• 제목/요약/키워드: Body trace element

검색결과 26건 처리시간 0.03초

Biological Aspects of Selenium in Farm Animals

  • Kim, Y.Y.;Mahan, D.C.
    • Asian-Australasian Journal of Animal Sciences
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    • 제16권3호
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    • pp.435-444
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    • 2003
  • In 1957, Schwarz and Foltz discovered that selenium (Se) was an essential trace mineral and nutritionists then started extensive studies to figure out the metabolic function of this element which has been called as toxic mineral. The discovery that glutathione peroxidase (GSH-Px) contained Se demonstrated a biochemical role for Se as an essential trace element. The major physiological function of Se containing GSH-Px is thought to maintain low levels of $H_2O_2$ and other hydroperoxides in the cell to prevent tissues from peroxidation damages. It is known that the GSH-Px activity is increased when animals were fed high dietary levels of Se. Chemical properties of Se have much in common with sulfur (S) therefore Se would follow the sulfur pathways in its metabolism in animal body. Two sources of Se are available for supplementation of Se in animal feed. Inorganic Se can also exist in selenide (-2), elemental (0), selenite (+4) and selenate (+6) oxidation state with other minerals. When sulfur in S containing amino acids is replaced by Se, organic Se can be made and named "eleno"prior to the name of S containing amino acid, i.e. selenomethionine. Selenium deficiency affects humans as well as animals and dysfunctions such as exudative diathesis, retained placenta, mastitis, liver necrosis, Keshan disease, numerous diseases and cancer. From several centuries ago, Se toxicity was recognized in various animal species and much of the current toxic Se levels has been established largely based upon the controlled toxicity studies used inorganic Se. Toxic effects of Se in animal result in reduced feed intake, growth retardation, ataxia, diarrhea, alopecia and sloughing of hooves. However, several experiments demonstrated that Se deficiencies or toxicities were varied by dietary Se levels and sources. Recent studies demonstrated that the incidence of colorectal and prostate cancer was reduced by approximately 50% when humans consumed 200 ${\mu}g$ of Se daily.

상동광산 석영맥의 조직 및 석영의 미량원소 분석을 통한 광맥 침전 기작 도출 (A Study on the Precipitation Mechanism of Quartz Veins from Sangdong Deposit by Analyses of Vein Texture and Trace Element in Quartz)

  • 이유성;박창윤;김영규
    • 자원환경지질
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    • 제56권3호
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    • pp.239-257
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    • 2023
  • 상동 텅스텐(W)-몰리브덴(Mo) 광산은 태백산 광화대에 위치하는 스카른 광상으로, 광화 작용 최후기에 수직적 분포양상을 보이는 회중석-석영맥을 산출한다. 본 연구에서는 이 석영맥의 조직 관찰과 LA-ICPMS를 통한 석영의 미량원소 함량 분석을 통해 석영맥을 형성한 유체의 조성 및 이들의 침전 기작에 대해 파악하고자 하였다. 석영맥 조직 관찰 결과, 상동광산의 상반맥과 하반맥에서는 각각 괴상조직과 신장형 괴상조직이 주로 발달하고, 본맥에서는 두가지 조직이 모두 관찰된다. 이러한 석영맥의 조직적 특징으로 볼 때, 괴상조직을 나타내는 상반맥의 석영맥은 맥상스카른 형성 단계에서 화성암체의 H2O 포화로 인한 수압 파쇄작용들 중 초기에 발생한 작용에 의해 침전되었고, 신장형 괴상조직을 나타내는 본맥과 하반맥의 석영맥은 상반맥의 석영맥 형성 이후 발생한 반복적 수압파쇄작용에 의해 형성된 것으로 생각된다. 석영의 미량원소 분석 결과 대부분 Li+ +Al3+↔Si4+의 치환관계를 만족하지만, 하반맥에서는 Li+이 우세하게 치환되는 경우와, Na+과 K+이 우세하게 치환되는 경우로 뚜렷하게 구분된다. 이는 하반맥의 신장형 괴상조직에 기반하여, 서로 다른 조성을 가지는 유체의 반복적 유입에 의한 결과로 해석된다. 석영의 Ti 함량은 상반맥, 본맥, 그리고 하반맥에서 각각 평균 28.6, 8.2, 그리고 15.7 ppm이며, 침전온도와 Ti 함량이 비례관계를 가진다는 점에서, 상반맥의 석영맥이 가장 고온환경에서 침전된 것으로 고려된다. 유체의 pH와 반비례관계를 가지는 석영의 Al 함량은 상반맥, 본맥, 그리고 하반맥에서 각각 평균 162.3, 114.2, 그리고 182.5 ppm으로 큰 차이를 보이지 않으며, 타 열수 광산들의 석영과 비교하여 매우 낮은 함량을 나타낸다. 이는 상동광산의 석영맥을 구성하는 석영 및 회중석이 약산성 내지 중성의 비교적 일정한 pH조건에서 침전되었음을 지시한다.

