• Journal of Astronomy and Space Sciences
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• 제18권2호
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• pp.109-118
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• 2001

1992년에 발사된 우리별 1호는 고에너지 양성자들이 OBC(On-Board Computer)186의 메모리에 SEU(Single Event Upset)을 일으키는 안쪽 반알렌대(Inner Van Allen Radiation Belt) 를 통과한다. 본 논문에서는 Chi-Square 방법을 이용하여 OBC(On-Board Compute.)186 메모리에서 측정된 SEU 데이터와 NASA/NSSDC의 AP-8 양성자 모델을 비교하여, SEU를 유발하게 되는 문턱 에너지를 추정해 보았다. OBC186위치에서의 양성자 선속을 유도하기 위해서 위성체에 의한 차폐 효과가 고려되었으며 모델의 신뢰성을 높이기 위해 태양 활동이 활발한 기간에 얻어진 데이터들은 제거되었다. 비교 결과 우리별 1호 OBC186 주 메모리의 문턱에너지는 $110{pm}10MeV$로 추정 되었다.

• 한국항공운항학회지
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• 제19권3호
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• pp.10-15
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• 2011

위성용 분리장치는 작동 전까지는 높은 체결력으로 위성의 부속물들을 안정된 체결 상태로 유지해야 한다. 작동 후에는 위성시스템에 손상이 없이 위성본체로부터 분리되어 태양전지판과 안테나와 같은 부속장치의 전개를 성공적으로 수행하여야 한다. 따라서 본 논문에서는 분리충격이 작고 취급이 용이하며 재장착이 가능한 형상기억합금구동기와 태엽스프링을 이용한 소형위성용 비폭발식 분리장치를 제안하였다. 성능을 검증하기 위하여 분리시간, 분리가 가능한 사전하중, 분리장치 작동 시 충격량 측정 실험을 수행하였다.

• 동의신경정신과학회지
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• 제14권2호
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• pp.191-198
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• 2003

Dissociative amnesia is a psychiatric disorder charicterized by a sudden loss of memory, but which has no organic disease or explanation, It usually occurs after severe psychosocial stress or traumatic experience. As for medical treatment, medicine, psychotherapy and hypnosis are used. This case describes a 35-years-old woman who developed amnesia and depression following severe troublesome events. So she suited without expression and appealed against headache, dizziness, chest discomfort and weakness. Psychoanalytic psychotherapy was enforced for three days with hypnosis. She expressed the felling over the incident which she dose not like, and canceled in the past. She became reconciled with the family and left the husband by the heart. Then she recovered memory completely and body condition also improved. Recovery and growth of self were helped using supportive expression in order to prevent a recurrence. The prognosis is good with complete recovery, and there was no relapse.

• 한국산업융합학회 논문집
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• 제24권6_1호
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• pp.693-698
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• 2021

As technology advances, there is increasing need for research in different fields where this technology is applied. On of the most researched topic in computer vision is Human activity recognition (HAR), which has widely been implemented in various fields which include healthcare, video surveillance and education. We therefore present in this paper a human activity recognition system based on scale and rotation while employing the Kinect depth sensors to obtain the human skeleton joints. In contrast to previous approaches that use joint angles, in this paper we propose that each limb has an angle with the X, Y, Z axes which we employ as feature vectors. The use of the joint angles makes our system scale invariant. We further calculate the body relative direction in the egocentric coordinates in order to provide the rotation invariance. For the system parameters, we employ 8 limbs with their corresponding angles each having the X, Y, Z axes from the coordinate system as feature vectors. The extracted features are finally trained and tested with the Long short term memory (LSTM) Network which gives us an average accuracy of 98.3%.

• International Journal of Computer Science & Network Security
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• 제23권5호
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• pp.53-64
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• 2023

Early detection of endometrial carcinoma in uterus is essential for effective treatment. Endometrial carcinoma is the worst kind of endometrium cancer among the others since it is considerably more likely to affect the additional parts of the body if not detected and treated early. Non-invasive medical computer vision, also known as medical image processing, is becoming increasingly essential in the clinical diagnosis of various diseases. Such techniques provide a tool for automatic image processing, allowing for an accurate and timely assessment of the lesion. One of the most difficult aspects of developing an effective automatic categorization system is the absence of huge datasets. Using image processing and deep learning, this article presented an artificial endometrium cancer diagnosis system. The processes in this study include gathering a dermoscopy images from the database, preprocessing, segmentation using hybrid Fuzzy C-Means (FCM) and optimizing the weights using the Whale Optimization Algorithm (WOA). The characteristics of the damaged endometrium cells are retrieved using the feature extraction approach after the Magnetic Resonance pictures have been segmented. The collected characteristics are classified using a deep learning-based methodology called Long Short-Term Memory (LSTM) and Bi-directional LSTM classifiers. After using the publicly accessible data set, suggested classifiers obtain an accuracy of 97% and segmentation accuracy of 93%.

• 한국약용작물학회지
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• 제22권1호
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• pp.46-52
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• 2014

In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of central nervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower could influence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day (200 mg/kg body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreased the induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedly decreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances (TBARS) ($55.2{\pm}9.4{\mu}mol\;mg^{-1}$) and significant improvement of activities of glutathione (GSH) ($27.2{\pm}5.0{\mu}mol\;mg^{-1}$) in hippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell loss induced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment of vascular dementia.

