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The Influence of Estrogen on Dopamine Metabolites in Schizophrenia (정신분열병에서 도파민 대사물에 대한 에스트로겐의 영향)

  • Cheon, Jin-Sook;Lee, Jang-Hyun;Oh, Byoung-Hoon
    • Korean Journal of Biological Psychiatry
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    • v.6 no.2
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    • pp.209-218
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    • 1999
  • Objectives : The aims of this study were to discriminate the clinical differences, to measure the estrogen and homovanillic acid levels, to evaluate a correlation between estrogen and homovanillic acid, and to identify an association of cognitive deficit with estrogen and homovanillic acid among male and female schizophrenics. Methods : In addition to the structured interviews, the plasma estrogen levels by radioimmunoassay and the homovanillic acid levels by HPLC were measured in 20 male and 21 female schizophrenics as well as 10 healthy male and 9 female controls. Results : 1) The plasma estrogen levels were higher in females than males, and significantly higher in female schizophenics than female controls. The homovanillic acid levels were higher in female schizophrenics than female controls, and were lower in male schizophrenics than male controls. 2) The onset age seemed to be earlier in male schizophrenics, and the frequency of admission, duration of antipsychotic drug administration, dosage of antipsychotics and duration of illnesses were more in males. The estrogen and homovanillic acid levels were significantly higher in female schizophrenics. 3) The estrogen levels had a significant positive correlation with sex, age and onset age, while the homovanillic acid levels did with sex. However, estrogen were not correlated with homovanillic acid levels. 4) The estrogen and homovanillic acid levels were not significantly different between male and female schizophrenics with cognitive deficits. In the schizophrenic patients without cognitive deficits, the estrogen levels were significantly higher in females, while there were no significant sex differences in homovanillic acid. 5) In the male and female schizophrenics predominantly with negative symptoms, there were no significant differences in estrogen and homovanillic acid levels. In those predominantly with positive symptoms, the estrogen levels were significantly higher in females, while there were no sex differences in homovanillic acid levels. 6) In schizophrenics with undifferentiated subtype, the estrogen and homovanillic acid levels were significantly higher in females. In those with paranoid or disorganized subtypes, the estrogen levels were significantly higher in females, while there were no sex differences in the homovanillic acid levels. 7) The mean values of PANSS-negative, PANSS-total, PANSS-CF, MMSE-K and estrogen levels were significantly higher in male schizophrenics with cognitive deficits. The mean values of illness duration, CGI, PANSS-positive, PANSS-negative, PANSS-total, PANSS-CF and MMSE-K were significantly higher in female schizophrenics with cognitive deficits. 8) The variables which showed significant correlation with cognitive deficits were PANSS-negative, PANSS-total, PANSS-CF, MMSE-K and estrogen levels in male schizophrenics. The variables which showed significant correlation with cognitive deficits were subtypes, onset age, illness durataion, CGI, PANSS-positive, PANSS-negative, PANSS-total, PANMSS-CF and MMSE-K in female schizophrenics. The estrogen levels were significantly correlated with admission frequencies, history of antipsychotic administration, duration of antipsychotic administration and cognitive deficits in male schizophrenics, while age were not correlated with in females. The homovanillic acid levels had a significant correlation with subtypes and onset age in male schizophrenics, while there were no correlation among variables in females. Conclusions : Although the plasma concentrations of estrogen and homovanillic acid in female schizophrenics were significantly higher than males, we could not find an association between them. Furthermore, the various factors affecting on the cognitive deficits, estrogen and homovanillic acid levels seemed to be somewhat different according to sex.

