• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.2
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• pp.131-139
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• 1996

This paper describes the chaotic neuron model to represent the complicated states of brain and analyzes the dynamical responses of chaotic neuron such as periodic, bifurcation, and chaotic phenomena which are simulated iwth numerical analysis. Next, the chaotic neuron circuit is implemented w ith the analog electronic devices. The transfer function of chaotic neuron is given by summed the linear and nonlinear property. The output function of chaojtic neuron is designed iwth the two cMOS inverters and a feedback resistor. By adjusting the external voltage, the various dynamical properties are demonstrated. In addition, we construt the chaotic neural networks which are composed of the interconnection of chaotic neuroncircuit such as serial, paralle, and layer connection. On the board experiment, we proved the dynamci and chaotic responses which exist in the human brain.

• Proceedings of the KIEE Conference
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• 2002.11c
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• pp.11-14
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• 2002

Incurable disease such as palsy and imbecility results from bolld pressure and bloodstream hitch. These diseases result in high blood pressure and brain bloodstream obstacle. So, we developed bloodstream improvement system that can improve bloodstream state using physical stimulation. It controls inflow and outflow of air to press and oppress human body sequentially. We can select stimulation region, pattern, pressure and time. Also, it can improve brain bloodstream state, because it can treat stress or headache putting pressure band on head. It can be used as breathing assistance system which has function for breath synchronization.

• Journal of Korean Medical classics
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• v.21 no.1
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• pp.257-283
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• 2008

Western Medicine had been taking the occurrence of a disease as a physical matter and had tried to step forward from this angle till the late twentieth. But lately for about 20 years, a lot of researchers have started to understand the disease and human function as those in holistic system They supposed that the human function was the result of the interactions in 'Mind-Brain-Body' system and tried to explain and prove about the theory at the molecular level. The name of this new field of human science is 'Mind-Body Medicine' and in the center stand the 'Psychoneuroendoimmunology. Traditional Korean Medicine of which the core system was formed 2500 years ago, explains the complex interaction between mind and body with the theory of 'Mind-Brain-Body' system. To research on the correlation between mind and body, we tried to explain from the viewpoint of medical classic about the philosophical background, relations among mind, five viscera, and body, interaction between mind and body.

• Journal of Genetic Medicine
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• v.18 no.2
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• pp.75-82
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• 2021

Speech and language functions are highly cognitive and human-specific features. The underlying causes of normal speech and language function are believed to reside in the human brain. Developmental persistent stuttering, a speech and language disorder, has been regarded as the most challenging disorder in determining genetic causes because of the high percentage of spontaneous recovery in stutters. This mysterious characteristic hinders speech pathologists from discriminating recovered stutters from completely normal individuals. Over the last several decades, several genetic approaches have been used to identify the genetic causes of stuttering, and remarkable progress has been made in genome-wide linkage analysis followed by gene sequencing. So far, four genes, namely GNPTAB, GNPTG, NAGPA, and AP4E1, are known to cause stuttering. Furthermore, thegeneration of mouse models of stuttering and morphometry analysis has created new ways for researchers to identify brain regions that participate in human speech function and to understand the neuropathology of stuttering. In this review, we aimed to investigate previous progress, challenges, and future perspectives in understanding the genetics and neuropathology underlying persistent developmental stuttering.

• Food Science of Animal Resources
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• v.42 no.6
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• pp.981-995
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• 2022

Cognitive dysfunction is a common symptom of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and is known to be caused by the structural and functional loss of neurons. Many natural agents that can improve cognitive function have been developed and assessed for efficacy using various cognitive deficit animal models. As the gut environment is known to be closely connected to brain function, probiotics are attracting attention as an effective treatment target that can prevent and mitigate cognitive deficits as a result of neurodegenerative diseases. Thus, the objective of this review is to provide useful information about the types and characteristics of cognitive deficit animal models, which can be used to evaluate the anti-cognitive effects of probiotics. In addition, this work reviewed recent studies describing the effects and treatment conditions of probiotics on cognitive deficit animal models. Collectively, this review shows the potential of probiotics as edible natural agents that can mitigate cognitive impairment. It also provides useful information for the design of probiotic treatments for cognitive deficit patients in future clinical studies.

