• 한국콘텐츠학회논문지
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• 제2권3호
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• pp.1-15
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• 2002

본 논문은 인간 뇌의 가시화 및 해석을 위하여 단일 채널 MR영상에서 자동화된 뇌영역 추출 방법을 제안한다. 이 방법은 쌍곡선 적합을 이용한 자동 문턱치화와 3차원 형태 학적 연산에 의하여 뇌 마스크 볼륨을 생성한다. 쌍곡선 적합은 MR영상의 히스토그램에 곡선을 적합할 때 오차를 줄일 수 있으며, 침식, 연결부위 레이블링, 최대특징 연산, 팽창 등 3차원 형태학적 연산은 문턱치화된 뇌 마스크로부터 생성된 정육각형 볼륨 마스크에 적용된다. 제안한 방법은 SPGR, T1, T2, PD MR영상 세트에서 뇌영역을 자동 추출할 수 있으며, 가장자리 슬라이스에도 적용 가능하고, 영상이 뇌 전체를 포함하지 않아도 된다. 실험에서 20 세트의 MR영상에 적용하여 수동 방법과 비교하여 0.97 이상의 유사도를 보였다.

• 한국초등수학교육학회지
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• 제17권1호
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• pp.67-86
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• 2013

본 연구는 수학영재학생들의 뇌선호유형에 따라 그들이 문제를 해결하는 과정에서 Schoenfeld의 문제해결 행동요인 4가지가 어떻게 활용되고 있는지를 분석하고 이를 통해 수학영재 수업 시 고려해야 될 뇌기능 분화와 관련된 교육적 시사점을 찾아보고자 하는 것이다. 연구 대상자는 BPI검사를 통해 좌, 우뇌별 선호도가 높은 6학년 영재학급 학생 4명이다. 분석 결과 좌뇌선호형 학생들의 경우 객관적이고 논리적인 판단을 좋아하는 좌뇌의 특성이, 우뇌선호형 학생들의 경우 주관적이고 직관적인 판단을 좋아하는 우뇌의 특성이 많이 관찰되었다. 또한 문제해결과정에 나타나는 Schoenfeld의 문제해결 행동요인도 뇌선호유형의 특성에 맞게 서로 다른 것들이 주로 선택되는 것을 확인하였다. 따라서 좌뇌선호형 학생들과 우뇌선호형 학생들이 각각 선택한 문제해결 행동요인을 분석하고 그들에게 상호 보완될 수 있는 문제해결 행동요인을 안내 및 제안해 줌으로써 뇌선호유형별 학생들의 문제해결지도에 활용할 수 있을 것이다.

• 동의생리병리학회지
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• 제18권2호
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• pp.419-426
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• 2004

This experimental study was designed to investigate the effects of Yukgunja-tang(YGJT) on the inhibition of cerebral ischemia in rats. And We measured regional cerebral blood f1ow(rCBF) and pial arterial diameter(PAD) in cerebral ischemic rats, and cytokines production in serum Of cerebral ischemic rats. The results were as follows; Both rCBF and PAD were significantly and stably increased by YGJT(10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production of serum by drawing from femoral arterial blood after middle cerebral arterial occlusion(MCAO) 1 hr, IL-1β and TGF-β production of sample group were similar to that of control group, but sample group was decreased TNF-α production compared with control group, and was significantly increased IL-10 production in compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 1 hr, sample group was significantly decreased IL-1β and TNF-α production compared with control group, but TGF-β production of sample group was similar to that of control group, and sample group was significantly increased IL-10 production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 4 hrs, sample group was significantly decreased IL-1β production compared with control group, and sample group was decreased TNF-α production in compared with control group, but TGF-β production of sample group was similar to that of control group, and sample group was increased IL-10 production compared with control group. This results were suggested that YGJT has inhibitive effect on the brain damage by inhibited IL-1β production and TNF-α production, but accelerated IL-10 production. We thought that YGJT should have an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.

