• Journal of Ginseng Research
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• 제33권2호
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• pp.149-154
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• 2009

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by inhibiting the secretion of inflammatory cytokines like $TNF-{\alpha}$, IL-1, -6, and -8, and $IPN-{\gamma}$. In this study, whether KRG extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To induce arthritis, type II collagen emulsified in Complete Freund's Adjuvant was intradermally injected into the base of the tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund's Adjuvant was administered. The oral administration of KRG extract for 8${\sim}$10 weeks at the dose of 300 mg/kg (three days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-${\alpha}$, but the plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that KRG has preventive and inhibitory effects on collagen-induced arthritis.

• Journal of the Optical Society of Korea
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• 제13권1호
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• pp.53-59
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• 2009

A chirped-pulse amplification Ti:sapphire laser system has been designed using a 10-Hz 100-TW Ti:sapphire laser to generate 0.1-Hz 0.5-PW laser pulses and optimize their temporal qualities such as temporal contrast and pulse duration. A high-energy booster amplifier to be added is expected to produce an energy above 30 J through the parasitic lasing suppression and the efficient amplification. To improve the temporal contrast of the laser pulses, a high-contrast 1-kHz amplifier system is used as a front-end. A grating stretcher which makes the laser pulse have 1-ns duration is used to prevent optical damages due to high pulse energy during amplification. A grating compressor has been designed with group delay analysis to obtain the recompressed pulse duration close to the transform-limited pulse duration. The final laser pulses are expected to have energy above 20 J and duration below 40 fs.

• 디지털융복합연구
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• 제13권5호
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• pp.195-204
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• 2015

본 논문은 New Module장치를 융합한 탄산수 정수기에 대한 CTQ(Critical to Quality)를 도출, QFD기법을 활용하여 소비자의 요구사항을 반영한 핵심 품질요소를 도출하는데 목적이 있다. 시음 대상자, 일반소비자와 New Module장치를 개발한 개발자를 대상으로 설문조사와 FGI(Focus Group Interview)를 실시하여 VOC(Voice of Customer)를 도출, 개발자를 통해 EC를 도출하여 VOC와 EC(Engineering Characteristic)간의 상간관계를 도표화하여 HOQ(House of Quality)를 작성하였다. HOQ 차트를 통해 탄산수 정수기는 일정한 맛, 소음, 출수량, CO2 실린더 교체주기, 사용 편리성 등의 요소가 중요한 품질요인이라는 결과를 도출 하였다. 부품별 요인으로는 물의 맛과 관련된 Module 장치 (혼합조)와 이와 밀접한 레귤레이터, 부스터펌프, 솔레노이드가 가장 핵심부품으로 고려해야 한다는 결과를 도출 하였다.

• 전기전자학회논문지
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• 제21권1호
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• pp.66-69
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• 2017

In recent year, energy harvesting technologies from the ambient environments such as light, motion, wireless waves, and temperature again a lot of attraction form research community [1-5] due to its efficient solution in order to substitute for conventional power delivery methods, especially in wearable together with on-body applications. The drawbacks of battery-powered characteristic used in commodity applications lead to self-powered, long-lifetime circuit design. Thermoelectric generator, a solid-state sensor, is useful compared to the harvesting devices in order to enable self-sustained low-power applications. TEG based on the Seebeck effect is utilized to transfer thermal energy which is available with a temperature gradient into useful electrical energy. Depending on the temperature difference between two sides, amount of output power will be proportionally delivered. In this work, we illustrated a low-input voltage energy harvesting circuit applied discontinuous conduction mode (DCM) method for getting an adequate amount of energy from thermoelectric generator (TEG) for a specific wearable application. With a small temperature gradient harvested from human skin, the input voltage from the transducer is as low as 60mV, the proposed circuit, fabricated in a $0.6{\mu}m$ CMOS process, is capable of generating a regulated output voltage of 4.2V with an output power reaching to $40{\mu}W$. The proposed circuit is useful for powering energy to battery-less systems, such as wearable application devices.

