• The Journal of Korean Physical Therapy
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• 제28권3호
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• pp.205-211
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• 2016

Purpose: This study investigated the influence of muscle activity of the trunk and lower limb during a bridge exercise using a unstable surface and during one-legged bridge hip abduction in healthy adults. Methods: Nineteen healthy participated in this study (12 males and 7 females, aged $29.0{\pm}5.0$). The participants were instructed to perform the bridge exercises under six different conditions. Trunk and lower limb muscle activation, such as the erector spinae (ES), gluteus maximus (GM), external oblique (EO), and internal oblique (IO), was measured using surface electromyography. The six different bridge exercise conditions were conducted randomly. Data analysis was performed by using the mean scores after three trials of each condition. Results: On the ipsilateral side, muscle activity of the IO, EO, and ES during the hip abduction condition (Single-legged hip abduction bridge, Bridge with use of a ball and single-leg hip abduction, Bridge with use of a sling and single-leg hip abduction) was significantly higher than those during Unstable surface (Bridge with use of a ball, Bridge with use of a sling) and General bridging exercise (p<0.05). In the contralateral side, activities of the GM and EO during Single-legged hip abduction bridge, Bridge with use of a ball and single-leg hip abduction and Bridge with use of a sling and single-leg hip abduction was significantly higher than that during Bridge with use of a ball, Bridge with use of a sling and General bridging exercise (p<0.05). Conclusion: This study demonstrated that performing a bridge exercise with use of a sling and single-leg hip abduction had an effect on trunk and gluteal muscle activation. The findings of this study suggest that this training method can be clinically effective for unilateral training and for patients with hemiplegia.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2000년도 가을 학술발표회논문집(I)
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• pp.99-104
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• 2000

In this paper, the crack properties fiber reinforced concrete(SFRC) beams by experimental method is discussed. The major role played by the steel fiber occurs in the post-cracking zone, in which the fibers bridge across the cracked matrix. Because of its improved ability to bridging cracks, SFRC has better crack properties than that of reinforced concrete(RC). Crack properties are influenced by longitudinal reinforcement ratio, volume and type of steel fibers, strength of concrete and the stress level. Crack width and number of cracks in SFRC beams have been evaluated from experimental test data at various levels of stress for the tested beams.

• 치과방사선
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• 제18권1호
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• pp.5-12
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• 1988

Several cases of jaw cyst-basal cell nevus-bifid rib syndrome are presented. This syndrome consists principally of multiple jaw cysts, basal cell nevi, and bifid ribs but no one component is present in all patients. The purpose of this paper is to review the multiple characteristics of this syndrome and present three cases in a family and additional 4 cases. The many malformations associated with the syndrome have variable expressivity. In the cases, multiple jaw cysts, palmar and plantar pittings, bridging of sella, temporoparietal bossing, hypertelorism, cleft palate, and dystopia canthorum have been observed.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.75-82
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• 2010

Specific diseases like cancer and acquired immune deficiency syndrome (AIDS) occur at various organs including lymphatics and spread through lymphatic system. Thus, if therapeutic agents for such diseases are more distributed or targeted to lymphatic system, we can obtain several advantages like reduction of systemic side effect and increase of efficacy. For these reasons, much interest has been focused on the nature of lymphatics and a lot of studies for lymphatic delivery of drugs have been carried out. Because lymphatics consist of single layer endothelium and have high permeability compared with blood capillaries, especially, the studies using nano-sized carriers have been performed. Polymeric nano-particle, liposome, and lipid-based vehicle have been adopted for lymphatic delivery as carriers. According to the administration route and the kind of carrier, the extent of lymphatic delivery efficiency of nano-sized carriers has been changed and influenced by several factors such as size, charge, hydrophobicity and surface feature of carrier. In this review, we summarized the key factors which affect lymphatic uptake and the major features of carriers for achieving the lymphatic delivery. Lymphatic delivery of drug using nano-sized carriers has many fold improved ability of lymphatic delivery compared with that of conventional dosage forms, but it has not shown whole lymph selectivity yet. Even though nano-sized carriers still have the potential and worth to study as lymphatic drug delivery technology as before, full understanding of delivery mechanism and influencing factors, and setting of pharmacokinetic model are required for more ideal lymphatic delivery of drug.

