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Effect of Bopaewon-tang on Allergic Reaction  

Jeon Yong-Keun (College of Pharmacy, Woosuk University)
Leem Jae-Yoon (College of Pharmacy, Woosuk University)
Song Jung-Mo (College of Oriental Medicine, Woosuk University)
Eun Jae-Soon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.6, 2005 , pp. 1604-1609 More about this Journal
Abstract
The purpose of this research was to investigate the effects of Bopaewon-tang (BT) on allergic reaction. In the present study, we examined the effect of BT on type 1 and type tV allergic reaction. BT (500 mg/kg) did not affect the systemic anaphylaxis induced by compound 48180 and the passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin in vivo. Also, BT did not affect the release of histamine from peritoneal mast cells in rats. In addition, BT did not affect the permeability of evans blue into peritoneal cavity, but inhibited the writhing syndrome induced by acetic acid. BT inhibited the delayed type hypersensitivity induced by SRBC and the contact dermatitis induced by dinitrofluorobenzene. These results indicate that BT may be useful for the prevention and treatment of type IV allergy related disease.
Keywords
Sopaewon-tang(補肺元湯); systemic anaphylaxis; histamine; delayed type hypersensitivity;
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