• Title/Summary/Keyword: Brain Cognition

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IDENTIFICATION OF GENES EXPRESSED IN LOW-DOSE-RATE γ-IRRADIATED MOUSE WHOLE BRAIN

  • Bong, Jin Jong;Kang, Yu Mi;Choi, Seung Jin;Kim, Dong-Kwon;Lee, Kyung Mi;Kim, Hee Sun
    • Journal of Radiation Protection and Research
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    • v.38 no.4
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    • pp.166-171
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    • 2013
  • While high-dose ionizing radiation results in long term cellular cytotoxicity, chronic low-dose (<0.2 Gy) of X- or ${\gamma}$-ray irradiation can be beneficial to living organisms by inducing radiation hormesis, stimulating immune function, and adaptive responses. During chronic low-dose-rate radiation (LDR) exposure, whole body of mice is exposed to radiation, however, it remains unclear if LDR causes changes in gene expression of the whole brain. Therefore, we aim to investigate expressed genes (EGs) and signaling pathways specifically regulated by LDR-irradiation ($^{137}Cs$, a cumulative dose of 1.7 Gy for total 100 days) in the whole brain. Using microarray analysis of whole brain RNA extracts harvested from ICR and AKR/J mice after LDR-irradiation, we discovered that two mice strains displayed distinct gene regulation patterns upon LDR-irradiation. In ICR mice, genes involved in ion transport, transition metal ion transport, and developmental cell growth were turned on while, in AKR/J mice, genes involved in sensory perception, cognition, olfactory transduction, G-protein coupled receptor pathways, inflammatory response, proteolysis, and base excision repair were found to be affected by LDR. We validated LDR-sensitive EGs by qPCR and confirmed specific upregulation of S100a7a, Olfr624, and Gm4868 genes in AKR/J mice whole brain. Therefore, our data provide the first report of genetic changes regulated by LDR in the mouse whole brain, which may affect several aspects of brain function.

The Effects of Task-Oriented Training on Motor and Cognitive Function in Focal Ischemic Brain Injury Model of Rat

  • Heo, Myoung;Kim, Gye-Yeop;Kim, Tae-Yeul;Nam, Ki-Won;Kim, Jong-Man
    • Physical Therapy Korea
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    • v.15 no.4
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    • pp.50-58
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    • 2008
  • The purpose of this study was to investigate the effects of the task-oriented training according to the application time with the change of motor and cognition function. Focal ischemic brain injury was produced in Sprague-Dawley rats (20 rats, $250{\pm}50$ g) through middle cerebral artery occlusion (MCAo). Before MCAo induction, all rats were trained in treadmill training and Morris water maze training for 1 week. Then they were randomly divided into groups: Group I : MCAo induction ($n_1$=5), Grop II: the application for simple treadmill task training after. MCAo induction ($n_2$=5). Group III: the application for Morris water maze cognitive task training after MCAo induction ($n_3$=5). Group IV: the application for progressive treadmill task training and Morris water maze cognitive task training after MCAo induction ($n_4$=5). Modified limb placing tests (MLPTs) and motor tests (MTs) were performed to test motor function and then Morris water maze acquisition test (MWMAT) and Morris water maze retention test (MWMRT) were performed to test cognitive function. For MTs, there were significant interactions among the groups with the time (p<.001). Group IV showed the steeper increasing pattern than those in other Groups on the 7th and 14th day. For MLPTs, there were significant interactions among the groups with the time (p<.001). The scores in Group III. IV had showed the more decreasing pattern than those in Group I, II since the 7th day and 14th day. For MWMAT, there were significant interactions among the groups with the time (p<.001). Group II found the Quadrant circular platform showed the steeper decreasing pattern than that in Group I on the 9th, 10th, 11th and 12th day. Group III. IV found the quadrant circular platform showed the slower decreasing pattern than that in Group I, II, For MWMRT, there were significant differences among the four groups (p<.001). The time to dwell on quadrant circular platform in Group IV on the 13th day was the longest compared with other groups. These results suggested that the combined task training was very effective to improve the motor and cognition function for the rats affected on their focal ischemic brain injury.

