• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.5
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• pp.419-424
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• 2020

Poroelasticity theory has been widely used for detecting cancellous bone deterioration because of the safe use for humans. The tortuosity itself is an important indicator for ultrasound detection for bone diseases. The transport properties of cancellous bone are also important in bone mechanotransduction. In this paper, two important factors, the wave velocity and attenuation are examined for permeability (or tortuosity). The theoretical calculation for the relationship between the wave velocity (and attenuation) and permeability (or tortuosity) for cancellous bone is shown in this study. It is found that the wave along the solid phase (trabecular struts) is influenced not by tortuosity, but the wave along the fluid wave (bone fluid phase) is affected by tortuosity significantly. However, the attenuation is different that the attenuation of a fast wave has less influence than that of a slow wave because the slow wave is observed by the relative motion between the solid and fluid phases.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1078-1080
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• 2002

The pressure variation of interstitial fluid is one of the most important factors in bone physiology. In order to understand the role of interstitial fluid and the biomechanical interactions between fluid and solid constituents within bone, poroelastic theory was applied. The purpose of this study is to describe the behavior of calf vertebral trabecular bone composed of the porous solid trabeculae and the viscous bone marrow by using a commercial finite element analysis program based on the poroelasticity. In this study, the model was numerically tested for 5 different strain rates, i. e., 0.001, 0.01, 0.1, 1.0, and 10 per second. The material properties of the calf vertebral trabecular bone were utilized from the previous experimental study. Two asymptotic poroelastic response, the drained and undrained deformation, were predicted. From the predicted results for the simulated five strain rate, it was found that the pore pressure generation has a linearly increasing behavior when the strain rate is the highest at 10 per second, other wise it showed a nonlinear the strain rate Increased. Based on the results of the present study, it was suggested that the calf vertebral trabecular bone could be modeled as a porous material and its strain rate dependent material behavior could be predicted.

• Journal of Biomedical Engineering Research
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• v.18 no.4
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• pp.333-338
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• 1997

Abnormal intraosseous flow and pressure in trabecular bone could cause various pathological conditions such as osteonecrosis and osteoarthritis. Characteristics of intraosseous fluid flow and pressure generation in porous trabecular bone can be significantly affected by the permeability. Factors which determine the permeability could be the porosity and apparent density of trabecular bone. However, there is little data on the permeability and the relationship among the permeability. porosity, and apparent density of trabecular bone. In this study. the permeability. porosity, and apparent density of human lumbar vertebral trabecular bone were experimentally measured. Also, a power relationship among the permeability, porosity, and apparent density was investigated to understand effects of the porosity and apparent density variations on the permeability of trabecular bone based on Kozeny-Carman equation. A near linear relationship between intraosseous fluid flow and time indicated that the fluid phase flowed through the pores in trabecular bone is governed by the permeability. The permeability of trybecular bone was found to have a significant power relationship with the porosity and apparent density (r: 0.84 and $\textit{p}$< 0.0005). The power relationship could be useful to determine the permeability of trybecular bone after measuring the apparent density and porosity.

• Journal of Audiology & Otology
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• v.24 no.2
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• pp.79-84
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• 2020

Background and Objectives: Hearing can be elicited in response to vibratory stimuli delivered to fluid in the external auditory meatus. To obtain a complete audiogram in subjects with normal hearing in response to pure tone vibratory stimuli delivered to fluid applied to the external meatus. Subjects and Methods: Pure tone vibratory stimuli in the audiometric range from 0.25 to 6.0 kHz were delivered to fluid applied to the external meatus of eight participants with normal hearing (15 dB or better) using a rod attached to a standard clinical bone vibrator. The fluid thresholds obtained were compared to the air conduction (AC), bone conduction (BC; mastoid), and soft tissue conduction (STC; neck) thresholds in the same subjects. Results: Fluid stimulation thresholds were obtained at every frequency in each subject. The fluid and STC (neck) audiograms sloped down at higher frequencies, while the AC and BC audiograms were flat. It is likely that the fluid stimulation audiograms did not involve AC mechanisms or even, possibly, osseous BC mechanisms. Conclusions: The thresholds elicited in response to the fluid in the meatus likely reflect a form of STC and may result from excitation of the inner ear by the vibrations induced in the fluid. The sloping fluid audiograms may reflect transmission pathways that are less effective at higher frequencies.

• Korean Journal of Audiology
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• v.24 no.2
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• pp.79-84
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• 2020

Background and Objectives: Hearing can be elicited in response to vibratory stimuli delivered to fluid in the external auditory meatus. To obtain a complete audiogram in subjects with normal hearing in response to pure tone vibratory stimuli delivered to fluid applied to the external meatus. Subjects and Methods: Pure tone vibratory stimuli in the audiometric range from 0.25 to 6.0 kHz were delivered to fluid applied to the external meatus of eight participants with normal hearing (15 dB or better) using a rod attached to a standard clinical bone vibrator. The fluid thresholds obtained were compared to the air conduction (AC), bone conduction (BC; mastoid), and soft tissue conduction (STC; neck) thresholds in the same subjects. Results: Fluid stimulation thresholds were obtained at every frequency in each subject. The fluid and STC (neck) audiograms sloped down at higher frequencies, while the AC and BC audiograms were flat. It is likely that the fluid stimulation audiograms did not involve AC mechanisms or even, possibly, osseous BC mechanisms. Conclusions: The thresholds elicited in response to the fluid in the meatus likely reflect a form of STC and may result from excitation of the inner ear by the vibrations induced in the fluid. The sloping fluid audiograms may reflect transmission pathways that are less effective at higher frequencies.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1055-1058
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• 2002

