• 대한핵의학회:학술대회논문집
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• 2000.05a
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• pp.58.1-58.1
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• 2000

• Annals of Clinical Neurophysiology
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• v.20 no.2
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• pp.57-65
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• 2018

Near-infrared spectroscopy (NIRS) monitoring has been used mainly to detect reduced perfusion of the brain during orthostatic stress in order to assess orthostatic intolerance (OI). Many studies have investigated the use of NIRS to reveal the pathophysiology of patients with OI. Research using NIRS in other neurological diseases (e.g., stroke, epilepsy, and migraine) is continuing. NIRS may play an important role in monitoring the regional distribution of the hemodynamic flow in real time and thereby reveal the underlying pathophysiology and facilitate the management of not only patients with OI symptoms but also those with various neurological diseases.

• Journal of Biomedical Engineering Research
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• v.15 no.1
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• pp.105-110
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• 1994

In this paper, we present a method to evaluate source locations and distributed region which is specified brain activity, as indicated by locations and strengths of intracranial sources, using potential gradients of interpolation polynomials and topographic mapping of the EEG records. This method can analyze the variance of source temporally or spatially and leads to enable a quantitative evaluation of potential gradients drawing methods which is now being used in the clinic. In the result, we obtained the overall potentials distribution on the entire scalp and the information of potential source locations from the EEG records of a patient which was known to epilepsy.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.2
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• pp.155-157
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• 2006

Myoclonus is manifested in a variety of situations including metabolic derangements, brain lesions, epilepsy, and drugs toxicity. We reported a rare case of amitriptyline-induced myoclonus. A 64-year-old man with a tension-type headache was administered amitriptyline at 15 mg/day. Eight days after initiation of amitriptyline, multifocal myoclonus developed, involving the face and upper extremities. Two hours after the administration of clonazepam at 1 mg, myoclonus resolved completely.

• The Journal of Pediatrics of Korean Medicine
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• v.16 no.1
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• pp.75-80
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• 2002

A 10-year-old boy with a history of epileptic seizure for 3 years, showed ataxia and left side weakness. In Brain MRI, hemiatrophy of the right hemisphere was noted. So we considered that he had a cerebral hemiatrophy caused by continued epileptic seizure and treated him with herbal medicine, acupuncture and physical therapy. We report a case of a 10-year-old boy who showed symptoms of a cerebral hemiatrophy caused by maintained epileptic seizure.

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.2
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• pp.115-123
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• 2008

Objectives : The purpose of this study is to report a case showed some clinical improvement in treating child aphasia with oriental medicine. Methods : The patient had some problems in communication, intelligence and behaviors due to aphasia after brain injury caused by epilepsy. We treated the patient with herbal medicine(Yangsintangkamibang), acupuncture, verbal remediation and intelligence-learning treatment. We observed the clinical progress of aphasia and evaluated the case with PRES. Results : Oriental medical treatment alleviated patient's symptoms of aphasia and PRES was also improved. Conclusions : This study shows oriental medicine can be a meaningful treatment for child aphasia, and more studies for oriental medical treatment for child aphasia is needed.

• Proceedings of the IEEK Conference
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• 2002.06e
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• pp.133-136
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• 2002

EEG(Electroencephalography) is generated by electrical activity between neurons in cortical. Waveform of EEG is changed according to body and mental states. Therefore EEG is used to diagnosis of encephalophyma and epilepsy, etc. Also EEG is used to HCI(Human-Computer Interface). This paper describes estimation of orientation and location of dipole sources. The forward model is three-layer spherical head model and current dipole model. Using analytical solution, EEG is generated. Using MNLS(Minimum-Norm Least-Square) method, orientation and location of dipole moment is estimated.

• Clinical and Experimental Pediatrics
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• v.54 no.6
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• pp.241-245
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• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.

• Korean Journal of Veterinary Research
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• v.57 no.1
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• pp.47-50
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• 2017

Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.

• Annals of Clinical Neurophysiology
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• v.20 no.1
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• pp.36-40
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• 2018

Lennox-Gastaut syndrome (LGS) is an electro-clinical syndrome composed of the triad of mental retardation, multiple seizure types, and the characteristic generalized slow spike-wave complexes in the electroencephalogram. In this article, we report on two patients with LGS whose brain magnetic resonance imaging showed dysgenesis of corpus callosum (CC). We discuss the role of CC in the genesis of secondary bilateral synchrony.