• Journal of the Korean Society of Physical Medicine
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• v.19 no.1
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• pp.31-41
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• 2024

PURPOSE: This study examined the distribution dynamics and proposed determinants, including morphological measurements, clinical laboratory tests, and lifestyle factors among young Korean men aged 20 to 29 years with the coexistence of age-related loss of skeletal muscle mass and obesity (CALSMO). METHODS: Six hundred and sixty-six participants were divided into two groups based on their skeletal muscle mass index, with 12 individuals categorized in the CALSMO group and the remaining 654 in the normal group. The proposed determinants variables consisted of three main components: morphological measurements, clinical laboratory tests, and lifestyle factors. The morphological measurement variables were height, weight, body mass index, waist circumference, and skeletal muscle mass index. The clinical laboratory tests were fasting glucose, triglyceride, total cholesterol levels, and systolic and diastolic blood pressure. The lifestyle factors considered were alcohol consumption and tobacco use. Complex sampling analysis was performed for the evaluation. RESULTS: The distribution dynamics were determined to be 1.81(1.02-3.18) %. Morphological factors, such as height, weight, body mass index, waist circumference, and skeletal muscle mass index, showed significant differences (p < .05). The clinical laboratory test variables, specifically the fasting glucose, triglyceride, and total cholesterol levels, also exhibited significant differences (p < .05). The lifestyle factor, alcohol consumption, also showed a significance (p < .05). CONCLUSION: This study provides insights into the distribution dynamics. The proposed determinants in young Korean individuals with CALSMO are height, weight, body mass index, waist circumference, skeletal muscle mass index, fasting glucose, triglyceride, total cholesterol levels, and alcohol consumption.

• Culinary science and hospitality research
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• v.23 no.6
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• pp.173-183
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• 2017

Conditions related to body composition and aging, such as osteopenic obesity, sarcopenia/ sarcopenic obesity, and the newly termed osteosarcopenic obesity(triad of bone, muscle and adipose tissue impairment), are beginning to gain recognition. Currently, it has begun to attract the attention of scholars from all over the world, however, for this disease, it still needs a more clear understanding and perception. Therefore, this article considered the osteoporosis, muscle depression, and obesity, these diseases as a gate to study the relationship among muscle, bone, and fat. In addition, in the aging process, the formation of IGF-cortisol, testosterone, and estrogen is sensitive. These hormones can not only absorb muscle protein metabolism, but also affect alienation. The decrease in IGF-cortisol in the elderly resulted in increased visceral fat, decreased muscle mass and bone mineral density, and then affected decreased skeletal muscle atrophy and decreased quality. The reduction of skeletal muscle quality and strength and increase body fat affected the adipose tissue to produce inflammatory cytokines, thereby reduced skeletal muscle, promoted cardiovascular disease, metabolic syndrome and insulin resistance in chronic diseases. Almost all chronic inflammatory diseases were associated with bone, muscle and fat. These mechanisms were complex and interrelated. Inflammation reduces bone formation, increases fat and reduces muscle mass. And thus not only had a significant impact on the motor system, but also made the incidence increase of fracture, osteoporosis, fragile syndrome, fall, osteomalacia and other bone disease. This article aimed to start from the interaction between the muscles and bones of the elderly, extended to obesity, muscle deficiency, osteoporosis and other diseases, finally, from a nutritional point of view, to discuss how to treat osteoporosis obesity.

• Journal of Electrical Engineering and Technology
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• v.9 no.5
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• pp.1774-1779
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• 2014

It is known that muscle strength of human body can alter or deteriorate as aging. In this study, we present an inverse dynamics simulation to investigate the effect of muscle strength on performing the daily activities. A 3D musculoskeletal model developed in this study includes several segments of whole body, long and short muscles, ligaments and disc stiffness. Five daily activities such as standing, flexion, finger tip to floor, standing lift close and lifting flexed were simulated with varying the maximum muscle force capacities (MFC) of each muscle fascicles from 30 to $90N/cm^2$ with an increment of $30N/cm^2$. In the result, no solution can be obtained for finger tip to floor and lifting flexed with $30N/cm^2$. Even though the solution was available for standing lift close activity in case of $30N/cm^2$ capacity, many of muscle fascicles hit the upper bound of muscle strength which means that it is not physiologically possible to perform the acvities in reality. For lifing flexed, even the case of $60N/cm^2$ capaciy, represents the moderate healthy people, was not able to find the solutions, showing that 18 muscles among 258 muscle fascicles reached 100% of muscle capacity. The estimated results imply that people who have low muscle strength such as elders or rehabilitation patients were required higher muscle work to perform and maintain the same daily activities than healthy one.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.3
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• pp.33-43
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• 2011