• 한국컴퓨터정보학회논문지
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• 제10권3호
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• pp.65-73
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• 2005

게임 개발의 성패는 창의적인가 아닌가에서 결정된다. 게임 개발 프로세스의 초기 단계인 시나리오 작성부분에서 특히 창의적인 아이디어 발상이 필요하다. 이를 위해 선행 개발된 웹 기반 창의적 발상 시스템(Creative Group Thinking System:이하 CGTS)을 게임 개발 디자인에 적용하여 활용하고자 한다. 따라서 본 연구는 게임 시나리오 작성 부분의 아이디어 발상 작업을 프로그램화하여 창의성을 높이고 작업시간을 단축하고자 한다.

• 한국컴퓨터정보학회논문지
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• 제11권4호
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• pp.175-180
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• 2006

컴퓨터 게임 개발에 있어서 가장 중요한 요소 중의 하나는 창의적인 아이디어이다. 컴퓨터 게임 개발의 프로세스의 1단계 작업과정에서 핵심은 창의적인 아이디어를 발상하는 것이다. 이러한 과정을 위해 선행연구 개발된 웹 기반 창의적 발상시스템(Creative Group Thinking System:이하 CGTS))을 통하여 게임 개발에 적용하여 활용하고자 한다. 따라서 본 연구는 게임디자인 작업부분의 아이디어발상 작업을 웹 환경에서 프로그램화하여 창의력을 높이고 작업시간을 단축하며, 완성도를 높이고자 한다.

• 동의생리병리학회지
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• 제18권6호
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• pp.1643-1651
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• 2004

This experimental study was designed to investigate the effects of SIEGESBECKIAE HERBA extract (SHE) on the change of cerebral hemodynamics 〔regional cerebral blood flow (rCBF) and mean arterial blood pressure(MABP)〕 in normal condition and cerebral ischemic rats, and to determine the mechanism of action of SHE. This study was designed to investigate whether or not SHE inhibit lactate dehydrogenase (LDH) activity in neuronal cells and cytokines production in serum of cerebral ischemic rats. The results were as follows SHE increased rCBF significantly in a dose-dependent manner, but MABP was not changed by SHE in normal rats. The SHE-induced increase in rCBF was significantly inhibited by pretreatment with indomethacin (IDN), an inhibitor of cyclooxygenase but was increased by methylene blue (MTB), an inhibitor of guanylate cyclase. SHE inhibited lactate dehydrogenase (LDH) activity significantly in neuronal cells. rCBF was increased significantly and stably by SHE(10㎎/㎏, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group in ischemic rats. In serum by drawing from femoral arterial blood after middle cerebral arterial occlusion(MCAO) for 1hr and reperfusion for 1hr, the sample group was decreased IL-1β production significantly compared to that of the control group. In serum by drawing from femoral arterial blood after MCAO 1hr and reperfusion 1hr, sample group decreased TNF-α production significantly compared to that of the control grolilp. In serum by drawing from femoral arterial blood after reperfusion 1hr, sample group increased TGF-β production significantly compared to that of the control group. In serum by drawing from femoral arterial blood after MCAO for 1hr and reperfusion for 1hr, IL-10 production of the sample group was similar to that of control group. These results suggested that SHE had inhibitive effect on the brain damage by inhibited LDH activity, IL-1β and TNF-α production, but accelerated TGF-β production.

• 대한한의학원전학회지
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• 제25권2호
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• pp.43-74
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• 2012

Objective : Due to the tendency of researchers to avoid anatomical approach to East Asian medical classics, their ideas on seminal pathways have not been clearly reconstructed yet. So we tried to concretely reconstruct the pathway of semen described in ancient East Asian classics. Methods : Besides analysing the literal description about seminal pathways, we gathered and classified the ancient Viscera Drawings drawn in East Asian countries - especially the drawings in lateral view, and morphologically analysed them with some literal material. Results : We found that there were 3 major streams in the ancient Asian ideas on the seminal pathways. The first one was the modality originated from Hwangjenaegyeong(黃帝內經), which suggested the semen flew out of the kidney. The second one was the modality arose under the influence of Taoist thinking, which suggested the semen was originated from the brain and spinal cord. The last one was revision of the first modality by Janggaebin(張介賓), which asserted semen was originated from the kidney, but was ejaculated via Myeongmun(命門). Conclusion : On the seminal pathways, there had been 2 types of ideas focussing on kidney and one idea focussing on brain and spinal cord in East Asian tradition.

