• 인지과학
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• 제21권4호
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• pp.559-602
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• 2010

본 연구는 정보처리 관점에서 기억과 주의와의 비교를 통하여 의식의 개념과 기능적 특성을 탐색해 보고, 의식과 기억과 주의의 관계에 기반한 정보처리와 작업기억의 특성에 대한 대안적 관점을 제시하고자 하였다. 인간의 심적 활동을 설명하기 위해서는 어떤 개념들이 설명에 사용될 만큼 충분히 잘 이해되고 있는지에 대한 합의가 필요하기 때문에 공통적으로 이해되는 기초개념이 무엇인지를 알아내는 것은 중요하다. 기억과 주의와의 비교를 통해 정보처리 관점에서 의식은 주변 환경과 자극에 대한 그리고 이를 처리하는 정보처리과정에 대해 자각하고, 필요한 행동을 결정내리고 수많은 정보들을 통합하고 통제할 수 있는 작동시스템의 특성을 가진다. 의식은 정보의 부호화와 저장, 인출이란 특성을 가진 기억, 그리고 정보의 선택과 분할이란 특성을 가진 주의와 개념적으로 기능적으로 구분되는 심적 구성체 일 수 있다. 이러한 경우 작업기억은 다양한 구성요소로 이루어진 하나의 시스템이라기 보다는 의식과 기억과 주의가 함께 혹은 독립적으로 작동하는 정보처리의 작업장일 수 있다. 또한 의식과 기억과 주의란 심적구성체가 함께 혹은 독립적으로 작동하는 심적구조에서 정보처리는 의식적인 처리과정과 무의식적인 처리과정의 연속선상에서 위계 병렬적으로 일어날 수 있다.

• 대한한방소아과학회지
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• 제24권3호
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• pp.106-120
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• 2010

Objectives: Sanjointang has been clinically used much for treating sleeplessness. However, the effects of Sanjointang in artificial sleep deprivation situations are not known. The purpose of this study is to evaluate the heart rate, left ventricular systolic pressure, left ventricular diastolic pressure, +dp/dt maximum, -dp/dt maximum, and -dp/dt / +dp/dt ratio which are related to the hemodynamic functions of the heart by using sleep-deprived Sparague-Dawley rats, in order to clarify the impact of Sanjointang on hemodynamic functions of the heart of sleep deprived rats. Methods: Eighteen hearts were removed from the male Sparague-Dawley rats weighting about 180g were perfused by the Langendorff technique with modified 37 Krebs-Henseleit's buffer solution at a constant perfusion pressure (60mmHg). They were randomly assigned to one of the following three groups, 1) Normal group (those which did not have sleep deprivation and received normal saline administration), 2) Control group (sleep deprived and normal saline administered), 3) Sample group (sleep deprived and Sanjointang was administered). Control and sample groups rats were deprived 96 hours of sleep by using the modified multiple platform technique. Heart rate, left ventricular systolic pressure, left ventricular diastolic pressure, +dp/dt maximum, -dp/dt maximum, -dp/dt / +dp/dt ratio were evaluated at baseline after the administration of either normal saline or Sanjointang. Results: The heart rate and -dp/dt / +dp/dt ratio was significantly decreased in rats with 96 hours of sleep deprived significantly decreased. The change in the heart rate after administering Sanjointang did not show any significant difference. The left ventricular systolic pressure of the removed heart significantly decreased due to Sanjointang administration, while the left ventricular diastolic pressure significantly increased (p<0.05). The +dp/dt maximum and -dp/dt maximum both significantly decreased in the removed heart after administering Sanjointang. (p<0.05). There was no significant difference observed in the -dp/dt / +dp/dt ratio after administering Sanjointang. Conclusions: According to the results above, sleep deprivation significantly decreases heart rate and -dp/dt / +dp/dt ratio. This is considered as a result of exhaustion due to accumulation of fatigue. Meanwhile, Sanjointang reduced left ventricular systolic pressure and raised left ventricular diastolic pressure, and relieved the contractility and relaxation of the myocardium. Consequently, this reduces the burden of the heart and creates a relatively stabilized heart condition similar to a sleeping condition.

