• Journal of Pharmaceutical Investigation
• /
• v.24 no.2
• /
• pp.95-104
• /
• 1994

Inclusion complexes of ketoconazole(KT) with ${\alpha}^_$, ${\beta}^_$cyclodextrin(CD) and $dimethy1-{\beta}-cyclodextrin$ (CD) and $dimethy1-{\beta}-cyclodextrin(DM{\beta}CD)$ as nasal absorption enhancer were prepared in 1: 2 molar ratios by freeze-drying and solvent evaporation methods. In order to compare with the intrinsic absorptivity of KT in the jejunum(J) and the nasal cavity(N), the in situ simultaneous perfusion method was employed. The in situ recirculation study revealed that KT-CD inclusion complexes with the greater stability constant and the faster dissolution rate proportionally increased the absorption of KT in the J and N of rats. The rank order of apparent KT permeability$(P_{app}\;:\;cm/sec\;{\time}\;1O^{-5}{\pm}S.E.)$, corrected by surface area of absorption, was $5.10{\pm}0.3(N,\; KT-DM{\beta}CD)$ )> $4.13{\pm}0.4(N,\;KT-{\beta}-CD)$ )> $3.52{\pm}0.2(N,\;KT-{\alpha}-CD)$ )> $2.76{\pm}0.3(J,\; KT-DM{\beta}CD)$ )> $2.61{\pm}0.5(J,\;KT-{\beta}-CD)$ )> $2.42{\pm}0.4(J,\;KT-{\alpha}-CD)$ at pH 4.0. The in crease in permeability of $KT-DM{\beta}CD$ inclusion complex was 2.6 folds in the J and 4.5 folds in the N when the perfusing solution was changed from the buffer(pH 4.0) to saline. The absorption rate of $KT-DM{\beta}CD$ inclusion complex after nasal administration was more rapid than those of ketoconazole alone and $KT-DM{\beta}CD$ inclusion complex after oral administration to rats. In comparision with an oral administration of ketoconazole suspension in corn oil, the relative bioavailability was calculated 137.3% for the oral and 195.0% for nasal $KT-DM{\beta}CD$ inclusion complex in rats. The present results suggest that $KT-DM{\beta}CD$ inclusion complex may serve as a potential nasal absorption enhancer for the nasal delivery of ketoconazole.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.11
• /
• pp.3260-3268
• /
• 2009

A test apparatus has been fabricated to simulate chemical effect on head loss through a strainer in a pressurized water reactor (PWR) containment water pool after a loss of coolant accident (LOCA). Tests were conducted under condition of same ratio of strainer surface area to water volume between the test appratus and the containment sump. A series of tests have been performed to investigate the effects of spray, existence of calcium-silicate with tri-sodium phosphate (TSP), and composition of materials. The results showed that head loss across the chemical bed with even a small amount of calcium-silicate insulation instantaneously increased as soon as TSP was added to the test solution. Also, the head loss across the test screen is strongly affected by spray duration and is increased rapidly at the early stage, because of high dissolution and precipitation of aluminum and zinc. After passivation of aluminum and zinc by corrosion, the head loss increase is much slowed down and is mainly induced by materials such as calcium, silicon, and magnesium leached from NUKONTM and concrete. Furthermore, it is newly found that the spay buffer agent, tri-sodium phosphate, to form protective coating on the aluminum surface and reduce aluminum leaching is not effective for a large amount of aluminum and a long spray.

• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.38 no.1
• /
• pp.67-76
• /
• 2020

This study aims to elicit criteria regarding reassessment and designation of linear scenic sites henceforth. The results are as follows; First, based on the documents from the Cultural Properties Protection Committee of Korea, 23 out of 113 scenic sites in Korea were drawn, and their linear characteristics were categorized into four types including valleys, paths, rivers, and ridges. The linear scenic sites provide certain features in terms of sequence and direction, which results in the similar utilization among the sites which share the linear similarity. Second, the 23 sites mentioned above were intensely examined on the basis of six criteria for linear scenic sites through FGI, focus group interview. The criteria consist of six elements involving core resource(12), lot number(8), unclear(8), management path(5), ridge(4), basin(3). Third, the Cultural Heritage Administration has prioritized core resource since 2010, when designating a scenic site, whereas it tended to consider lot number as priority prior to 2010. It is thought that the authority gave consideration to issues related to private ownership of property in the scenic sites and the purpose of designation. Fourth, scenic sites are generally designated in accordance with the boundary of core resource, and in most cases, there are buffer zones alongside the core resource.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.16 no.2
• /
• pp.1-15
• /
• 2013