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Effect of Bright Light Exposure on Adaptation to Rapid Night Shift : A Field Study of Shift Work Nurses in Psychiatric Ward (순환제교대근무자에서 야간 근무 적응에 대한 광치료 효과)

  • Ko, Young-Hoon;Joe, Sook-Haeng
    • Sleep Medicine and Psychophysiology
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    • v.9 no.1
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    • pp.41-47
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    • 2002
  • Objectives: In a number of simulated night shift studies, timed exposure to bright light improves sleep quality and work performance. We evaluated the effect of bright light on adaptation to night shift work with a field study. Methods: Five female nurses working shifts at Korea University Hospital were recruited for participation in this study. We investigated two series of six consecutive shift rotations comprising three day and three night shifts, using wrist Actigraphy, the Stanford Sleepiness Scale, Visual-analogue scales, STIM and tympanic membrane temperature for daytime sleep quality, alertness, subjective feeling, attention performance, and temperature rhythm. The subjects were exposed to bright light (2,500 lux) from 24:00 to 04:00 a.m. on three consecutive night shifts during the second series, whereas they worked under normal lightening (650 lux) conditions during the first series. Results: Actigraphic assessment of daytime sleep showed no significant difference between the first and third night shift in both baseline and light exposure phase. The mean lowest temperature shifted earlier during baseline phase but not during the light exposure phase. Also, the score for subjective feelings of depression, anxiety, physical discomfort and sleepiness was significantly higher in the third night shift than the first during baseline phase but not during the light exposure phase. Attention and attention switching ability was significantly improved in the third night shift compared to the first night during the light exposure phase but there were no significant changes during the baseline phase. Conclusion: This result suggests that there were no significant differences between the two phases in measures of quality of daytime sleep, but subjective feelings, attention and alertness were enhanced during light exposure. Although some placebo effects and learning effects might influence this result, bright light exposure between midnight and 4:00 a.m. may improve adaptation to night shift. In future, further controlled studies with a larger sample size, including melatonin measurement, are needed for real shift workers.

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Movement of the Silla-the Tang army and Baekje military deployment (나(羅)·당(唐) 군의 이동과 백제군 배비 - 서기 660년 -)

  • Yoon, Il-Young
    • Journal of National Security and Military Science
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    • s.13
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    • pp.137-658
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    • 2016
  • 1. Movement of the leaders of the Silla army The leaders of the Silla army traveled from Gyeongju(경주) to Icheon (이천), Deokjeokdo(덕적도) Island, and Hwangsanwon(황산원) during the period of the Against Baekje(백제) War that began in 660. Movement route between Gyeongju and Icheon : Gyeongju(경주)-Daegu(대구)-Gumi(구미)-Gimcheon(김천)-Chupungryeong(추풍령)-Geumdol Fortress(금돌성)-Boeun(보은)-Jincheon(진천)-Juksan(죽산)-Bubal-eup(부발읍) Movement route between Bubal-eup and Deokjeokdo Island : Bubal-eup(부발읍)-Ipo(이포) Ferry-Haengju(행주) Ferry-Palmido (팔미도) Island-Seonjaedo(선재도) Island-Yeongheungdo(영흥도) Island-Pido(피도) Island-Soyado(소야도) Island-Deokjeokdo(덕적도) Island Movement route between Deokjeokdo Island and Hwangsan: Deokjeokdo(덕적도) Island-Danghangpo(당항포)-Jincheon(진천)-Boeun (보은)-Okcheon(옥천)-Geumsan(금산)-Tanhyeon(탄현)-Hwangsan (황산)-Ganggyeong(강경)-Buyeo(부여) 2. Movement of the combat units of the Silla army Jincheon area : 4,325 persons of the Geupdang unit(急幢) and 611 persons of the Kaegeumdang unit(罽衿幢) were deployed. These units moved from Jincheon to Cheongju, Yeongi, and Gongju, and contained Ungjin Fortress(熊津城) (6,650 Baekje troops). Boeun area : 4,763 persons of the Daedang(大唐) unit, 3,548 persons of the Hajujeong unit(下州停), 3,017 persons of the Namcheonjeong unit(南川停), and 4,500 persons of the Saseoldang unit(四設幢) were deployed. These units moved from Boeun(보은) to Okcheon(옥천), Geumsan(금산), Tanhyeon,(탄현) and Hwangsan(황산). Geumdol Fortress area : 3,753 persons of the Sangjujeong unit(上州停), 5,762 persons of the Seodang unit(誓幢), 3,753 persons of the Guidang unit(貴幢), and 5,562 persons of the Nangdang uni(郎幢)t were deployed. These units moved from Geumdol Fortress to Hwanggan(황간), Yeongdong(영동), Geumsan(금산), Tanhyeon(탄현), and Hwangsan(황산). Jirye area: 3,017 persons of the Eumrihwajeong unit(音里火停) and 3,017 persons of the Ehwahyejeong unit(伊火兮停) were deployed. These units moved from Jirye(지례) to Juchiryeong(走峙嶺), Mupung (무풍), Muju-eup(무주읍), and Bunam-myeon(부남면) in Muju-gun. Goryeong area: 3,017 persons of the Samryanghwajeong unit(三良火停) and 3,017 persons of the Sosamjeong unit(召參停) were deployed. These units moved from Goryeong(고령) to Geochang(거창), Hamyang(함양), Namwon(남원), Sunchang(순창), and Jeongeup(정읍). 3. Movement of the Tang army Dangjin area(당진 방면) : 1,000 persons were deployed. These units moved from Dangjin(당진) to Myeoncheon(면천), Yesan(예산), and Imjon Fortress(임존성). Garijeo area(가리저 방면) : 1,000 persons were deployed in the Garijeo(加里渚) area. These units moved from Garijeo(가리저) to Myeoncheon(면천), Yesan(예산), and Imjon Fortress(임존성). Geumganggu area(금강구 방면) : 000 persons were deployed. These units moved from Geumganggu(금강구) to Ganggyeong(강경) and Sabi Fortress(사비성). 4. Baekje military deployment Total troops of the Baekje army : There were 60 thousand Baekje troops according to the Old Book of Tang(舊唐書). Troop deployment by the Baekje army: 62,230 persons were deployed in 15 regions: 1,000 in Dangjin(당진), 1,000 in Garijeo(가리저), 6,120 in Imjon Fortress(임존성), 1,120 in Namjam Fortress(남잠성), 1,350 in Dooryangyun Fortress(두량윤성), 870 in Wangheungsajam Fortress(왕흥사잠성), 6,650 in Ungjin Fortress(웅진성), 1,120 in Jinhyeon Fortress(진현성), 1,000 in Dooshiwonak(두시원악), 1,000 in Irye Fortress(이례성), 5,000 in Gosaburi Fortress(고사부리성), 5,000 in Gujiha Fortress(구지하성), 3,000 plus 3,000 in Gibeolpo and Yangan(기벌포 양안), 5,000 in Deukan Fortress(득안성), and 20,000 in Sabi Fortress(사비성).