• 동의생리병리학회지
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• 제22권3호
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• pp.684-691
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• 2008

As part of studies to develop new materials to lower blood glucose levels using crude polysaccharide, this study was attempted to analyze the characteristics of crude polysaccharide obtained from the extracts of a mixed herbal medium(OCM) where Trichloloma matsutake mycelium and Cordyceps militaris mycelium were cultured together and to look into the influence of administering these by concentration upon the blood glucose and serum lipid levels of rats with diabetes which was induced by STZ(Streptozotosin). Experimental group was divided into 6 groups: first, it was divided into normal control group(NC group) and diabetes-induced group, and diabetes-induced group was subdivided into diabetic control group(DC group), acarbose-treated group(PC group), 100 mg/kg/body weight-treated by crude polysaccharide of OCM(UE) group(UE100 group), 200 mg/kg/body weight-treated group(UE200 group), and 300 mg/kg/body weight-treated group(UE300 group). In diabetic-induced groups, after streptozotocin was melted in 0.01M citrate buffer at 50 mg/kg/body weight, when the non-fasting blood glucose level not on an empty stomach was 300 mg/dl or more in blood collected from the tail vein, it was regarded as diabetic induction and then such diabetic-induced experimental animals were used in this experiment. The yield of crude polysaccharide obtained from OCM was found to be 0.31% and the ${\beta}$-glucan content 39.40%. As a result of analyzing NO on immune function, which is known as major physiological activity of crude polysaccharide, high NO viability was shown; when 1 mg/ml LPS was treated at 1 ug/ml, it was found to be 50.77 uM, and when LPS was treated at 10 ug/m, it was found to be 53.78 uM. Also, regarding cancer cells, cell count was decreased by about 26% in proportion to sample concentration, while for normal cells, it was a little decreased in proportion to concentration, however, cell count was maintained in the range of $81.92{\sim}98.16%$ at all concentrations. In case of blood glucose level, it was decreased in all extract-treated groups compared to DC group and in the cases of ALT and AST, they were found to be lower in extract-treated groups compared to PC group and for serum lipid, it was found to be lower in UE100 group compared to PC group. Thus this study tried to utilize these results as fundamental data for development of preventive and therapeutic agents against diabetes as well as functional foods using the crude polysaccharide of mushrooms.

• 한국수정란이식학회지
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• 제16권1호
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• pp.35-40
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• 2001

Artificial insemination (AI) with frozen or cooled semen is widely used in commercial fields of cattle and pig. Little is known about characteristics of canine sperm after freezing or cooling. For both practical and commercial goal, the canine semen treated with cooling and freezing should be carried out to exam the fundamentals, including sperm motility, survivability and fertilizing capacity. The aim of this study, thus, was to identify the effects of extended exposure to 4$0^{\circ}C$ on canine semen by motility, survivability, acrosomal changes following different duration. Fifteen ejaculates collected by digital manipulation twice per week from 3 dogs (Shih-Tzu) were divided to 16 aliquots after adding Tris-egg yolk (TE) buffer formulated by our laboratory, and cooled from 37 to 4$^{\circ}C$, by ramp rate of 0.6$^{\circ}C$/min. Each sample was evaluated by their motility, survivability and the acrosomal status at 0h (control), 2h, 12h and 1 d~10 d, respectively. The motility of spermatozoa was graded to 6 levels using the modified method of Seager. The survivability of sperm was assessed using an epifluorescence microscope after Fert/Light (Mole-cular Probes Inc.) staining. To estimate the proportion of the spermatozoa of intact acrosome, 200 spermatozoa were assessed in randomly selected fields, using epifluorescence microscope after FITC/PSA (Sigma) staining. At 2 h after cooling, the motility of most spermatozoa were assessed to be grade 0 and 1. At 12 h, high number of sperm were in grade 0 to 1, however, it was significantly (P<0.05) lower than that of 2 h. From 1 d to 4 d, ~50% of sperm was assessed to grade 0 to 1. On day 7, a little sperm were in grade 0 to 1. No sperm showed motility on day 10. Sperm motility was rapidly reduced by the percent of 10% of grade 0 to 1. From 2 h to 6 h, the number of live sperm was 90% and the sperm chilled for 10 days lived>50%. Acrosomal intact of spermatozoa exposed to 4$^{\circ}C$ for 2 h was 51%, supposed the sperm of control was 100%. Our results suggest that 1) this is easy to transfer and preservation for short periods 2) AI can be used by semen chilled for 6-Day.

