• Journal of Korean Neurosurgical Society
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• v.50 no.3
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• pp.179-184
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• 2011

Objective : The aim of this study is to evaluate the therapeutic effects of gamma knife radiosurgery (GKRS) in patients with multiple brain metastases and to investigate prognostic factors related to treatment outcome. Methods : We retrospectively reviewed clinico-radiological and dosimetric data of 36 patients with 4-14 brain metastases who underwent GKRS for 264 lesions between August 2008 and April 2011. The most common primary tumor site was the lung (n=22), followed by breast (n=7). At GKRS, the median Karnofsky performance scale score was 90 and the mean tumor volume was 1.2 cc (0.002-12.6). The mean prescription dose of 17.8 Gy was delivered to the mean 61.1% isodose line. Among 264 metastases, 175 lesions were assessed for treatment response by at least one imaging follow-up. Results : The overall median survival after GKRS was $9.1{\pm}1.7$ months. Among various factors, primary tumor control was a significant prognostic factor ($11.1{\pm}$1.3 months vs. $3.3{\pm}2.4$ months, p=0.031). The calculated local tumor control rate at 6 and 9 months after GKRS were 87.9% and 84.2%, respectively. Paddick's conformity index (>0.75) was significantly related to local tumor control. The actuarial peritumoral edema reduction rate was 22.4% at 6 months. Conclusion : According to our results, GKRS can provide beneficial effect for the patients with multiple (4 or more) brain metastases, when systemic cancer is controlled. And, careful dosimetry is essential for local tumor control. Therefore, GKRS can be considered as one of the treatment modalities for multiple brain metastase.

• Biomolecules & Therapeutics
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• v.25 no.4
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• pp.411-416
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• 2017

Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with water solubility less than $1{\mu}g/mL$, which restricts its therapeutic application. To overcome the problem, hyaluronic acid-complexed paclitaxel nanoemulsions (HPNs) were prepared by ionic complexation of paclitaxel (PTX) nanoemulsions and hyaluronic acid (HA) to specifically target non-small cell lung cancer. HPNs were composed of ${\small{DL}}-{\alpha}$-tocopheryl acetate, soybean oil, polysorbate 80, ferric chloride, and HA and fabricated by high-pressure homogenization. The HPNs were $85.2{\pm}7.55nm$ in diameter and had a zeta potential of $-35.7{\pm}0.25mV$. The encapsulation efficiency was almost 100%, and the PTX content was 3.0 mg/mL. We assessed the in vivo antitumor efficacy of the HPNs by measuring changes in tumor volume and body weight in nude mice transplanted with CD44-overexpressing NCI-H460 xenografts and treated with a bolus dose of saline, $Taxol^{(R)}$, PTX nanoemulsions (PNs), or HPNs at a dose of 25 mg/kg. Suppression of cancer cell growth was higher in the PN- and HPN-treated groups than in the $Taxol^{(R)}$ group. In particular, HPN treatment dramatically inhibited tumor growth, likely because of the specific tumor-targeting affinity of HA for CD44-overexpressed cancer cells. The loss of body weight and organ weight did not vary significantly between the groups. It is suggest that HPNs should be used to effective nanocarrier system for targeting delivery of non-small cell lung cancer overexpressing CD44 and high solubilization of poorly soluble drug.

• Women's Health Nursing
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• v.10 no.4
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• pp.301-310
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• 2004

Purpose: The purpose of this study was to develop an exercise program for postmastectomy patients. Method: This study was conducted from October, 2003 to June, 2004. The exercise program was developed based on literature review and needs assessment using focus group interviews. The subjects for the focus group interview consisted of 11 patients, 13 recovering patients, and 20 nurses from 3 hospitals. Development of the program was proceeded with analysusm design and development steps. Result: The results of the needs assessment using the focus group interview showed that the exercise program was imperative for postmastectomy patients. Based on the results, a home video tape containing 3 steps, was developed. Each step includes warming-up, stretching, the main exercise, and cool-down. Steps 2 and 3 include exercises with an elastic band, and an elastic ball. The program was modified after conducting a pre-test. A self-checklist including shoulder mobility, hand strength, arm volume and subjective comments on how they feel will be used before and after the exercise program. Conclusion: The exercise program will improve breast cancer patients' quality of life and their physical well-being. Further studies are recommended to test the effectiveness of the exercise program.

