• Korean Journal of Medicinal Crop Science
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• v.4 no.2
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• pp.145-152
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• 1996

The dietary Root Powder Mixture of Angelicae gigantis Radix and Bupleurum falcatum Linne (RPM of AGR & BFL) was feded for 6 weeks to added 0. 0, 0. 4, 1. 0, 2. 0% respectively in the broiler diets. The ,RPM of AGR & BFL was found to be palatable as birds consumed moreyof the test diets than the control diet. The BW gain of 1. 0% RPM of AGR & BFL group was higher than the control group. Feed efficiency (F/G) was improved significantly (P by feeding of 1. 0% RPM of AGR & BFL diet. The carcass weight was improved by feeding with 1. 0% added diet and the carcass ratio was increased in added diets. The amounts of chest meat and drumsticks were heaver in 0. 4% added deit than control. There was no consistent trend in various organ weight by the addition of RPM of AGR & BFL. Fat accumulation of abdominal and gizzard surrounding was highly measured in the broiler fed 0. 4% RPM of AGR & BFL diet. Total serum protein, cholesterol and triglyceride contents were tended to increased with 2. 0% RPM of AGR & BFL ration, and in the 1. 0% addled diet to enhenced BW gain total serum protein, cholesterol and triglyceride concentration were analyzed the lowest among treatments.

• KSBB Journal
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• v.29 no.3
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• pp.210-219
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• 2014

Sayuksan has been widely applied to treat a variety of diseases such as acute hepatitis, gastritis, and colitis. Sayuksan consists of medicinal herbs such as Glycrrhizae uralensis Fischer, Paeonia lactiflora Pallas, Bupleurum falcatum Linne, and Poncirus trifoliata Rafinesqul. Methanol extracts (1 mg/mL) from the four kinds of medicinal herbs did not show antibiotic activities against general test strains and multi-drug resistant strains. The antibacterial activity of fermented medicinal herbs extracts with Lactobacillus spp. strain was confirmed as Gram-positive bacteria which are higher than Gram-negative bacteria. Extracts of Glycrrhizae uralensis Fischer fermented with Lb. casei KCTC 3109 displayed inhibitory diameters of 16 mm against Pseudomonas aeruginosa P01828. Superoxide dismutase (SOD)-like activity of the medicinal herb extracts was not determined, but the extract of Paeonia lactiflora Pallas fermented with six strains of Lactobacillus spp. had the highest antioxidant activity. SOD-like activity of Paeonia lactiflora Pallas extracts fermented by Lb. brevis KCTC 3498 was $41.4{\pm}0.8%$, which was the highest antioxidant activity among the fermented extracts with the other medicinal herbs.

• Korean Journal of Oriental Medicine
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• v.18 no.2
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• pp.151-157
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• 2012

In this research, the genotoxic effect of Bupleuri Radix (BR), the dried roots of Bupleurum falcatum Linne has been traditionally used as anti-inflammatory agent, was evaluated using the mouse micronucleus test. BR aqueous extract (yield = 16.52%) was administered once a day for 2 continuous days by oral gavage to male ICR mice at doses of 2,000, 1,000 and 500 mg/kg. Cyclophosphamide (CPA) 70 mg/kg was used as a known genotoxic agent in a positive control. The appearance of a micronucleus (MN) in polychromatic erythrocyte (PCE) is used as an index for genotoxic potential, and PCE ratio is used as an index of cytotoxicity. Although significant (p<0.01) increase of the number of PCE with one or more nuclei (MNPCE) was detected in CPA treated groups, no significant increases of MNPCE numbers were observed in all three different dosages of BR extracts treated mice with over 0.30 of the individual polychromatic erythrocyte ratio in all mice used in this study. The results obtained indicated that BR extract shows no genotoxicity effects up to 2,000 mg/kg dosing levels the limit dosage in rodents.

• The Korea Journal of Herbology
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• v.35 no.5
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• pp.23-31
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• 2020