The movement of bone fluid from the region of the bone vasculature through the canaliculi and the lacunae of the surrounding mineralized tissue accomplishes three important tasks. First it transports nutrients to the osteocytes in the lacunae buried in the mineralized matrix. Second, it carries away the cell waste. Third, the bone fluid exerts a force on the cell process, a force that is large enough for the cell to sense. This is probably the basic mechanotrasduction mechanism in bone, the way in which bone senses the mechanical load to which it is subjected. The mechanism of bone fluid flow are described below with particular emphasis on mechanotransduction. Also described is the cell to cell communication by which higher frequency signals might be transferred, a potential mechanism in bone by which the small whole tissue strain is amplified so the bone cells can respond to it. One of the conclusions is that higher frequency low amplitude strains can maintain bone as effectively as low frequency low amplitude strains can maintain bone as effectively as low frequency high amplitude strains. This mechanism has many similarities with the mechanotransduction of acoustical signals in the ear. These conclusion leads to a paradigm shift in how to treat osteoporosis and how to cope with microgravity.

• Brain Tumor Research and Treatment
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• v.6 no.2
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• pp.68-72
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• 2018

We report a rare case of arachnoid granulations mimicking multiple osteolytic bone lesions. A 66-year-old woman was admitted to a local clinic for a regular checkup. Upon admission, brain CT showed multiple osteolytic lesions in the occipital bone. These needed to be differentiated from multiple osteolytic bone tumor. Subsequent brain MRI revealed that the osteolytic lesions were isointense to cerebrospinal fluid, hyperintense on T2-weighted image, hypointense on T1-weighted image, and with subtle capsules around the osteolytic lesions that were visible after gadolinium injection. A bone scan revealed no radiotracer uptake. The lesions were in both the transverse sinuses and the torcular herophili. With typical radiological appearances of the lesions, the osteolytic lesions were diagnosed as multiple arachnoid granulations. No further treatment was planned. A 1-year follow-up brain CT scan revealed no change. We should consider the possibility of arachnoid granulations when multiple osteolytic lesions are observed in the occipital bone.

• Journal of Korean Medical classics
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• v.13 no.2 s.17
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• pp.155-155
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• 2000

Body fluid(津液) is a general term for normal mucus in human body, including saliva, gastric juice, intestinal juice and articular fluid in joints as well as tear, running nose, sweat, etc.. The formation of Body fluid goes through two phases. First phase is digestion of food at stomach, and then evaporation and classification of energy at Triple warmer(三焦). More technically speaking, Body fluid is divided into the Jin(津) & the Aek(液). Aek is a very mild and water-like fluid, runs deep into the internal organs. Jin is a thick and sticky liquid, running shallow under the skin or in the joints of limbs. Major roles of body fluid over the body are to moisturize the internal organs, flesh, skin, etc., to soften the joints, to fill the bone marrow, and to balance Yin and Yang. This article deals with the role of body fluid and how to differentiate them, the liquid metabolism in the human body, and the formation and change of sweat, urine, tear, spit, bone marrow, etc.. The imbalance of Yin and Yang and disturbance of Triple warmer's evaporation lead into lumbago, leg weakness and edema is also explained here.

• Journal of Korean Medical classics
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• v.13 no.2 s.17
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• pp.156-171
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• 2000

Body fluid(津液) is a general term for normal mucus in human body, including saliva, gastric juice, intestinal juice and articular fluid in joints as well as tear, running nose, sweat, etc.. The formation of Body fluid goes through two phases. First phase is digestion of food at stomach, and then evaporation and classification of energy at Triple warmer(三焦). More technically speaking, Body fluid is divided into the Jin(津) & the Aek(液). Aek is a very mild and water-like fluid, runs deep into the internal organs. Jin is a thick and sticky liquid, running shallow under the skin or in the joints of limbs. Major roles of body fluid over the body are to moisturize the internal organs, flesh, skin, etc., to soften the joints, to fill the bone marrow, and to balance Yin and Yang. This article deals with the role of body fluid and how to differentiate them, the liquid metabolism in the human body, and the formation and change of sweat, urine, tear, spit, bone marrow, etc.. The imbalance of Yin and Yang and disturbance of Triple warmer's evaporation lead into lumbago, leg weakness and edema is also explained here.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.3 no.4
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• pp.10-15
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• 2010

Cortical bone is composed of an osteon, which is a subunit of the cortical bone. At the center of the osteon, Haversian is located and it consists of blood vessels and nerves. Osteon is known to be inclined 5 to 15 degrees with respect to the long axis of a cortical bone, but the reason why it is inclined is not clear. Using the poroelastic calculation provides the pore pressure varies at the lacunar-canalicular network from -200KPa to 200KPa. This estimation is close to the result shown in the previous literature and it helps further cell culture experiment for elucidating the bone remodeling process.