Breast cancer is the most prevalent type of cancer among women around the world, and mortality is primarily caused by micro-metastatic disease. The complex mechanisms of breast cancer invasion and metastasis are intrinsically related to the malignant cell type so that early detection of micro-metastases can help prolongation of survival for patient. The aim of the present research work was evaluation of the expression status of mammoglobin protein as a candidate molecular marker in the negative sentinel lymph node (SLN). Fifty tumor specimens, and 50 normal adjacent breast tissue samples from the same patients were selected on the basis of having more than 10% tumor content for RNA extraction from SLNs. Tumor samples and normal adjacent breast tissue were archived in the form of frozen fresh tissue in liquid nitrogen. Real-time PCR was performed on a Bioner life express gradient thermal cycler system. Mammoglobin gene overexpression in breast cancer metastasis was investigated. Single marker results were mammaglobin 66.7% and CK19 50.0%, with 58.3% for the two in combination. Due to improved outcome with at least 3 genes (83.3%), it seems, triple marker evaluation will be most likely useful for detecting micro-metastases instead of studying separate genes.
The study objected to the 120 persons out of 360 persons who have registered under the association of the dental technicians in Pusan to grasp contents about improvement of life long education of the present day of November, 1987, and its results, which we have acquired by this study were as follows : 1. A sense of satisfaction toward the system of life long education appeared as unsatisfaction and its unsatisfaction decreased from the rate of member's attendance or exam. marks, the contents of education, and place of education. 2. The problem of the exam. mark which derived by the presence by the substitute appeared which 46.7 percent(56 persons), lack of opportunity for the recompletion at branch association appeared which 19.2%(23 persons), given 4. exam. marks at the over all scientific contest was appeared 14.2 percent(17 persons), relation which legal treatment when ones didn't completed exam. mark was appeared 10.8 percent(13 persons) and lastly, appeared 8.3 percent (10 persons) with time of delivery of the exam mark card. 3. The frequency of the opening for the life long education which related with the rate of members attendance was fixed as nowadays two times per annually, but they perferred the opening per academic blanch once out of the firest half year and the latter half of the year and, they liked the openings at the first week or second week and preferred the holding on saturdays and sundays. 4. The subject of the life long education have appeared the opinion that the thesis was lop-sided toward the allocation of time schedule of lecture appeared the opinion of which they perferred the rate of an hour of cultural subject and two hours of major studies, and invitation for an instructor they preferred one dentist, one member, one dean for the cultural subject, and there are lots of opinions which they wished display of materials. 5. A sence of satisfaction about the place they perferred was decreased such as ; an auditorium concerned of the colleges was 46.7 Percent(56 Persons), hotels 26.7 Percent(32 Persons), an auditorium of the general hospital 20 percent(24 persons) 6. And lastly, there are lots of opinions who have required the necessities to constitute for the academic branch.
Journal of the Korea Society of Computer and Information
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v.10
no.3
s.35
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pp.297-306
/
2005
Compendium of arithmetic, geometry, and proportions and proportionality' that was published in Venice in 1494 has been recognized as the first bookkeeping data in the world. Major characteristics of Pacioli's bookkeeping rules were reviewed in this study as follows: All the necessary particulars for double entry bookkeeping were provided in Pacioli's bookkeeping rules;. List of property was described at the time of start of business; Three major books were used; Details of daily transactions were considered to be important; Strike through was lined at each description in journal books, details of daily transactions, and list of property after entry of ledger; Amount columns were provided and Arabic numerals were used; Annual settlement custom was being initiated; Profit and loss account was prepared at year-end; Trial balance sheet was inevitably described; Books were verified prior to closing accounts; Control account was not established; Financial statements were not prepared and business analysis was made, too; Finished goods inventory was not adjusted; Mark was assigned to books; Inter-office account was prepared; Branch accounts and branch ledgers were prepared; There was entries of trust; Current arrangement was described; The principle 'Cost or market price, whichever is lower basis' was promoted: Petty cash system is explained Checks and bills of exchange are used in bank account. As mentioned, characteristics of Pacioli's bookkeeping rules were reviewed; the signs of necessity for preparation of profit and loss statement and balance sheet is found as well as preparation of trial balance sheet and the rules may be considered as a very excellent one in terms of the bookkeeping on initiating stage of double entry bookkeeping.