• Korean Journal of Human Ecology
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• v.24 no.6
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• pp.847-857
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• 2015

The ratio of small-breasted women occupies over 20% among Korean women in their twenties. However, the commercial brassieres for the small-breasted women were not fitted well to their breast shapes. In this research, the various commercial mold brasseries for small-breasted women were evaluated through the wearing test and the analysis of 3D images which were scanned from their torsos wearing the brassieres. In addition, professional panels performed the appearance evaluation based on the 2D front and side images captured from 3D images taken by 3D measurement systems. As the results, we found that small-breasted women preferred a 3/4 cup brassiere, of which volume is concentrated in the lower cup. The most preferred brassiere in wearing state shows that the characteristic angle between the chest and the upper cup is about 167 degrees, which is smaller than those of another brassieres, and that the ratio of the radius of curvature of the nipple part to that of the lower cup was about 0.78. These results provide important implications regarding the design of mold brassieres for small-breasted women in spite of the fact that these results represent the selected set of commercial brassieres. Therefore, further studies are highly demanded for the most suitable design information of mold cup for small-breasted women.

• Archives of Plastic Surgery
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• v.36 no.6
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• pp.806-810
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• 2009

Purpose: Gynecomastia is an abnormal increase in the volume of the male breast. Subcutaneous mastectomy was the first surgical treatment for gynecomastia. But because of the complications such as nerve injury and scar formation, subcutaneous mastectomy has been substituted with liposuction. Recently various techniques including ultrasound - assisted liposuction has been used for treatment of gynecomastia. The purpose of this study is to evaluate the results of XPS$^{(R)}$ microresector(Shaver) for treatment of gynecomastia. Methods: 17 patients, 33 breasts of gynecomastia, Simon grade I or II have been treated with XPS$^{(R)}$ microresector(Shaver). The mean age was 24.5. The subcutaneous tissue and glandular tissue were removed with XPS$^{(R)}$ microresector(Shaver). The operation time, the weight of removed tissue and patients' satisfaction score were accessed. Results: The mean operation time was 78.2 minutes. The mean weight of removed tissue was 113.8 g. There was no significant complications such as necrosis, hematoma, infection or scar contracture. Patients' satisfactory score of scar, shape and confidence were 8.4, 8.2 and 8.4 respectively. As the average score was 8.3, almost patients were satisfied with their breasts. Conclusion: The authors have treated 17 patients suffering from gynecomastia with XPS$^{(R)}$ microresector(Shaver). We obtained short operation time, early recovery, minimal operative scar and less complications with XPS$^{(R)}$ microresector(Shaver) for the treatment of gynecomastia, and patients were satisfied with the results of our method. We concluded XPS$^{(R)}$ microresector(Shaver) is an alternative option for the treatment of gynecomastia.

• Radiation Oncology Journal
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• v.5 no.2
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• pp.119-129
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• 1987

With the introduction of X-rays of higher energy that have higher penetrability, it has become possible to treat the deep-seated tumor with increased local control rate. But at the same time it has incrased the damage to the deep seated organs, especially to the lung which is known to be the less radiotolerable tissue in the body. This study analyses the 66 patients who were exposed to the irradiation of the lung, and examines the development of radiation pneumonitis and its related factors. The results of the study are summarized as follows: 1, The 66 patients were consisted of 40 cases of lung cancer, 15 cases of breast cancer and 11 cases of mediastinal tumors. There were 37 males and 29 females with the male to female ratio 1.3: 1. A male to female ratio in the lung cancer was 3: 1. 2. Among 66 patients, 26 patients $(39\%)$ developed the radiographical changes of acute radiation pneumonitis and 13 out of 26 patients $(50\%)$ showed the clinical features of acute radiation pneumonitis. 3. The onest of acute radiation pneumonitis ranged from 10 days to 6 months after the completion of radiotherapy. 4. There was a statistically significant close relationship between the development of radiation pneumonitis and the radiation dose. 5. As the irradiated lung volume increased, the development of radiation pneumonitis increased. But the statistical significance was not strong. 6. The increased incidence of radiation pneumonitis was observed when the chemotherapy was given before or concomittantly with radiotherapy. 7 There was no significant correlation between the development of radiation pneumonitis and the age, smoking and the presence of underlying lung disease.

