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Effect of Bopaewon-tang on Immune Reaction  

Jeon Yong-Keun (College of Pharmacy, Woosuk University)
Lee Kyung-A (College of Pharmacy, Woosuk University)
Leem Jae-Yoon (College of Pharmacy, Woosuk University)
Kwon Jin (Korea National College of Rehabilitation & Welfare)
Jang In-Soo (College of Oriental Medicine, Woosuk University)
Song Jung-Mo (College of Oriental Medicine, Woosuk University)
Eun Jae-Soon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.1, 2006 , pp. 125-130 More about this Journal
Abstract
The purpose of this research was to investigate the effects of Bopaewon-tang (BT) on immune reaction in mice. BT (500 mg/kg, p.o.) increased the viability of thymocytes, but decreased the viability of splenocytes in vivo. BT enhanced the population of $CD4^+$cells in thymocytes and enhanced the population of $Thy1^+$ cells in splenocytes and splenic $CD8^+$ cells. Also, BT decreased the production of IL-4 from splenocytes. Furthermore, BT enhanced the production of nitric oxide and the phagocytic activity of peritoneal macrophages. These results suggest that BT enhances the immune response via activation of thymocytes and macrophages.
Keywords
Bopaewon-tang(補肺元湯); thymocytes; splenocytes; macrophages;
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