• 대한수의학회지
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• 제39권1호
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• pp.34-44
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• 1999

Ischemic damage in the selectively vulnerable populations of neurons is thought to be caused by an abnormal accumulation of intracellular calcium. It has been reported that the neurons, expressing specific calcium binding proteins, might effectively control intracellular calcium concentrations because of a high capacity to buffer intracellular calcium in the brain ischemic condition. It is uncertain that parvalbumin, one of the calcium binding proteins, can protect the neurons from the cerebral ischemic damage. Recently, treatment of kappa opioid agonists increased survival rate, improved neurological function, and decreased tissue damage under the cerebral ischemic condition. Many evidences indicate that these therapeutic effects might result from regulation of calcium concentration. This study was designed to analyze the changes of number in parvalbumin-positive neurons after cerebral ischemic damage according to timepoints after cerebral ischemic induction. In addition, we evaluated the effect of GR89696 (kappa opioid agonist) or naltrexone(non selective opioid antagonist) on the changes of number in parvalbumin expressing neurons under ischemic condition. Cerebral ischemia was induced by occluding the common carotid artery of experimental animals. The hippocampal areas were morphometrically analyzed at different time point after ischemic induction(1, 3, 5 days) by using immuno-histochemical technique and imaging analysis system. The number of parvalbumin-positive neurons in hippocampus was significantly reduced at 1 day after ischemia(p<0.05). Furthermore, the number of parvalbumin-immunoreactive neurons was dramatically reduced at 3 and 5 days after cerebral ischemic induction(p<0.05) as compared to 1 day group after ischemia, as well as sham control group. Significant reduction of parvalbumin positive neurons in CA1 region of hippocampus was observed at 1 day after cerebral ischemic induction. However, significant loss of MAP2 immunoreactivity was observed at 3 day after cerebral ischemia. The loss of parvalbumin-positive neurons and MAP2 immunoreactivity in CA1 region was prevented by pre-administration of GR89696 compared to that of saline-treated ischemic group. Furthermore, protective effect of GR89696 partially reversed by pre-treatment of naltrexone. These data indicate that parvalbumin-positive neurons more sensitively responded to cerebral ischemic damage than MAP2 protein. Moreover, this loss of parvalbumin-positive neurons was effectively prevented by the pretreatment of kappa opioid agonist. It was also suggested that the changes of number in parvalbumin-positive neurons could be used as the specific marker to analyze the degree of ischemic neuronal damage.

• 전자공학회논문지
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• 제50권11호
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• pp.70-77
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• 2013

본 논문에서는 새로운 기법의 PWM 발생기를 이용한 저면적, 고효율 SMPS를 제안한다. 제안된 회로에서 PWM의 duty ratio는 pseudo relaxation-oscillation technique를 이용한 PWM 발생기의 내부 커패시터 전압 기울기를 제어하는 방식으로 결정된다. 기존의 SMPS들에 비해, 제안된 제어 방식은 loop bandwidth 보상을 위해 기존의 아날로그 제어방식의 SMPS에서 요구되는 필터회로나 디지털 제어방식의 SMPS에서 요구되는 디지털 compensator가 필요 없기 때문에 단순한 구조로 구성된다. 또한, 제안된 회로는 PWM 발생기의 내부 캐패시터 용량 변화를 통해 1MHz~10MHz까지 스위칭 주파수를 사용자가 선택할 수 있다. 시뮬레이션 수행결과 제안된 SMPS는 10MHz 스위칭 주파수를 선택했을 때 내부회로에서 소모되는 전류는 최대 2.7mA, 파워 Trail을 제외한 전체 시스템의 전류 소모는 15mA였다. 또한, 제안된 SMPS는 시뮬레이션으로 3.3V출력에서 9mV의 최대 리플 전압이 발생하였다. 본 논문에서는 동부하이텍 BCD $0.35{\mu}m$ 공정 파라미터를 이용한 시뮬레이션 및 칩 테스트를 통해 제안된 회로를 검증하였다.