• 한국안전학회지
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• 제26권1호
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• pp.1-7
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• 2011

When the pumps stopped in the operation by the power failure, the hydraulic transients take place in the sudden change of a velocity of pipe line. Each and every water hammer problem shows the critical stage to be greatly affected the facts of safety and reliability in case of power failure. The field tests of the water hammer executed at Cheong-Yang booster pump station having an air chamber. The effects were studied by both the practical experiments and the CFD(Computational Fluid Dynamics : Surge 2008). The result states that the system with water hammering protection equipment was much safer when power failure happens. The following data by a computational fluid dynamic analysis are to be shown below, securing the system stability and integrity. (1) With water hammering protection equipment. (1) Change of pressure : Up to $15.5\;kg/cm^2$ in contrary to estimating $16.88\;kg/cm^2$. (2) Change rate of water level : 52~33% in contrary to estimating 55~27%. (3) Note that the operational pressure of pump runs approx. 145 m, lowering 155 m of the regularity head of pump. (4) Note that the cycle of water hammering delays from 80 second to 100 second, together with easing the function of air value at the pneumatic lines. (2) Change of pressure without water hammering protection equipment : Approximate $22.86\;kg/cm^2$. The comprehensive result says that the computational fluid dynamics analysis would match well with the practical field-test. It was able to predict Max. or Min. water hammering time in a piping system. This study aims effectively to alleviate water hammering in a pipe line to be installed with air chamber at the pumping station and results in making the stability of pump system in the end.

• 한국군사과학기술학회지
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• 제22권6호
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• pp.745-753
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• 2019

Recently, with the development of long-range / high-altitude guided weapon system for defense against ballistic missile, test range and firing altitude for guided weapons are increasing. Due to the increase in the test range and the intercepting altitude, it is expected to increase the range of safety area required for the firing test. Comparing to the foreign countries which have many desert or non-residence, in the domestic circumstances where the population is concentrated and distributed, it is more important to predict the falling area and to set the safety area for safely carry out the long-range / high-altitude intercept test. In this paper, we consider the following three points. The first is the booster fall trajectory modeling, the second is the shroud fall trajectory modeling, and finally, the debris dispersion modeling for the missile intercept. Especially, the AUTODYN model was used to predict debris falling area which produced in the high-speed guided missile intercepting test.

• 한국진공학회지
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• 제20권3호
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• pp.165-175
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• 2011

본 논문에서는 건식 진공펌프에서 측정한 다중 변수로 구성된 배치데이터의 통계적인 특성을 소개한다. 흡입구 및 배출구 압력과 부스터/드라이 펌프의 소비전류와 같은 상태변수의 변위분포는 2개나 3개의 특정적인 구간으로 나뉘는 특성이 있다. 이런 관측을 통해 발견한 통계학적 특성을 나타내기 위해 적응형 인자 모델(APM)을 사용하였다. APM 모델기반의 배치 데이터는 건식 진공펌프의 상태를 진단하는데 적절함을 증명하였고, 이전의 동적 시간 왜곡 알고리즘과 비교하였을 때 계산시간 및 필요 메모리 면에서 효율적임을 확인하였다.

• Journal of Korean Medical Science
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• 제33권50호
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• pp.321.1-321.7
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• 2018

Background: Pertussis is highly contagious respiratory disease. Healthcare workers (HCWs) can be an important mediator of the disease. A seroprevalence of pertussis was investigated in HCWs to determine the immune status against pertussis and to detect the unidentified pertussis. Methods: This study was conducted for HCWs at a hospital located in Korea in 2011. After obtaining written informed consent for HCWs voluntarily participating in the study, 10 mL of blood was collected from each subject. Demographic and medical data were collected using questionnaire. Data on the underlying disease and vaccination history were reviewed again through medical records. The presence of anti-pertussis toxin (anti-PT) immunoglobulin G (IgG), and immunoglobulin A (IgA) was detected by quantitative analysis using a commercially available ELISA kit (EUROIMMUN, $L{\ddot{u}}beck$, Germany). Results: A total of 412 HCW participated in the study. Among them, 14 were excluded due to the inadequate sample amount or medical history not secured. Of the 398 HCWs analyzed, 16.6% (66/398) were men and the mean age was $33.82{\pm}9.10years$ (range, 21-67). The mean anti-PT IgG titer was $8.32{\pm}20.40IU/mL$ (range, 0.4-287.5 IU/mL). The overall seroprevalence (rate of anti-PT IgG antibody [Ab] titer > 5 IU/mL) was 33.7%. Three (0.8%) HCWs had the Ab level > 100 IU/mL indicated acute infection. There was no statistically significant difference in the seroprevalence and mean titer of anti-PT IgG Ab according to age group, type of occupation, patient-facing position, or working in the pediatric department. Conclusion: The seroprevalence of pertussis of the HCWs of a university hospital in Korea was low, and there were some unrecognized acute infections. Therefore, booster immunization of pertussis to HCWs should be actively considered.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2018년도 학술발표회
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• pp.18-18
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• 2018