• BMB Reports
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• 제42권5호
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• pp.245-259
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• 2009

The process by which adult neural stem cells generate new and functionally integrated neurons in the adult mammalian brain has been intensely studied, but much more remains to be discovered. It is known that neural progenitors progress through distinct stages to become mature neurons, and this progression is tightly controlled by cell-cell interactions and signals in the neurogenic niche. However, less is known about the cell-intrinsic signaling required for proper progression through stages of adult neurogenesis. Techniques have recently been developed to manipulate genes specifically in adult neural stem cells and progenitors in vivo, such as the use of inducible transgenic mice and viral-mediated gene transduction. A critical mass of publications utilizing these techniques has been reached, making it timely to review which molecules are now known to play a cell-intrinsic role in regulating adult neurogenesis in vivo. By drawing attention to these isolated molecules (e.g. Notch), we hope to stimulate a broad effort to understand the complex and compelling cascades of intrinsic signaling molecules important to adult neurogenesis. Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain.

• 한국산학기술학회논문지
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• 제16권5호
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• pp.3344-3352
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• 2015

본 연구는 외상성 뇌손상 환자를 대상으로 한국형 전산화 인지재활프로그램(CoTras)이 전두엽-집행기능에 미치는 효과를 알아보고자 하였다. 2013년 8월부터 2014년 3월까지 경남 창원에 위치하는 C병원에 내원한 외상성 뇌손상 환자 10명을 두 그룹으로 무작위 할당한 후 실험군에게 한국형 전산화 인지재활프로그램을, 대조군에는 자가인지훈련을 1일 1회, 주 5회, 4주 동안 적용하고 그룹 간 비교를 실시하였다. 이때 중재의 효과를 검증하기 위하여 한국판 몬트리올 인지평가(Korean Montreal Cognitive Assessment; K-MoCA), 시계 그리기 검사(Executive Clock Drawing Test; ECDT), 선로잇기 검사(Trail Making Test; TMT), Rey-도형 검사(Rey Complex Figure Test; RCFT)를 사용하였다. 그 결과, 실험군은 K-MoCA, TMT, RCFT-delayed recall에서 유의하게 향상된 반면(p<.05), 대조군은 모든 평가에서 유의한 변화가 없었다. 또한, K-MoCA, TMT, RCFT-delayed recall에서 실험군과 대조군의 변화량이 서로 유의한 차이가 있음을 확인하였다(p<.05). 본 연구는 한국형 전산화 인지재활프로그램이 외상성 뇌손상 환자의 전두엽-집행기능을 향상시키기 위해 국내 임상 환경에서 사용하기에 적절한 중재 도구임을 지지한다.

• 동의생리병리학회지
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• 제18권6호
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• pp.1714-1721
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• 2004

This experimental study was designed to investigate the mechanism of Palmul-Tang(PMT) on the changes of cerebral hemodynamics in rats. The changes of cerebral hemodynamics in normal rats were as follows ; The PMT-induced increase in regional cerebral blood flow was significantly inhibited by pretreatment with indomethacin(1㎎/㎏, i.p.), an inhibitor of cyclooxygenase, and was inhibited by methylene blue(10㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The PMT-induced dilation in pial arterial diameter was significantly inhibited by pretreatment with indomethacin and methylene blue. The PMT-induced increase in mean arterial blood pressure was significantly inhibited by pretreatment with indomethacin but was increased by methylene blue. This results were suggested that the mechanism of PMT was mediated by cyclooxygenase. The changes of cytokine production in cerebral ischemic rats were as follows ; In cytokine production of serum by drawing from femoral arterial blood after middle cerebral arterial occlusion 1hr, sample group was decreased IL-1β and TNF-α production compared with control group, IL-10 production of sample group was similar to that of control group, but sample group was significantly increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 1hr, sample group was significantly decreased IL-1β production compared with control group and decreased TNF-α production compared with control group. IL-10 production of sample group was similar to that of control group, but sample group was significantly increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 4 hrs, sample group was significantly decreased IL-1β production compared with control group, but IL-10 production of sample group was similar to that of control group. sample group was increased TNF-α and TGF-β production compared with control group. These results suggested that PMT had inhibitive effect on the brain damage by inhibiting IL-1β and TNF-α production, but by accelerating TGF-β production. The present author thought that PMT had an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.