pp.45-50
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• 2012

A family of multi-die DRAM packages was developed that incorporate the full functionality of an SODIMM into a single package. Using a common ball assignment analogous to the edge connector of an SODIMM, a broad range of memory types and assembly structures are supported in this new package. In particular DDR3U, LPDDR3 and DDR4RS are all supported. The center-bonded DRAM use face-down wirebond assembly, while the peripherybonded LPDDR3 use the face-up configuration. Flip chip assembly as well as TSV stacked memory is also supported in this new technology. For the center-bonded devices (DDR3, DDR4 and LPDDR3 ${\times}16$ die) and for the face up wirebonded ${\times}32$ LPDDR3 devices, a simple manufacturing flow is used: all die are placed on the strip in a single machine insertion and are sourced from a single wafer. Wirebonding is also a single insertion operation: all die on a strip are wirebonded at the same time. Because the locations of the power signals is unchanged for these different types of memories, a single consolidated set of test hardware can be used for testing and burn-in for all three memory types.

• Transactions of the Korean Society of Automotive Engineers
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• v.9 no.5
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• pp.46-53
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• 2001

To optimize the intake flow condition in the heavy-duty LPG SI engine, five different swirl ratios of intake port were investigated experimentally by oil spot method, LDV and single cylinder engine test. The flow characteristics near the piston surface were observed by oil spot method and magnitudes of swirl flow were measured quantatively by LDV method in the steady flow rig. The engine performances of various swirl flow were also tested with the heavy-duty LPG SI single cylinder engine. In the results, high swirl ratio, above $R_s$=2.3, was not suitable to develope a stable flame kernel and to produce high engine performance. Especially it was more serious under lean burn conditions, since turbulence intensity was smaller than bulk flow though those are increased together. These results were also confirmed by LDV measurement and oil spot method. On the contrary, low swirl ratio($R_s$=1.3) is not good to propagate a flame since the turbulence intensity and bulk flow are vanished during compression stroke and low swirl ratio has too weak initial energy for stable combustion. Therefore, the of optimized swirl ratio f3r the heavy-duty LPG engine in this work was found around $R_s$=2.0.