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The Inhibitive Effects of Yukgunja-tang on the Cerebral Ischemia  

Kim Hee Seong (Department of Pathology, College of Oriental Medicine, Dongshin University)
Lee Sang Lock (Department of Pathology, College of Oriental Medicine, Dongshin University)
Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.2, 2004 , pp. 419-426 More about this Journal
Abstract
This experimental study was designed to investigate the effects of Yukgunja-tang(YGJT) on the inhibition of cerebral ischemia in rats. And We measured regional cerebral blood f1ow(rCBF) and pial arterial diameter(PAD) in cerebral ischemic rats, and cytokines production in serum Of cerebral ischemic rats. The results were as follows; Both rCBF and PAD were significantly and stably increased by YGJT(10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production of serum by drawing from femoral arterial blood after middle cerebral arterial occlusion(MCAO) 1 hr, IL-1β and TGF-β production of sample group were similar to that of control group, but sample group was decreased TNF-α production compared with control group, and was significantly increased IL-10 production in compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 1 hr, sample group was significantly decreased IL-1β and TNF-α production compared with control group, but TGF-β production of sample group was similar to that of control group, and sample group was significantly increased IL-10 production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 4 hrs, sample group was significantly decreased IL-1β production compared with control group, and sample group was decreased TNF-α production in compared with control group, but TGF-β production of sample group was similar to that of control group, and sample group was increased IL-10 production compared with control group. This results were suggested that YGJT has inhibitive effect on the brain damage by inhibited IL-1β production and TNF-α production, but accelerated IL-10 production. We thought that YGJT should have an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.
Keywords
Yukgunja-tang(六君子湯); cerebral ischemia; regional cerebral blood flow; pial arterial diameter; cytokines production; brain damage;
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Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 흰쥐의 중대뇌동맥 결찰로 유발된 腦虛血에서 星香正氣散과 藿香正氣散이 神經細胞에 미치는 효과 /
[ 김선영;이원철 ] / 大韓韓醫學會誌
2 滋陰健脾湯加枳殼·天麻가 腦細胞 및 腦血流力學 變動에 미치는 영향 /
[ 임광모;정현우 ] / 동의생리병리학회지
3 청피활성분획이 일과성 뇌허혈 병태모델의 뇌혈류역학에 미치는 실험적 효과 /
[ 이원석;정현우 ] / 동의생리병리학회지
4 육군자탕이 위액분비 및 적출 위운동에 미치는 영향에 관한 연구 /
[ 장인규;박성일 ] / 생약학회지
5 육군자탕이 Cyclophosphamide로 손상된 비장조직의 회복에 미치는 영향 /
[ 강윤호;권오성 ] / 동국한의학연구소 논문집
6 四君子湯, 二陳湯, 六君子湯이 腦血流力學 變動에 미치는 實驗的 硏究 /
[ 鄭鉉雨;金羲成 ] / 東醫病理學會誌
7 Mechanisms of disease : oxygen-derived free radicals in postischemic tissue injury /
[ McCord, J.M. ] / New Eng J. Med.   DOI   ScienceOn
8 Polymorphonuclear leukocyteaccumulation in brain region with low blood flow during the early postischemic period /
[ Hallenbeck, J.M.;Dutka, A.J.;Tanishima, T.;Kochanek, P.M.; Kumaroo, K.K.; Thompson, C.B.; Obrenovich, T.P.; Contreras, T.J. ] / Stroke
9 Influx of leukocytes and platelets in an evolving brain infarct(Wistar rat) /
[ Garcia, J.H.; Liu, K.F.; Yoshida, Y.; Lian, J.; Chen, S.; del Zoppo, G.J. ] / Am J. Pathol.