비대칭단면을 갖는 박벽 공간뼈대구조의 횡-비틂 후좌굴 유한요소해석 (Lateral-Torsional Post-Buckling Analyses of Thin-Walled Space Frames with Non-symmetric Sections)

  • 박효기;김성보;김문영;장승필
    • 한국강구조학회 논문집
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    • 제11권2호통권39호
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    • pp.153-165
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    • 1999
  • 비대칭단면을 갖는 박벽 공간뼈대구조의 횡후좌굴거동을 조사하기 위하여 기하학적 비선형 유한요소 해석법을 제시한다. 대변형효과를 고려한 연속체의 증분평형방정식으로부터, 도심에서 정의되는 딤(warping)함수를 고려하고 유한한 회전각의 2차항 효과를 포함하는 변위장을 도입하여 초기응력을 받는 박벽 공간뼈대요소의 증분평형방정식을 유도한다. 박벽 공간뼈대구조를 유한요소로 나누고 변위장을 요소변위에 관한 Hermitian 다항식으로 나타내어 이를 평형방정식에 대입함으로써 접선강도행렬을 유도한다. 또한 updated Lagrangian co-rotational formulation에 근거하여, 증분변위로부터 강체회 전변위와 순수변형성분을 분리시켜서 강체회전은 요소의 방향변화를 결정하고, 순수변형은 부재력증분을 산정하는 불평형하중 산정법을 제시한다.

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Electrochemical Behaviors of PEO-treated Ti-6Al-4V Alloy in Solution Containing Zn and Si Ions

  • Hwang, In-Jo;Choe, Han-Cheol
    • 한국표면공학회:학술대회논문집
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    • 한국표면공학회 2017년도 춘계학술대회 논문집
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    • pp.160-160
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    • 2017
  • Commercially pure titanium (Cp-Ti) and Ti alloys (typically Ti-6Al-4V) display excellent corrosion resistance and biocompatibility. Although the chemical composition and topography are considered important, the mechanical properties of the material and the loading conditions in the host have, conventionally. Ti and its alloys are not bioactive. Therefore, they do not chemically bond to the bone, whereas they physically bond with bone tissue. The electrochemical deposition process provides an effective surface for biocompatibility because large surface area can be served to cell proliferation. Plasma electrolyte oxidation (PEO) enables control in the chemical composition, porous structure, and thickness of the TiO2 layer on Ti surface. Silicon (Si) in particular has been found to be essential for normal bone and cartilage growth and development. Zinc (Zn) plays very important roles in bone formation and immune system regulation, and is also the most abundant trace element in bone. The objective of this work was to study on electrochemical behaviors of PEO-treated Ti-6Al-4V Alloy in solution containing Zn and Si ions. The morphology, the chemical composition, and the microstructure analysis of the sample were examined using FE-SEM, EDS, and XRD. The potentiodynamic polarization and AC impedance tests for corrosion behaviors were carried out in 0.9% NaCl solution at similar body temperature using a potentiostat. The promising results successfully demonstrated the immense potential of Si/Zn-TiO2 coatings in dental and biomaterials applications.

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Effects of proteinate complex zinc on growth performance, hepatic and splenic trace elements concentrations, antioxidative function and immune functions in weaned piglets

  • She, Yue;Huang, Qiang;Li, Defa;Piao, Xiangshu
    • Asian-Australasian Journal of Animal Sciences
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    • 제30권8호
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    • pp.1160-1167
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    • 2017
  • Objective: To assess the effects of proteinate complex zinc (PC-Zn) on growth performance, antioxidative function, trace element concentrations and immune function in weaned piglets. Methods: Three hundred newly weaned barrows ($Duroc{\times}Landrace{\times}Yorkshire$), 28 days of age, were randomly allotted to 3 dietary groups of 5 replicate pens per group for 4 weeks of feeding. Experimental diets were: i) zinc deficient diet (ZnD, 24 mg/kg Zn supplementation from $ZnSO_4$), ii) inorganic Zn diet supplemented with 120 mg/kg of Zn from Zn sulfate ($ZnSO_4$), and iii) organic Zn diet supplemented with 120 mg/kg of Zn from PC-Zn. The body weight of pigs were recorded at the beginning, at the middle and at the end of the experiment, and the amount of feed supplied each day was recorded. Five barrows from each dietary treatment group were selected to be anesthetized and euthanized at the end of the trial to determine the Zn, Cu, Fe, and Mn concentrations, the hepatic metallothionein content, the levels of methane dicarboxylic aldehyde (MDA), Mn, and Cu/Zn superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in the spleen, the levels of interleukin (IL)-2, IL-4, IL-10, interferon $(IFN)-{\gamma}$, $CD3^+$, $CD4^+$, and $CD8^+$ T lymphocyte. Results: The accumulation of Zn in the spleen, levels of SOD, GSH-Px, IL-4, IL-10, the proportions of $CD3^+$ and $CD4^+$ T lymphocyte, and the ratio of $CD4^+/CD8^+$ T lymphocyte were increased by organic Zn supplementation compared to ZnD, while the levels of MDA, $IFN-{\gamma}$, and proportion of $CD8^+$ T lymphocyte were lowered. Conclusion: These findings indicate that Zn can improve the antioxidant potential and immune functions of weaned piglets.

