• 생물정신의학
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• 제22권3호
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• pp.101-108
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• 2015

Recent breakthroughs in functional neuroimaging techniques have launched the quest of mapping the connections of the human brain, otherwise known as the human connectome. Imaging connectomics is an umbrella term that refers to the neuroimaging techniques used to generate these maps, which recently has enabled comprehensive brain mapping of network connectivity combined with graph theoretic methods. In this review, we present an overview of the key concepts in functional connectomics. Furthermore, we discuss articles that applied task-based and/or resting-state functional magnetic resonance imaging to examine network deficits in post-traumatic stress disorder (PTSD). These studies have provided important insights regarding the etiology of PTSD, as well as the overall organization of the brain network. Advances in functional connectomics are expected to provide insight into the pathophysiology and the development of biomarkers for diagnosis and treatment of PTSD.

• Journal of Korean Neurosurgical Society
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• 제38권1호
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• pp.12-15
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• 2005

Objective : Cerebral edema develops in the brain tumors by loosening of the endothelial tight junction. Tight junction[TJ] proteins, such as occludin and claudin bind adjacent cells tightly. Authors examine the expression rate of occludin in human brain tumors to evaluate the effect of altered expression of occludin on cerebral edema. Methods : Seventy surgical specimens stored at $-70^{\circ}C$ were used. It included 14 astrocytic tumors, 27 meningiomas, 12 scwannomas, 7 pituitary adenomas, 6 hemangioblastomas. and 4 craniopharyngiomas. After protein extraction, expression of occludin was investigated by Western blot analysis. The tumors were classified according to World Health Organization[WHO] classification. Results : The expression rates of occludin in brain tumors were : glioma [8/14=57.1%]. meningioma [16/27=59.3%], schwannoma [10/12=83.3%], pituitary adenoma [6/7=85.7%], hemangioblastoma [6/6=100%], and craniopharyngioma [3/4=75.0%]. The expression rate in glioma and meningioma was lower than other brain tumors. In gliomas, high grade tumor [1/4=25.0%] exhibited lower expression rate of occludin than low grade one [7/10=70.0%]. Conclusion : These results suggest that the expression of occludin is different among the various kinds of brain tumors. In gliomas, its expression is correlated with the histological grade. It may indicate that occludin plays a role in the development of edema in the brain tumors.

• The Journal of Asian Finance, Economics and Business
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• 제7권2호
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• pp.181-193
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• 2020

The midst competition makes a brand all together with its offering products and services is becoming a crucial element for company existence. This requires direct involvement from internal organizational to develop effective strategic branding. According to Asosiasi Penyelenggara Internet Indonesia (APJII), Indonesia's internet penetration is among the highest in Asia. The purpose of this research is to improve the strategic role of brand orientation within Internet Service Provider (ISP) for maximizing return on the company's financial and non-financial benefits by proposing organization change readiness variable. The data collection is taken using an online survey with a non-parametric sampling method and collected 68 qualified respondents for data analysis using SEM-PLS (Structural Equation Modeling with Partial Least Square). The result indicates partial hypotheses on the constructed model between variables brand orientation, brand commitment, and internal brand equity is acceptable. Another finding is stated hypotheses on organization change readiness as moderation is not accepted and means there is no significance to the constructed model. The main conclusion resumes associative human memory can shape up organization change readiness inside internal toward then brand. Relevant cues generate information received in the human brain then will create common associative and becoming social identity on internal brand equity.

• 한국실내디자인학회논문집
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• 제20권2호
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• pp.120-130
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• 2011

The purpose of this study is to propose cognitive ecological effects of fractal patterns in space design. This study investigated the perception and cognition problems regarding landscape patterns showing fractal properties from the cognitive perspective instead of the traditional speculative approach. In particular, the researcher has verified that fractal geometry theory and fractal pattern concept provide insight in space aesthetic values and cognitive effects. Research results are as follows. First, most environmentally-friendly fractal urban forms provide cognitive connectivity. In particular, this space provides a positive emotional response and preference to humans and displays self-organized complexity. This study found that such complexity of space form has characteristics corresponding to parallel cognitive structures of the human brain. Simultaneously, the researcher suggests that the fractal landscape pattern is an alternative for stiff and homogenized modern space. Second, fractal patterns provide hierarchical connectivity within the brain through continuous difference and repetition. In particular, self-similarities of fractal patterns administer significant visual grouping and coherence in human perception. It can be determined whether scaling coherence facilitates easier organization in cognitive organization. Third, fractal patterns in space design provide the basic method for achieving the connection between concept, construction, and urban factors. As a result, the researcher has suggested that scale distribution of geometrical factors, such as fractal patterns, an be a design method to connect various space typologies.

• 생물정신의학
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• 제20권4호
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• pp.129-135
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• 2013

Aggression can be defined as 'behavior intended to harm another' which can be seen both from humans and animals. However, trying to understand aggression in a simplistic view may make it difficult to develop an integrated approach. So, we tried to explain aggression in a multidisciplinary approach, affected by various factors such as neuroanatomical structures, neurotransmitter, genes, and sex hormone. Parallel with animal models, human aggression can be understood with two phenomena, offensive aggression and defensive aggression. Neurobiological model of aggression give a chance to explain aggression with an imbalance between prefrontal regulatory influences and hyper-reactivity of the subcortical areas involved in affective evaluation, finally in an aspect of brain organization. Serotonin and GABA usually inhibit aggression and norepinephrine while glutamate and dopamine precipitate aggressive behavior. As there is no one gene which has been identified as a cause of aggression, functions between gene to gene interaction and gene to environment interaction are being magnified. Contributions of sex hormone to aggression, especially molecular biologic interaction of testosterone and regulation of estrogen receptor have been emphasized during the research on aggression. This multidisciplinary approach on aggression with types, neurochemical bases, and animal models can bring integrated interpretation on aggression.

