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http://dx.doi.org/10.7783/KJMCS.2014.22.1.46

Neuroprotective Effects of the Extracts from the Aerial Parts of Carthamus tinctorius L. on Transient Cerebral Global Ischemia in Rats  

Kim, Young Ock (Department of Herbal Crop Research, NIHHS, RDA)
Lee, Sang Won (Department of Herbal Crop Research, NIHHS, RDA)
Yang, Seung Ok (Department of Herbal Crop Research, NIHHS, RDA)
Na, Sae Won (Department of Veterinary Medicine, Chonbuk National University)
Kim, Su Kang (Kohwang Medical Research Institute, School of Medicine, Kyung Hee University)
Chung, Joo Ho (Kohwang Medical Research Institute, School of Medicine, Kyung Hee University)
Publication Information
Korean Journal of Medicinal Crop Science / v.22, no.1, 2014 , pp. 46-52 More about this Journal
Abstract
In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of central nervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower could influence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day (200 mg/kg body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreased the induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedly decreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances (TBARS) ($55.2{\pm}9.4{\mu}mol\;mg^{-1}$) and significant improvement of activities of glutathione (GSH) ($27.2{\pm}5.0{\mu}mol\;mg^{-1}$) in hippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell loss induced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment of vascular dementia.
Keywords
Carthamus tinctorius L; Ischemia; Cognitive; Memory;
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