• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.92-110
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• 2015

Objectives : The water extract of Bowon-tang composited with thePanax, AstragalusandGlycyrrhiza Radixhas been traditionally used for treatment of a sickly child and smallpox in oriental medicine. However, little is known about the regulatory effects of Bowon-tang on the production, expression and activity of immune mediators [nitric oxide, prostaglandin E2, inducible nitric oxide synthetase, cyclooxygenase-2], the macrophage activation factor production, the proliferation, subset expression, the killing activity, and the capping in immune cells.Methods : In this study, we investigated the effects of water extracts from Bowon-tang,Panax, AstragalusorGRin mouse immune cells or human Jurkat T cells. Each extract (25-200 ㎍/㎖)perse had no cytotoxic effect in unstimulated macrophages, but concentration-dependently regulated NO and PGE₂production, iNOS expression, and COX-2 activity in mouse peritoneal macrophages with MAF stimulation. These regulatory effects were synergistically increased by their combination (Bowon-tang).Results : The extract of Bowon-tang concentration-dependently regulated T cell proliferation, CD4⁺and CD8⁺expression, and NK killing activity in mouse splenocytes and capping in Jurkat T cells.Conclusions : These results suggest that the water extract of Bowon-tang composited with thePanax, AstragalusandGRmay be useful for therapeutic drugs against a sickly constitution and immune diseases, probably by regulating the production of immune mediators.

• Journal of Sasang Constitutional Medicine
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• v.21 no.2
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• pp.42-47
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• 2009

1. Objects : This paper was written in order to understand of Taeumjowitang(太陰調胃湯). 2. Methods : We analysis prescription's combination of Taeumin's experior diseases through pathology and new prescription in DongyiSuseBowonSasangChoBonKywun(東醫壽世保元 四象草本卷), DongyiSuseBowon GabObon(東醫壽世保元 甲午本), DongyiSuseBowon ShinChukBon(東醫壽世保元 辛丑本). 3. Results and Conclusions : 1) The origin of Taeumjowitang(太陰調胃湯) is BoPyeSaengMacTang(補肺生脈湯) which is combination of SaengMacSane(生脈散) and SanYakHwaWiJun(山藥和胃煎). 2) BoPyeSaengMacTang(補肺生脈湯) was changed to GilGyungSaengMacSan(桔梗生脈散) in DongyiSuseBowon GabOBon(東醫壽世保元 甲午本). GilGyungSaengMacSan(桔梗生脈散) was changed to HanDaYulSoTang(寒多熱少湯) and Taeumjowitang(太陰調胃湯) in DongyiSuseBowon ShinChukBon(東醫壽世保元 辛丑本). 3) Taeumjowitang(太陰調胃湯) is combination of BoPyeWonTang(補肺元湯) which help Exhale Dispersing Qi of Lung, and adlay(薏苡仁), dry nut(乾栗) and radish seed(羅葍子) which help Stomach Qi, calamus(石葍蒲) which regular Qi, ephedra(麻黃) which is exhale experior cold Qi.

• Journal of Sasang Constitutional Medicine
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• v.17 no.1
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• pp.25-32
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• 2005

1. Objectives There are two kind of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ and ${\ulcorner}$ShinchukBon${\lrcorner}$ These books are similar each other, and there are difference from the contents of books. Among them we studied the sentence of Gyemagakban-tang between ${\ulcorner}$GaboBon${\lrcorner}$ and ${\ulcorner}$ShinchukBon${\lrcorner}$ of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$2. Methods The study is to compare to ${\ulcorner}$GaboBon${\lrcorner}$ and ${\ulcorner}$ShinchukBon${\lrcorner}$ on the basis of texts of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$. 3. Results 1) We can see that Lee Je-Ma was trying to cure Soeumin by the treatment of ascent and grow up Yang(陽) and Ki(氣) as seen in the text of Gyemagakban-tang. 2) We can see that Lee Je-Ma considers sweating as the symptom of Taeumin and evacuating of stools as the symptom fo Soyangin in the text of ${\ulcorner}$GaboBon${\lrcorner}$ 3) We can see fever in the text of Gyemagakban-tang is the fundamental of the pathology of Soyangin. 4. Conclusions In addition more bliolographic study, clinical investigation will be needed.