10 /
[ 全國韓醫科大學 本草學敎授 (共編) ] / 本草學
11 Correlation of continnous electroencephalograms with cerebral blood flow measurments during carotid endarterectomy /
[ Sharbrough, F.W.; Messick, M.K. Jr.; Sundt, T.M. Jr. ] / Stroke
12 Relation between EEG, regional cerebral blood flow and internal carotid artery pressure during carotid endarterectomy /
[ Trojaborg, W.; Boysen, G. ] / Electroencephalogr Clin Neurophysiol   DOI   ScienceOn
13 Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke /
[ Vila, N.; Castillo, J.; Davalos, A.; Esteve, A.; Planas, A.M.; Chamorro, A. ] / Stroke
14 /
[ 하대유(외25인) ] / 면역학
15 Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia /
[ Hayashi, Y.; Jikihara, I.; Yagi, T.; Fukumura, M.; Ohashi, Y.; Ohta, Y.; Takagi, H.; Maeda, M. ] / Brain Res   DOI   ScienceOn
16 Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function /
[ Cain, B.S.; Meldrum, D.R.; Dinarello, C.A.; Meng, X.; Joo, K.S.; Banerjee, A.; Harken, A.H. ] / Crit Care Med   DOI   ScienceOn
17 Recipient intramuscular cotransfection of naked plasmid transforming growth factor beta1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injury /
[ Daddi, N.; Suda, T.; D'Ovidio, F.; Kanaan, S.A.; Tagawa, T.; Grapperhaus, K.; Kozower, B.D.; Ritter, J.H.; Yew, N.S.; Mohanakumar, T.; Patterson, G.A. ] / J. Thorac Cardiovasc Surg.   DOI   ScienceOn
18 /
[ 虞 搏 ] / 醫學正傳
19 /
[ 許 浚 ] / 東醫寶鑑
20 /
[ 張介賓 ] / 景岳全書(上)
21 /
[ 김기석 ] / 뇌
22 /
[ 대한병리학회 ] / 병리학
23 The nitrous oxide method for the man ; theory, procedure and normal values /
[ Kety, S.S.; Schmidt, C.F. ] / J. Clin Invest   DOI
24 Changes in extracellular calcium activity in cerebral ischemia /
[ Harris, R.J.;Symon, L.;Branston, N.M.;Bayhan, M ] / J. Cereb Blood Flow Metab   DOI
25 허혈, 재관류 손상에서 뇌조직 아민 변동과 Free Radical과의 관련성 /
[ 이경은;김경환 ] / 大韓神經科學會誌
26 /
[ 의학교육연구원 ] / 물리요법
27 /
[] / 신경외과학
28 牛黃淸心元이 중대뇌동맥 결찰로 유발된 뇌허혈에 미치는 영향 /
[ 조규선;정승현;신길조;이원철 ] / 대한한의학회지
29 Reversible middle cerebral artery occlusion without craniectomy in rats /
[ Longa, E.Z.;Weinstein, P.R.;Carlson, S.;Cummins, R. ] / Stroke
30 A model of focal ischemic stoke in the rat ; reproducible extension cortical infarction /
[ Chen, S.T.;Hsu, C.Y.;Hogan, E.L.;Maricque, H.; Balentine, J.D. ] / Stroke
31 Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide ; with detailed description of the closed cranial window technique in rats /
[ Morii, S.;Ngai, A.C.;Winn, H.R. ] / J. Cereb Blood Flow Metab.   DOI
32 Detailed description of a cranial window technique for acute and chronic experimentals /
[ Joseph, E.;Lebasseur, M.S.;Wei, E.P.;Raper, A.J.; Kontos, H.A. and Patterson, J.L. ] / Stroke
33 Injurious ventilatory strategiea increase cytokines and c-fos mRNA expression in an isolated rat lung model /
[ Trembaly, L.F.; Valenza, S.P. and Ribelro, J.Li. ] / J. Clin. Invest   DOI   ScienceOn
34 Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat /
[ Wang, C.X.; Olschowka, J.A. and Wrathall, J.R. ] / Brain Res   DOI   ScienceOn
35 A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats /
[ Stepaniak, J.A.; Gould, K.E.; Sun, D.; Swanborg, R.H. ] / J. Immunol.
36 Interleukin-10 attenuates experimental fetal growth restriction and demise /
[ Rivera, D.L.; Olister, S.M.; Liu, X.; Thompson, J.H.; Zhang, X.J.; Pennline, K.; Azuero, R.; Clark, D.A.; Miller, M.J. ] / FASEB J.   DOI
37 Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats /
[ Okura, Y.; Takeda, K.; Honda, S.; Hanawa, H.; Watanabe, H.; Kodama, M.; Izumi, T.; Aizawa, Y.; Seki, S.; Abo, T. ] / Circ Res   DOI
38 Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis /
[ Lobell, A.; Weissert, R.; Storch, M.K.; Svanholm, C.; de Graaf, K.L.; Lassmann, H.; Andersson, R.; Olsson, T.; Wigzell, H. ] / J. Exp. Med.   DOI   ScienceOn
39 Transforming growth factor-beta ; expression in normal and pathological conditions /
[ Kim, S.J.; Romeo, D.; Yoo, Y.D.; Park, K. ] / Horm. Res.   DOI
40 Expression of transforming growth factor-beta(TGF-beta) isoforms in osteosarcomas ; TGF-beta3 is related to disease progression /
[ Kloen, P.; Gebhardt, M.C.; Perez-Atayde, A.; Rosenberg, A.E.; Springfield, D.S.; Gold, L.I.; Mankin, H.J. ] / Cancer
41 /
[ Snedecor, G.H. and Cocharn, W.G. ] / Statistical Methods
42 /
[ 李 挻 ] / 醫學入門
43 /
[ 汪 昻 ] / 醫方集解
44 Ischemic brain injury ; the importance of calcium, lipolytic activities and free fatty acids /
[ Wieloch, T.; Siesjo, B.K. ] / Pathol Biol
45 /
[ 黃度淵 ] / 證脈·方藥合編
46 Cascading glia reactions ; a common pathomechanism and its differentiated control by cyclic nucleotide signaling /
[ Schubert, P.; Morino, T.; Miyazaki, H.; Ogata, T.; Nakamura, Y.; Marchini, C.; Ferroni, S. ] / Ann. N. Y. Acad Sci.   DOI
47 /
[ 朱丹溪 ] / 丹溪心法
48 Induction of higher expression of IL-beta and TNF-alpha, lower expression of IL-10 and cyclic guanosine monophosphate by pulmonary arterial hypertension following cardiopulmonary bypass /
[ Lei, Y.; Zhen, J.; Ming, X.L.; Jian, H.K. ] / Asian J. Surg.   DOI   ScienceOn