Objectives : The purpose of this study was to investigate the influence of modified fasting therapy using fermented herbal medicine on the changes of body compositions. Methods : This study was carried out on 11 patients who carried out modified fasting therapy using fermented herbal medicine. They went through reducing food intakes period(7 days), fasting period(10~14 days) and refeeding period(10~14 days). Body compositions(weight, BMI(body mass index), skeletal muscle mass, body fat mass, percent body fat, basal metabolic rate, waist-hip ratio, visceral fat area) were measured at each state. And then the data was analyzed. Results : 1. The weight and BMI decreased during the reducing food intakes period and the fasting period, and increased during the refeeding period. But the weight and BMI decreased during the fasting therapy period, as a whole. 2. The skeletal muscle mass decreased during the fasting period and increased during the refeeding period. As the final outcome, for the whole fasting therapy period, decrease of skeletal muscle mass didn't show significance. The body fat mass and percent body fat decreased during the reducing food intakes period, the fasting period and the refeeding period. 3. The basal metabolic rate decreased during the fasting period and increased during the refeeding period. As the final outcome, for the whole fasting therapy period, decrease of basal metabolic rate didn't show significance. 4. The waist-hip ratio decreased during the fasting period and the refeeding period. The visceral fat area decreased during the fasting period and refeeding period. Conclusions : Results from this investigation showed that modified fasting therapy using fermented herbal medicine have positive effects on changes of body compositions. This results are expected to compensate the defects of existing fasting therapy.

• PNF and Movement
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• v.19 no.3
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• pp.331-340
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• 2021

Purpose: The purpose of this study was to investigate the differences in body composition, upper and lower limb muscle strength, and functional physical ability in urban-dwelling elderly women with or without obesity. Methods: All study participants were assigned to the normal weight group (n=8, BMI<25) and the obesity group (n=7, BMI>25) based on their obesity rate. Anthropometric measurement was conducted and body composition was measured. For the upper and lower limb strength, grip strength and maximal isometric knee extension and flexion were evaluated by a dynamometer. The senior fitness test was performed to measure functional ability. Data analysis was conducted by the independent t-test and the alpha level was set at 0.05. Results: The waist, hips, and thighs of obese elderly women were thicker than those of normal-weight elderly women. This physical difference resulted from body fat mass, not muscle mass. Despite a similar level of limb muscle mass between the two groups, the upper limb grip strength was higher (24.00% for left, 19.95% for right) in the normal-weight women than the obese women (p<0.05), but otherwise there was no difference in maximal knee flexion or extension isometric strength. Functional physical ability showed no difference in a 30-second chair sit and stand test and a six-minute walk test, but a 30-second arm-curl (11.00% for left, 14.81% for right), back stretch (8.54cm for left, 8.99cm for right), chair sit and reach (9.22cm for left, 6.24cm for right), and 2.44 meter round trip walk (0.62 sec, 9.39%) were faster in performance for normal-weight elderly women than obese elderly women (p<0.05). Conclusion: Taken together, despite similar levels of upper and lower extremity muscle mass, normal-weight elderly women showed higher performance in upper limb strength, flexibility, and agility than obese elderly women, but there was no difference in lower extremity functional muscle strength and cardiopulmonary endurance.

• Journal of Gastric Cancer
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• v.22 no.2
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• pp.145-155
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• 2022

Purpose: Weight loss and deterioration in body composition are observed in patients with gastric cancer (GC) following gastrectomy. This study aimed to investigate the impact of residual stomach volume (RSV) on the nutritional status and body composition of patients with GC treated with distal gastrectomy. Materials and Methods: In total, 227 patients who underwent minimally invasive distal gastrectomy with Billroth 1 anastomosis for stage I GC between February 2015 and May 2018 were enrolled. Clinicodemographic and laboratory data were collected from the GC registry. The RSV, abdominal muscle area, and subcutaneous/visceral fat areas were measured using computed tomography data. Results: A larger RSV was associated with a lower decrease in the nutritional risk index (P=0.004) and hemoglobin level (P=0.003) during the first 3 months after surgery, and better recovery at 12 months. A larger RSV demonstrated an advantage in the preservation of abdominal muscle area (P=0.02) and visceral fat (P=0.04) after surgery, as well as less reduction in weight (P=0.02) and body mass index (P=0.03). Conclusions: Larger RSV was associated with improved nutritional status and better preservation of muscle and fat after distal gastrectomy.

