• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.5
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• pp.386-391
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• 2010

Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor ${\kappa}B$ ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin $E_2$ ($PGE_2$) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth. Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients. Results: 1. The levels of IL-1, IL-6, OPG and $PGE_2$ expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth. Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.6
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• pp.466-472
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• 2010

Introduction: This study examined the effect of recombinant human bone morphogenetic protein (rhBMP)-2 and $\beta$-tricalcium phosphate ($\beta$-TCP) on new bone formation in a rabbit calvarium using a rapid prototype titanium cap (RP Ti cap). Materials and Methods: Eight New Zealand white rabbits were used in this study. Hemispherical RP Ti caps (10 mm in diameter) were implanted subperiosteally on the rabbit calvaria. $\beta$-TCP was filled in the RP Ti cap in the control group, and rhBMP-2 soaked $\beta$-TCP was used in experimental group. The rabbits were sacrificed 2 and 4 weeks after the operation. The volume and pattern of newly formed bone was analyzed by micro computed tomography (CT). Results: Macroscopically, there were no abnormal findings in any of the animals. The micro CT images revealed new bone from the calvaria that expanded gradually toward the top of the titanium cap, particularly along the inner surface of the titanium cap in the experimental group at 4 weeks after grafting. There was no significant difference in new bone volume ratio between the control and experimental groups at 2 weeks after grafting. There was a statistically significant difference in the new bone volume ratio between the experimental ($14.1{\pm}1.8\;%$) and control ($7.2{\pm}1.5\;%$) groups at 4 weeks after grafting (P<0.01). Conclusion: The RP Ti cap can effectively guide new bone formation and rhBMP-2 can induce the new bone formation.

• Journal of Engineering Education Research
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• v.16 no.3
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• pp.20-27
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• 2013

The purpose of this study is to compare the key research-related constructs, research insterest, research self-efficacy, research productivity, and research outcome expectation of the graduate students, who are participating in Global Ph.D Fellowship (GPF) and Brain Korea (BK) 21 projects. The overall results show that the mean scores of GPF students in research interest, research self-efficacy, research productivity, and research outcome expectation are higher than those of BK21. However, the higher mean scores of doctoral students in both GPF and BK21 projects imply that the longer you stay in graduate program, the better researcher you can be. Although GPF program selected higher potential students and they seem to work very hard with high expectation to be competent researchers, compatible outcome also could be possible by BK21 project.

• IE interfaces
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• v.17 no.3
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• pp.249-260
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• 2004

The objective of this study is to measure and to predict the efficiency of participating groups of BK 21 by using DEA. DEA is a methodology to measure and to evaluate the relative efficiency of a homogeneous set of decision-making units (DMUs) in a process which uses multiple inputs to produce multiple outputs. In order to reflect the effect of the environmental factors of BK 21, we consider not only a general DEA model but also a logistic model for DEA. As a result, location of participating groups of BK 21 turns out to be significant. Our proposed approach can predict the efficiency of a new BK 21 group with given environmental factors. It is expected that these models can give a feedback for effective management of BK 21.

• IE interfaces
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• v.14 no.4
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• pp.429-440
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• 2001

Brain Korea(BK) 21 is a plan launched in 2000 to strengthen the competitiveness of research and education quality of universities in Korea. In this paper, we evaluate BK21 plan using both ACSI and SEM in terms of the satisfaction level of graduate students in various dimension. The results of our study indicate that in general BK21 has a significant impact on the satisfaction of the graduate students involved in BK21. It turns out that the scholarship is the only one component which is positively related to the students' satisfaction while the industry-university cooperation system and the international conference attendance and Journal publication have negative relationship with satisfaction. In addition, it appears that those who graduated from other college and participate in BK21 tend to be more satisfied than those who admitted to the graduate program from the same college. Our study results imply that some strategies for BK21 need to be modified and effectively implemented in order to increase the number of applicant of good quality and level up the satisfaction level of the graduate students in Korea.

• Animal cells and systems
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• v.15 no.4
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• pp.268-273
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• 2011

Transgenic mice expressing green fluorescent protein (GFP) under the control of human glial fibrillary acidic protein promoter (hGFAP) have been utilized for in vivo labeling of astrocytes. Although it has been considered that virtually all astrocytes express GFP in this transgenic mouse, we found that different subsets of GFAP-expressing astrocytes express considerably different levels of GFP in the adult brain. Astrocytes in the spinal cord, the molecular layer of thecerebellum, meninges, white matter, corpus callosum and blood vessels exhibited strong GFP, whereas subsets of astrocytes associated with granule cells in the cerebellum and dentate gyrus did not or only marginally exhibited GFP. We also found that a small subset of GFP-expressing cells in the periglomeruli of the olfactory bulb did not express GFAP immunoreactivity. Collectively, these results suggest that human GFAP promoter-derived GFP expression does not faithfully recapitulate the endogenous GFAP expression in mice, suggesting that upstream regulatory mechanisms controlling GFAP transcription are different in different populations of astrocytes, and may reflect the functional diversity of astrocytes.