• Journal of Haehwa Medicine
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• v.11 no.1
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• pp.285-294
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• 2002

The purpose of this study was to find the way of treatment and prevention the stroke by Sasang constitutional medical therapy. I came to get some conclusions after considering literatures of ${\ll}$Dongyi Suse Bowon${\gg}$ and the conclusion as follows. 1. In ${\ll}$Dongyi Suse Bowon${\gg}$ the stroke of Soumin is caused by 'Interior cold disease'. When 'Interior Yin' can not descend, the disease arise. In this case Lee Je-ma used 'Sohabhyang-won(蘇合香元)', 'Chulaek-su(鐵液水)'. 2. The stroke of Soyangin is caused by 'Interior heat disease'. When the hot Qi of stomach and spleen is blocked, the disease arise. In this case Lee Je-ma used 'Dokhwal-jihwang-tang(獨活地黃湯)', 'Jihwang-baekho-tang(地黃白虎湯)'. 3. The stroke of Taeumin is caused by 'Dry and heat disease'. When the heat of liver and the dryness of lung is excessive, the disease arise. In this case Lee Je-ma treated with 'Woohwang-chungsim-hwan(牛黃淸心丸)', 'Wonji-sukchangpo-tang(遠志石菖蒲湯)', and 'Kwache-san(瓜帶散)' etc. Above results indicate that not only taking medicine but also filling up the Healthy energy(保命之主) is important to treat stroke.

• The Journal of Internal Korean Medicine
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• v.45 no.2
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• pp.167-175
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• 2024

Hospital-acquired bacterial infections, including vancomycin-resistant enterococci (VRE) infection (MIC: 32 mcg/ml), are common. We describe the case of a 63-year-old female patient with subarachnoid hemorrhage and VRE infection treated with Jashin-bowon-tang and Samhuang-sashim-tang for 57 days and 22 days, respectively. The therapeutic effect was assessed weekly via culture, color and viscosity of pus from a coccyx sore, and C-reactive protein (CRP). Vital signs were checked four times a day. Seventeen days after treatment, VRE was not colonized in patient and color and viscosity of pus, CRP and vital sign were improved. This case report suggests that Jashin-bowon-tang and Samhuang-sashim-tang might be an alternative option for VRE infection patients reducing the need for extended isolation periods and speeding up recovery times.

• Journal of Sasang Constitutional Medicine
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• v.15 no.1
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• pp.12-26
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• 2003

1. Purpose This study is intend to catch DongMu(東武)'s viewpoint of Chobongeun Soyangin prescription. 2. Method Through Comparing Chongeun Soyangin prescriptions and medications on those of DongEuiBoGam(東醫寶鑑), DongyiSooseBowon Gabobon and DongyiSooseBowon Sinchukbon, we can find DongMu(東武)'s viewpoint of Sasang Constitutional Medicine. 3. Results 1) The same Hi prescriptions between DongEuiBoGam(東醫寶鑑) and Chobongeun Soyangin are not entirely identical. 2) GamCho(甘草), GaengMi(粳米) and Sagunja(使君子) were used in the Chobongeun Soyangin prescriptions. that means DongMu(東武)'s viewpoint of Sasang Constitutional Medicine was not entirely established. 3) PaedockSan(敗毒散), VukmijihwangTang(六味地黃湯) and BaekhoTang(白虎湯) were representative prescriptions in the Chobongeun Soyangin prescriptions. And that prescriptions were connected to DongyiSooseBowon Sinchukbon. 4) The same kind medications which were record on DongEuiBoGam(東醫寶鑑) and Chobongeun Soyangin are eighteen. And that medications are the structural principle of Chobongeun Soyangin prescriptions.

