Browse > Article
http://dx.doi.org/10.5125/jkaoms.2010.36.5.386

Expression of osteoclastogenesis related factors in dental implant patients  

Ryu, Seong-Hee (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Kim, Bang-Sin (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Jung, Seung-Gon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Han, Man-Seung (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Ohk, Seung-Ho (Department of Oral Microbiology, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Oh, Hee-Kyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 32nd stage of Brain Korea 21 (BK21), Chonnam National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.36, no.5, 2010 , pp. 386-391 More about this Journal
Abstract
Introduction: Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor ${\kappa}B$ ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin $E_2$ ($PGE_2$) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth. Materials and Methods: The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients. Results: 1. The levels of IL-1, IL-6, OPG and $PGE_2$ expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth. Conclusion: These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.
Keywords
Dental implants; Cytokines; Osteoclasts;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S, Findlay DM, et al. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med 1995;182: 1461-8.   DOI   ScienceOn
2 Pavlin D, Dove SB, Zadro R, Gluhak-Heinrich J. Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model: effect on type I collagen and alkaline phosphatase genes. Calcif Tissue Int 2000;67:163-72.   DOI   ScienceOn
3 Lim CD, Moon JK, Kim HS. The protein composition of gingival crevicular fluid and serum sampled from normal subjects. J Periodontal Implant Sci 1994;24:178-84.
4 Basdra EK, Komposch G. Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis. Eur J Orthod 1997;19:615-21.   DOI   ScienceOn
5 Shimizu N, Ogura N, Yamaguchi M, Goseki T, Shibata Y, Abiko Y, et al. Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells. Arch Oral Biol 1992;37:743-8.   DOI   ScienceOn
6 Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000;15:2-12.   DOI   ScienceOn
7 Hofbauer LC, Heufelder AE. Role of receptor activator of nuclear factor-$\kappa$B ligand and osteoprotegerin in bone cell biology. J Mol Med 2001;79:243-53.   DOI   ScienceOn
8 Okada N, Kobayashi M, Mugikura K, Okamatsu Y, Hanazawa S, Kitano S, et al. Interleukin-6 production in human fibroblasts derived from periodontal tissues is differentially regulated by cytokines and a glucocorticoid. J Periodontal Res 1997;32:559-69.   DOI   ScienceOn
9 Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res 1996;11:1043-51.
10 Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995;332:305-11.   DOI   ScienceOn
11 Grieve WG 3rd, Johnson GK, Moore RN, Reinhardt RA, DuBois LM. Prostaglandin E (PGE) and interleukin-1 $\beta$(IL-1 $\beta$) levels in gingival crevicular fluid during human orthodontic tooth movement. Am J Orthod Dentofacial Orthop 1994;105:369-74.   DOI   ScienceOn
12 Rody WJ Jr, King GJ, Gu G. Osteoclast recruitment to sites of compression in orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2001;120:477-89.   DOI   ScienceOn
13 Chung HJ. Collagenolytic activity of gingival crevicular fluid in progressive periodontitis. J Periodontal Implant Sci 1996;26:161- 75.
14 Kanzaki H, Chiba M, Shimizu Y, Mitani H. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor $\kappa$B ligand up-regulation via prostaglandin $E_{2}$ synthesis. J Bone Miner Res 2002;17:210-20.   DOI   ScienceOn
15 Basdra EK. Biological reactions to orthodontic tooth movement. J Orofac Orthop 1997;58:2-15.
16 Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, Williams DC, et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 1992;89:883-91.   DOI
17 Koka S, Petro TM, Reinhardt RA. Estrogen inhibits interleukin- 1beta-induced interleukin-6 production by human osteoblast-like cells. J Interferon Cytokine Res 1998;18:479-83.   DOI   ScienceOn
18 Roberts WE, Goodwin WC Jr, Heiner SR. Cellular response to orthodontic force. Dent Clin North Am 1981;25:3-17.
19 Hernandez CJ, Beaupre′GS, Carter DR. A model of mechanobiologic and metabolic influences on bone adaptation. J Rehabil Res Dev 2000;37:235-44.
20 Ducy P, Schinke T, Karsenty G. The Osteoblast: A Sophisticated Fibroblast under Central Surveillance. Science 2000;289:1501-4.   DOI   ScienceOn
21 Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science 2000;289:1508-14.   DOI