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A study on Teacher Perception and Classroom Practice of Practical Problem-Focused Home Economics Instruction (실천적 문제 중심 가정과 수업에 대한 교사의 인식과 실행에 관한 연구)

  • Go, Mi-Young;Yu, Nan-Sook
    • Journal of Korean Home Economics Education Association
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    • v.23 no.1
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    • pp.159-176
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    • 2011
  • The purpose of this study was to investigate 1) how the middle school Home Economics teachers perceive the importance of the practical problem-focused instruction, 2) how often they perform the instruction, and 3) what they require for the implementation the instruction. Data were collected from 150 Home Economics teachers via e-mail survey and from 6 Home Economics teachers' face-to-face interviews. Descriptive statistics including frequency, percentage, average, and standard deviation, and the results of such analyses as ANOVA, T-test, and correlation were reported using SPSS/win 10.1. The results of this research were as follows: First, even though the majority of the respondents recognized the high need for practical problem-focused instruction, only a small portion of the respondents reported that they performed that instruction in the classroom. There was no correlation between the perception of the need for practical problem-focused instruction and the degree of performance of practical problem-focused instruction. Secondly, the of performance of practical problem-focused instruction was significantly different depending on the years of teaching experience and the subject that the teachers majored in. Job satisfaction had positive correlations with the perception of the need for practical problem-focused instruction and the degree of performance of practical problem-focused instruction. Thirdly, the more teachers shared information and materials with colleagues, the better they tended to be at practical problem-focused instruction. On the other hand, insufficient time for their instruction and a deficiency in understanding the rationale of the instruction were pointed out as barriers to classroom practice. The respondents answered that long-term training programs on the philosophical foundation of practical problem-focused instruction, materials related to the instruction as well as additional credits for Home Economics are most critical to reduce the discrepancy between the teacher perception and the classroom practice of practical problem-focused instruction.