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Improving Effect of Silk Peptides on the Cognitive Function of Rats with Aging Brain Facilitated by D-Galactose

  • Park, Dong-Sun;Lee, Sun-Hee;Choi, Young-Jin;Bae, Dae-Kwon;Yang, Yun-Hui;Yang, Go-Eun;Kim, Tae-Kyun;Yeon, Sung-Ho;Hwang, Seock-Yeon;Joo, Seong-Soo;Kim, Yun-Bae
    • Biomolecules & Therapeutics
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    • v.19 no.2
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    • pp.224-230
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    • 2011
  • In order to develop silk peptide (SP) preparations possessing cognition-enhancing effect, several candidates were screened through in vitro assays, and their effectiveness was investigated in facilitated brain aging model rats. Incubation of brain acetyl-cholinesterase with SP-PN (1-1,000 ${\mu}g/ml$) led to inhibition of the enzyme activity up to 35%, in contrast to a negligible effect of SP-NN. The expression of choline acetyltransferase (ChAT) mRNA of neural stem cells expressing ChAT gene (F3.ChAT) was increased by 24-hour treatment with 10 and 100 ${\mu}g/ml$ SP-NN (1.35 and 2.20 folds) and SP-PN (2.40 and 1.34 folds). Four-week subcutaneous injections with D-galactose (150 mg/kg) increased activated hippocampal astrocytes to 1.7 folds (a marker of brain injury and aging), decreased acetylcholine concentration in cerebrospinal fluid by 45-50%, and thereby impaired learning and memory function in passive avoidance and water-maze performances. Oral treatment with SP preparations (50 or 300 mg/kg) for 5 weeks from 1 week prior to D-galactose injection exerted recovering activities on acetylcholine depletion and brain injury/aging as well as cognitive deficit induced by D-galactose. The results indicate that SP preparations restore cognitive functions of facilitated brain aging model rats by increasing the release of acetylcholine, in addition to neuroprotective activity.

Effect of N-BACK Program for Cognition, Visual-Perception, Depression, Anxiety, Activity of Daily Living in Stroke Patients (N-BACK 프로그램이 뇌졸중 환자의 인지, 시지각, 우울, 불안과 일상생활활동에 미치는 효과)

  • Kim, S.Y.;Kwon, S.N.;Kim, J.H.
    • Journal of rehabilitation welfare engineering & assistive technology
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    • v.9 no.3
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    • pp.185-193
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    • 2015
  • The purpose of this study was to demonstrate clinical effects on cognition, visual perception, depression, anxiety, and activities of daily living by applying the N-BACK program, a brain stimulated training program, which is used for the clinical purpose. To prove this, subjects suspected of cognitive impairment with 18-23 points in a Korean version of mental status examination (MMSE-K) were recruited among the population who had been diagnosed with stroke duration and suffered from it for six months of duration, and 10 of the subjects were selected into the experimental group and the control group, respectively. A total of 20 sessions were carried out for 30 minutes per day 5 times for 4 weeks. As a result, the experimental group who has been applied the N-BACK program showed positive results in the improvement of cognition, visual perception, depression, anxiety, and daily living skills. The results obtained from this study expect us that applying the N-BACK program for the improvement of cognition, visual perception, depression, and anxiety to stroke patients has a positive effect on the rehabilitation of patients and will lead them to improve daily living activities more independently.

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The Effects of Dementia Prevention Program on Cognition, Depression, Self-esteem and Quality of life in the Elderly with Mild Cognitive Disorder (치매예방 통합프로그램이 경증인지 장애노인의 인지기능, 우울, 자아 존중감 및 삶의 질에 미치는 효과)

  • Lee, Yun Mi;Park, Nam Hee
    • Korean Journal of Adult Nursing
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    • v.19 no.5
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    • pp.104-114
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    • 2007
  • Purpose: This study was conducted to develop and evaluate a dementia prevention intervention program for the elderly with mild cognitive disorder. Methods: The study was nonequivalent control group pretest-posttest design. The subjects of the study were a total of 68 elderly who ranged from 21 to 24 of total scores of K-MMSE, aged over 65, in home. The program consisted of music therapy, humor therapy, art therapy, dancing therapy, recreation, and health education to enhance brain function. The program was applied to the experimental group twice a week, ninety minutes per session for eight weeks. The data were analysed by using chi-square test and t-test. Results: The variables measured in the experimental group and the control group before the intervention were not significantly different in the homogeneity test. The dementia prevention program improved the cognition(t=9.243, p<.001), self-esteem(t=.4.336, p<.001), quality of life(t=8.375, p<.001) and reduced depression(t=-3.913, p<.001). Conclusion: These findings confirmed that the dementia prevention program made a contribution to improving cognitive function, self-esteem, and quality of life and also to reduce depression in the elderly with mild cognition disorder. Therefore, it is recommended that this program could be used in clinical practice as an effective nursing intervention for the elderly with mild cognitive disorder.

