• Asian-Australasian Journal of Animal Sciences
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• v.18 no.1
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• pp.133-140
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• 2005

Although amino acids are substrates for the synthesis of proteins and nitrogen-containing compounds, it has become more and more clear over the years that these nutrients are also extremely important as regulators of body protein turnover. The branched-chain amino acids (BCAAs) together or simply leucine alone stimulate protein synthesis and inhibit protein breakdown in skeletal muscle. However, it was only recently that the mechanism(s) involved in the regulation of protein turnover by BCAAs has begun to be defined. The acceleration of protein synthesis by these amino acids seems to occur at the level of peptide chain initiation. Oral administration of leucine to food-deprived rats enhances muscle protein synthesis, in part, through activation of the mRNA binding step of translation initiation. Despite our knowledge of the induction of protein synthesis by BCAAs, there are few studies on the suppression of protein degradation. The recent findings that oral administration of leucine rapidly reduced $N^{\tau}$-methylhistidine (3-methylhistidine; MeHis) release from isolated muscle, an index of myofibrillar protein degradation, indicate that leucine suppresses myofiblilar protein degradation. The details of the molecular mechanism by which leucine inhibits proteolysis is just beginning to be elucidated. The purpose of this report was to review the current understanding of how BCAAs act as regulators of protein turnover.

• JSTS:Journal of Semiconductor Technology and Science
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• v.13 no.4
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• pp.402-409
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• 2013

An innovative application of voltage-contrast (VC) inspection allowed inline detection of NMOS leakage in dense SRAM cells is presented. Cell sizes of SRAM are continual to do the shrinkage with bit density promotion as semiconductor technology advanced, but the resulting challenges include not only development of smaller-scale devices, but also intra-devices isolation. The NMOS leakage caused by the underneath n+/P-well shorted to the adjacent PMOS/N-well was inspected by the proposed electron-beam (e-beam) scan in which VC images were compared during the in-line process step of post contact tungsten (W) CMP (Chemical Mechanical Planarization) instead of end-of-line electrical test, which has a long response time. A series of experiments based on the mechanism for improving the intra-well isolation was performed and verified by the inline VC inspection. An optimal process-integration condition involved to the tradeoff between the implant dosage and photo CD was carried out.

• Proceedings of the Technology Innovation Conference
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• 2003.06a
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• pp.108-115
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• 2003

Government R&D Project Management in Korea has had considerable difficulties because of the lack of project monitoring systems and insufficient communication. The National Program for Tera-level Nanodevices (TND Program) is a ten-year R&D program for commercialization in the area of nano technology. Collaboration and communication among the various participants such as business companies, universities, and government R&D institutes are key success factors in this R&D program. TND Program office has developed a Web-based project management system. This system consists of mostly four sub-management functions: (1) Milestones management of all R&D projects; (2) DR (Design Review) management as the mechanism for checking the performance against milestones; (3) Project activity management using the WBS (Work Breakdown Structure); (4) Budget management. Additionally, it also has many R&D supporting functions such as technology information bulletin board, community management, and visual summary of project progress and performance. This system is effective for monitoring research project as well as measuring project performance of the overall research program. This Web-based system has become the useful tool of R&D moving target mechanism and effective communication and collaboration tool. System features and adoption process of the system are also suggested.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.1
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• pp.53-61
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• 1996

A clear understanding of the surface formation mechanism due to cutting is very important to help produce a good quality surface. Much of the roughness along the length of a bar being cut in a lathe can be explained in terms of macroscopic tool shape and feed rate. However, the roughness along the direction of cutting requires a different explanation. The formation of surface roughness is a problem in flow and fracture of materials in the vicinity of the tool edge. On a microscopic scale the cutting edge is rounded because it is impossible to grind a perfectly sharp cutting edge. Even if a perfectly sharp cutting edge were obtained it would soon become dull as a result of rapid breakdown and wear of the cutting edge. A research project is proposed in which in the main object is to model the surface formation mechanism due to cutting. The tool was assumed to be dull, that is, its edge has a finite radius. In order to study the effect of the radius of cutting edge on the surface formation, tools having different cutting edges were used. For orthogonal cutting experiment, cast iron and glass were chosen as brittle materials. Plowing forces acting in the cutting edge were estimated and its effect on the surface roughness was studied by observing the machined surface using optical microscope.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.7
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• pp.918-927
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• 1999

