• Korean Journal of Clinical Pharmacy
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• v.23 no.3
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• pp.239-247
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• 2013

Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.

• Research in Community and Public Health Nursing
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• v.14 no.3
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• pp.520-532
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• 2003

Purpose: The purpose of this study was to identify the health status and request of community residents. This study is part of development of efficient health life enhancement programs. Methods: The subjects of this study were 586 households in a rural community and well-trained interviewers visited every household in the designated area and individually interviewed heads of households for general information and health service utilization. The data were collected using a questionnaire for seven months from March 25 to September 24, 2002. The data were analyzed using frequency. percentage by SPSSWIN (v 10.0). Results: 1. 58.9% of subjects were above sixty, and 60.8% of them were women. 2. The most serious problems they identified were health problems (45.6%), and the second was(##-was+were) economic problems(22.0%). 3. Almost half of the study population regarded themselves as healthy (46.2%). The types of illness they had were neuralgia, arthritis, hypertension, diabetes, and heart disease. 4. Most of the study population answered that they didn't do anything special for health enhancement. 5. Among medical facilities, hospitals or medical clinics (55.3%) were most commonly utilized when they were sick. 6. The highest request of the subjects was 'Home visiting service (45.4%)', and 'free treatment connected to the service of hospitals' was the second. What they needed most regarding health enhancement programs in health life enhancement centers was 'free health examination (58.2%), and heath education programs (57.7%). 7. As a result of investigating the subjects' demand for nursing services in health life enhancement center, 'the clinical examination' was the most requested, and next was 'blood pressure check', 'emergency treatment', and 'rehabilitation service', in that order.

• Research in Community and Public Health Nursing
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• v.18 no.3
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• pp.373-381
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• 2007

Purpose: An exercise program, which was composed of motions simple and easy to follow, was developed and applied to aged women as a way to improve their health conditions. Method: To ascertain the effects of the exercise, which was conducted twice a week and 16 times in total for 8 weeks from September 10 to November 5, 2005 in two experimental groups (31 Persons) and a control group (31 persons), this study conducted quasi-experiments of nonequivalent control group pre-post test design. Data were analyzed using SPSS/PC Win 10.0, the reliability of the measuring tools using Cronbach's alpha, the verification of equivalence for general properties and dependent variables using Chi-square test and t-test, and the verification of hypotheses using t-test and ANCOVA. Results: After the exercise program. the aged women showed profitable evaluation of decisional balance, high feeling of self-efficacy as well as improved subjective awareness of health. Their diastolic blood pressure and total cholesterol were also reduced significantly after the exercise. Conclusion: After the conduct of the exercise program for 8 weeks, aged women showed increased profitable decisional balance, self-efficacy and subjective awareness of health. This suggests that continuous and proper exercise is effective as an intervention for health improvement for the aged as well as the prevention of and recovery from geriatric diseases.

• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.289-297
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• 2020

This study was to explore factors determining school-based student health screening participation. Participants were six health coordinators in West Virginia, the United States. They have responsibilities in the student health screening and conducted a phone interview. The results are as follows. First, opt-in of health screening came from the interest in students' health, peer pressure, and free screening. Second, opt-out of health screening came from the indifference to a school newsletter, anxiety about an information disclosure, and the fear of drawing blood. Third, the advantage of health screening was provided for free. Fourth, the primary decision-maker was parents, but sometimes was children. Fifth, non-family members also influenced on the participation in the health screening. Therefore, a school newsletter, parents and teachers education, and free screening may be required to improve the participation rate.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.3
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• pp.710-721
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• 1999

This study was conducted to investigate the hematological characteristics and risk factors of hypercholesterolemia(HC) in Korean. 344 adult men who took the annual health check ups at D or J hospitals were participated in this cross sectional study. The subjects were grouped by plasma total cholesterol level into three groups: normal cholesterolemic(n=139), borderline hypercholesterolemic (n=93) and hypercholesterolemic(n=112) groups. The data of systolic and diastolic blood pressure (SBP/DBP), hemoglobin, plasma glucose, albumin and cholesterol levels were collected from medical records. The levels of plasma triglyceride(TG), HDL C, phospholipid, insulin, apo A and apo B were measured. The levels of plasma LDL C, VLDL C and atherogenic index(AI) were calculated. The subjects with HC had significantly higher SBP and DBP, albumin, TG, phospholipid, HDL C, LDL C, VLDL C and apo B level than those of the normal subjects. The relative and attributable risks on HC were 1.59 and 0.18 for hypertension(SBP/DBP$\geq$160/95), 2.08 and 0.35 for hypertriglyceridemia (TG $\geq$400mg/dl). Plasma total cholesterol level was positively correlated with several hematologic parameters: age(r=0.1242, p<0.05), DBP(r=0.1194, p<0.05), albumin(r=0.2029, p<0.001), plasma TG(r= 0.3829, p<0.001), phospholipid(r=0.6036, p<0.001), LDL C(r=0.8572, p<0.001), HDL C(r=0.2399, p< 0.001), AI(r=0.3116, p<0.001), apo B(r=0.2602, p<0.05) and Lp(a)(r=0.1372, p<0.05). However, plasma total cholesterol level was negatively correlated with the levels of Apo A1(r= 0.2922, p<0.001), and ABR(r= 0.3598, p<0.001).