• 전자공학회논문지
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• 제50권11호
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• pp.50-57
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• 2013

본 논문은 하나 이상의 다양한 길이의 패킷을 동시에 복호할 수 있는 고 처리율 병렬 터보 복호기의 설계를 보인다. 터보 복호기의 병렬 구조는 반복 복호로 인한 긴 디코딩 시간을 절감시키며, 입/출력의 이중 버퍼 구조 설계는 패킷들의 연속적인 복호를 가능하게 함으로써 복호기의 처리율을 향상시킨다. 병렬 터보 복호기는 가장 긴 길이의 패킷을 복호할 수 있도록 설계되기 때문에, 이보다 짧은 길이의 패킷의 복호 시에는 사용하지 않는 PE(Processing Element)가 존재한다. 본 논문의 아이디어는 이 유휴 PE들을 연속적으로 이어지는 다음 패킷의 복호에 즉시 이용함으로써, 복호기 내의 PE 사용 효율을 높이고 처리율을 향상시키는 데 있다. 이를 위하여 여러 패킷의 복호를 동시에 가능하게 하는 제어가 필요하며, 본 논문에서는 이러한 제어 방법을 기술한다. 제안한 방법을 적용하여, 32개의 PE를 사용하면서 최대 6144비트 길이의 패킷을 복호 할 수 있는 병렬 터보 복호기를 구현하였으며, 기존 터보 복호기와 비교하여 약 16% 의 면적 증가가 있었으나, 짧은 패킷의 경우 기존 복호기에 비해 최대 28배의 높은 처리율 향상 효과를 보였다.

• 생명과학회지
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• 제22권9호
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• pp.1180-1186
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• 2012

본 연구는 사회적 고립 스트레스로 인한 해마에서의 nerve growth factor (NGF), Synapsin I 및 choline acetyltranferase (ChAT) 감소에 있어서 사전운동경험(exercise preconditioning: EPC)이 미치는 영향을 규명하고자 실시되었다. 목적을 위해 Sprague-Dawley (SD) 쥐(수컷, 22주령, $500.1{\pm}48.41$ g)를 이용해 크게 통제집단(Con)과 운동(Ex)집단으로 구분하여 운동(트레드밀, 5일/주, 최대 18-20 m/min; 50분까지 점진적 증가, 경사 없음, 8주)을 적용하였으며, 이후 각각 사회적 고립(Isolation, 8주)을 적용하여 분석하였다(Group/Con: GC, Group/Ex: GE, Isolation/Con: IC, Isolation/Ex: IE, 각 집단별 n=8). 실험결과, IC집단에서 GC집단에 비해 해마에서 NGF, Synapsin I 및 ChAT가 유의하게 감소한 것으로 나타났다. 반면 IE집단에서 IC집단에 비해 NGF, Synapsin I 및 ChAT의 감소가 유의하게 개선된 것으로 나타났다. 이상의 결과 사회적 고립에 의한 해마에서의 NGF, Synapsin I 및 ChAT 단백질 감소는 EPC에 의해 개선되며, 이를 통해 해마의 기능 저하를 일부 완충 시킬 수 있을 것으로 판단된다.