It is important to empirically investigate the typological characteristics of subway station areas considering the comprehensive elements of transit-oriented development (TOD) planning so that its implementation can be effective in attaining both increase in transit ridership and decrease in inordinate automobile dependence. This article aims to identify diverse features of subway station areas in Seoul known for good public transit system. After collecting and manipulating the measures on planning elements such as density, diversity and accessibility for TOD planning by distance-based buffer from a subway station, the article tried to interpret analysis results on their typological characteristics. They can be summarized with two conclusions. First, characteristics of landuse and public transit system can be distinctly differentiated in the Seoul subway station areas. It implies that both planning elements should have not been integrated for now. Second, the characteristics of public transit system can be divided by modes. They provide us that public transit system in Seoul needs to be more strongly integrated than current system.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.48 no.12
• /
• pp.91-96
• /
• 2011

In this paper, a low-power direct-conversion transmitter based on current-mode operation, which satisfies the IEEE 802.15.4 standard, is proposed and implemented in a $0.13{\mu}m$ CMOS technology. The proposed transmitter consists of DACs, LPFs, variable gain I/Q up-conversion mixer, a divide-by-two circuit with LO buffer, and a drive amplifier. By combining DAC, LPF, and variable gain I/Q up-conversion mixer with a simple current mirror configuration, the transmitter's power consumption is reduced and its linearity is improved. The drive amplifier is a cascode amplifier with gain controls and the 2.4GHz I/Q differential LO signals are generated by a divide-by-two current-mode-logic (CML) circuit with an external 4.8GHz input signal. The implemented transmitter has 30dB of gain control range, 0dBm of maximum transmit output power, 33dBc of local oscillator leakage, and 40dBc of the transmit third harmonic component. The transmitter dissipates 10.2mW from a 1.2V supply and the die area of the transmitter is $1.76mm{\times}1.26mm$.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.50 no.11
• /
• pp.50-57
• /
• 2013

This paper provides a design of high-throughput parallel turbo decoder that is able to decode several packets of various length simultaneously. For high-speed communications, designing of Turbo decoder as parallel structures reduces the long decoding time caused by iterative turbo decode way. Also, by employing the double buffer structure for input and output packets improves the decoder throughput by enabling continuous decoding. Because parallel turbo decoder is designed to be able to decode the packet of the longest length, there exist idle PE's(Processing Element) in the case of decoding packets of short length. The main idea of this paper is to increase the utilization of PE's in parallel Turbo decoder and to improve the decoder throughput by using the idle PE's immediately for the subsequent packets decoding. For this, the control is necessary to enable the concurrent decoding of several short packets and we propose the method of this control. Applying the proposed method, we implemented Turbo Decoder with 32 PE's that can decode packets of 6144 bits maximum. Compared to the conventional Turbo decoder, although the area was increased about 16%, the decoder throughput was improved 28 times for short packets.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.38 no.3
• /
• pp.359-363
• /
• 2009

This study was performed to establish a rapid and simple analytical method for niacin (nicotinic acid and nicotinamide) using HPLC. A pretreatment method for the extraction and clean-up of niacin in infant formula sample and an instrumental condition for HPLC were optimized. Niacin was extracted by 5 mM hexanesulfonate with ultrasonication for 30 min. For the clean-up of the sample, the extract was applied to a HLB cartridge, and then niacin was eluted from the cartridge using 5 mL of 80% methanol after washing with 5 mL of n-hexane. The total recoveries were $83{\sim}104%$ and relative standard deviation were in the range of $1.5{\sim}3.5%$ during the extraction and clean-up process. Niacin was determined by gradient elution with sodium hexanesulfonate/methanol buffer as a mobile phase and a photodiode array detector (260 nm). It showed a high linearity between the content of niacin and the peak area ($r^2$=1.000) in the range of $0.02{\sim}10.0$ mg/L of nicotinic acid and nicotinamide. The detection limit was 0.02 mg/L (0.2 mg/kg in the sample). The method was successfully applied for the determination of niacin in infant formula. Total niacin contents were in the range of $53.5{\sim}140.3$ mg/kg.