• 국제물리치료학회지
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• 제4권2호
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• pp.595-599
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• 2013

The purpose of this study is to identify the bridge exercise posture for the efficient exercise by comparing the muscle activity of the lower limbs according to the changes in muscle length because of knee angle in bridge exercise. The subjects of this study were 9 randomly selected males in their 20s living in D city from those who satisfied inclusion criteria. The measured muscles were Vastus medialis oblique, Vastus lateralis, Semitendinosus, Biceps femoris, Gluteus maximus, Gluteus medius, Tensor faciae latae, and Adductor longus. Data were analyzed through paired comparison test. In the result, ST, BF, and TFL muscle activities were high when knee joint flexion angle was $90^{\circ}$ Although in most cases higher muscle activity was shown at $90^{\circ}$ than $60^{\circ}$ there was no statistical significance. Interestingly, it was lower at $90^{\circ}$ than $60^{\circ}$ in VL. In ST, BF, and TFL, it was significantly higher at $90^{\circ}$ than $60^{\circ}$ (p<.05). Conclusively, knee angles in bridge exercise may affect the muscle activity, and in particular when the activity of two joint muscles such as semimenbranosus muscle, biceps femoris muscle, and tensor fasciae latae muscle increase as the angle gets higher. Therefore, it is considered that this study will provide helpful tips to develop muscular strength enforcement program for the patients with damages in the lower limbs through bridge exercise in clinical situations.

• Journal of Pharmaceutical Investigation
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• 제38권6호
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• pp.365-372
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• 2008

The aim of this study was to investigate the frequency of the SNPs on MDR1 exon 12, 21 and 26 in Korean population and to analyze haplotype frequency on MDR1 exon 12, 21 and 26 in Korean population. A total of 426 healthy subjects was genotyped for MDR1, using polymerase chain reaction-based diagnostic tests. Haplotype was statistically inferred using an algorithm based on the expectation-maximization (EM). MDR1 C1236T genotyping revealed that the frequency for homozygous wild-type (C/C), heterozygous (C/T) and for homozygous mutant-type (T/T) was 20.19%, 46.48% and 33.33%, respectively. MDR1 G2677T/A genotyping revealed that the frequency for homozygous G/G, heterozygous G/T, homozygous T/T, heterozygous G/A, heterozygous T/A and for homozygous A/A type was 30.75%, 42.26%, 9.86%, 7.51 %, 7.04% and 2.58%, respectively. MDR1 C3435T genotyping revealed that the frequency for homozygous wild-type (C/C), heterozygous (C/T) and for homozygous mutant-type (T/T) was 38.73%, 50.24% and 11.03%, respectively. Twelve haplotypes were observed. Of the three major haplotypes identified (CGC, TTT and TGC), the CGC haplotype were mainly predominant in the Korean populations and accounted for 29.96% of total haplotype in Korean.

• 한국산업정보학회논문지
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• 제20권1호
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• pp.63-77
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• 2015

SNS(social network service) 이용환경의 변화 및 증가에 따라 소비자들은 SNS를 일상의 일부로 받아들이고 있으며, 인터넷을 기반으로 상호소통하는 활동과 영향력은 지속적으로 확대되고 있다. 이에 따라 본 연구에서는 SNS를 통해서 형성될 수 있는 사회자본과 소비자들의 정서적 웰빙 수준의 차이점을 고찰하고자 한다. 또한 SNS 이용 이유 및 활용도는 소비자들마다 상이하게 나타날 수 있는 점을 고려하여 본 연구에서는 세대별 차이를 살펴보았다. 즉, SNS를 통해 나타날 수 있는 사회적 자본과 정서적 웰빙의 형태는 세대별로 어떠한 차이가 있는지를 검증하였다. 본 연구는 SNS사용 경험이 있는 소비자들을 대상으로 설문조사를 실시하였으며, 최종 83부의 표본을 활용하여 세대 간 사회자본 및 정서적웰빙의 효과를 살펴보았다. 연구결과, SNS를 통해 형성된 사회적 자본의 크기 및 유형에 따른 효과는 세대에 따라 차이가 있는 것으로 나타났다. 특히, 사회적 자본의 크기는 고령세대보다 젊은세대가 크게 나타났으며, 사회적 자본의 유형 중 연결적(bridging) 사회자본도 고령세대보다 젊은세대가 크게 나타났다. 또한 전반적인 정서적 웰빙은 세대에 따라 차이가 없었지만, 정서적 웰빙의 유형 중 부정적 웰빙은 고령세대가 젊은세대 보다 더욱 민감하게 나타나 세대별 차이를 보였다. 이러한 결과들을 토대로 SNS관리방향을 제시함으로써 세대별 세분화된 SNS활용방안을 제시하였다.

