[KSCI] Korea Science Citation Index Service

Mechanism of Palmul- Tang on the Change of Cerebral Hemodynamics in Rats

Park Cheol Hun (College of Oriental Medicine, Dongshin University)
Kim Gye Yeop (College of Oriental Medicine, Dongshin University)
Jeong Hyun Woo (College of Oriental Medicine, Dongshin University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1714-1721 More about this Journal

Abstract

This experimental study was designed to investigate the mechanism of Palmul-Tang(PMT) on the changes of cerebral hemodynamics in rats. The changes of cerebral hemodynamics in normal rats were as follows ; The PMT-induced increase in regional cerebral blood flow was significantly inhibited by pretreatment with indomethacin(1㎎/㎏, i.p.), an inhibitor of cyclooxygenase, and was inhibited by methylene blue(10㎍/㎏, i.p.), an inhibitor of guanylate cyclase. The PMT-induced dilation in pial arterial diameter was significantly inhibited by pretreatment with indomethacin and methylene blue. The PMT-induced increase in mean arterial blood pressure was significantly inhibited by pretreatment with indomethacin but was increased by methylene blue. This results were suggested that the mechanism of PMT was mediated by cyclooxygenase. The changes of cytokine production in cerebral ischemic rats were as follows ; In cytokine production of serum by drawing from femoral arterial blood after middle cerebral arterial occlusion 1hr, sample group was decreased IL-1β and TNF-α production compared with control group, IL-10 production of sample group was similar to that of control group, but sample group was significantly increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 1hr, sample group was significantly decreased IL-1β production compared with control group and decreased TNF-α production compared with control group. IL-10 production of sample group was similar to that of control group, but sample group was significantly increased TGF-β production compared with control group. In cytokine production of serum by drawing from femoral arterial blood after reperfusion 4 hrs, sample group was significantly decreased IL-1β production compared with control group, but IL-10 production of sample group was similar to that of control group. sample group was increased TNF-α and TGF-β production compared with control group. These results suggested that PMT had inhibitive effect on the brain damage by inhibiting IL-1β and TNF-α production, but by accelerating TGF-β production. The present author thought that PMT had an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.

Keywords

Palmul-Tang; cerebral hemodynamics; cyclooxygenase; guanylate cyclase cytokines production;

Citations & Related Records

Times Cited By KSCI : 7 (Citation Analysis)

Reference
Cited By KSCI

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KSCI

Mechanism of Palmul- Tang on the Change of Cerebral Hemodynamics in Rats 팔물탕이 뇌혈유력학 변화에 미치는 작용기전

Mechanism of Palmul- Tang on the Change of Cerebral Hemodynamics in Rats