In the fully developed internal flow fields, there are complex transition flows caused by interaction of the cross flow and jet when jet is Injected Into the flow. These interactions are studied by means of the flow visualization methods. An instantaneous laser tomographic method is used to reveal the physical mechanism and the structure of vortices formation in the branch pipe flow. The velocity range of cross flow of the pipe is 0.7m/s and the corresponding Reynolds number $R_{cf}$, based on the duct height is $5.6{\times}10^3$, diameter/height ratios(d/H) 0.14 and velocity ratios 3.0. Oil mist with the size of $10{\mu}m$ diameter is used for the scattering particle. The instantaneous topological features of the vortex ring roll-up of the jet shear layer and characteristics of this flow are studied in detail by performing flow visualization in rectangular duct flow. It is found that the formation and roll-up of ring vortices is a periodic phenomenon. The detailed topology of the vortices in the near field of a cross -flow jet and the mechanism associated with them give enforced hints of vortex breakdown within the vortex system due to the interaction of the jet and the cross-flow.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.07a
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• pp.13-16
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• 2004

The reliability of 1.550m-wavelength InGaAs mesa waveguide photodiodes(WGPDs), which developed for 40-Gbps optical receiver applications, fabricated by metal organic chemical vapor deposition is investigated. Reliability is examined by both high-temperature storage tests and the accelerated life tests by monitoring dark current and breakdown voltage. The median device lifetime and the activation energy of the degradation mechanism are computed for WGPD test structures. From the accelerated life test results, the activation energy of the degradation mechanism and median lifetime of these devices in room temperature are extracted from the log-normal failure model by using average lifetime and the standard deviation of that lifetime in each test temperature. It is found that the WGPD structure yields devices with the median lifetime of much longer than $10^6$ h at practical use conditions. Consequently, this WGPD structure has sufficient characteristics for practical 40-Gbps optical receiver modules.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.04a
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• pp.253-257
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• 2011

Vortex generation mechanism by inhibitor in a solid rocket motor have been investigated by 3D Large Eddy Simulation turbulent model. Most of the result of the present study are in good agreement with experimental data and previous numerical calculation. Vortex generation and breakdown behind inhibitor are periodically observed between inhibitor and nozzle head by flow-acoustic coupling mechanism. Vortex generation frequency is the same as the second-mode frequency in the motor. The roll shape vortex generation behind inhibitor induces non-uniform flow field at the nozzle entrance and its throat.

• Geomechanics and Engineering
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• v.6 no.2
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• pp.139-151
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• 2014

Mudstone is a very common rock that, when in contact with water, can exhibit considerable volume change and breakdown. This behavior of mudstone is frequently encountered in geotechnical engineering and has a considerable influence on infrastructure stability. This is particularly important in the present work, which focuses on mitigating the harmful properties of mudstone. The samples studied are of Permian Age mudstone from Shandong Province, China. Modification tests using organic silicone additive material were carried out. The mechanisms of physical properties modification of mudstone were comparatively studied using corresponding test methods, and the modification mechanism of organic silicone additive material acting on mudstone was analyzed. The following conclusions were drawn. The surface texture and characters of mudstone changed dramatically, surface character turns from hydrophilic to hydrophobic after organic silicone additive material modification. The changes in the surface character indicate a reduction in the water sensitivity of mudstone. After modification, the shape of porosity and fracture of mudstone changed unremarkable, and the total and free expansion ratios decreased obviously, whereas the strength increased markedly.

• Journal of the Korean Institute of Telematics and Electronics
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• v.17 no.1
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• pp.36-39
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• 1980

Studies have been perfor mad on the normalization of V-I characteristics, the dependence of current runaway on the applied step voltage and the analysis of the current channet in the sintered 5Fe$_2$O$_3$-5Bi$_2$O$_3$. From the measurement of snitching Properties of the sintered 5Fe$_2$O$_3$-5Bi$_2$O$_3$, it is exe]twined that the electrical switching mechanism is that of thermal ionic breakolown.

• Corrosion Science and Technology
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• v.5 no.4
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• pp.137-140
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• 2006

The effect of pre-existing barrier-type film on porous aluminum oxide film formation during anodization was investigated to control the uniform film growth rate. Initial potential fluctuations during anodization indicated that the breakdown of barrier-film is preceded before the porous formation and the induction time for the porous film growth increases with the increases of pre-existing film thickness. The porous film growth mechanism is lot affected by the presence of barrier film on aluminum surface. In parallel, uniform growth of barrier film underneath the porous structure was attained by two-step anodization processes.