함정용 Al 및 Zn 희생양극의 효율에 미치는 첨가원소 영향 (Effect of Additional Elements on Efficiency of Al and Zn Sacrificial Anode for Naval Vessels)

  • 최우석;박경철;김병호
    • 한국항해항만학회지
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    • 제39권4호
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    • pp.277-283
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    • 2015
  • 함정에 사용되는 선체재료로는 연강, 고장력강, 고강도강, 알루미늄 합금 및 복합재료 등이 있다. 그 중 함정의 선체는 수밀과 강도의 유지 및 탑재장비의 지지 등 기본적인 기능을 위하여 철강 재료를 주로 사용하고 있다. 함정의 주 임무는 해양에서 작전을 수행하는 것이므로 해수에 의한 선체 부식이 필연적으로 발생하게 된다. 선체의 부식을 방지하기 위하여 도장 방법, 희생양극법 및 강제 전류 방식이 사용되고 있다. 특히 Al 및 Zn을 활용한 희생양극법의 경우 부식특성 개선을 위하여 인듐(In), 카드뮴(Cd) 및 납(Pb) 등의 중금속이 첨가되어 있다. 하지만 이러한 중금속은 인체 및 환경에 매우 유해하므로 전 세계적으로 사용이 점차 규제되고 있다. 이에 본 논문에서는 인체 및 환경에 무해한 미세원소(Ma, Ca, Ce 및 Sn)를 첨가하여 Al 및 Zn 합금을 제조하였다. 제조된 함정용 Al 및 Zn 희생양극의 효율 특성 측정을 위하여 SEM, XRD, 동전위 분극실험 및 전류효율 평가를 실시하였으며, 실험결과 Al-3Zn-0.6Sn 및 Zn-3Sn 합금의 양극 성능이 다른 합금 보다 효율성이 우수하였다.

유연기구를 이용한 초정밀 단일체 3축 스테이지의 모델링 및 최적설계에 관한 연구 (Modeling and optimal design of monolithic precision XYZ-stage using flexure mechanism)

  • 심종엽;권대갑
    • 대한기계학회논문집A
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    • 제22권4호
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    • pp.868-878
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    • 1998
  • There are recently increasing needs for precision XYZ-stage in the fields of nanotechnology, specially in AFMs(Atomic Force Microscope) and STMs(Scanning Tunneling Microscope). Force measurements are made in the AFM by monitoring the deflection of a flexible element (usually a cantilever) in response to the interaction force between the probe tip and the sample and controlling the force neasyred constant topography can be obtained. The power of the STM is based on the strong distance dependence of the tunneling current in the vacuum chamber and the current is a feedback for the tip to trace the surface topography. Therefore, it is required for XYZ-stage to position samples with nanometer resolution, without any crosscouples and any parasitic motion and with fast response. Nanometer resolution is essential to investigate topography with reasonable shape. No crosscouples and parasitic motion is essential to investigate topography without any shape distortion. Fast response is essential to investigate topography without any undesirable interaction between the probe tip and sample surface ; sample scratch. To satisfy these requirements, this paper presents a novel XYZ-stage concept, it is actuated by PZT and has a monolithic flexible body that is made symmetric as possible to guide the motion of the moving body linearly. PZT actuators have a very fast response and infinite resolution. Due to the monolithic structure, this XYZ-stage has no crosscouples and by symmetry it has no parasitic motion. Analytical modeling of this XYZ-stage and its verification by FEM modeling are performed and optimal design that is to maximize 1st natural frequencies of the stage is also presented and with that design values stage is manufactured.

