• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.119-119
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• 1997

Valacyclovir is a L-valyl ester prodrug of acyclovir which is a highly effective and selective antiviral agent in the treatment of herpes virus diseases. Valacyclovir is rapidly and almost completely converted to acyclovir and increases the oral bioavailability of acyclovir three to five fold. However, the intestinal absorption mechanism of valacyclovir is not clear. If the improved absorption mechanism of valacyclovir is fully understood, it will provide a rationale of designing the amino acid ester prodrugs of polar drugs containing hydroxyl group. The main objective of our present study is to characterize the membrane transport mechanism of valacyclovir. Methods : Intestinal absorption of valacyclovir was investigated by using in-situ rat perfusion study and its wall permeability was estimated by modified boundary layer model. The membrane transport mechanism was also investigated through the uptake study in Caco-2 cells and in CHO-hPepTl cells. Results : In the rat perfusion study, the wall permeability of valacyclovir was ten times higher than acyclovir and showed concentration dependency, Valacyclovir also demonstrated a D,L stereo-selectivity with L-isomer having an approximately five-fold higher permeability than D-isomer. Mixed dipeptides and cephalexin, which are transported by dipeptide carriers, strongly competed with valacyclovir for the intestinal absorption, while L-valine did not show any competition with valacyclovir. This indicated that the intestinal absorption of valacyclovir could be dipeptide carrier-mediated. In addition, the competitive uptake study in Caco-2 cells presented that dipeptides reduced the valacyclovir uptake but valine did not. Also, in IC$\sub$50/ study, valacyclovir showed strong inhibition on the $^3$H-gly-sar uptake in CHO-hPepTl cells over-expressing a human intestinal peptide transporter. Taken together, the result from our present study indicated that valacyclovir utilized the peptide transporter for the intestinal absorption.

• Economic and Environmental Geology
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• v.27 no.3
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• pp.281-287
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• 1994

The present paper deals with numerical modeling of Love channel waves in transversely isotropic elastic medium. First, an explicit finite-difference scheme of second order approximation is formulated with the wave equation of SH particle displacement in transversely isotropic medium. Since it is a heterogeneous formulation, it should enable efficient modeling of complex model structures without additional treatment of the internal boundary matching. With a model of isotropic coal seam embedded in high velocity host rock, seismograms are synthesized and tutn out to be essentially identical with published ones of Korn and $St{\ddot{o}}ckl$. Next, anisotropic coal seams are investigated. It is found that the horizontal velocity of the seam appears to play a major role of determining the group velocity of Love channel waves. The group velocity increases with the increase of the horizontal velocity or vice versa. However, further study will be needed to exploit fully Love channel waves for the determination of lithology, stratification, fracture in sedimentary rocks, for instance, for hydrocarbon exploration and development.

• Cartoon and Animation Studies
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• s.14
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• pp.83-99
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• 2008

In general, the cut or dissolve or etc., collective changeover represents the change of scene in the film. Animation film makes scene's various parts to allow intended sensibility and narrative factors by special manufacturing skill generating frame image one by one and transfer it to the different symbolic dimensional expression. Nowadays sequential scene composition is not any more the unique special treatment for 2D animation according to image handling skill like morphing, metamorphosis, etc. becomes diverse and elaborate. But 2D manual animation makes spectator to be absorbed into different visual dimensions continuously and strongly beyond character and background, namely object and space. that is 2D manual animation's strong attractiveness. Finally these characteristics enable literary function which makes it possible to do delicate metaphorical through full scene composition basis and to communicate a implicative meaning system The analysis about scene broke boundary between symbolic perspective world and plane formative world and it became more diverse and complicated. Hereupon the analyzing the composition basis of formative element in the animation film scene and it's application effect make it helpful to analysis and application in the modern image scene having new absorbing methods

• Journal of Korean Medical classics
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• v.30 no.3
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• pp.1-9
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• 2017

Objectives : Chimgugyeongheombang's Byulhyul, or special points, is a list of extra points, and its acupoint types and positions are different from other books. Its source, however, is kept behind the vale. This paper aims to reveal Byulhyul's contents and source. Methods : Qixiaoliangfang, Jinjiudacheng, and Donguibogam's Gihyul were studied to determine the source of Chimgugyeongheombang's Byulhyul. Results & Conclusions : Chimgugyeongheombang lists a total of 59 special points. It cites 22 meridian points from Qixiaoliangfang, 26 points from Jinjiudacheng, and 36 points from Donguibogam. The Dictionary of Acupuncture records the source of 6 meridian points that aren't found in conventional books, namely the Soongol, Backro, Yeose, Eumdo, Naetaechoong, and Gabgeun points, as Zhenjiujicheng. However, Zhenjiujicheng, in reality, is a book put together with excerpts from three books: Donguibogam, Chimgugyeongheombang, and Leijingtuyi. This means that it's Chimgugyeongheombang that is the source of Zhenjiujicheng. Moreover, all of the points save for Soongol and Eumdo were also used in the acupunctural treatment of 9 diseases including epilepsy. In other words, it can be safely assumed that Heo Im came up with and utilized new special points based on his personal clinical experiences, and this is significant in that he expanded the boundary of the conventional study of acupuncture through his independent experiences and studies.