Ha, Jung-Rae;Kim, Jong-Min;Kim, Byung-Ki;Lee, June-Sang;Bae, Hyeon-Ju;Kim, Jung-Yup;Lee, Hak-Joo;Nah, Wan-Soo
The Journal of Korean Institute of Electromagnetic Engineering and Science
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v.21
no.7
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pp.831-841
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2010
The conventional vertical probe has the thin and long signal path that makes transfer characteristic of probe worse because of the S-shaped structure. So we propose the new vertical probe structure that has branch springs in the S-shaped probe. It makes closed loop when the probe mechanically connects to the electrode on a wafer. We fabricated the proposed vertical probe and measured the transfer characteristic and mechanical properties. Compared to the conventional S-shaped vertical probe, the proposed probe has the overdrive that is 1.2 times larger and the contact force that is 2.5 times larger. And we got the improved transfer characteristic by 1.4 dB in $0{\sim}10$ GHz. Also we developed the simulation model of the probe card by using full-wave simulator and the simulation result is correlated with measurement one. As a result of this simulation model, the cantilever probe and PCB have the worst transfer characteristic in the probe card.
Journal of Korean Society of Environmental Engineers
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v.35
no.2
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pp.94-100
/
2013
In this study, we have investigated the water quality and flow rate at the 3 sites of main stream and 11 sites of the branch stream of Hwang River from January, 2007 to 2010, and analyzed the effects on Hwang River with the purpose of using the data for as the fundamental information for water quality improvement and water resource management in the water system of Hap-Cheon Lake Upper Stream. The flow rate at 3 sites of the main stream and 11 sites of the branch stream increased during the rainy season between June and September, and continuously decreased during the dry season starting from autumn to winter. The results of correlation analysis with Pearson correlation coefficient showed that $BOD_5$ and $COD_{Mn}$, $BOD_5$ and T-P, and $COD_{Mn}$ and TSS at the 3 sites of the main stream had high correlation with each other. We have also analyzed the correlation between Chl-a and major factors at the 3 sites of the main stream. Chl-a and the water temperature Negative correlation coefficient and that of Chl-a and $BOD_5$, $COD_{Mn}$ Positive correlation coefficient showed. The N/P ratio at all the 3 sites of the main stream was higher than 16 by DIN/DIP and T-N/T-P, indicating that phosphorus is acting as the limited nutrient.
KSCE Journal of Civil and Environmental Engineering Research
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v.26
no.5A
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pp.861-872
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2006
The element free Galerkin method is extended by the local partition of unity method to model the cohesive cracks in two dimensional continuum. The shape function of a particle whose domain of influence is completely cut by a crack is enriched by the step enrichment function. If the domain of influence contains a crack tip inside, it is enriched by a branch enrichment function which does not have the LEFM stress singularity. The discrete equations are obtained directly from the standard Galerkin method since the enrichment is only for the displacement field, which satisfies the local partition of unity. Because only particles whose domains of influence are influenced by a crack are enriched, the system matrix is still sparse so that the increase of the computational cost is minimized. The condition for crack growth in dynamic problems is obtained from the material instability; when the acoustic tensor loses the positive definiteness, a cohesive crack is inserted to the point so as to change the continuum to a discontiuum. The crack speed is naturally obtained from the criterion. It is found that this method is more accurate and converges faster than the classical meshless methods which are based on the visibility concept. In this paper, several well-known static and dynamic problems were solved to verify the method.
Recently, forest fires have become frequent due to climate change, and the size of forest fires is also increasing. Forest fires in Korea continue to cause more than 100 ha of forest fire damage every year. It was found that 90% of the large-scale wildfires that occurred in Gangwon-do over the past five years were concentrated in the east coast area. The east coast area has a climate vulnerable to forest fires such as dry air and intermediate wind, and forest conditions of coniferous forests. In this regard, studies related to various forest fire analysis, such as predicting the risk of forest fires and calculating the risk of forest fires, are being promoted. There are many studies related to risk analysis for forest areas in consideration of weather and forest-related factors, but studies that have conducted risk analysis for forest-friendly areas are still insufficient. Management of forest adjacent areas is important for the protection of human life and property. Forest-adjacent houses and facilities are greatly threatened by forest fires. Therefore, in this study, a grid-based forest fire-related disaster risk map was created using factors affected by forest-neighboring areas using national branch numbers, and differences in risk ratings were compared for forest areas and areas adjacent to forests based on Gangneung forest fire cases.
