• 동의생리병리학회지
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• 제20권1호
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• pp.125-130
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• 2006

The purpose of this research was to investigate the effects of Bopaewon-tang (BT) on immune reaction in mice. BT (500 mg/kg, p.o.) increased the viability of thymocytes, but decreased the viability of splenocytes in vivo. BT enhanced the population of $CD4^+$cells in thymocytes and enhanced the population of $Thy1^+$ cells in splenocytes and splenic $CD8^+$ cells. Also, BT decreased the production of IL-4 from splenocytes. Furthermore, BT enhanced the production of nitric oxide and the phagocytic activity of peritoneal macrophages. These results suggest that BT enhances the immune response via activation of thymocytes and macrophages.

• 동의생리병리학회지
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• 제19권6호
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• pp.1604-1609
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• 2005

The purpose of this research was to investigate the effects of Bopaewon-tang (BT) on allergic reaction. In the present study, we examined the effect of BT on type 1 and type tV allergic reaction. BT (500 mg/kg) did not affect the systemic anaphylaxis induced by compound 48180 and the passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin in vivo. Also, BT did not affect the release of histamine from peritoneal mast cells in rats. In addition, BT did not affect the permeability of evans blue into peritoneal cavity, but inhibited the writhing syndrome induced by acetic acid. BT inhibited the delayed type hypersensitivity induced by SRBC and the contact dermatitis induced by dinitrofluorobenzene. These results indicate that BT may be useful for the prevention and treatment of type IV allergy related disease.