Objectives : This study was conducted to evaluate the anti-hyperlipidemia effect of Scutellariae Radix, Aucklandiae Radix and Bupleuri Radix(SAB). Methods : FL83B cells were mouse liver hepatocytes, and we used this cell line. FL83B cells were treated with 0.5 mM oleic acid(OA) for 24 h, SAB extract was treated. After OA treatment, intracellular triglyceride (TG) and free fatty acid contents were measured with AdiopoRed™ assay and Free Fatty Acid Quantitation assay kit, respectively. Further, we evaluated several lipogenesis and metabolic markers such as sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), 3-hydroxy3-methyl-glutaryl CoA reductase (HMGCR), hormone-sensitive lipase (HSL), carnitine palmitoyltransferase (CPT-1), peroxisome proliferator activated receptor alpha (PPARα), and cluster of differentiation (CD36) using RT-PCR and Western-blot analysis. Results : OA markedly increased intracellular TG and free fatty acid, which plays a key role in reducing hepatic lipid accumulation, in FL83B cells. These increases were alleviated by SAB extract. The mRNA and protein expression of Fatty acid(FA) oxidation factors (CPT-1, PPARα), lipolysis factor(HSL), FA transporter(CD36), cholesterol synthesis factors (HMGCoA) and Lipodenesis (SREBP-1c, FAS, and ACC-1) were significantly increased by treatment of SAB extract in the OA-induced fatty liver cell model. Conclusions : In summary, the treat of SAB extract showed a significant reduction of the influx of fatty acids into hepatocytes, promoted the oxidation of fatty acids, and regulated fat synthesis-related factors, thereby regulating the accumulation of TG and free fatty acids.

• Korean Journal of Medicinal Crop Science
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• v.3 no.3
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• pp.187-194
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• 1995

The male broiler chichens (Hibreed Ross P. S 120 birds) were experimented for 6 weeks in cage. while experimental diets were feded to addition 0, 0, 0. 2, 0. 5 and 1.0% levels with Root Powder of Bupleurum Falcatum Linne (RPBFL). The results were as following; The tast of RPBFL added diets was favorite as the feed intake of RPBFL diets were increased than control diet. Body weight gain (1. 845g) in 1. 0% RPBFL diet was higher enhenced by 226g/per bird than control (1. 619g). was effected above 14%. Feed re­quierment was the lowest by 2. 02 in control, and was significantly enhenced to 1. 81 in 1. 0% RPBFL diet (P<0. 01). The amounts of carcass ratio were significantly defferent effected from the broilers feding diet added with 1. 0% RPBFL (P<0. 01). Greater amounts of chest meat was produced by 253g from the broilers fed diet added 1. 0% RPBFL, was enhenced 42g than the control broilers. The chest meat vs live body weight ratio was increaced in 1. 0% added diet. According to the tendency be increased' of the RPBFL levels, the drumst­ick weight was enhenced with 1. 0% RPBFL diet. The ratio of the drumstick vs live body weight was im­proved in 1. 0% RPBFL diet. The weights of liver. spleen, heart and gizzard were heavied according to live body weight, then was improved in 1. 0% RPBFL diet. Fat accumulation (abdominal and gizzard sur­rounding) was greater abserved by 50. 12g from the broiler fed ration with 1. 0% RPBFL. Content of total serum protein was high concetration in control, then was decrased by RPBFL level. Total serum cholesterol and triglyceride contents were increased in proportion to fat accumulation ratio.

• Journal of Oriental Neuropsychiatry
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• v.25 no.2
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• pp.179-190
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• 2014

Objectives: This study was performed to review the research trends regarding the treatment of Postpartum Depression (P.P.D) in the Traditional Chinese Medicine (TCM). Methods: We searched articles in CNKI (China National Knowledge Infrastructure) from 2004 to 2013. Search key words were "产后抑郁症", "Postpartum Depression", and we selected 27 studies except for non-clinical studies, insufficient number of studies, unrelated studies and tests on animals. Results: We selected 27 articles with following results: 1) One study of Jadad Quality Assessment Scale score showed 3 points, 4 studies showed 2 points and 22 studies showed less than 1 point. Overall, the quality of the studies was low. 2) DSM - IV was frequently used as a diagnostic criteria and HAMD was mostly used as evaluation criteria. Diagnostic criteria and evaluation criteria were the same in HAMD and EPDS. 3) In TCM, there are various ways, such as herbal medicine, acupuncture, electro acupuncture, auricular acupuncture and/or massage to treat the postpartum depression. 4) The roots of Bupleurum falcatum Linne, Glycyrrhiza uralensis Fisch, Angelica gigas Nakai and Paeonia lactiflora Pall, the rhizome of Atractylodis macrocephala Koidz, the semen of Zizyphus jujuba Mill, the radix of Curcuma aromatica Salisb, the sclerotium of Poria cocos Wolf and the rhizomas of Cyperus rotundus L and of Cnidium officinale Makino are mainly used in the herbal medicine. BaekHoi (GV20) and Yindang (Ex-HN3) are mainly used in acupuncture points. 5) Most of the studies showed effective results. Some of the results were similar to those of the control groups which were cured by western medicine. Other results were better than those of control groups. Conclusions: Research on postpartum depression has been actively conducted in TCM and all studies showed effective results in the study group patients. Therefore, with this study, we hope to activate more clinical research on the treatment of patients in Korean traditional medicine.