• Journal of Biomedical Engineering Research
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• v.33 no.4
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• pp.169-176
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• 2012

Tumor cell morphology is closely related to its migratory behaviors. An active tumor cell has a highly irregular shape, whereas a spherical cell is inactive. Thus, quantitative analysis of cell features is crucial to determine tumor malignancy or to test the efficacy of anticancer treatment. We use 3D time-lapse phase-contrast microscopy to analyze single cell morphology because it enables to observe long-term activity of living cells without photobleaching and phototoxicity, which is common in other fluorescence-labeled microscopy. Despite this advantage, there are image-level drawbacks to phase-contrast microscopy, such as local light effect and contrast interference ring. Therefore, we first corrected for non-uniform illumination artifacts and then we use intensity distribution information to detect cell boundary. In phase contrast microscopy image, cell is normally appeared as dark region surrounded by bright halo ring. Due to halo artifact is minimal around the cell body and has non-symmetric diffusion pattern, we calculate cross sectional plane which intersects center of each cell and orthogonal to first principal axis. Then, we extract dark cell region by analyzing intensity profile curve considering local bright peak as halo area. Finally, we calculated the Fourier descriptor that morphological characteristics of cell to classify tumor cells into active and inactive groups. We validated classification accuracy by comparing our findings with manually obtained results.

• 한국초전도학회:학술대회논문집
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• v.9
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• pp.363-368
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• 1999

Y-5a-Cu-O superconductors were prepared by TSMG (Top-Seeded Melt Growth) process with multiseeding technique. By using several seeds at the same time, large samples could be fabricated in a short time with simple heat treatment. However, the samples fabricated by normal multiseeding technique show the rapid decrease of trapped magnetic field value across the grain boundaries because of the residual liquid layer. To remove the residual liquid layer, modified multiseeding was newly suggested. The individual grains were combined as single domain, and did not show deterioration of magnetic property at the boundary. The formation mechanism of a well-combined domain by multiseeding technique was discussed.

• Journal of Welding and Joining
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• v.28 no.6
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• pp.35-39
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• 2010

Generally, ceramic material is very difficult to machine due to high strength and hardness. However, ceramic material can be machined at high temperature by plastic flow as metallic material due to the deterioration of the grain boundary glassy phase. Recently, a new method was developed to execute cutting process with CBN cutting tool by local heating of surface with laser. There are various parameters in LAM because it is a complex process with laser treatment and machining. During laser assisted machining, high power results in reducing of cutting force and increasing tool life, but excessive power brings oxidation of the surface. The effect of laser power, feed rate, cutting depth and etc. were investigated on the life of cutting tool. Chips were observed to find out suitable machining conditions. Chips of SSN had more flow-types than HIPSN. It means SSN is easier to machining. The life of cutting tool was increased with increasing laser power and decreasing feed rate and cutting depth.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1183-1188
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• 2005

In this paper, we propose a 3D automated measuring system which measures the mandibular movements and the reference plane of the jaw movements. In diagnosis and treatment of the malocclusions, it is necessary to estimate the mandibular movements and the reference plane of the jaw movements. The proposed system is configured with double stereo-cameras, PC, two moving pattern plates(MPPs), two fixed pattern plates(FPPs) and one orbital marker. The virtual pattern plate is applied to calculate the homogeneous transformation matrices which describe the coordinates systems of the FPP and MPP with respect to the world coordinates system. To estimate the parameters of the hinge axis, the Euler's theorem is applied. The hinge axis points are intersections between the FPPs and the hinge axis. The coordinates of a hinge axis point with respect to the MPP coordinates system are set up to fixed value. And then, the paths of the jaw movement can be calculated by applying the homogeneous transformation matrix to fixed hinge axis point. To examine the accuracy of the measurements, experiments of measuring the hinge axis points and floating paths of them are performed using the jaw motion simulator. As results, the measurement errors of the hinge axis points are within reasonable boundary, and the floating paths are very similar to the simulator's moving path.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.1
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• pp.40-46
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• 1985

Some problems such as toughness decrement and stess relief cracking (SRC), many occur when post weld heat treatment (PWHT) is applied to remove residual stress adn hydrogen. In this paper PWHT was carried out under the stress of 0, 98, 196 and 294 MPa (0, 10, 20 and 30kgf/mm$^{2}$ each) to simulate residual stress in HAZ of Cr-Mo steel. The effect of applied stress during PWHT on fracture toughness was evaluated by COD fracture toughness test, micro-hardnes test and observation of SEM. The experimental results are as follows; (1) Fracture toughness of weld HAZ was improved by PWHT, but it decreased as heat treated under the stress. (2)Hardness ratio under the stress of 294MPa (30kg/mm$^{2}$) was lower and fracture toughness was decreased than that of the no stress. (3) Applied stress in weld HAZ during PWHT assisted precipitation of over saturated alloying elements in the structure, so fracture surface at the stress of 294MPa (30kg/mm$_{2}$) appeared the grain boundary failure possibly one of the reasons for PWHT embrittlenment.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.6
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• pp.1679-1688
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• 1990

The method of nonlinear parameter estimation(NPE), which is a statistical and an inverse method, is used to estimate the thermal diffusivity of the porous insulation material. In order to apply the NPE method for measuring the thermal diffusivity, and algorithm for programing suitable to IBM personal computer is established, and is studied the statistical treatment of experimental data and theory of estimation. The experimental data obtained by discrete measurement using a constant heat flux technique are used to find the boundary conditions, initial conditions, and the thermal diffusivity, and then the final values are compared with the values obtained by some different methods. The results are presented as follows:(1) NPE method is used to establish the estimation of the thermal diffusivity and compared results with experimental output shows, that this method can be applicable to define the thermal diffusivity without considering hear flux types. (2) Because of all of the temperatures obtained by the discrete measurement on each steps of time are used to estimate the thermal diffusivity. Although some error in the temperature measurements of temperature are included in estimating process, its influences on the final value are minimzed in NPE method. (3) NPE method can reduce the experimental time including the time of data collecting in a few minutes and can take smaller specimen compared with steady state method. If the tube-type furnace is used, also the adjusting time of surrounding temperature can be reduced.