• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.153-161
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• 2007

Stroke is the second most significant disease leading to death in Korea. The conventional therapeutic approach is mainly based on physical training, however, it usually provides the limited degree of recovery of the normal brain function. The electric stimulation therapy is a novel and candidate approach with high potential for stroke recovery. The feasibility was validated by preliminary rat experiments in which the motor function was recovered up to 80% of the normal performance level. It is thought to improve the neural plasticity of the nerve tissues around the diseased area in the stroked brain. However, there are not so much research achievements in the electric stimulation for stroke recovery as for the Parkinson's disease or Epilepsy. This study aims at the developments of a wireless variable pulse generator using ZigBee communication for future implantation into human brain. ZigBee is widely used in wireless personal area network (WPAN) and home network applications due to its low power consumption and simplicity. The developed wireless pulse generator controlled by ZigBee can generate various electric stimulations without any distortion. The electric stimulation includes monophasic and biphasic pulse with the variation of shape parameters, which can affect the level of recovery. The developed system can be used for the telerehabilitation of stroke patient by remote control of brain stimulation via ZigBee and internet. Furthermore, the ZigBee connection used in this study provides the potential neural signal transmission method for the Brain-Machine Interface (BMI).

• Journal of KIISE
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• v.44 no.6
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• pp.587-594
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• 2017

Recently, motor imagery electroencephalogram(EEG) based Brain-Computer Interface(BCI) systems have received a significant amount of attention in various fields, including medicine and engineering. The Common Spatial Pattern(CSP) algorithm is the most commonly-used method to extract the features from motor imagery EEG. However, the CSP algorithm has limited applicability in Small-Sample Setting(SSS) situations because these situations rely on a covariance matrix. In addition, large differences in performance depend on the frequency bands that are being used. To address these problems, 4-40Hz band EEG signals are divided using nine filter-banks and Regularized CSP(R-CSP) is applied to individual frequency bands. Then, the Mutual Information-Based Individual Feature(MIBIF) algorithm is applied to the features of R-CSP for selecting discriminative features. Thereafter, selected features are used as inputs of the classifier Least Square Support Vector Machine(LS-SVM). The proposed method yielded a classification accuracy of 87.5%, 100%, 63.78%, 82.14%, and 86.11% in five subjects("aa", "al", "av", "aw", and "ay", respectively) for BCI competition III dataset IVa by using 18 channels in the vicinity of the motor area of the cerebral cortex. The proposed method improved the mean classification accuracy by 16.21%, 10.77% and 3.32% compared to the CSP, R-CSP and FBCSP, respectively The proposed method shows a particularly excellent performance in the SSS situation.

• Investigative Magnetic Resonance Imaging
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• v.4 no.2
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• pp.128-135
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• 2000

Purpose : The aim of this study is to develope the Magnetic Resonance Spectroscopy(MRS) data processing S/W which plays an important role as a diagnostic tool in clinical field. Materials and methods : Post-processing software of MRS based on graphical user interface(GUI) under windows operating system of personal computer(PC) was developed using MATLAB(Mathwork, U.S.A.). This tool contains many functions to increase the quality of spectrum data such as DC correction, zero filling, line broadening, Gauss-Lorentzian filtering, phase correction, etc. And we obtained the normal human brain $^1H$ MRS data from parietal white matter, basal ganglia and occipital grey matter region using 1.5T Gyroscan ACS-NT R6 (philips, Amsterdam, Netherland) MRS package. The analysis of the MRS peaks were performed by obtaining the ratio of peak area. Results : The peak ratios of NAA/Cr, Cho/Cr, MI/Cr for the different MRS machines have a little different values. But these peak ratios were not significantly different between different echo time MRS peak ratios in the same machine (p<0.05). Conclusion : MRS post-processing S/W based on GUI using PC was developed and applied to the analysis of normal human brain $^1H$ MRS. This independent MRS processing job increases the performance and throughput of patient scan of main console. Finally, we suggest that the database for normal in-yivo human MRS data should be obtained before clinical applications.

• Journal of Semiconductor Engineering
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• v.1 no.3
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• pp.88-98
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• 2020

As biosensors are widely used in the medical field, flexible devices compatible with live animals have aroused great interest. Especially, significant research has been carried out to develop implantable or skin-attachable devices for real-time bio-signal sensing. From the device point of view, various biosensor types such as field-effect transistors (FETs) and multi-electrode arrays (MEAs) have been reported as diverse sensing strategies. In particular, the flexible FETs and MEAs allow semiconductor engineering to expand its application, which had been impossible with stiff devices and materials. This review summarizes the state-of-the-art research on flexible FET and MEA biosensors focusing on their materials, structures, sensing targets, and methods.

