• Herbal Formula Science
• /
• v.26 no.1
• /
• pp.81-102
• /
• 2018

Objectives : I analysed daehwangmokdan-tang's compatibility principle by the system of chief, deputy, assistant, and envoy and investigated pharmacological activities by categorizing with chemical components, molecular level, cellular level, animal level and human level based on Korean and Chinese studies for this formula. Methods : Daehwangmokdan-tang's compatibiltity principle was examined by the system of chief, deputy, assistant, and envoy. I looked into studies that presented in Korea from 1956 to 2016 about daehwangmokdan-tang through KOREA INSTITUTE OF ORIENTAL MEDICINE, Korean medicine information system (OASIS) and in Chinese for 20 years about daehwangmokdan-tang through China National Knowledge Infrastructure, CNKI. Then classify into chemical components, molecular level, cellular level, animal level and human level to analyse. Results : According to the system of chief, deputy, assistant, and envoy, chief herb is Rhei Radix et Rhizoma and Moutan Cortex, deputy herb is Natrii Sulfas and Persicae Semen, assistant and envoy herbs are Trichosanthis Semen. The amount of extraction of paeonol, total anthraquinone, and conjugated anthraquinone from daehwangmokdan-tang with the formulation of the system of chief, deputy, assistant, and envoy was the highest, and in the formulation of chief herb and deputy herb, the extraction amount of paeonol and conjugated anthraquinone was the lowest. With other formulations, the amount of extraction of total anthraquinone and conjugated anthraquinone was improved, although the degree was different. In particular, when it is blended with Persicae Semen as a deputy herb, the extraction amount of total anthraquinone and conjugated anthraquinone of Rhei Radix et Rhizoma as a chief herb is greatly increased, and the extraction amount of paeonol is rather different, but it is lowered. It was found that the amount of Mg Ca K Na in daehwangmokdan-tang was the highest. Pharmacological activities can be detected in inflammatory mediators and enzymes for molecular level. For cellular level, it can be determined in lipopolysaccharide (LPS)-stimulated RAW 264.7 cell line. In mouse and rats for animal level and human level, in inflammatory diseases (acute appendicitis, acute pancreatitis, acute cholecystitis, acute abdominal disease, ect.), pharmacological activities was caught. Conclusions : From the above results, daehwangmokdan-tang is composed in line with the system of chief, deputy, assistant, and envoy, suggesting that there is certain rationality and scientific. Pharmacological activities of daehwangmokdan-tang are effective to anti-inflammation, improvement of sepsis, analgesic, muscle relaxation, and improvement of intestinal flora and its metabolites. Daehwangmokdan-tang is consistent with the action of diuresis and anti-inflammation in terms of the content of elements, suggesting that there is action of purging fire and removing blood stasis, defecation detoxification, cooling blood and clearing heat and activating blood and dispersing stasis.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.20 no.6
• /
• pp.1431-1441
• /
• 2006

Following conclusions were drawn from the examination of the usage of semen persicae and fols carthami from the view of Hyungsang Medicine. Semen persicae is used to vitalize the blood flow and eliminate the blood stagnation of the whole body in ${\ulcorner}$Donguibogam${\lrcorner}$, and therefor it is used for the blood flow of the heptal meridian and sometimes the intestinal meridian. Flos carthami is applied to vitalize the blood flow, remove obstructions in meridians, eliminate the blood stagnations, and stop the pain in ${\ulcorner}$Donguibogam${\lrcorner}$, therefore used in such symptoms of blood flow of the heptal meridian as amenorrhea, spasm of muscles, and coldness of the genitals. Also is applied in those cases of exhaustion, perspiration, and in digestive remedies which belong to the symptoms of cardiac blood flow. And it is used for dryness of the skin in which case the blood should be developed and malaria for the elimination of the blood stagnation and production of new blood. The combination of semen persicae and flos carthami is applied to eliminate the blood stagnation and stimulate menstrual discharge in uterus, as well as in the cases of lumbago and stomachache due to blood stagnation, blood stasis, mass in the abdomen, and abdominal distention. This combination is also used for the eyes, ears, numbness, and paralysis of hands and feet for the purpose of making the flow of the meridian smooth, and for diabetes, dryness of the skin, malaria, anal itching and pain for the purpose of eliminating the mass and renewing the tissues. The combination is diversly used in the book of ${\ulcorner}$Special lectures on clinical cases${\lrcorner}$ for the aftereffects of traffic accident, constipation, diabetes, dryness of the skin, paralysis of hands and feet, numbness of finger of hand and foot, and especially used frequently with prescription of Yijintang and Samultang combined in the cases of numbness. The prescription is used in Hyungsang medicine when the uterus, the external appearance(axis), hands and feet, heart, and the stomach is not good for the vitalization of the flow of the 12 meridians. It was though difficult to find extinguishing differences between the two herbs in the clinical cases applied in the book of ${\ulcorner}$Special lectures on clinical cases${\lrcorner}$.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.6
• /
• pp.1359-1367
• /
• 2008