• Korean Journal of Agricultural and Forest Meteorology
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• v.14 no.4
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• pp.236-245
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• 2012

This research was performed to analyze growth performance and pattern of eighteen families of hinoki cypress (Chamaecyparis obtusa), which were imported in Jeju region. The growths of 'Yako-7', 'Muei-1', and 'Sangsong-9' families were superior to other families whereas those of 'Sanguen-3', 'Yago-6', and 'Hyena-2' families were poor. The height growth between age 9-year to 15-year was superior to those between other ages. No specific growth pattern was observed in the diameter at breast height (DBH) by ages. Family heritability of height, DBH, and volume were estimated at 0.68, 0.75, and 0.75, respectively. Pearson's correlation analysis showed that there was little juvenile-mature correlation in the growth of C. obtusa.

• 대한방사선치료학회:학술대회논문집
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• 2005.06a
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• pp.27-32
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• 2005

Electron is used for the treatment of skin cancer, breast cancer, and head and neck cancer in clinic. Our study is performed to check the isodose distribut ion in source surface distance(SSD) and source bolus distance(SBD) setup, nipple influence to isodose distribution of electron, junctional area isodose variation of photon and electron field. Dosimetry is carried out with phantom, acryl, and film as the same condition of treatment setup. $8\%$ of isodose difference is noted with the surface distance(SSD) and source bolus distance(SBD) setup. To reduce the influence of nipple. corresponding volume of bolus should be removed. And bolus covering all the electron field reduced hot and cold spot of junctional area of photon.

• Fashion & Textile Research Journal
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• v.21 no.4
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• pp.480-487
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• 2019

This study used 3D technology to develop a multi-functional sports brassiere with increased comfort and fit that can be worn as a base layer during exercise or as underwear. A 75A size industrial lingerie figure was used to develop a standard pattern. 3D tools for scanning and pattern making, such as Vivid 910, Geomagic Design X, 2C-AN and Yuka CAD were used. The sports brassiere was designed as a tank top style with dual structure and linings attached to a pad utilized with a sport brassiere mold cup. 3D outer and lining's pattern was differently developed in consideration of the body's curvature with pad's shape and structure. Shoulder and neck part reduction rates were adjusted to increase the neck areas fit that considered the nude pattern's structure due to uncomfortableness felt by wearers who were uncomfortable with the neck areas fit on existing brand products. The reduction rate was also set differently on each part. For example, the reduction rate on outer side panel was set strongly to increase the breast's volume. Two products, developed by a 3D sports brassiere and previously released product, were worn on 8 subjects in their 20's to evaluate fit, comfort, and purchase preferences. The evaluation proved that newly developed 3D products were superior to comparative products. The results of the clothing pressure measurement indicate that the newly developed sports brassiere's front part had less pressure on upper bust and shoulder areas compared to comparative products as well as showed less pressure on the back side, which shows improved wearing comfort compared to comparative products.

• Archives of Plastic Surgery
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• v.49 no.4
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• pp.531-537
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• 2022

Wide-awake, local anesthesia, no tourniquet (WALANT) is a technique that removes the requirement for operations to be performed with a tourniquet, general/regional anesthesia, sedation or an anesthetist. We reviewed the WALANT literature with respect to the diverse indications and impact of WALANT to discuss the importance of future surgical curriculum integration. With appropriate patient selection, WALANT may be used effectively in upper and lower limb surgery; it is also a useful option for patients who are unsuitable for general/regional anesthesia. There is a growing body of evidence supporting the use of WALANT in more complex operations in both upper and lower limb surgery. WALANT is a safe, effective, and simple technique associated with equivalent or superior patient pain scores among other numerous clinical and cost benefits. Cost benefits derive from reduced requirements for theater/anesthetic personnel, space, equipment, time, and inpatient stay. The lack of a requirement for general anesthesia reduces aerosol generating procedures, for example, intubation/high-flow oxygen, hence patients and staff also benefit from the reduced potential for infection transmission. WALANT provides a relatively, but not entirely, bloodless surgical field. Training requirements include the surgical indications, volume calculations, infiltration technique, appropriate perioperative patient/team member communication, and specifics of each operation that need to be considered, for example, checking of active tendon glide versus venting of flexor tendon pulleys. WALANT offers significant clinical, economic, and operative safety advantages when compared with general/regional anesthesia. Key challenges include careful patient selection and the comprehensive training of future surgeons to perform the technique safely.