• 대한예방한의학회지
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• 제12권2호
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• pp.13-25
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• 2008

The purpose of this study was to investigate extract from mixed culture with Trichloloma matsutake mycelium in oriental medicine and cereal medium(OCM) to develop new material for pharmaceutical products and medicinal food for diabetes mellitus. To evaluate of hypoglycemic activity of OCM extracts, we examined the inhibitory activity of ${\alpha}$-glucosidasein OCM, blood glucose level and liver function of streptozotocin(STZ) induced diabetic rat. Experimental group was divided into 6 groups: first, it was divided into normal control group(hereafter NC group) and diabetes-induced group, and diabetes-induced group was subdivided into diabetic control group(DC group), treated by hot water extracts group(HE), ultra sonic waves, micro waves, and micro bubble extracts g roup(UE), crude polysaccharide of HE group (HEE) and crude polysaccharide of UE group(UEE) at a dose of 300mg/kg/body weight, respectively. In diabetic-induced groups, after streptozotocin was melted in 0.01M citrate buffer at 50mg/kg/body weight, when the non-fasting blood glucose levelwas 300 mg/dl or more in blood collected from the tail vein, it was regarded as diabetic induction and then such diabetic-induced experimental animals were used in this experiment. At the end of the experiment, blood glucose level increased by 4.19% in DC group but significantly decreased by 32.34%, 19.19%, 17.81% and 17.64%, respectively in UEEE, UE, HE, and HEE groups. In the cases of AST, ALT, and ALP, the experiment group treated with extracts showed significantly lowerblood glucose level than DC group. The levels of BUN and uric acid were found to be lower in the UMPM extract group(UE) than HW extract group(HE), which implies that herb medicine medium extracts in which Tricholoma matsutake mycelia were cultured are effective in reducing impaired liver function as well as high blood glucose level caused by diabetes. In addition, the administration of low temperature UMPM extracts was found to produce better results than that of high temperature hot water extracts. In this regard, it is expected that extracts from herb medicine obtained by cultivating Tricholoma matsutake mycelia will be widely used as new ingredients for foods and medicines for prevention and treatment of diabetes.

• 한국정보처리학회논문지
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• 제4권7호
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• pp.1770-1780
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• 1997

ATM 망에서의 폭주로 인한 셀 손실은 피할 수 없기 때문에 영상 데이터 전송시 화질의개선 여지가 문제점으로 남아있다. ATM망에서 MPEG 비디오 전송시에 무차별적인 셀들의 손실은 서비스 품질의 심각한 저하를 가져올 수 있다. 본 논문에서는 이러한 문제점을 해결하기 위해 두 가지 방법을 제안한다. 첫째, MPEG 부호화기의 데이터 스트림의 트래픽 특성을 분석하여 높은 우선 순위의 데이터 스트림을 생성한다. 그리고 망의 폭주시에 가능한 한 낮은 우선 순위의 셀들을 폐기시키고 높은 우선 순위의 셀들을 전송하게 함으로써 사용자의 QOS를 보장한다. 이 때 부호화기의 데이터 스트림에 대한 우선 순위는 파라미터 ${\beta}$값의 증감에 따라 우선 순위 단계를 조절한다. 둘째, ${\beta}$값이 클수록 우선 순위가 높은 셀들의 수가 증가하게 된다. 이것은 망의 폭주시 우선 순위가 높은 셀의 손실을 초래한다. 이를 예방하기 위하여 본 연구에서는 사용량 감시 제어기를 설치하여 버퍼의 상태에 따라 전송률을 재 조절하는 방법을 취한다. 즉, 부호화기의 대역폭은 부호화기와 네트워크 사이의 재협상을 통하여 얻는다. 본 논문에서는 부호화기의 대역폭 요구사항을 최대 셀 전송률, 버스트 길이, 지속율을 다루는 사용 파라미터 제어(UPC)에 의하여 얻는다. 네트워크 인터페이스 카드(NIC : Network Interface Card)에 있는 적용 부호화기의 비트율 제어 알고리즘은 사용자의 QOS를 유지하기 위해 필요한 UPC 파라미터를 계산한다. 시뮬레이션시에는 동적인 UPC를 지원하는 ATM 네트워크 인터페이스 환경을 통하여 MPEG 부호화기의 비트율을 조절함으로써 측정하였다. 우선 순위가 주어진 데이터 스트림의 대역폭 재협상을 통한 실험의 결과는 대역폭의 이득과 우선 순위가 높은 데이터 스트림의 손실을 방지함으로써 영상의 화질이 개선됨을 보여준다.