• Korean Journal of Food Science and Technology
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• v.30 no.6
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• pp.1476-1479
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• 1998

Effect of chitosan oligosaccharides on the ACE (angiotensin I converting enzyme) inhibition and antihypertension in SHR (Spontaneously hypertensive rat) was examined. The ACE inhibition activity was observed in all the chitosan oligosaccharides used in this study, and chitosan trimer exhibited the highest inhibitory activity $(IC_{50}=0.9{\mu}M)$ compared with other chitosan oligosaccharides $(IC_{50}\;:\;2.4{\sim}100\;{\mu}M)$. The results suggested that chitosan trimer was a good inhibitor of ACE in molecular level. When the single oral dose (2.14 mg/kg, similar to dose level of Captopril, known as strong ACE inhibitor) of chitosan trimer was given to 8 or 21 week aged SHR, the blood pressure reduction of both SHRs in 4hrs were $27{\pm}4.8\;mmHg\;and\;36{\pm}4.3\;mmHg$, respectively. Therefore, it was suggested that chitosan trimer could be applicable as natural ACE inhibitor related to antihypertension.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.9 no.1
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• pp.9-14
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• 2016

Recently the number of the elderly who live alone are increasing more and more as the average life span is prolonged. The elderly are probably in danger at home without being helped due to external aggressions or sudden health problems. Accordingly, more and more interests are taken in medical welfare for the healthy life of the seniors. In this paper, we have developed a mobility and vitality signal monitoring system based on ZigBee-PSTN gateway for the elderly. This combination of ZigBee wireless sensor network and PSTN can be easily established even in the poor internet infrastructure as is usually common for the elderly, with the advantage of providing non-constrained monitoring feature. The research result can be extended to the future tele-medicine system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.3
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• pp.537-545
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• 2009

Though there were many research and development about telemedicine on land recently, not yet applied to that on the shore. In this paper, when emergency clinic situation were generated in a ship on shore, the telemedicine system was designed and implemented for transfer and clinic service to doctors on the land by measuring basic body signals of patients. Presently, wireless communication and inmarsat telephone are usually used by simple questions and clinic consults to remote doctors when emergency situation were happened in the ship. In this paper, the telemedicine system on the shore were developed for improving this problems by measuring patient's fundamental conditions such as the blood pressure, pulse, the respiratory condition, electrocardiogram, body temperature, patient image and sending these information to remote doctors on land for more accurate prescription. The developed system can supply the high level clinic service to emergency patients on the shore and cope with the emergency situation in ship.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.14 no.1
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• pp.44-56
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• 2010

Objective : To characterize Five Woons of Asian women who live at Los Angeles area in U.S.A Methods : A set of physical tests and diagnostic questions were given to 242 Asian female subjects who were treated for their symptoms at a clinic of Asian medicine near Los Angeles in USA. The participants were given their constitutions, one of the Five Woons based on their birthdays. The physical tests included a body composition via Inbody 4.0 and an autonomic bioelectric response record via ABR2000. The oneway analysis of variance was applied to compare the means of the Five Woons and the physical test results. The Cross tabulation analysis was also applied to look for the effectiveness of Five Woons on the symptoms. Results : 1. In the body composition items, the LSD(least significant difference) showed that there were significant differences between the Soil Woon and the other Four Woons which are Water, Metal, Fire and Wood Woons in weight, fat, body fat %, BMI (p<0.2). 2. Based on the LSD, significant differences were observed among the Five Woons in R5, R6 and R7(p<0.2). 3. The cross tabulation analysis showed the significant effectiveness of the Five Woons on the five symptoms including dizziness, hot and cold, lower body edema, fatigue and to take a medication for high blood pressure out of 24 diagnostic questions (p<0.2). Conclusions : Further clinical research is necessary to develop a more delicate questionnaire and look for ways of characterizing the Five Woons. The diagnosis and corresponding treatment based on the Five Woons should be further studied in view of the Oriental medicine.

• The Korean Journal of Physiology
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• v.20 no.1
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• pp.89-102
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• 1986

It has long been suggested that the change of renin-angiotensin system is responsible for the increased arterial blood pressure in the experimental hypertension. But the exact nature of the cause and maintenance of early and late Phase of renal hypertension is still controversial. Increased renin-angiotensin system has been suggested. To clarify the altered renin-angiotensin system in the early phase of two kidney one clip Goldblatt hypertension(2K1C GH), experiments were carried out in the rats of 3,7, and 14 days of 2K1C GH rats, sham-operated, and control rats. Responses of the plasma renin activity to the intravenous infusion of L-isoproterenol were dose-dependent. Responses of the plasma renin activity to the intravenous L-isoproterenol in 2K1C GH rats were not different from sham-operated control rats. Hypotensive responses of the 2K1C GH rats were not different from sham-operated rats. Suppression by intravenous infusion of angiotensin II of plasma renin activity showed a dose-dependent manner. Suppression by angiotensin ll of plasma renin activity was attenuated or abolished in the early phase of 2K1C GH rats. Intravenous infusion of arginine vasopressin(AVP) showed a dose-dependent suppression of plasma renin activity, Attenuated responses by AVP of plasma renin activity were noticed in the early phase of 2K1C GH rats. These results suggest that the altered renin-angiotensin system in the early phase of the two kidney one clip Goldblatt hypertension may be caused by failure of the short loop negative feedback control mechanism.