• Investigative Magnetic Resonance Imaging
• /
• 제26권2호
• /
• pp.125-134
• /
• 2022

Purpose: The aim of this study was to investigate the change in signal sensitivity over different acquisition start times and optimize the scanning window to provide the maximal signal sensitivity of [1-¹³C]pyruvate and its metabolic products, lactate and alanine, using spatially localized hyperpolarized 3D ¹³C magnetic resonance spectroscopic imaging (MRSI). Materials and Methods: We acquired 3D ¹³C MRSI data from the brain (n = 3), kidney (n = 3), and liver (n = 3) of rats using a 3T clinical scanner and a custom RF coil after the injection of hyperpolarized [1-¹³C]pyruvate. For each organ, we obtained three consecutive 3D ¹³C MRSI datasets with different acquisition start times per animal from a total of three animals. The mean signal-to-noise ratios (SNRs) of pyruvate, lactate, and alanine were calculated and compared between different acquisition start times. Based on the SNRs of lactate and alanine, we identified the optimal acquisition start timing for each organ. Results: For the brain, the acquisition start time of 18 s provided the highest mean SNR of lactate. At 18 s, however, the lactate signal predominantly originated from not the brain, but the blood vessels; therefore, the acquisition start time of 22 s was recommended for 3D ¹³C MRSI of the rat brain. For the kidney, all three metabolites demonstrated the highest mean SNR at the acquisition start time of 32 s. Similarly, the acquisition start time of 22 s provided the highest SNRs for all three metabolites in the liver. Conclusion: In this study, the acquisition start timing was optimized in an attempt to maximize metabolic signals in hyperpolarized 3D ¹³C MRSI examination with [1-¹³C] pyruvate as a substrate. We investigated the changes in metabolic signal sensitivity in the brain, kidney, and liver of rats to establish the optimal acquisition start time for each organ. We expect the results from this study to be of help in future studies.

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 2009년도 정보 및 제어 심포지움 논문집
• /
• pp.145-147
• /
• 2009

This research measures EEG signals which are generating on head skin and extracts brain concentration level related with brain activity. We have developed concentration wireless transmission system by displaying this EEG signal on PDA mobile device. The front head was used for measuring EEG signal and INA128 with TL084 and analog elements was used for measuring EEG signal, amplifying and filtering the signal. Measured analog EEG signals changed into digital signals by using ADC of PIC24FJ192 with 10bit resolution and 500Ks/s sampling rate. So The changed digital signals have transmitted to the PDA by using bluetooth. LabView 8.5 was also used for FFT transformation, frequency and spectrum analysis of the transferred EEG signal. As a result, $\alpha$ wave, $\beta$ wave, $\theta$ wave and $\delta$ wave were classified. we extracted the concentration index by adapting concentration extraction algorithm. This concentration index was transferred into PDA by wireless module and displaying.

• Journal of Preventive Medicine and Public Health
• /
• 제31권4호
• /
• pp.644-665
• /
• 1998

This study was conducted to evaluate the health hazards and to develop early diagnostic methods of the manganism in experienced welders and to know the meaning of signal intensities on the brain Magnetic Resonance images. It was carried out from December 1996 to february 1997 with 277 male welders, the duration of welding was at least 5 years or more. The study was consisted of a questionnaire, physical examination and measurements of blood & urine manganese concentrations. Brain Magnetic Resonance imaging was done on 19 study subjects by random sampling. As the duration of welding increases, the positive rates of clinical symptoms, neurological examinations and blood manganese concentrations were also increased. However, physical examinations and urine manganese concentrations were not statistically significant with the duration of welding. Authors couldn't observe any Parkinsonism-like diseases. There were statistically significant correlations between duration of welding and blood manganese concentration(r=0.16, p<0.01). There were not statistically significant correlations between duration of welding and urine manganese concentrations (r=0.06). There were statistically significant correlations between blood & urine manganese concentration(r=0.34, p<0.01). By viewing brain Magnetic Resonance images, 13 welders(68.4 %) among 19 welders were found to have signal intensities. The positive rates of clinical symptoms, physical examinations, neurological examinations and blood & urine manganese concentrations were not statistically different between those with signal intensities and those without signal intensities. We would like to suggest that some non-specific clinical symptoms and neurological signs are correlated with the duration of welding but any Parkinsonism-like diseases had not been observed with these welders. Next we suggest that the high signal intensities on TlWI of brain Magnetic Resonance images are not the sign of manganese intoxication but the sign of manganese deposition.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2015년도 제46회 하계학술대회
• /
• pp.1427-1428
• /
• 2015