• Food Science and Industry
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• v.40 no.3
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• pp.31-35
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• 2007

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.45-60
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• 2020

The Brain Korea 21 (i.e., BK21) is a state-led higher education funding project that started in 2013. Previous literature investigating the effectiveness of the project mainly focused on massive quantitative outcomes of funded teams, and many studies reporting only self-reported data of graduate students who participated in the project. Therefore, there were not many BK21 studies that thoroughly examined the graduate students' performance, ability, satisfaction, etc. This study aims to determine the effect of the BK21 project participation on graduate students' academic performance, using objective (the number of published papers), self-rating (graduates' satisfaction), and other-rating (advisor's performance evaluation) data, which were sampled from 2013 to 2019 from a single funded team on a one-departmental-unit. The results showed that the participating graduate students had more published papers, and had higher performance evaluation scores in research, and overall abilities, than the non-participating graduate students. Further, participating students were largely satisfied with BK21 supports. This study has significance in that it demonstrates the positive influence of the BK21 project on graduate students' academic performance and satisfaction by the thorough investigation of a single social science funded team.

• Journal of agriculture & life science
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• v.50 no.2
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• pp.125-138
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• 2016

To assess the industrial possibility of mixed-extracts containing Hovenia dulcis Thunberg and 12 different botanical ingredients, a protective effect was confirmed in the chronic ethanol-induced the liver, brain, and blood injury in mouse. Blood glucose levels of the normal control group(NG) and ethanol administration group(EG) were respectively 119.43mg/dL and 305.25mg/dL, and the mixed-extracts administration group(100, 200mg/kg body weight + 25% ethanol 5g/kg body weight respectively; ME100 & ME200) were decreased to 272.76mg/dL and 234.60mg/dL. Blood ethanol contents were decreased in ME100 and ME200(3.85mg/dL, 3.08mg/dL) compared to EG(4.08mg/dL), and blood acetaldehyde contents were also decreased in ME(15.76mg/dL, 15.16mg/dL) compared to EG(18.72mg/dL). The contents of hepatotoxic indicators such as glutamine pyruvic transaminase(GPT) and glutamic oxaloacetic transaminase (GOT), nephrotoxic indicators such as blood urea nitrogen(BUN), and creatine(CRE), and total cholestero(TCHO), and triglyceride(TG) in mouse blood serum were significantly decreased in the ME compared to EG. The acetylcholinesterase(AChE) activity of ME(109.00% and 108.47%, respectively) in mouse brain tissues was decreased in ME compared to EG(116.10%). Finally, ME was remarkable in vivo antioxidant activities in the mouse liver and brain tissues by superoxide dismutase(SOD), oxidized glutathione(GSH)/total GSH ratio and the malondialdehyde (MDA) assay. Therefore, the mixed-extracts was considered to be effective a high value food with protective effect against chronic ethanol traetment-induced cytotoxicity in liver and brain tissues.

• (The)Korea Educational Review
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• v.14 no.2
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• pp.155-179
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• 2008

The objective of this study was to analyze the satisfaction of graduate students participating in the Brain Korea21 (BK21) project in five supporting areas of the project: curriculum, job searching and career development, academic development, the globalization of education, and educational environment. A further objective was to find efficient methods of providing students with stable academic and financial support for their research in order to develop them as distinguished researchers. In order to answer research questions, this study conducted a survey of the BK21 project satisfaction with students majoring in humanities or social sciences and analyzed the survey results. The tool has 7 dimensions: 'curriculum', 'job searching and career development', 'stable support for academic development', 'support for academic activities out of school', 'globalization of education', 'lectures in English', and 'educational environment'. The survey found that survey participants were in general satisfied with the BK21 project. Of these 7 dimensions, the results showed remarkably high satisfaction dimensions for 'stable support for academic development' and 'support for academic activities out of school' while indicating a comparatively low satisfaction for 'job searching and career development'. The result and analysis of this study suggests that the BK21 project needs to emphasize the following: PR for the project, provide opportunities for the training for career development and job information to students, modify the areas of academic support, remodel programs of short- and long-term studies in foreign countries, improve the educational service system for lectures in English, and secure research facilities.