• The Korean Journal of Physiology and Pharmacology
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• 제21권6호
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• pp.579-589
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• 2017

Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies have indicated that brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are involved in learning and memory processes. Genistein, a plant-derived isoflavone, has been shown to exhibit neuroprotective effects. The present study was performed to examine the protective effect of genistein against isoflurane-induced neurotoxicity in rats. Neonatal rats were exposed to isoflurane (0.75%, 6 hours) on postnatal day 7 (P7). Separate groups of rat pups were orally administered genistein at doses of 20, 40, or 80 mg/kg body weight from P3 to P15 and then exposed to isoflurane anesthesia on P7. Neuronal apoptosis was detected by TUNEL assay and FluoroJade B staining following isoflurane exposure. Genistein significantly reduced apoptosis in the hippocampus, reduced the expression of proapoptotic factors (Bad, Bax, and cleaved caspase-3), and increased the expression of Bcl-2 and Bcl-xL. RT-PCR analysis revealed enhanced BDNF and TrkB mRNA levels. Genistein effectively upregulated cAMP levels and phosphorylation of CREB and TrkB, leading to activation of cAMP/CREB-BDNF-TrkB signaling. PI3K/Akt signaling was also significantly activated. Genistein administration improved general behavior and enhanced learning and memory in the rats. These observations suggest that genistein exerts neuroprotective effects by suppressing isoflurane-induced neuronal apoptosis and by activating cAMP/CREB-BDNF-TrkB-PI3/Akt signaling.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.33-46
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• 2006

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease associated with aging in the human population. This disease is characterized by the extracellular deposition of beta-amyloid peptide $(A{\beta})$ in cerebral plaques. $A{\beta}$ is derived from the ${\beta}-amyloid$ precursor protein (APP) by the enzymes, ${\beta}-$ and ${\eta}o-secretase$. Compounds that ${\beta}-$ or ${\eta}o-secretase$ inhibit activity, can reduce the production of $A{\beta}$ peptides, and thus have therapeutic potential in the treatment of AD. Increasing body of evidence has been demonstrated that Bee Venom(BV) Acupuncture could compete with complex protein involving in multiple step of $NF-{\kappa}B$ activation and exert the anti-inflammatory potential of combined inhibition of the prostanoid and nitric oxide synthesis systems by inhibition of IKK and $NF-{\kappa}B$. In this study, I investigated possible effects of BV on memory dysfunction caused by lipopolysaccharide (LPS) and $A{\beta}$ through inhibition of secretases activities and $A{\beta}$ aggregation. I examined the improving effect of BV on the LPS (2.5 mg/Kg, i.p.)-induced memory dysfunction using passive avoidance response and water maze tests in the mice. BV (0.84, $1.67\;{\mu}g/ml$) reversed the LPS-induced memorial dysfunction in dose dependent manner. BV also dose-dependently attenuated LPS-induced ${\beta}$ and ${\eta}o-secretase$ activities in cerebral cortex and hippocampus of the mice brain. This study therefore suggests that BV acupuncture method may be useful for prevention of development or progression of AD.

• 품질경영학회지
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• 제49권4호
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• pp.581-594
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• 2021

Purpose: The purpose of this study is to compare machine learning models for anomaly detection of mechanical facility equipment and suggest an anomaly detection system for mechanical facility equipment in subway stations. It helps to predict failures and plan the maintenance of facility. Ultimately it aims to improve the quality of facility equipment. Methods: The data collected from Daejeon Metropolitan Rapid Transit Corporation was used in this experiment. The experiment was performed using Python, Scikit-learn, tensorflow 2.0 for preprocessing and machine learning. Also it was conducted in two failure states of the equipment. We compared and analyzed five unsupervised machine learning models focused on model Long Short-Term Memory Variational Autoencoder(LSTM-VAE). Results: In both experiments, change in vibration and current data was observed when there is a defect. When the rotating body failure was happened, the magnitude of vibration has increased but current has decreased. In situation of axis alignment failure, both of vibration and current have increased. In addition, model LSTM-VAE showed superior accuracy than the other four base-line models. Conclusion: According to the results, model LSTM-VAE showed outstanding performance with more than 97% of accuracy in the experiments. Thus, the quality of mechanical facility equipment will be improved if the proposed anomaly detection system is established with this model used.

• 동의신경정신과학회지
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• 제29권4호
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• pp.207-221
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• 2018

Objectives: The objective of this study was to observe the anti-amnesic effects of Yukmijihwang-tang (YMJHT), on the scopolamine (Sco)-induced memory impairment in C57BL/6 mice through its favorable acetylcholine (ACh). Also, to observe acetylcholinesterase (AChE) activity, Choline acetyltransferase (ChAT) mRNA expressions, and antioxidant effect. Methods: Six groups, with a total of 20 normal and 100 Sco treated mice were selected based on their body weights after 1 week of acclimatization, were used in this study as follows. Half of the mice in each group were used for passive avoidance task tests and hippocampus ACh content, AChE activity and ChAT mRNA expression measurement, and the remaining half in each group used for Morris water maze test and measurement of cerebral antioxidant defense system. Results: Amnesia due to AChE activations and destroyed cerebral cortex antioxidant defense systems were markedly and dose-dependently inhibited after 28 days of continuous oral pre-treatment with YMJHT 400, 200 and 100 mg/kg, respectively. The overall effects of YMJHT 400 mg/kg were similar to those of tacrine 10 mg/kg. Conclusions: Based on the results, it was established that oral administration of YMJHT favorably alleviates Sco-induced memory impairment, through preservation of ACh, mediated by up-regulation of ChAT mRNA expressions and related AChE inhibition and augmentation of cerebral antioxidant defense system, at least in a condition of this experiment. The overall effects of YMJHT 400 mg/kg were similar to those of tacrine 10 mg/kg.