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Middle school Home Economics teachers' perception and actual performance of self-supervision at school related to Home Economics (중학교 가정과 교사의 교과 관련 교내 자율장학에 대한 인식과 실태)

  • Go, Mi-Young;Chae, Jung-Hyun
    • Journal of Korean Home Economics Education Association
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    • v.22 no.4
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    • pp.91-107
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    • 2010
  • The purpose of this study was to investigate what middle school Home Economics(HE) teachers perceive, practice and need for self-supervision at school related to HE. Questionnaires were sent by E-mail and 150 were collected. Descriptive statistics including frequency, percentage, average, standard deviation, t-test and ANOVA analysis were reported using SPSS/win 10.1. The results of this research were as follows: First, middle school HE teachers perceived that self-supervision at school was essential since it promoted self reflection of teachers themselves and improved professional skills. Furthermore, peer-coaching was highly preferred. Second, negative responses to the supervision of principal, vice-principal, and peer teachers overwhelmed positive answers. Information exchange among peer teachers was frequent, yet, approximately 22.6% of middle school HE teachers were still avoiding sharing information process for several reasons. About half of the teachers answered that all teachers needed to participate in this process. Third, they pointed out that self-supervision at school was not implemented well because of the lack of time due to the heavy work load, negative and passive attitude for the improvement of teaching-learning activities, administration-centered supervision that did not reflect teachers' opinion, and shortage of economical, and environmental support.. HE teachers perceived that peer teachers who were doing good practices were most helpful for the supervision. Also, they preferred self-evaluation at the end of the self-supervision at school. Forth, to improve self-supervision at school, there were very high demands for reduction of administrative work, additional time, fundamental philosophy toward HE education. Fifth, the purpose and detailed plans of self-supervision were recognized as the results that were democratically derived by the HE teachers. Sixth, class inspection and informal inspection were operated once in a year, and self-training was rarely operated. Peer coaching and self-coaching were operated occasionally. Self-coaching and peer coaching were reported as the most helpful types of supervision. In addition, HE teachers answered that supervision was helpful to teaching method followed by contents, evaluation, and philosophy of education.

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The Relationship between the Therapeutic Response to Antipsychotic Drugs and the Dopamine D2, D3, and D4 Receptor Gene Polymorphisms in Korean Schizophrenic Patients (한국인 정신분열병 환자에서 항정신병 약물의 치료 반응과 도파민 D2, D3 및 D4 수용체 유전자 다형성)

  • Kim, Hee-Cheol;Jung, Sung-Won;Kim, Dae-Kwang;Jung, Chul-Ho
    • Korean Journal of Biological Psychiatry
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    • v.14 no.3
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    • pp.167-176
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    • 2007
  • Objectives:A considerable number of pharmacogenetic studies have been performed in recent years to define the association of antipsychotic drug response with dopamine receptor polymorphisms. The purpose of this study was to investigate the relationship between the therapeutic response to antipsychotic drugs and the polymorphisms of the dopamine D2, D3, and D4 receptor genes(DRD2, DRD3 and DRD4, respectively). Methods:We conducted retrospective chart review of 200 consecutively hospitalized patients with the diagnosis of schizophrenia(DSM-IV) who were treated with various antipsychotics(94% atypical antipsychotics) at Bugok National Hospital, Korea. The patients were divided into two groups, responders and non-responders, by responsiveness to antipsychotic drugs according to a four-point scale used in previous studies; responders included moderate to marked responded patients and non-responders included none to minimal responded patients. We analyzed the Ser311Cys polymorphism in the DRD2, the Ser9Gly polymorphism in the DRD3, and the exon III 48 bp repeat polymorphism in the DRD4. Results:Among the total patients of 200, 141(70.5%) were categorized as responders. There were no significant differences in the frequencies of the DRD2, DRD3, and DRD4 alleles and genotypes between responders and non-responders. Conclusion:These results suggest that the Ser311Cys polymorphism in the DRD2, the Ser9Gly polym- orphism in the DRD3, and the exon III 48bp repeat polymorphism in the DRD4 are not associated with the therapeutic response to antipsychotic drugs in Korean schizophrenic patients. A larger prospective study is needed to elucidate the association between antipsychotic response and dopamine receptor gene polymorphism.