전남지역에서 출토된 고대 도자기의 태토조성과 소성온도 (Body Composition and Firing Temperature of Ancient Pottery Excavated in Chonnam Province)

  • 강경인;정창주
    • 보존과학회지
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    • 제6권1호
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    • pp.15-30
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    • 1997
  • 전남지역 도요지에서 출토된 토기, 시유도편, 녹청자와 청자편의 제조기술과 산지추정은 X선회절분석, 유도결합 플라즈마 발광분석, 열기계적 분석을 통한 물리화학적 성질의 검토로 이루어졌다. 도편의 사용원료는 점토, 석영, 장석광물로 유사하지만 그 함량비는 출토지에 따라 약간의 차이가 있으며, 철분함량에서 토기, 흑갈유, 녹갈유 도편은 $4\~7\%$, 녹청자 및 청자편은 $2\~3\%$로 기종에 따라 두드러진 차이를 나타내고 있다 흑갈유, 녹청자의 구성광물은 $\alpha-Quartz$, mullite와 일부 tridymite, cristobalite로 이루어졌으며, 청자는 $\alpha-Quartz$, mullite만으로 구성되어 있다. 도편의 소성온도는 토기가 $1000\~1100^{\circ}C$, 흑갈유, 녹갈유, 녹청자 청자가 $l130\~1200^{\circ}C$ 정도로 추정되었다. 도편에 대한 출토지의 구분은 분석된 21개의 미량원소중 14개의 원소가 매우 근접되어 불가능하였으며, 도자기제조에 사용된 원료의 지질학적인 특성이 유사한 것으로 판단하였다. 이들 지역에서 출토된 도편의 특성원소는 Rb, Sr, V, Zr, Y, Nd, Sc, La, Ce, Nb, Sm, Eu, Dy, Yb로 14개이다. 영암의 도편은 Zn과 Fe원소에 의해 다른 지역에서 출토된 도편들과 명확히 구분되었고, 출토지가 다른 녹청자, 청자편은 동일한 범위에 군집되는 특징을 나타내어 사용원료가 비슷한 것으로 추정된다.

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Zinc and Zinc Related Enzymes in Precancerous and Cancerous Tissue in the Colon of Dimethyl Hydrazine Treated Rats

  • Christudoss, Pamela;Selvakumar, R.;Pulimood, Anna B.;Fleming, Jude Joseph;Mathew, George
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권2호
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    • pp.487-492
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    • 2012
  • Trace element zinc deficiency or excess is implicated in the development or progression of some cancers. The exact role of zinc in the etiology of colon cancer is unclear. To cast light on this question, an experimental model of colon carcinogenesis was applied here. Six week old rats were given sub cutaneous injections of DMH (30 mg/kg body weight) twice a week for three months and sacrificed after 4 months (precancer model) and 6 months (cancer model). Plasma zinc levels showed a significant decrease (p<0.05) at 4 months and a greater significant decrease at 6 months (p<0.01) as compared with controls. In the large intestine there was a significant decrease in tissue zinc levels (p<0.005) and in CuZnSOD, and alkaline phosphatase activity (p<0.05) in the pre-cancerous model and a greater significant decrease in tissue zinc (p<0.0001), and in CuZnSOD and alkaline phosphatase activity (p<0.001), in the carcinoma model. The tissue zinc levels showed a significant decrease in the small intestine and stomach (p<0.005) and in liver (p<0.05) in the cancer model. 87% of the rats in the precancer group and 92% rats in the cancer group showed histological evidence of precancerous lesions and carcinomas respectively in the colon mucosa. This study suggests that the decrease in plasma zinc, tissue zinc and activity of zinc related enzymes are associated with the development of preneoplastic lesions and these biochemical parameters further decrease with progression to carcinoma in the colon.

2020 한국인 영양소 섭취기준: 아연 (2020 Dietary Reference Intakes for Koreans: zinc)

  • 이미경;김은미;권인숙
    • Journal of Nutrition and Health
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    • 제55권4호
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    • pp.441-449
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    • 2022
  • This review is focused on analyzing the limits and shortage of zinc (Zn) for the 2020 Dietary Reference Intakes for Koreans (KDRIs), and provides suggestions for the future establishment of the 2025 KDRIs for Zn. The 2020 KDRIs for Zn have been established to estimate the adequate requirement (EAR), recommended nutrient intakes (RNI), adequate intake (for only 0-5 mon) and tolerable upper intake level (UL). EAR was estimated in 2-stages: the first stage was to construct of the frame of analysis for Zn requirement and the second stage involved a factorial approach by considering the various factors which affect Zn requirement, such as intestinal and urine Zn loss, Zn requirement for growth and development, and Zn absorption rate. For a more precise and accurate establishment of the Zn requirement, we suggest for the following to be considered: 1) considering that Zn is present in minuscule amounts as a trace element in our body, the present values for Zn EAR (as 6-9 mg/d) should be expressed as a decimal point for more accurate DRIs; 2) the frame of analysis for Zn requirement has to be more specifically and should includes the factors which affect Zn requirement; 3) both, the factorial approach and extrapolation method need to be well reviewed and thoroughly understood for establishing precise Zn requirement; 4) currently, human clinical study and balance study (Zn intake, excretion and absorption rate) are limited and more human Zn subject studies are required. All these suggestions are provided to better establish the Zn requirement in the 2025 KDRIs.