• Journal of Yeungnam Medical Science
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• v.40 no.3
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• pp.225-232
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• 2023

Cognitive dysfunction is relatively less considered a complication of hypertension. However, there is sufficient evidence to show that high blood pressure in middle age increases the risk of cognitive decline and dementia in old age. The greatest impact on cognitive function in those with hypertension is on executive or frontal lobe function, similar to the area most damaged in vascular dementia. Possible cognitive disorders associated with hypertension are vascular dementia, Alzheimer disease, and Lewy body dementia, listed in decreasing strength of association. The pathophysiology of cognitive dysfunction in individuals with hypertension includes brain atrophy, microinfarcts, microbleeds, neuronal loss, white matter lesions, network disruption, neurovascular unit damage, reduced cerebral blood flow, blood-brain barrier damage, enlarged perivascular damage, and proteinopathy. Antihypertensive drugs may reduce the risk of cognitive decline and dementia. Given the high prevalence of dementia and its impact on quality of life, treatment of hypertension to reduce cognitive decline may be a clinically relevant intervention.

• Journal of The Korean Association For Science Education
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• v.30 no.5
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• pp.647-667
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• 2010

The purpose of this study was to develop a brain-based analysis framework for evaluating teachinglearning program in science. To develop the framework, this study categorized educational constructs of the teachinglearning programs into one of three teaching-learning factors: cognition, motive, and emotion, using previous studies on science program. Ninety-three articles on the brain functions associated with science program were analyzed to extract brain activation regions related to the three educational constructs. After delineating the brain activation regions, we designed the brain function map, "the CORE Brain Map." Based on this brain map, we developed a brain-based analysis framework for evaluating science teaching-learning program using R & D processes. This framework consists of the brain regions, the bilateral dorsolateral prefrontal cortex, the bilateral ventrolateral prefrontal cortex, the bilateral orbitofrontal cortex, the anterior cingulate gyrus, the bilateral parietal cortex, the bilateral temporal cortex, the bilateral occipital cortex, the bilateral hippocampus, the bilateral amygdala, the bilateral nucleus accumbens, the bilateral striatum and the midbrain regions. These brain regions are associated with the aforementioned three educational factors; cognition, motivation, and emotion. The framework could be applied to the analysis and diagnosis of various teaching and learning programs in science.

• Korean Journal of Food Science and Technology
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• v.36 no.4
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• pp.637-642
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• 2004

Effects of defatted sesame and perilla methanol extracts on cognitive function and antioxidant activity of learning- and memory-impaired animal model SAMP8 mice. Animals were divided into 4 groups and fed with diets containing 0.3%(w/w) defatted sesame (S) or defatted perilla methanol extracts (P) for 12 weeks. Step through latency of SAMP8 control group was significantly higher than that of SAM R1 normal group, whereas significantly increased in S and P groups compared with SAMP8 control on passive avoidance test (p<0.001). Acetylcholinesterase activity of brain in SAMP8 increased compared with SAMR1 but no difference between SAMP8 control group and sample-treated group. Brain TBARS contents of SAMP8 control significantly increased compared with SAMR1 and were lowered significantly by supplementation of defatted sesame and perilla methanol extracts. Defatted sesame and perilla methanol extracts attenuated increased brain superoxide dismutase and glutathione peroxidase activities in SAMP8. These results suggest defatted sesame and perilla methanol extracts could attenuate cognitive deficits induced by aging possibly through activation of antioxidant activity of defatted sesame and perilla methanol extracts.

• CELLMED
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• v.14 no.4
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• pp.73.1-73.4
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• 2024

Objective: Case study on improving body homeostasis by ortho-cellular nutrition therapy. Methods: A 48-year-old Korean man underwent OCNT due to symptoms of insomnia and decreased physical function due to extreme chronic stress. Results: After exposure to OCNT, fatigue, sleep quality, and brain fog symptoms improved, and overall physical performance improved, including liver function recovery. Conclusion: For people who suffer from symptoms of decreased physical function in various aspects due to extreme stress, applying OCNT can help alleviate symptoms.

• Journal of Cardiovascular Imaging
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• v.30 no.3
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• pp.197-201
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• 2022