• Asian Journal of Turfgrass Science
• /
• v.12 no.1
• /
• pp.49-78
• /
• 1998

Nowadays, there are increasing demands of golf courses and it is necessary to make more golf courses than the present. To do this, we need to improve the environmental problems with the regional inhabitants, and it is said that the first thing to be considered in developing any golf course in Korea is to preserve the environment. In this context, the purpose of this study is to set forth several design factors to lessen the negative impacts which are accompanied with the development of golf courses. 1. The present conditions of golf courses in Korea Many new golf courses have come into being, particularly since the late 1980s, and now, in the year of 1997, over one hundred of golf courses are doing their business, yet the number of golf course is still less than required. So far, over a half of them have been made in the vicinity of Seoul on account of various reasons, and this has adversely affected on our natural environment. This unreasonable development of golf courses has caused serious water pollution, landslides and the other problems. Also, the topography of Korea is not good for golf courses. Although the demands of golf courses are increasing, the suitable sites for them are very limited, and therefore it is sometimes unavoidable to make golf courses on steep hills. Consequently, in designing golf courses in Korea, the most important thing is the balance between natural environment and artificial environment. 2.Eco-friendly golf course design factors 1) The concept of eco-friendly golf courses Ecologically sustainable and sound golf courses which are made by eco-friendly approaches 2)Basic conditions of eco-friendly golf courses (1)The most suitable sites (2) Conservation of existing ground as much as possible (3)Proper use of agricultural chemicals which have great impacts on the environment (4) Reasonable use of fertilizers (5) Developing a specialized fertilizer only for grass (6) Adaptation of organic agriculture (7) Improvement of grass sorts (8) Establishing reservoirs for purifying the water from golf courses 3) Eco-friendly golf courses (1) Location-Enough area /Gentle slope/Winding ground/Including lakes or streams /Not crossing wind's main direction Facing south or southeast /Suitable soIl for grass /Good drainage /Low level of underground water (2)Course layout and design -Consideration about existing contours as much as possible -Adaptation of Scotish design trend -Various holes' configuration -Consideration toward surrounding landscapes -Reducing grass areas -Giving buffer zones -Adapting computer methods in the process of site analysis and design (3) Eco-friendly considerations in constructing and managing golf courses -Protection of wildlife -Reuse of existing forests and preservation of topsoil -Renovation of old-fashioned courses -Reducing grass areas -Purification of water -Standization of management -Strict regulations against chemicals -Recycling organic materials -Through separation of the water inside golf courses and out of bounds -Getting proper construction works done in a due time 4.Eco-friendly considerations from a viewpoint of cultural environment 1) Well-matched landscape design and events planning 2) Implement of identifications and awarding systerns 3)Acknowledgement of superintendents' qualitications in the maintenance of golf courses 4)Increasing public golf courses and keeping good relationships with the neighbors near golf courses Key words: Pro-environmental development, Golf course.

• Restorative Dentistry and Endodontics
• /
• v.24 no.2
• /
• pp.372-380
• /
• 1999

The purpose of this study was to investigate the distribution of calcitonin gene-related peptide(CGRP) containing nerve fivers after pulp exposure in rats. The Spague-Dawley rats weighing about 250 - 300g were used. The animals were devided into normal control group and experimental groups. Experimental animals were sacrified on 2, 4, 7, 10 days after pulp exposure. The maxillary teeth and alveolar bone were removed and immersed in the 4% paraformaldehyde plus 0.1M phosphate buffer (pH 7.4). Serial frozen $50{\mu}m$ thick sections were cut with a cryostat. In the immunohistochemical staining procedure, the rabbit CGRP antibody was used as a primary antibody. The sections were incubated for 48 hours at $4^{\circ}C$, and placed into biotinylated anti-rabbit IgG as a secondary antibody and incubated in ABC (avidin-biotin complex), The sections were visualized by 0.05% 3.3 diaminobenzidine tetrahydrochloride. The results of this study were as follows: 1. In control group, CGRP containing nerve fibers ran parallel to the long axis of root and reached the coronal pulp. They were distributed on Raschkow plexus under the odontoblastic layer. 2. In 2 day group after pulp exposure, tissue necrosis and acute inflammation occurred and CGRP containing nerve fibers increased. In 4 day group, the necrotic tissue extended to the pulp and CGRP containing nerve fibers were distributed around the inflammation zone. 3. In 7 day group after pulp exposure, pulp necrosis occurred, and in 10 day group, the abscess under the necrotic pulp extended to the root apex area and CGRP containing nerve fibers were not observed in root canals. 4.The sprouting of CGRP nerve fibers was most remarkable at the pulp chamber under injury in 4 day group, and it was found at inflammation zone under the necrotic tissue in 7 day group and the remaining root pulp tissue in 10 day group. As mentioned above, CGRP nerve fibers had a tendency to increase around the inflammatory zone, especially around the acute inflammation tissue, when compared with control group. It is suggested that CGRP nerve fibers maybe related to the control of inflammatory response of pulp tissue.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.8 no.2
• /
• pp.430-439
• /
• 2004

This paper describes a design of 8192/2048-point FFT/IFFT processor (CFFT8k2k), which performs multi-carrier modulation/demodulation in OFDM-based DVB-T receiver. Since a large size FFT requires a large buffer memory, two design techniques are considered to achieve memory-efficient implementation of 8192-point FFT/IFFT. A hybrid structure, which is composed of radix-4 single-path delay feedback (R4SDF) and radix-4 single-path delay commutator (R4SDC), reduces its memory by 20% compared to R4SDC structure. In addition, a memory reduction of about 24% is achieved by a novel two-step convergent block floating-point scaling. As a result, it requires only 57% of memory used in conventional design, reducing chip area and power consumption. The CFFT8k2k core is designed in Verilog-HDL, and has about 102,000 Bates, RAM of 292k bits, and ROM of 39k bits. Using gate-level netlist with SDF which is synthesized using a $0.25-{\um}m$ CMOS library, timing simulation show that it can safely operate with 50-MHz clock at 2.5-V supply, resulting that a 8192-point FFT/IFFT can be computed every 164-${\mu}\textrm{s}$. The functionality of the core is fully verified by FPGA implementation, and the average SQNR of 60-㏈ is achieved.