DSOM(Diagnosis System of Oriental Medicine) was made as a computerized assistant program for oriental medicine doctors to be able to diagnose with statistical basis. Then DSOM uses questionnaires filled out by subjects without enough explanatory guide. If the subject misunderstand the meaning of the passages, we might not rely on that result. So I designed this study to investigate the diagnostic correspondent rates between DSOM and practitioners. First, let the respondents answer to DSOM(DSOM-Ⅰ for the rest). After that, three doctors diagnosed the respondents and marked how much they had symptoms about 16 pathogenic factors in the score range 0${\sim}$5('0' means they didn't have that symptom, '1' means they had that symptom but mild, '3' means they had that symptom moderately, '5' means they had that symptom severely. And let the respondents answer to DSOM(DSOM-Ⅱ for the rest) again. Finally, we investigated the correspondent rates of diagnosis between DSOM-Ⅰ,Ⅱ and doctors'. We obtained conclusions as following. In the comparison of output frequency rate of the pathogenic factors, the difference between DSOM-Ⅰ and Ⅱ was 1%. In the correspondent rates of diagnosis between DSOM-Ⅰ,Ⅱ and doctors', In DSOM-Ⅰ and Ⅱ answered by subjects two times respectively, the correspondent rate was highest in insufficiency of Yang(陽虛) and liver(肝) as 93.2%, lowest in damp(濕) as 69.5% and showed 81.9% in all 16 pathogenic factors mean. In DSOM-Ⅰ and Ⅱ, and Doctors' diagnose, they showed the complete correspondent rates of 15.3${\sim}$61.0%, 15.3${\sim}$59.3% in individual pathogenic factor, 36.5%, 37.3% in all 16 pathogenic factors mean each, and within ${\pm}$1 errorrange, they showed the correspondent rates of 32.2${\sim}$93.2%, 35.6${\sim}$89.8% in individual pathogenic factor, 67.6%, 67.3% in all 16 pathogenic factors mean each, and within ${\pm}$2 error range, they showed the correspondent rates of 62.7${\sim}$98.3%, 71.2${\sim}$100% in individual pathogenic factor, 85.1 87.6%% in all 16 pathogenic factors mean each. In the correspondent rates of the severe case, In the cases that the Doctors' diagnostic score mean was over 3(the severity of disease is middle), there were deficiency of qi(氣虛), stagnation of qi(氣滯), blood stasis(血瘀), damp(濕), liver(肝), heart(心), spleen(脾) and they all showed the correspondent rates of over 60 except blood stasis(血瘀). In the cases that the weighed pathogenic factor was above 9, the correspondent rates were 50${\sim}$100%. deficiency of qi(氣虛), blood-deficiency(血虛), stagnation of qi(氣滯), blood stasis(血瘀), insufficiency of Yin(陽虛), insufficiency of Yang(陽虛), coldness(寒), heat (熱), damp(濕), dryness(燥), liver(肝), heart(心), spleen(脾), kidney(腎), phlegm(痰).

• Journal of Acupuncture Research
• /
• v.26 no.1
• /
• pp.23-28
• /
• 2009

Objectives & Methods : The main point of this literatual study was to develop an external treatment on sprain using adhesive herbal pack. Results & Conclusions : The herbs which was used in adhesive treatment matched the same function with oral herb medicine such as, promoting blood flow to remove blood stasis, relieving rheumatic conditions, and removing obstruction in meridians and collaterals. Based on these function it was reviewed that adhesive herbal pack directly effected the sprain region from herbs by using alcohol, water to produce the pack. But even though it is known that the method of adhesive herbal treatment changes, most treatment still uses the traditional method. So researching on adhesive herbal treatment is required in the future.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
• /
• v.5 no.1
• /
• pp.119-136
• /
• 1999

Anti-cancer medi-alcohols in oriental herb prescriptions were divided by chef effects. Each medi-alcohols were analyzed and studied abut frequency, character, target, effect. Also, they were divided into the method of making medi-alcohols. The results were summerized as follows. 1. The department of using medi-alcohol in anticancer herbal scriptions were limited in gynecology, dermatology and digestive internal medicine. There were a lot in gynecology. 2. In analysis about medi-alcohols of dermato scriptions by chef effect, the herbs of relieving exterior syndrome were a lot first and the herbs of invigorating-qi were second. 3. In analysis about meld-alcohols of dermato scripions by chef effect, the herbs of promoting blood circulation to remove blood stasis were a lot first and the herbs of invigorating-qi were second. 4. The method of making medi-alcohol was divided into four types ; boiling, making up pills, extration, filtration. I hope that the medi-alcohol will be used as practional references.

