• Nutrition Research and Practice
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• 제2권4호
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• pp.252-258
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• 2008

This study was designed to determine whether acute fructose or sucrose administration at different levels (0.05 g/kg, 0.1 g/kg or 0.4 g/kg body weight) might affect oral glucose tolerance test (OGTT) in normal and type 2 diabetic rats. In OGTT, there were no significant differences in glucose responses between acute fructose- and sucrose-administered groups. However, in normal rats, the AUCs of the blood glucose response for the fructose-administered groups tended to be lower than those of the control and sucrose-administered groups. The AUCs of the lower levels fructose- or sucrose-administered groups tended to be smaller than those of higher levels fructose- or sucrose-administered groups. In type 2 diabetic rats, only the AUC of the lowest level of fructose-administered (0.05 g/kg body weight) group was slightly smaller than that of the control group. The AUCs of fructose-administered groups tended to be smaller than those of the sucrose-administered groups, and the AUCs of lower levels fructose-administered groups tended to be smaller than those fed higher levels of fructose. We concluded from this experiment that fructose has tendency to be more effective in blood glucose regulation than sucrose, and moreover, that smaller amount of fructose is preferred to larger amount. Specifically, our experiments indicated that the fructose level of 0.05 g/kg body weight as dietary supplement was the most effective amount for blood glucose regulation from the pool of 0.05 g/kg, 0.1 g/kg and 0.4 g/kg body weights. Therefore, our results suggest the use of fructose as the substitute sweetener for sucrose, which may be beneficial for blood glucose regulation.

• Design & Manufacturing
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• 제12권2호
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• pp.57-62
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• 2018

In diabetics, daily blood glucose testing is generally required at home, and thus, performing blood collection several times a day using a blood line is essential. Blood collection in the home and in the hospital is a source of pain and is the second most common cause of infection. In blood collecting device generally consists of four major parts: inner-case, outer case, main shaft and triger, and the most import part among those for necessary functionality is the main shaft. Filling time and injection pressure, filling balance, strain-rate analysis of change based on availability of the product. The Moldflow of FEM simulation is used for the analysis of injection molding process. In this study, aims to create a technique for injection molding and manufacturing of a main shaft of a high-performance blood-collecting apparatus capable of automatically extracting a lancet to relieve pain through depth control of the lancet.

• 한국간호교육학회지
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• 제12권2호
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• pp.265-271
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• 2006

Purpose: To analyze the newly developed vacuum assisted auto-lancing technique applied to the forearm for the purpose of obtaining an adequate blood sample for glucose test with minimal pain. Methods: Visual and facial pain measures were introduced to compare lancing pain between the forearm and fingertip in 58 normal females. Sampled blood volumes were accurately measured by computer scanning technique. Results: Visual pain measure demonstrated significant pain reduction effect of the forearm sampling compared with the traditional fingertip sampling, which was also consistent with facial pain measure results. Blood volume more than $0.5{\mu}L$, enough for blood glucose testing with modern glucometers, was collected in 399(86%) of 464 forearm samples. Conclusions: Capillary blood sampling could be performed with minimal pain on the forearm by the newly developed vacuum assisted auto-lancing technique. With some resampling when necessary, the forearm sampling seemed very useful, considering almost no pain felt by the patients.

• Journal of Nutrition and Health
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• 제19권6호
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• pp.402-408
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• 1986

Since diet is an essential component of the treatment for diabetic mellitus, a progressive educational plan was designed to educate diabetic children for the proper selection of their foods. Seven suspicious children were chosen according to the previous oral glucose tolerance test and present blood glucose levels (fasting and postprandial 2 hours). The education program includes the basic nutrition study, learning of the five basic food groups. familiarization with the food exchange lists. calorie calculation and menu planning, and follow-up evaluation by checking every day -food intake. The duration of the education was five weeks. The levels of fasting blood glucose and postprandial -2 hours blood sugar of the seven children were significantly reduced after the 5-weeks education:FBS:from 92-125mg% to 67-80mg%, pp-2hours BS: from 130-169mg% to 69-90mg%. The children have felt much better with profound self-confidence after to program . Their oral glucose tolerance test levels were also significantly decreased after the 5-weeks education in comparison with those of one year ago.