• Journal of Sasang Constitutional Medicine
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• v.11 no.1
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• pp.63-77
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• 1999

This research was intended to make the writer and the written times of "Dongyi Suse Bowon Sasang ChobonGuen" clear. Considering the contents of "Dongyi Suse Bowon Sasang ChobonGuen", it was the manuscripts of "Dongyi Suse Bowon". So it was written by Lee Je-ma and it was written when he was in the late of 40s and the beginning of the 50s. The chapter of "The origin of human being" was the manuscript of the "Dongyi Suse Bowon" and it had many clues to understand the view points to recoginze the human being, and the chapter of "The herbology and The prescription" had many drafts of original prescription of the "Dongyi Suse Bowon". 'Bangang-tang' is the original prescription of 'GyejiBanhaSnggang-tang' of "Dongyi Suse Bowon" and 'GumiChyunMunDong-tang' is the original prescription of 'CheongsimYeonja-tang' of "Dongyi Suse Bowon". Compared with the 'The pharmacology' of "Dongyi Suse Bowon", it showed the order when the pharmacology of each constitution was completed. The pharmacology of Soyangin was completed the early ears of his c1inical experience, and secondly that of Taeumin was completed, and that of Soeumin was completed in the end.

• Journal of Sasang Constitutional Medicine
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• v.22 no.1
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• pp.9-16
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• 2010

1. Background: GalgeunNabokja-Tang(葛根蘿葍子湯) is suggested as treatment and prescription of Exterior Heat syndrome Diarrhea(表熱證泄瀉) in Donguisusebowon Tae-eumin Interior febrile disease induced form the liver affected by heat("東醫壽世保元" "太陰人肝受熱裏熱病論"), but is not recorded the treatment contents in Sinjungbang("新定太陰人病應用要藥二十四方"). 2. Methods: Accordingly, the writer surveyed, compared, and arranged the relevant contents by collecting books of doctors of Four-Constitutional Medicine(四象醫) since Lee Je-ma including Lee Je-ma's books. 3. Results: and Conclusions: 1) The treatment contents in GalgeunNabokja-Tang are thought to be valid to have the criterion as the contents of appearing in SanggyohyuntoDonguisusebowon Boyubang("詳校懸吐東醫壽世保元" "補遺方"). 2) The origin in GalgeunNabokja-Tang is GalgeunNabokja-Tang in Bimang-lok("備忘錄"). And the period of having made treatment for the first time may be estimated to be the one between Donguisuse- bowonSasangchobonguan("東醫壽世保元四象草本卷") and HamsansachonDonguisusebowonGabogubon ("咸山沙村東醫壽世保元甲午舊本"). 3) GalgeunNabokja-Tang is thought to be probably what Han Du-jeong recorded in Boyubang by searching for what Lee Je-ma modified some of GalgeunNabokja-Tang in Bimang-lok while writing Pathological Syndromes("病證論") in Donguisusebowon("東醫壽世保元").

• The Journal of Internal Korean Medicine
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• v.21 no.5
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• pp.863-867
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• 2000

Byun-jo(煩躁) is the word that including in irritability, restlessness, delirium, chest discomfort, insomnia in oriental medicine. Byun-jo is one of symptom in Soyangin(少陽人)(one of human type in Sasang constitutional medicine(四象醫學)) Interior-overheated-disease(裏熱證). In the book 'dongyi soose bowon(東醫壽世保元)', Soyangin Gihwangbeakho-tang(地黃白虎湯) is used at Soyangin Interior-overheated-disease. One post-stroke patient developed new syptom named Byun-jo for 2 months. the patient was classified as Soyangin by somatotype, the emotional patterns. the patient treated with Soyangin Gihwangbeakho-tang for 7days, and the symptom Byun-jo was disappeared. This result revealed that Soyangin Gihwangbeakho-tang was effect on reducing the symtom Byun-jo in Soyangin patient.

• Journal of Sasang Constitutional Medicine
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• v.14 no.3
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• pp.153-159
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• 2002

Parkinson's disease(PD) is characterized by chronic progress of mesencephalic dopaminergic neuronal death. Diagnostic criteria for PD require at least two of three motor sign: tremor, rigidity, or bradykinesia. Levodopa and the dopamine agonists are considerd first-line drug therapy. In the book ‘dongyi soose bowon(東醫壽世保元)’, Soyangin Gihwangbeakho-tang(地黃白虎湯) is used at Soyangin Interior-overheated-disease. This case is patient who is 69 years old lady, suffered by the tremor of jaw and a slight rigidity, bradykinesia etc. This patient was classified as Soyangin by features, somatotype and emotional patterns. She improved in the tremor of jaw and others with Gihwangbeakho-tang for 67days. The result revealed that Soyangin-Gihwangbeakho-tang was effected on the tremor of jaw and others with Parkinson's disease patient.