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A Study on Inventory and Grade Evaluation of the Visual Landscape Resource in Mt. Chiak National Park (치악산국립공원의 시각적 경관자원 인벤토리 구축 및 등급평가에 관한 연구)

  • Lee, Sook-Hyang
    • Journal of the Korean Institute of Landscape Architecture
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    • v.44 no.4
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    • pp.57-65
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    • 2016
  • This study was conducted a visual landscape resources inventory and grade assessment on natural resources and cultural resources of Chiaksan National Park. Landscapes of National Parks are categorized into four types: seascape, mountain landscape, village landscape, and temple historical landscape. Landscape lists were constructed for each district for a total of 120 lists through field research on 7 trails. The landscape list per trail has Guryong~Birobong(31%), Seungnam~Namdaebong(22%), Geumdae~Namdaebong(16%), Bugok~Hanenggu(165), Hwanggol~Ipseoksa(6%), Hyangrobong~Nandaebong(5%) and Godeunjae~Wontonggol(4%). Landscape Assessment items were divided into five characteristics of view, unique, use, history culture, natural reflected by item. Items were divided into three grades of landscape by 4, 3, 2, 1 for each item of the assessment criteria and Delphi survey. Mountain landscapes were assessed in I grade of 72 sites, II grade of 26 sites, III grade of 7 sites. Temple Historical landscapes were assessed in I grade of 4 sites, II grade of 7 sites, III grade of 4 sites. The study results can be used as a basis for mountain parks management. It is necessary to focus on managing the landscape of I grade site. The higher ratings of the Mountain landscapes are related to the view and natural score. Also, the grading of Temple Historical landscapes is related to the history cultural, natural and use score. In addition, the mountain landscape were identified as being included outside landscape resources, the place of landscape resources with outside ratings were higher and the view was related. Landscape management is needed for the conservation of Mountain landscape and Temple Historical landscape type rating as excellent areas on the basis of the results of the inventory and assessment. For future improvement the Guryong-Birobong trail is judged as a harmonious representative landscape of the Mountain and Temple Historical landscape and will require conservation as a focus management area. In the case of Mountain landscape improvements, maintenance such as pruning trees, wood observatory and interpretation sign for a landscape with minimal inhibitory landscaping is needed. When installing artificial facilities in the Temple Historical landscapes, the use of materials harmonizing with the surroundings landscape must be considered as well as the standards of facilities limitation.

A Study on Neurosis According to Experience of Sexual Abuse among Female High School Students in Taegu (대구지역 여고생들의 성(性)적 학대 경험에 관련된 신경증에 관한 연구)

  • Park, Hyung-Bae;Kim, Jin-Sung;Jang, Sang-Ruyl;Rho, Tae-Yong;Suh, Hye-Soo;Kim, Chang-Su;Lee, Kwang-Hun;Kim, Young-Uck
    • Journal of Yeungnam Medical Science
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    • v.12 no.1
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    • pp.113-123
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    • 1995
  • This study was intended to identify the neurotic traits related to sexual abuse in female high school students. The Neurosis Scale of Middlesex Hospital Questionnaire was conducted to 320 female high school students in Taegu, Korea from July 10 to July 17, 1994. The results were as follows: 1) The sexual abuse victim group showed significantly higher neurotic traits of Free floating anxiety (p<0.05), Phobic(p<0.01), Obsession(p<0.01), Somatic(p<0.05), Depression(p<0.01) than the control group. 2) The Neurotic traits of Somatic(p<0.01), Depression(p<0.01), Hysteric(p<0.01) were higher in the multiple-abused than the single-abused. 3) When the duration of being abused was concerned, subjects with more than 1 year duration had significantly higher neurotic traits of Obsession(p<0.05), Somatic(p<0.05), Depression(p<0.05) than subjects with less than 1 year duration. 4) The neurotic traits of Phobic, Somatic, Depression were significantly higher in the subjects with higher intensity of sexual abuse than with lower intensity. S) Among 68 victims, 31 girls(45%) were assaulted by strangers, 10(14%) were by relatives, 7(10.3%) were by siblings, 6(8.8%) were by neihbors. Among them, 34 girls(50%) bad counselling or psychotherapy and the people to whom they had sought for help were friends(23 girls; 68%), parents (7 girls; 11.7%) and mental health professonals (2 girls; 5.9%).