• Korean Journal of Veterinary Research
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• v.36 no.3
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• pp.571-575
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• 1996

Sulfamethazine sodium was orally administrated to Sprague Dawley female rats(body weight: 200~250g) with the sonde caude at the dose of 20mg of sulfamethazine sodium per 100g of body weight for 3 days to investigate the depletion rate of the drug from liver, kidney and muscle of rat. The results obtained were summerized as follows; 1. The mean concentrations of sulfamethazine in liver according to the time lapsed after oral administration of the sulfamethazine sodium were decreased from 1.27ppm at day 1 to 0.28ppm at day 4. 2. Sulfamethazine concentrations in kidney according to the time lapsed after oral administration of the sulfamethazine sodium were decreased from 0.77ppm at day 1 to 0. 12ppm at day 4. 3. The mean concentration of sulfamethazine in skeletal muscle according to the time lapsed after oral administration of the sulfamethazine sodium was at or below 0.09ppm within 4 days after withdrawl of medicated solution.

• Journal of TMJ Balancing Medicine
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• v.1 no.1
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• pp.13-18
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• 2011

Objectives: We investigated muscle force from the upper limb lifting resistance test to conform the objectivity in manual muscle test. Methods: We made standard method in upper limb lifting resistance test to compare with experiment method switching the lower limb position left & right. And resistance forces of upper limb of subject were checked to inspector with closing eyes. Results: 1. The lifting resistance of right upper limb was stronger when the lower limb of right and left were abducted. 2. The lifting resistance of right upper limb was weaken when the lower limb of right and left were adducted. 3. The lifting resistance of right upper limb was weaken when the lower limb of right and left were elevated. Conclusions: As the above results, the deltoid muscle force checked in the upper limb lifting resistance test is affected by the location of lower limbs, it suggested that the muscle force of some part in the body will be affected by the other parts. It will be useful to understand the symmetry principle of body in muscle function.

• Journal of Biomedical Engineering Research
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• v.22 no.2
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• pp.151-156
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• 2001

A computer model of the musculoskelotal system that provides accurate prediction of muscle force and body movement trom the stimulation input is desired for the effective control system design in FES. This paper aims to investigate the fundamental properties of the gradual muscle force potentiation that was not included in the previous muscle models, for future development of a model that provides vetter prediction of FES-induced muscle force and body movement. Specifically, hou the muscle length was investigated. The experimental results showed that both the force increment ratio and the time-to-peak during electrical stimulation decreased with stimulatino frequency. When the muscle potentiation state was saturated by preceding stimulation. the force did not increase any more during additive stimulation. Muscle length significantly affected the force potentiation in such a way that the force increment ratio decreased with muscle length. A new model of the muscle potentiation based on these results is desired in the future.

• Diabetes and Metabolism Journal
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• v.42 no.6
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• pp.488-495
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• 2018

Background: Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition, we examined the role of body mass index (BMI) as a potential effect modifier in this association. Methods: This prospective study included 399 Japanese Americans without diabetes (mean age 51.6 years) who at baseline had an estimation of thigh muscle mass by computed tomography and at baseline and after 10 years of follow-up a 75-g oral glucose tolerance test and determination of homeostasis model assessment of insulin resistance (HOMA-IR). We fit regression models to examine the association between thigh muscle area and incidence of T2DM and change in HOMA-IR, both measured over 10 years. Results: Thigh muscle area was inversely associated with future HOMA-IR after adjustment for age, sex, BMI, HOMA-IR, fasting plasma glucose, total abdominal fat area, and thigh subcutaneous fat area at baseline (P=0.033). The 10-year cumulative incidence of T2DM was 22.1%. A statistically significant interaction between thigh muscle area and BMI was observed, i.e., greater thigh muscle area was associated with lower risk of incident T2DM for subjects at lower levels of BMI, but this association diminished at higher BMI levels. Conclusion: Thigh muscle mass area was inversely associated with future insulin resistance. Greater thigh muscle area predicts a lower risk of incident T2DM for leaner Japanese Americans.