• Biomolecules & Therapeutics
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• 제5권4호
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• pp.364-368
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• 1997

Onion (Allium cepa Linn) has been reported to have hypoglycemic activity in human and several animal models. In the present study, we performed intraperitoneal glucose tolerance test (IPGTT) in young (1.5mo) and aged (5 mo) rats treated with onion in order to determine whether aging can influence on the anti-hy-perglycemic effect of onion. In addition, we investigated the hypoglycemic effect of onion in streptozotocin- induced diabetic rats treated with aqueous extracts of onion (500 mg/kg, i.p., daily) for 4 weeks. Blood glucose level was determined in fasted and fed rats by using a glucometer (Johnson & Johnson). In glucose tolerance test, blood glucose level was maximally increased 15 min after glucose load (2 g/kg, i.p.), and recovered to the basal level 3 hr after glucose challenge in young and old rats. The maximum blood glucose levels of young and aged rat were 184$\pm$7.49 and 225.2$\pm$ 12.55 mg/dl, respectively. A single i.p. injection of aqueous extract of onion (1 g/kg) 30 min before glucose challenge significantly decreased blood glucose levels at 15, 30, 60, 90 min after glucose load in aged rats, while the administration of onion did not show any significant effect in young rats. In onion-treated diabetic rats, significant hypoglycemic effect (p<0.05) was observed, and the effect was greater in fasted rats than in fed. In conclusion, these results suggest that anti-hyperlycemic effect of onion can be changed by age and fasting.

• 동의생리병리학회지
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• 제20권5호
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• pp.1254-1260
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• 2006

The purpose of this study was to the Pre-Post submaximal exercise for analyze the Blood Lactate, LDH(Lactate Dehydrogenase) and Glucose in the runners. The subjects were 12 volunteers 6 sprinters and 6 distance runners who agreed to intention of this study. Subjects peformed until possible all-out trials. Blood samples were taken from a Ante cubital vein Pre-Post exercise and every rest 5min during the all-out trial. The results obtained were summarized as follow; 1) Blood Lactate of Pre-Post exercise in treadmill test showed no significant difference between sprinters and distance runners, but showed significant in sprinters and distance respectively. 2) Serum LDH of Pre-Post exercise in treadmill test showed no significant difference between sprinters and distance runners, and that showed no significant in sprinters and distance respectively. 3) Blood Glucose of Pre-Post exercise in treadmill test showed no significant difference between sprinters and distance runners, and showed no significant in distance, but showed significant in sprinters. These data indicate first that the value of 4mmol/${\ell}$, commonly referred to as OBLA(Onset of Blood Lactate),may often underestimate the upper limit of tolerance to lactate during a maximal endurance peformance test until all-out. second, our date suggested that the sprinters exercise decreases serum LDH activities and the distance increases serum LDH activities. therefore serum LDH concentration changed following a different exercise. Third. for the concentration of the glucose in blood the sprinters was show to be higher. However it needs more studies to find out the relationship between this result and the fitness factor. therefor, since the runners has an intermittent characteristic which includes a frequent momentary change, it needs the fitness training that being consisted of various training. in the training method, it needs the training process which is from the whole fitness to specific fitness to improve general physical ability.

• 한국산림과학회지
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• 제99권1호
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• pp.47-51
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• 2010

본 연구의 목적은 일회성 산림 걷기 운동이 내당능장애(impaired glucose tolerance, IGT)와 인슐린 비의존성 당뇨병(non-insulin-dependent diabetes mellitus, NIDDM)환자의 혈당치 변화에 어떠한 영향을 미치는 가를 알아보기 위한 것이었다. 연구의 대상자는 노인 여성(n=60)을 IGT 산림 걷기 운동군(n=15; $66.21{\pm}4.16$ yrs), NIDDM 산림 걷기 운동군(n=15; $64.85{\pm}3.23$ yrs), IGT 운동장 걷기 운동군(n=15; $67.44{\pm}1.78$ yrs), NIDDM 운동장 걷기 운동군(n=15; $65.55{\pm}8.21$ yrs)으로 구분하여 운동강도 HRmax 50~60%의 산림 걷기 운동(인터벌+저항성 근육운동)과 운동장 걷기 운동(유산소성 운동) 프로그램을 적용하여 운동 전과 후에 혈당을 측정하여 분석하였다. 그 결과, 첫째 내당능장애군에서 산림 걷기와 운동장 걷기 집단은 운동 후에 모두 유의한 수준에서 혈당치의 감소를 보였고, 둘째 인슐린 비의존성 당뇨병군에서 산림 걷기 집단은 운동 후에 혈당치가 유의하게 감소되었지만 운동장 걷기 집단은 특별한 혈당치의 변화가 없었다. 따라서 본 연구는 유산소 운동으로 지속적으로 운동장을 걷는 운동보다 오르막 내리막 지형을 이용한 인터벌 운동과 저항성 근육운동의 복합 형태인 산림 걷기 운동이 내당능장애와 인슐린 비의존성 당뇨병 환자에 더 효과적인 것으로 제안한다.