• Molecules and Cells
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• 제40권7호
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• pp.450-456
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• 2017

Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-$erb{\alpha}$ induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.

• 한국산학기술학회논문지
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• 제18권11호
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• pp.166-175
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• 2017

이 연구는 범죄피해자 지원기관인 (사)한국피해자지원협회(KOVA; Korea Organization Victicm Assistance)에서 2017년 7월 피해상담 전문가의 심리상담을 진행한 두 폭력 가정의 피해자녀들을 대상으로 이루어졌다. 연구참여자는 가정폭력에 대한 피해 호소가 10년이 넘은 가정으로서 폭력피해사실에 대해 경찰서에 직접 신고되어 접수된 이력이 있고 또 피해자녀와 피해자인 어머니가 단기쉼터에 입소하여 함께 거주한 경험이 있는 가정이었다. 가정폭력의 경우 자녀들은 특히, 미성년자인 경우 부모가 제공하는 생활공간에서 폭력피해를 입더라도 자발적으로 벗어나기 어려운 상태에 있으며, 폭력경험을 지속적이고 반복적으로 당하게 된다. 이에 가정폭력 피해자녀들이 현재 가해자-피해자 관계의 부모와 함께 거주하면서 어떤 감정 양상을 나타내고 있는지 그 특성을 정량화된 뇌파 데이터를 수집하고 분석하여 확인하고자 하였다. 뇌파측정은 서울불교대학원 부설 뇌과학연구소에서 진행하였으며, 뇌파측정 데이터 수집은 국제적으로 표준화된 19채널 뇌파측정도구인 브레인마스터를 사용하였고, 데이터 처리는 뉴로가이드를 사용하였다. 가정폭력을 경험한 피해자녀의 감정양상을 정량적 수치 및 뇌지형도를 통하여 분석한 결과 전두엽에 있어서 과잉서파의 문제, 알파파 좌우비대칭, 고베타파 좌우비대칭의 문제를 발견하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권6호
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• pp.498-504
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• 2012

The odontogenic keratocyst (OKC) was originally classified as a developmental cyst, and OKC is histologically divided into orthokeratic and parakeratic types. According to revised histopathological classification of odontogenic tumors by the World Health Organization (2005), the term, keratocystic odontogenic tumor (KCOT) has been adopted to describe parakeratic OKC. The KCOT is noted for its capacity to recur after treatment. The aggressive, or potentially aggressive, nature of KCOT has led to alternative treatments. Among the treatments is noted the use of Carnoy's solution as adjunctive intralesional therapy having a low rate of recurrence. This study suggests a possible benefit of Carnoy's solution against recurrence of KCOT.

• 정보과학회 논문지
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• 제43권1호
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• pp.54-60
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• 2016

뇌의 유전자 발현 정보는 영역별 기능과 밀접한 관련이 있어 이를 분석하기 위해 다수의 유전자들 간의 발현 정도 및 발현 위치 정보와의 관계에 대한 연구가 이루어지고 있다. 본 논문에서는 컴퓨터 기술을 통해 알렌 뇌과학연구소에서 제공하는 약 2만여개의 쥐 뇌 유전자 발현 정보 중 뇌의 해마 영역을 중점적으로 분석하여 유전자들을 자동으로 분류해내고 발현 위치 정보를 기반으로 군집화하여 가시화하는 방법을 제안한다. 이를 통해 해마 내 전체적으로 발현되는 유전자들과 특정 영역에만 발현되는 유전자들을 분류할 수 있었고 그 중 특정 영역에 발현되는 유전자들의 위치정보 기반으로 군집화된 데이터를 뇌 지도와 함께 관찰 할 수 있었다. 본 연구는 뇌의 기능과 영역과의 관계성 관련 생물학적 연구를 위한 실험군 선정작업에 이용되어 실험설계시간을 줄일 수 있고 기존에 알려진 뇌의 해부학적 구조보다 더욱 세분화된 구조를 발견할 수 있는 가능성을 제시할 것으로 기대된다.

• Journal of Korean Neurosurgical Society
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• 제56권6호
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• pp.509-512
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• 2014

Primary intraosseous meningioma is a rare tumor, and atypical pathologic components both osteolytic lesion and dura and soft tissue invasion is extremely rare. A 65-year-old woman presented with a 5-month history of a soft mass on the right frontal area. MR imaging revealed a 4 cm sized, multilobulated, strongly-enhancing lesion on the right frontal bone, and CT showed a destructive skull lesion. The mass was adhered tightly to the scalp and dura mater, and it extended to some part of the outer and inner dural layers without brain invasion. The extradural mass and soft tissue mass were totally removed simultaneously and we reconstructed the calvarial defect with artificial bone material. The pathological study revealed an atypical meningioma as World Health Organization grade II. Six months after the operation, brain MR imaging showed that not found recurrence in both cranial and spinal lesion. Here, we report a case of primary osteolytic intraosseous atypical meningioma with soft tissue and dural invasion.