MEMS(Micro Electro-mechanical System) are getting attention as promising industry in the 21st century. Car air bags, acceleration sensors, and medical, information appliances are being actively applied in MEMS. This paper suggest the electrical electrodes of brain signal applied MEMS model and the prototype design for EEG signal amplification circuit. Also, we suggest an independent BCI(Brain Computer Interface) system with brain electrical signal of electrode models and wireless communication platform.

• Journal of Ginseng Research
• /
• 제21권1호
• /
• pp.19-27
• /
• 1997

The present study was conducted to assess the effect of total saponins from Korean red ginseng on the biosynthesis of inositol phospholipids in vivo and also effects on the metabolic enzymes, such as phosphatidylinositol-specific phospholipase C(Pl-PLC) and PI-kinases. The administration of 0.1% saponin solution, 0.1 ml 3 times a day intraperitoneally to 5 mice for 30 days has increased a 23% of the body weight when it compared with a control group. The amounts of 32P-phoschorus radioactivity incorporated into the phosphoinositides from the liver and brain tissues have increased a 310% and 260%, respectively, in the saponin treated mice. The activities of PI-PLC from liver and brain were stimulated in the various amounts by the conditions treated with saponins. The PI-kinases from liver and brain were also activated by saponins, but its effect was lower than that of PI-PLC. From these results, it was confirmed that red ginseng saponins have affected positively not only on the biosynthesis of phosphoinositides but also on the PI-PLC and PI-kinases related to the cellular signal transduction.

• 한국HCI학회:학술대회논문집
• /
• 한국HCI학회 2009년도 학술대회
• /
• pp.642-645
• /
• 2009

Brain Computer Interface (BCI) is a communication pathway between devices (computers) and human brain. It treats brain signals in real-time basis and discriminates some information of what human brain is doing. In this work, we develop a EEG BCI system using a feature extraction such as common spatial pattern (CSP) and a classifier using Fisher linear discriminant analysis (FLDA). Two-class EEG motor imagery movement datasets with both cued and uncued are tested to verify its feasibility.

• 전자공학회논문지SC
• /
• 제46권2호
• /
• pp.41-46
• /
• 2009

본 연구는 두피에서 발생하는 EEG(Electroencephalogram)신호를 측정한 후 두뇌활동과 관련된 지표 중 집중도를 추출하여 집중도의 크기에 따라 하드웨어를 제어하는 집중도 무선전송 시스템을 구연하고자 하였다. 뇌파신호를 측정하여 집중도를 추출하기 위해 두피의 좌, 우 두 채널을 사용하였으며 Biopac의 MP100과 EEG100C을 이용하여 뇌파신호 계측 증폭 및 필터링을 하였다. 계측된 EEG 신호로부터 특정 주파수 대역 및 스펙트럼을 분석하기 위해서 LabVIEW 8.5를 이용하여 FFT(Fast Fourier Transformation)처리를 하였다. 이를 통해 SMR파, Mid-Bata파, Theta파 주파수영역으로 분류 한 후 집중도 추출 알고리즘을 적용하여 집중도 지표를 추출하였고 추출된 집중도 신호를 무선전송하여 BCI(Brain Computer Interface)기술에 응용하고자 레고 자동차에 적용하여 보았다.