• 한국잠사곤충학회지
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• 제41권3호
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• pp.129-134
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• 1999

The purpose of this study is to investigate the effects of the ice-cream containing mulberry leaves on glucose levels in blood and on sensory characteristics. Mulberry leaves were treated with sodium hydrogencarbonate (NaHCO3) to remove the fresh green note out of dried mulberry powder with ball mill. The recovery rate of dried mulberry leaf powder was 28.9% from fresh mulberry leaves. The points of ice-cream with (treatment 2 : milk-fatty 23%) and without (treatment 7 : coconut butter 9.5%) milk-fatty in the sensory characteristics were 8.31 and 8.47, respectively, of 9.00 as a full point. The range of age of volunteers taken part in the glucose level test were 21∼25 years old. The glucose levels in blood were measured before and after taking up ice-cream. In case of ice-cream with vanilla, the glucose levels increased 27.8%, while those in the up take of ice-cream with mulberry powder decreased 1.6%. In conclusion, the present study has demonstrated that ice-cream containing mulberry leaf powder has an effect to decrease blood glucose levels after the application.

• 한국축산식품학회지
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• 제28권4호
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• pp.445-450
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• 2008

The effects of fermented goat milk supplemented with citrus concentrate on blood glucose levels in streptozotocin-nicotinamide-induced diabetic rats were examined. Streptozotocin-nicotinamide-induced diabetic rats (type II) were divided into five experimental groups treated with metformin, goat milk, fermented goat milk, fermented goat milk containing citrus concentrate, or no supplementation (control). The rats in each group were examined weekly for blood levels of glucose, total cholesterol, triglyceride. HDL-cholesterol, LDL-cholesterol. and body weight. On the $24^{th}$ day of the experiment, an oral glucose tolerance test (OGTT) was carried out. Administration of fermented goat milk to the diabetic rats significantly decreased blood glucose and triglyceride levels, while administration of metformin (33.3 mg/kg body weight) did not significantly lower blood glucose levels. Fermented goat milk containing citrus concentrate caused a significant decrease in blood glucose levels in the OGTT at 30 min. This study shows that supplementation with fermented goat milk containing citrus concentrate may be a practical method of reducing blood glucose levels in type II diabetics.

• 한국식품조리과학회지
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• 제15권4호
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• pp.401-409
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• 1999

본 연구는 혈당반응이 낮은 식품인 미역, 시금치, 돌미나리, 산마, 토마토를 활용하여 37종의 부식에 대한 조리법을 개발하고, 일반식과 저GI식단을 정상인을 대상으로 혈당반응을 비교 분석함으로써, 혈당조절효과가 있고 기호성이 있는 당뇨조절식단을 개발하는데 도움이 되고자 한다. 조리법은 전통식 조리형태에 가까울수록 높은 평가를 받았다. 기호성이 높은 조리법으로는 미역쇠고기국, 미역된장국, 미역건새우죽, 미역수제비, 미역줄기볶음, 미역버섯회, 미역고추장무침, 시금치당근즙, 시금치된장국, 시금치전, 시금치두부무침 , 돌미나리굴생채, 돌미나리쇠고기무침, 돌미나리즙, 돌미나리초대, 마조림 , 마전등으로 6.8-8.2점의 평가를 받았다. 정상인에 대하여 일반식과 당뇨조절식의 혈당반응을 조사한 결과, 일반식 GI 100에 대하여 당뇨조절식은 GI 91.3-GI 57.9로서 혈당강하효과가 있었다. 특히, GI 57.9로서 가장 효과가 컸던 식단은 30% 검정콩 혼식에 당뇨식 반찬이었다.