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Visuospatial Cognitive Performance Following Oxygen Administration in Healthy Young Men (고농도 산소 공급에 따른 젊은 성인 남자의 공간지각 능력 변화)

  • Chung, S.C.;Tack, G.R.;Yi, J.H.;Sohn, J.H.
    • Journal of Korean Institute of Industrial Engineers
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    • v.30 no.1
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    • pp.11-16
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    • 2004
  • Oxygen is an essential element for human beings' physical and mental activities, and in particular, plays an important role in brain functions. The present study attempted to investigate the effects of supply of highly concentrated (30%) oxygen on human ability of visuospatial cognition, compared to air of normal oxygen concentration (21%). This study sampled eight male university students (the average age: 23.5) as subjects. An equipment that supplies 21% and 30% oxygen at a constant rate of 8L/min was developed. Two types of questionnaire containing 20 questions were developed to measure the ability of visuospatial cognition, and accuracy and reaction time were calculated from the result of task performance. The average accuracy was $50.63{\pm}8.63$ [%] and $62.50{\pm}9.64$[%] for 21%and 30% oxygen respectively, and a statistically significant difference was found in the accuracy between the two types of oxygen. The average reaction time was $6.60{\pm}O.77$ [sec] and $7.23{\pm}0.69$ [sec] for 21%and 30% oxygen respectively, and a statistically significant difference was not found in the reaction time. The results showed that there is no difference in the average reaction time but the average accuracy rises with the supply of highly concentrated (30%) oxygen, indicating that the supply of highly concentrated oxygen has a partially positive effect on the ability of visuospatial cognition.

Nerveous System Diseases Associated with Psychiatric Disorders (정신과적 장애와 연관되는 신경계 질환들)

  • Lee, Dae-Hee
    • Korean Journal of Psychosomatic Medicine
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    • v.4 no.2
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    • pp.286-293
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    • 1996
  • The studying and teaching of behavioral neurology remain in their infancy. As the arena for studying how the brain subserves cognition, emotion and consciousness, behavioral neurology straddles the boundaries of numerous, more established disciplines-extending from the most fundamental explorations of molecular biology to the broadest questions of philosophy. In behavioral neurology, the area of neural dysfunction as well as the pathogenesis must be determined. There are cases in which a more thorough mental status examination must be performed. These are practically the cases with known or suspected brain lesions and acute psychiatric disorders.

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Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes

  • Kim, Eun-Hee;Ko, Tae-Sung
    • Clinical and Experimental Pediatrics
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    • v.59 no.4
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    • pp.155-164
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    • 2016
  • Cognitive impairment associated with childhood-onset epilepsy is an important consequence in the developing brain owing to its negative effects on neurodevelopmental and social outcomes. While the cause of cognitive impairment in epilepsy appears to be multifactorial, epilepsy-related factors such as type of epilepsy and underlying etiology, age at onset, frequency of seizures, duration of epilepsy, and its treatment are considered important. In recent studies, antecedent cognitive impairment before the first recognized seizure and microstructural and functional alteration of the brain at onset of epilepsy suggest the presence of a common neurobiological mechanism between epilepsy and cognitive comorbidity. However, the overall impact of cognitive comorbidity in children with epilepsy and the independent contribution of each of these factors to cognitive impairment have not been clearly delineated. This review article focuses on the significant contributors to cognitive impairment in children with epilepsy.

Hypertension and cognitive dysfunction: a narrative review

  • Eun-Jin Cheon
    • Journal of Yeungnam Medical Science
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    • v.40 no.3
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    • pp.225-232
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    • 2023
  • Cognitive dysfunction is relatively less considered a complication of hypertension. However, there is sufficient evidence to show that high blood pressure in middle age increases the risk of cognitive decline and dementia in old age. The greatest impact on cognitive function in those with hypertension is on executive or frontal lobe function, similar to the area most damaged in vascular dementia. Possible cognitive disorders associated with hypertension are vascular dementia, Alzheimer disease, and Lewy body dementia, listed in decreasing strength of association. The pathophysiology of cognitive dysfunction in individuals with hypertension includes brain atrophy, microinfarcts, microbleeds, neuronal loss, white matter lesions, network disruption, neurovascular unit damage, reduced cerebral blood flow, blood-brain barrier damage, enlarged perivascular damage, and proteinopathy. Antihypertensive drugs may reduce the risk of cognitive decline and dementia. Given the high prevalence of dementia and its impact on quality of life, treatment of hypertension to reduce cognitive decline may be a clinically relevant intervention.