• 한국전문물리치료학회지
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• 제27권4호
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• pp.257-263
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• 2020

Background: The hip muscle plays various roles. Several types of functional performance tests are used for the assessment of patients with various lower extremity injuries. Hip muscle functions are important to test the performance of maintaining the spine, pelvic, and leg during bridging exercise. We designed a novel functional performance test tool, which we named close kinetic chain dynamic lower extremity stability (CKCLE) test to assess hip muscle functions. Objects: The purpose of this study was to determine the relationship between CKCLE test and hip extensor, external rotator, and abductor strengths. Methods: Twenty-two subjects were recruited in the present study (13 males and 9 females). The hip extensor, external rotator, and abductor muscle strengths were measured using a Smart KEMA strength sensor. When the examiner said "Go", the subject performed the CKCLE test by moving one leg from the floor and touching the opposite knee and then return to the floor while maintaining the bridging position. The subjects attempted as many "touches" as possible in the allotted time (20 seconds) during the maximal tests. The correlation between the hip muscle (extensor, external rotator, and abductor) strength of the supporting leg and the number of CKCLE tests performed in 20 seconds was determined using the Pearson correlation. Results: Hip extensor (r = 0.626, p < 0.05), hip external rotator (r = 0.616, p < 0.05), and hip abductor muscle strengths (r = 0.475, p < 0.05) positively correlated with the number of CKCLE tests performed. Conclusion: We designed a CKCLE test and found that performance in the test correlated with hip extensor, external rotator, and abductor muscle strengths. The result suggests that the CKCLE test can be applied as a performance test to assess the functions of the hip extensor, external rotator, and hip abductor muscles.

• Archives of Pharmacal Research
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• 제28권10호
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• pp.1196-1202
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• 2005

Omeprazole (OMP) is a proton pump inhibitor used as an oral treatment for acid-related gastrointestinal disorders. In the liver, it is primarily metabolized by cytochrome P-450 (CYP450) isoenzymes such as CYP2C19 and CYP3A4. 5-Hyroxyomeprazole (5-OHOMP) and omeprazole sulfone (OMP-SFN) are the two major metabolites of OMP in human. Cimetidine (CMT) inhibits the breakdown of drugs metabolized by CYP450 and reduces, the clearance of coad-ministered drug resulted from both the CMT binding to CYP450 and the decreased hepatic blood flow due to CMT. Phenobarbital (PB) induces drug metabolism in laboratory animals and human. PB induction mainly involves mammalian CYP forms in gene families 2B and 3A. PB has been widely used as a prototype inducer for biochemical investigations of drug metabolism and the enzymes catalyzing this metabolism, as well as for genetic, pharmacological, and toxicological investigations. In order to investigate the influence of CMT and PB on the metabolite kinetics of OMP, we intravenously administered OMP (30 mg/kg) to rats intraperitoneally pretreated with normal saline (5 mL/kg), CMT (100 mg/kg) or PB (75 mg/kg) once a day for four days, and compared the pharmacokinetic parameters of OMP. The systemic clearance ($CL_{t}$) of OMP was significantly (p<0.05) decreased in CMT-pretreated rats and significantly (p<0.05) increased in PB-pretreated rats. These results indicate that CMT inhibits the OMP metabolism due to both decreased hepatic blood flow and inhibited enzyme activity of CYP2C19 and 3A4 and that PB increases the OMP metabolism due to stimulation of the liver blood flow and/or bile flow, due not to induction of the enzyme activity of CYP3A4.

• 디지털융복합연구
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• 제14권1호
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• pp.387-398
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• 2016

2000년대 들어 꾸준히 성장한 국내 게임시장 규모는 10조 원 대 진입을 눈앞에 두고 있다. 게임 시장의 규모만 커진 것이 아니라 온라인 게임의 사용 행태도 변하고 있다. 전통적인 비디오 게임과 다르게 온라인 게임은 인터넷을 통해 사회적 상호작용을 허용한다. 온라인 게임은 일상적인 활동이 되었고, 사회적 상호작용은 큰 영향을 미치고 있다. 사회적 상호작용이 긍정적인 영향만을 미치는 것이 아니라 이로 인해 온라인 게임을 과도하게 이용하는 경우도 발생하고 있다. 이러한 상황에서 포괄적으로 바라보았던 사회적 요인을 체계화하여 온라인 게임의 과도한 이용 행태에 미치는 영향을 살펴볼 필요가 있다. 본 연구에서는 사회적 상호작용 요인을 고독 탈피, 가상세계 연계 확대, 현실세계 결속 강화로 세분화하고, 이러한 사회적 상호작용 요인이 온라인 게임 과몰입에 미치는 영향을 파악하였다. 본 연구는 온라인으로 수집된 자료의 분석을 통해 고독 탈피, 가상세계 연계 확대, 현실세계 결속 강화 모두 온라인 게임의 과몰입에 통계적으로 유의한 영향을 준다는 점을 실증하였다.