• Biomolecules & Therapeutics
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• v.23 no.1
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• pp.90-97
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• 2015

Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular $H_2O_2$-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-${\alpha}$- and interleukin-6-induced nuclear factor-${\kappa}B$ activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.22 no.1
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• pp.1-13
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• 2018

Boosting, one of the most successful algorithms for supervised learning, searches the most accurate weighted sum of weak classifiers. The search corresponds to a convex programming with non-negativity and affine constraint. In this article, we propose a novel Conjugate Gradient algorithm with the Modified Polak-Ribiera-Polyak conjugate direction. The convergence of the algorithm is proved and we report its successful applications to boosting.

• Steel and Composite Structures
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• v.24 no.2
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• pp.265-276
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• 2017

Structures are designed in such a way that they behave in a nonlinear manner when subject to strong ground motions. Energy concepts have been widely used to evaluate the structural performance for the last few decades. Energy based design can be expressed as the balance of energy input and the energy dissipation capacity of the structure. New research is needed for multi degree of freedom systems (MDOFs)-real structures- within the framework of the energy based design methodology. In this paper, energy parameters are evaluated for low-, medium- and high-rise steel special concentrically braced frames (SCBFs) in terms of total energy input and hysteretic energy. Nonlinear dynamic time history analyses are carried out to assess the variation of energy terms along the height of the frames. A seismic energy demand spectrum is developed and hysteretic energy distributions within the frames are presented.

• Korean Journal of Veterinary Research
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• v.41 no.3
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• pp.293-298
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• 2001

This study was conducted to observe the bone and cartilage formation of mouse fetuses. Mouse litters were sacrificed at pregnant 14th and 18th day and examined for gross skeletal formation using cartilage and bone staining. We identified well developed cartilage formation at the 14th pregnant day in mouse fetus. However mouse fetus at the 14th pregnant day did not show any part of bone formation. At 18th pregnant day, mouse fetus showed well developed body shape and bone and cartilage formation. This results will provide basic information for the evaluation of mouse malfromation and impairment of skeleton formation. Further study will be needed for exact explanation of bone formation from cartilage portion.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.04a
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• pp.306-308
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• 2017

디지털 정보의 활용이 보편화된 최근의 사회는 수사와 재판과정에도 많은 변화를 주었다. 사람들의 행위에 따르는 법적인 문제들을 해결하기 위해서는 디지털 방식의 자료들을 이용할 수 밖에 없으며, 특히나 산업보안 수사에서 디지털 자료는 필수 불가결하다. 대부분의 기술유출사건이 이동식 저장매체 또는 네트워크와 같은 디지털 자료를 이용하여 발생하기 때문이다. 이렇듯 디지털 증거의 중요성이 날로 증가하고 있는 상황에서 증거로서의 능력을 인정받기 위해서는 과학적이고 객관적인 절차를 필요로 한다. 하지만 기하급수적으로 늘고있는 디지털 증거에 대한 기술력과 분석력에 비해 디지털 포렌식 관련 법과 제도의 확립은 아직 부족한 실정이다. 본 연구를 통해 디지털 포렌식 관련 연구동향을 파악하고 연구 활성화를 위한 객관적인 데이터를 제공하고자 한다.

• Annals of Clinical Neurophysiology
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• v.19 no.2
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• pp.145-147
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• 2017

Trigeminal neuralgia (TN) is generally characterized by lancinating, unilateral, paroxysmal pain occurring in the distribution of the fifth cranial nerve. TN is diagnosed clinically based on the typical patient history, negative findings in a neurologic examination, and the response to medication. Idiopathic TN is the most common type, but TN can result from vascular malformation, compression, trauma, neoplasm, multiple sclerosis, or inflammation. We report a TN case diagnosed as recurrent trigeminal neuritis of the maxillary branch confirmed by magnetic resonance imaging.

• Earthquakes and Structures
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• v.11 no.4
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• pp.563-582
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• 2016

The failure mechanism and maximum collapse load of masonry structures may change significantly under static and dynamic excitations depending on their internal arrangement and material properties. Hence, it is important to understand correctly the nonlinear behavior of masonry structures in order to adequately assess their safety and propose efficient strengthening measures, especially for historical constructions. The discrete element method (DEM) can play an important role in these studies. This paper discusses possible collapse mechanisms and provides a set of parametric analyses by considering the influence of material properties and cross section morphologies on the out of plane strength of masonry walls. Detailed modeling of masonry structures may affect their mechanical strength and displacement capacity. In particular, the structural behavior of stacked and rubble masonry walls, portal frames, simple combinations of masonry piers and arches, and a real structure is discussed using DEM. It is further demonstrated that this structural analysis tool allows obtaining excellent results in the description of the nonlinear behavior of masonry structures.

• Journal of the Korean Applied Science and Technology
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• v.37 no.4
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• pp.674-681
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• 2020

The root of Codonopsis lanceolata has been used in traditional medicine. This study was conducted to confirm the comparative effect of ethanol solvent extraction (CLE) and supercritical carbon dioxide extraction (CLS) of C. lanceolata roots. CLS had higher antioxidant than CLE. For supercritical co-solvent modified carbon dioxide extraction (CLS), it were extracted at 250 bar 50℃ 150 min at a flow rate of ethyl alcohol 3 mL/min for 90min. In addition, CLS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 ㎍/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells increased approximately by 3-folds compared to that of the untreated control group. Also, the treatment by CLS (50 ㎍/mL) showed a significant increase of involucrin expression. These results indicate that supercritical carbon dioxide extract of C. lanceolatamay serve as a cosmeceutical agent for improving skin barrier function and the treatment of obesity.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1136-1142
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• 2019

The root of Paeonia lactiflora has been used in Chinese medicine. We conducted to check the comparative qualities of ethanol solvent extraction (PLE) and supercritical carbon dioxide extraction (PLS) of P. lactiflora root. PLE had higher antioxidant and polyphenol contents than PLS. But, PLS were significantly increased peroxisome proliferator-activated receptor (PPAR)-α. In addition, PLS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 ㎍/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells increased approximately by 3-folds compared to that of the untreated control group. These results indicate that P. lactiflora supercritical carbon dioxide extract may serve as a cosmeceutical for improving skin barrier function and the treatment of obesity.

• Journal of Korean Neurosurgical Society
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• v.53 no.1
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• pp.57-58
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• 2013

Thinning of parietal bone bilaterally is extremely rare but well known phenomenon. Approximate prevalence is 0.4-0.5% according to radiological scans, case reports and anthropologic researches. Even though biparietal osteodystrophy occurs mostly in over 60-year-old women, it shows no special association with race or geographical area tendency. Current definition was changed by understanding that is a pathological situation, not an anatomical variety or result of growing old in time. Biparietal osteodystrophy may have an unusual presentation and treatment still remains unclear. We aim to present a patient with biparietal osteodystrophy associated with minor head trauma that caused parietal fracture and epidural hematoma underneath.