• 전기전자학회논문지
• /
• 제14권2호
• /
• pp.16-23
• /
• 2010

최근 뇌 과학 연구에 관심이 높아지면서 두뇌 훈련게임, 교육응용분야 및 BCI(brain Computer Interface)등 여러 분야에서 뇌파를 이용한 장치들이 개발 되고 있다. 본 논문에서는 전두엽 뇌파를 이용해서 간편하고 손쉽게 사용할 수 있는 블루투스 기반 무선 포터블형 뇌파 측정장치를 설계 제작하였다. 10~100 ${\mu}V$의 낮은 진폭을 가진 뇌파를 증폭하여 수V까지 증폭하였고 불필요한 잡음신호와 60 Hz의 전원 노이즈를 제거 하기위하여 저역필터, 고역필터 및 노치 필터를 설계하였다. 또한, 아날로그 뇌파신호를 디지털신호로의 변환과 PC로의 무선 전송을 위해 PIC24F192 마이크로컨트롤러를 사용하였다. AD변환 샘플링율은 1kHz로 하였고, 블루투스방식의 무선전송방식을 이용하여 38,400bps로 PC로 전송하였다. PC로 입력할 때 LabVIEW 프로그램를 이용하여 뇌파신호를 수신하여 모니터링 하였다. 상용 뇌파측정 장치인 Biopac MP100과 개발된 장치에 각각 $1{\mu}V$, 0~200Hz의 동일한 사인파 시뮬레이션 신호를 입력한 후 FFT 변환 후 각각 파워스펙트럼을 분석하여 성능 검증을 비교했다. 상용 Biopac 시스템 MP100과 비교해 본 결과 특히, 30Hz이하의 주파수영역에서 유사한 주파수 응답 특성결과를 얻어 제작된 시스템의 정확도가 우수함을 알 수 있었다.

• 대한의용생체공학회:의공학회지
• /
• 제35권3호
• /
• pp.50-54
• /
• 2014

It is being tried to control robot arm using brain signal in the field of brain-machine interface (BMI). This study is focused on applying guidance laws for efficient robot arm control using 3D coordinates obtained from Magnetoencephalography (MEG) signal which represents movement of upper limb. The 3D coordinates obtained from brain signal is inappropriate to be used directly because of the spatial difference between human upper limb and robot arm's end-effector. The spatial difference makes the robot arm to be controlled from a third-person point of view with assist of visual feedback. To resolve this inconvenience, guidance laws which are frequently used for tactical ballistic missile are applied. It could be applied for the users to control robot arm from a first-person point of view which is expected to be more comfortable. The algorithm which enables robot arm to trace MEG signal is provided in this study. The algorithm is simulated and applied to 6-DOF robot arm for verification. The result was satisfactory and demonstrated a possibility in decreasing the training period and increasing the rate of success for certain tasks such as gripping object.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2008년도 학술대회 논문집 정보 및 제어부문
• /
• pp.155-156
• /
• 2008

본 연구는 두피에서 발생하는 EEG(electroencephalog ram)신호를 측정한 후 두뇌활동과 관련된 지표 중 집중도를 추출하여 집중도의 크기에 따라 하드웨어를 제어하는 집중도 무선전송 시스템을 구연하고자 하였다. 뇌파신호를 측정하여 집중도를 추출하기 위해 두피의 좌, 우 두 채널을 사용하였으며 Biopac의 MP-100과 EEG100C을 이용하여 뇌파신호 계측, 증폭 및 필터링을 하였다. 계측된 EEG 신호로부터 특정 주파수 대역 및 스펙트럼을 분석하기 위해서 LabVIEW 8.5를 이용하여 FFT(Fast Fourier Transformation) 처리를 하였다. 이를 통해 ${\alpha}$파, ${\beta}$파, ${\theta}$파, ${\delta}$파 주파수영역으로 분류한 후 집중도 추출 알고리즘을 적용하여 집중도 지표를 추출하였고 추출된 집중도 신호를 무선전송하여 BCI(Brain Computer Interface) 기술에 응용하고자 레고 자동차에 적응하여 보았다.