• Journal of the Institute of Convergence Signal Processing
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• v.18 no.2
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• pp.31-36
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• 2017

This study aims to develop an BCI speller utilizing eye-closed and double-blinking EEG based on asynchronous mechanism. The proposed system comprised a signal processing module and a graphical user interface (virtual keyboard-VK) with 26 English characters plus a special symbol. A detected "eye-closed" event induces the "select" command, whereas a "double-blinking" (DB) event functions the "undo" command. A three-class support vector machine (SVM) classifier involving EEG signal analysis of three groups of events ("eye-open"-idle state, "eye-closed", and "double -blinking") is proposed. The results showed that the proposed BCI could achieve an overall accuracy of 92.6% and a spelling rate of 5 letters/min on average. Overall, this study showed an improvement of accuracy and the spelling rate resulting from in the feasibility and reliability of implementing a real-world BCI speller.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.6
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• pp.1333-1342
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• 2018

Until now, Electroencephalography(: EEG) has been the most important and convenient method for the diagnosis and treatment of epilepsy. However, it is difficult to identify the wave characteristics of an epileptic EEG signals because it is very weak, non-stationary and has strong background noise. In this paper, we analyse the effect of dimensionality reduction methods on Epileptic EEG feature selection and classification. Three dimensionality reduction methods: Pincipal Component Analysis(: PCA), Kernel Principal Component Analysis(: KPCA) and Linear Discriminant Analysis(: LDA） were investigated. The performance of each method was evaluated by using Support Vector Machine SVM, Logistic Regression(: LR), K-Nearestneighbor(: K-NN), Decision Tree(: DR) and Random Forest(: RF). From the experimental result, PCA recorded 75% of highest accuracy in SVM, LR and K-NN. KPCA recorded 85% of best performance in SVM and K-KNN while LDA achieved 100% accuracy in K-NN. Thus, LDA dimensionality reduction is found to provide the best classification result for epileptic EEG signal.

• Journal of the Ergonomics Society of Korea
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• v.31 no.2
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• pp.319-325
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• 2012

Objective: The aim of this study was to develop the assistive device for accelerator and brake pedals using bio-signals from the prefrontal lobe in the driving simulator and evaluate its performance. Background: There is lack of assistive devices for the driving in peoples with disabilities in Korea. However, if bio-signals and/or brain waves are used at driving a car, the people with serious physical limitations can improve their community mobility. Method: 15 subjects with driver's license participated in this study for experiment of driving performance evaluation in the simulator. Each subject drove the simulator the same course 10 times in three separated groups which use different interface controllers to accelerate and brake: (1) conventional pedal group, (2) joystick group and (3) bio-signal group(horizontal quick glance of the eyes and clench teeth). All experiments were recorded and the driving performances were evaluated by three inspectors. Results: Average score of bio-signal group for the driving in the simulator was increased 3% compared with the pedal group and was increased 9% compared with the joystick group(p<0.01). The subjects using bio-signals was decreased 44% in number of deduction compared with others because the device had the built-in modified cruise control. Conclusion: The assistive device for accelerator and brake pedals using bio-signals showed significantly better performance than using general pedal and a joystick interface(p<0.01). Application: This study can be used to design adaptive vehicle for driving in people with disabilities.

• Journal of KIISE
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• v.41 no.12
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• pp.1050-1057
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• 2014

Electroencephalogram (EEG)-based brain-computer interfaces (BCI) can be used for a number of purposes in a variety of industries, such as to replace body parts like hands and feet or to improve user convenience. In this paper, we propose a method to decompose and extract motor imagery EEG signal using Empirical Mode Decomposition (EMD) and Fast Fourier Transforms (FFT). The EEG signal classification consists of the following three steps. First, during signal decomposition, the EMD is used to generate Intrinsic Mode Functions (IMFs) from the EEG signal. Then during feature extraction, the power spectral density (PSD) is used to identify the frequency band of the IMFs generated. The FFT is used to extract the features for motor imagery from an IMF that includes mu rhythm. Finally, during classification, the Support Vector Machine (SVM) is used to classify the features of the motor imagery EEG signal. 10-fold cross-validation was then used to estimate the generalization capability of the given classifier., and the results show that the proposed method has an accuracy of 84.50% which is higher than that of other methods.

• Journal of Broadcast Engineering
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• v.27 no.5
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• pp.738-750
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• 2022

In this study, we reviewed and discussed whether auditory stimuli with short length can evoke emotion-related neurological responses. The findings implicate that if personalized sound tracks are provided to XR users based on machine learning or probability network models, user experiences in XR environment can be enhanced. We also investigated that the arousal-relaxed factor evoked by short auditory sound can make distinct patterns in functional connectivity characterized from background EEG signals. We found that coherence in the right hemisphere increases in sound-evoked arousal state, and vice versa in relaxed state. Our findings can be practically utilized in developing XR sound bio-feedback system which can provide preference sound to users for highly immersive XR experiences.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.10 no.1
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• pp.9-15
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• 2017

In this study we performed the experiment to detect the ERP using SVM with wavelet features. The EEG signal that is generated visual stimulated ERP database in SCCN applied for the experiment. The feature vectors for experiment are categorized frequency and continuous wavelet- based vectors. In experimental results, the detection rate of SVM with wavelet feature vectors improved above 10% comparing with frequency- based feature vector. Based on the experimental results we analyzed the relation between the activity degree of the ERP and the band split characteristics of the ERP by wavelet transform.