The major purpose of this paper is to analyze the evolution of the presidential system in South Korea during the past three decades ever since the country's democratization in 1987 from the comparative institutional perspective. As imperial presidentialism during the so-called three Kim's era(1987-2003) disappeared right after the political retirement of the three Kims in 2003, then president-centered presidentialism emerged during the post-three Kim's era, since the country's recent three presidents possessed their relatively low-level of partisan power in terms of their control of National Assemblies and their respective presidents' parties during their presidencies. South Korea has now a strong possibility to transform the current president-centered presidentialism into the American-style separatist presidential system in the near future, since the country's National Assembly has continuously been making its efforts to function as an effective governing body being compatible with the American Congress. In addition, the country's judiciary branch has effectively been playing a political role like the US supreme court ever since the country's democratization in 1987. It is also emphasized that South Korea's civic society is currently playing as a guardian of democracy through its effective and responsive political participations in many public sectors for promoting civic liberties, public welfare, and other democratic values. South Korea now needs to carry out constitutional revisions, political reforms of legislative system, party system, and electoral system as well as correct some contradictory political understandings and habits in a way to transform the current president-centered presidentialism into American-style separatist presidential system in the near future.
Journal of the Korea Institute of Information Security & Cryptology
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v.26
no.4
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pp.985-994
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2016
Since the inauguration of Defense Acquisition Program Administration(DAPA) in 2006, the national defense core technology research & development business has not only pertained to the weapons systems development but also to the improvement of the national science & technology capability via the acquisition of cutting-edge technologies. Furthermore, it has been closely related to the promotion of the defense industry and the mutual improvements of defense and civil technologies. The cyber warfare weapon system, a newly added national defense weapon system field since 2015, has become a promising weapon system branch for improving the national defense power as well as the national defense industry as shown in the case of Israel. By utilizing the existing result of the national defense core technology level, in order to establish the direction of technology planning of the cyber warfare weapon system, this paper analyzes the technology level and features of the cyber warfare weapon system in various aspects via comparisons with other weapons systems. The result of these analyses shows that the cyber warfare weapon system possesses a relatively high technology level due to the technology accumulation in the civilian sector while the relatively slow inclusion to the national weapons systems and the lack of the correspondence case regarding aggressive cyber responses in the defense sector yields a relatively low national rank. However, the technological gap between South Korea and the most advanced country in the field of cyber warfare technology is analyzed to be among the lowest, which indicates that with efficient and effective pursuits in terms of pthe weapons systems acquisitions as well as the core technologies research & development business, an outstanding cyber warfare capacity can be obtained in a short time.
The Journal of Korean Institute of Electromagnetic Engineering and Science
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v.9
no.4
/
pp.427-438
/
1998
The bit error rate(BER) performance of Trellis Coded QPSK signal in the presence of cochannel interference (CCI) and Rician fading is investigated. The trellis coded QPSK system adopts Maximum Ratio Combining (MRC) diversity reception and Reed-Solomon code to enhance system performance. Using the derived error probability equation, the error performance of trellis coded QPSK system has been evaluated and shown in figures to discuss as a function of signal power to noise power ratio (SNR), signal power to interference power ratio(SIR), direct to indirect signal power ratio ($K_R$), the number of diversity branch (M), the frame length of Reed-Solomon code (n), the number of error correction symbol (t), and the number of state of trellis encoder. From the results, we know that proposed system is affected by cochannel interference and fading in microcell environment. Also, BER performance of Trellis Coded QPSK system can be improved as increasing either the power of desired signal or the value of SIR. And the BER floor in microcellular system is caused by the cochannel interference and it occurs at high BER when SIR is low. And Reed-Solomon code (n=15, t=2) is more effective to restrain the affection of CCI and fading than MRC diversity reception (M=2).
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