상수관망 시스템(Water Distribution System, WDS)은 이용자에게 양질의 상수도를 공급하기 위해 구축된 사회기반시설물로써, 정수된 물이 사용처에 도달하기까지 송수과정에서 발생 가능한 수질저하를 고려해야 한다. 일반적으로 정수장에서 염소처리를 한 후, 도달시간을 고려한 시스템 내 잔류 염소농도를 유지함으로써 수질저하를 예방한다. 여기서 상수도 내 잔류 염소농도는 미생물 번식 및 관내 부식물 등 다양한 생물 화학적 오염을 효과적으로 예방하는 반면, 과다할 경우 이용자의 음용성을 저해할 수 있어 시스템 전반에 걸쳐 염소농도의 적절한 관리가 요구된다. 특히, 상수관망에서는 공급경로 및 공급량에 따라 각 수요처의 도달 염소농도가 다르게 분포할 수 있으므로, 시설운영자는 균등하고 적절한 염소농도를 유지하기 위해 추가적인 염소 재투입시설을 설치하여 함께 관리하고 있다. 이 때, 염소투입 시설의 운영계획은 EPANET과 같은 상수관망 해석모형의 수질모의를 바탕으로 수립된다. 그러나 일반적으로 수질모의는 수리해석과는 달리 긴 시간이 소요되는 단점이 존재한다. 본 연구에서는 이러한 단점을 개선하기 위해, 특정 네트워크의 수질모의 결과를 학습시킨 인공신경망(ANN) 모형을 구축하고 이를 이용하여 상수관망 수질모의 계산시간을 단축하고자 하였다. 여기서 ANN모형의 학습은 EPANET을 통해 미리 선정된 다양한 염소 투입지점의 염소 투입농도와 용수 공급량 자료, 그리고 주요 관측지점에서 측정된 염소농도자료를 이용하였다. 학습된 ANN모형을 EPANET 수질모의 결과와 비교 및 검증을 실시한 결과, 사전에 소요된 학습시간을 제외하면 수질모의 소요시간 측면에서 큰 개선효과를 보였으며, 대표지점에서의 수질모의 결과가 유사하였다. 추가적으로, 본 연구에서는 학습된 ANN모형과 최적화 알고리즘인 GA(Genitic Algorithm)를 연계하여 상수관망에서의 염소 재투입 스케줄링을 최적화하는 프로그램을 개발함으로써, 안전하고 경제적인 상수관망의 수질운영에 기여하고자 하였다.

• 한국추진공학회지
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• 제23권3호
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• pp.119-126
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• 2019

극저온 액체산소나 액체수소를 사용하는 액체로켓 엔진은 냉각이 충분하지 않을 경우 펌프 인입부에서 의 케비테이션과 연소기 메니폴드부에서의 급격한 기화에 의한 서지 현상이 발생할 수 있다. 극저온 추진제 사용을 위한 냉각은 유로의 충전을 위한 냉각/충전단계와 충전 후 온도유지 단계로 구분된다. 발사체의 위성투입 능력 향상을 위해서는 상단엔진의 다점화 기능이 필요하며 다점화를 위해서는 무추력 구간 중 다음 시동을 위한 냉각이 수행되어야 한다. 본 연구에서는 지상에서의 엔진의 냉각/충전 및 온도유지, 그리고 상단 엔진이 1차 점화하기 위한 냉각과 무추력 구간에서의 냉각유지, 그리고 다점화를 위한 냉각에 대해 논의한다.