• Journal of Pharmacopuncture
• /
• v.6 no.3
• /
• pp.57-63
• /
• 2003

Background : This study was to investigate existing studies on the mushroom Phellinus linteus for possible applications in treating hard to cure diseases and uses in herbal acupuncture as the above is known to have an anti-cancer effects and stimulating the immune system. Results : Based on the literary consideration, the following results were obtained : 1. Proteins and polysaccharides of the Class Basidiomycetes activate the host immune system for anti-cancer action without known side effects, thus it can be given for the prevention and treatment of cancer as a supplement. Phellinus linteus mushroom showed the most significant effects. 2. The Phellinus linteus mushroom is a fungi in the family Hymenochaetaceae and Phellinus, under the class Basidiomycetes. Phellinus linteus can be often found on the trunk of mulberry trees and other latifoliate trees. 3. The characteristics of Phellinus linteus are sweet, neutral in temperature, non-toxic, dissipate the stagnated blood, stop bleeding, invigorate the blood circulation and remove stasis, and nourish qi. It has been used for treating continuous menstrual discharge among the female patients and removing masses in the abdomen to name a few. 4. Phellinus linteus contains agaric acid, fatty acid, C23 and other numerous enzymes. 5. Phellinus linteus is known to have anti-cancer and anti-oxidant effects, stimulation of the immune system, as well as anti-inflammatory effects, inhibition of angiogenesis, and analgesic actions.

• The Journal of Korean Medicine
• /
• v.16 no.2 s.30
• /
• pp.149-176
• /
• 1995

The results were as follow: 1. In classification of the virulence of medicines, it is the virulent animal that have a deadly poison and the rest is the animal of weak nor non-toxic. 2. In classification of the channel distribution, the most is the medicine that belongs to liver channel, the next are the stomach, lung, kidney and spleen channel. 3. In classification of four characters, the most parts are cool, common and warm medicine and there is a few that is hot and cooling. 4. In classification of five tastes, the most numerous tastes are sweet and salty and the next are acrid, bitter and sour tastes. 5. In classification of the medical action, there are few medicine of invigorating vital energy, tonic therapy and astringent and a great part of the medicine are regulating vital energy and blood, removing blood stasis and mass, clearing away heat-evil and eliminating sputum, calming the river to inhibit the wind-evil and pain control. 6. In classification of the application of cancer, the most numerous disease is the liver cancer and the next are stomach cancer, esophageal cancer, lung cancer, leukemia, uterine cancer,mastitis, brain tumor.

• Journal of Haehwa Medicine
• /
• v.14 no.1
• /
• pp.83-94
• /
• 2005

1. The external treatment of sprain and strain using the herb used adhesive(貼敷), using soaking in medicinal smoke to focuses and rinsing methods(熏洗), rubbing(擦擦) and hot compression(熱熨). 2. In the external treatment of sprain and strain using the herb, Adhesive(貼敷) is used most. Because Adhesive(貼敷) brings fast reactions, has less side effects, and can control the processing time. 3. The effects of herbs used in this external treatment are almost the same as oral herb-medicines such as, promoting blood flow to remove blood stasis(活血化瘀), relieving rheumatic conditions(祛風濕), and removing obstruction in meridians and collaterals(通經絡).

• The Journal of Dong Guk Oriental Medicine
• /
• v.5
• /
• pp.97-129
• /
• 1996

According to the literatural study om ryuk-jeol disease(歷節病), we obtained the result as follows : First, ryuk-jelo disease(歷節病) was stated a kind of arthralgia syndrome(痺病), Because ryuk-jeol disease(歷節病) is only joint disease while arthrlgia syndrome(痺病) affects skin, muscle, joint, bone, organs, etc. Second, ryuk-jeol disease(歷節病) can bne thought to be a category of rheumatoid arthritis in western medical science. Third, etiology factors of ryuk-jeol disease(歷節病) was classified endogenous and exogenous pathogenic factors. The formers was the deficiency in both Qi and Blood(氣血不足), the deficiency in both the liver and kidney(肝腎虧損), dam(痰), blood stasis(瘀血). The latter was Windg風), Cool(寒), Dampness(濕), Heat(熱). Forth, the therapy of ryuk-jeol disease(歷節病) was based on 'diagnosis and trentment based on over all analysis of symptoms and sings(辨證施治)'

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.14 no.2
• /
• pp.224-230
• /
• 2001

In the Clinical study on 1 Case of Patient with Obstruction of the retinal artery, the results were as follows. 1. Obstruction of the retinal artery is acute disease that vision isdiminished fastly and become a blindness. 2. It belong to the cathegory of Pock Maeng(暴盲) in Oriental Medicine. 3. The causes of Obstruction of the retinal artery were the yin-deficiency of liver and kidney, the stagnation of vital energy and blood stasis, the abundance of phlegm-heat, the yang-deficiency of spleen and kidney, the yin-deficiency of spleen and kidney, the nonfastness of primordial energy etc. 4. We could get the effective result by providing the patient with Jinkansikpung-tang-gami(鎭肝熄風湯加味) in the acute period 5. In Acupuncture treament and other treament, Electro-acupuncture theraphy ana Lodestone theraphy were useo for neurologic stimulation, Body acupuncture and Auricula-acupuncture were used for promoting the circulation of vital energy and blood.