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An Elementary School Children Screen Test for Attention Deficit Hyperactivity Disorder in Taegu City (대구지역 국민학교 어린이의 주의력 결핍 과잉 운동 장애 경향에 대한 선별 검사)

  • Park, Hyung-Bae;Kim, Jin-Sung;Jang, Sang-Ruyl;Park, Sung-Chan;Suh, Hye-Sao;Lee, Kwang-Hun;Kim, Young-Uck;Kim, Chang-Su
    • Journal of Yeungnam Medical Science
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    • v.12 no.1
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    • pp.56-74
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    • 1995
  • The authors applied ADDES-HV parent evaluation scale for the purpose of screening test to 538 2nd grade elementary school students from March 1994 to May. The results were as follows: There was no differences in scores of ADHD between schools. In comparing the male and female between three school students, male students showed signifieant high scores (p<0.05) than female students in the score of ADDES-HV subscale and total. There was no significant differences in ADDES-HV scale between male students and female students in both ADHD patients and normal controls. In reliability test for test and retest, the reliability coefficient was higher satisfatorily and that of inattention was 0.80, inpulsivity was 0.69, hyperactivity was 0.63 and the total score was 0.82. In reliability test by internal consistancy, the Cronbach ${\alpha}$ coefficient of patient group was 0.85(p<0.05) and that of normal control was 0.84(p<0.05). The Concurrent validity between ADDES-HV scale and DSM-III-R scale was 0.57(p<0.05) in ADHD patient group and 0.84(p<0.05) in normal control group. In discriminant validity test between ADHD patient group and normal control, the ADHD patient group showed higher score(p<0.05). The total disciminant capacity of the patient group in ADDES-HV scale was 94.44%. When we regard the cut off point as standard deviation 1.5, the male student was 80 score and the female student was 69 score. In this point of view, ADDES-HV scale was proved to be the useful screening test tool for ADHD research and showed higher reliability and validity in applying to Korean subjects.

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Developing a Tool to Assess Competency to Consent to Treatment in the Mentally Ill Patient: Reliability and Validity (정신장애인의 치료동의능력 평가 도구 개발 : 신뢰도와 타당화)

  • Seo, Mi-Kyoung;Rhee, MinKyu;Kim, Seung-Hyun;Cho, Sung-Nam;Ko, Young-hun;Lee, Hyuk;Lee, Moon-Soo
    • Korean Journal of Health Psychology
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    • v.14 no.3
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    • pp.579-596
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    • 2009
  • This study aimed to develop the Korean tool of competency to consent to psychiatric treatment and to analyze the reliability and validity of this tool. Also the developed tool's efficiency in determining whether a patient possesses treatment consent competence was checked using the Receiver Operating Characteristic curve and the relevant indices. A total of 193 patients with mental illness, who were hospitalized in a mental hospital or were in community mental health center, participated in this study. We administered a questionnaire consisting of 14 questions concerning understanding, appreciation, reasoning ability, and expression of a choice to the subjects. To investigate the validity of the tool, we conducted the K-MMSE, insight test, estimated IQ, and BPRS. The tool's reliability and usefulness were examined via Cronbach's alpha, ICC, and ROC analysis, and criterion related validation was performed. This tool showed that internal consistency and agreement between raters was relatively high(ICC .80~.98, Cronbach's alpha .56~.83)and the confirmatory factor analysis for constructive validation showed that the tool was valid. Also, estimated IQ, and MMSE were significantly correlated to understanding, appreciation, expression of a choice, and reasoning ability. However, the BPRS did not show significant correlation with any subcompetences. In ROC analysis, full scale cutoff score 18.5 was suggested. Subscale cutoff scores were understanding 4.5, appreciation 8.5, reasoning ability 3.5, and expression of a choice 0.5. These results suggest that this assessment tool is reliable, valid and efficient diagnostically. Finally, limitations and implications of this study were discussed.