• Title/Summary/Keyword: Blood flow rate

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Blood Flow Rate Estimation using Proximal Isovelocity Surface Area Technique Based on Region-Based Contour Scheme and Surface Subdivision Flow Model (영역기반 윤곽선 기법과 표면 분할 유동모델에 기반한 근위 등속 표면적 기법을 이용한 혈류량 추정)

  • Jin, Kyung-Chan;Cho, Jin-Ho
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.38 no.1
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    • pp.45-52
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    • 2001
  • The proximal isovelocity surface area (PISA) method is an effective way of measuring the regurgitant blood flow rate in the mitral valve. This method defines the modelling required to describe the geometry of the isotach of the PISA. In the normal PISA flow model, the flow rate is calculated assuming that the surface of the isotach is either hemispherical or non-hemispherical numerically. However, this paper evaluated the estimate flow rate using a direct surface subdivision flow model based on the height field after isotach extraction using a region-based scheme. To validate the proposed method, the various PISA flow models were compared using pusatile color Doppler images with flow rates ranging from $30\;cm^3/sec\;to\;60\;cm^3/sec$ flow rate. Whereas the hemispherical flow model had a mean value of $29\;cm^3/sec$ and underestimated the measured flow rate by 35%, the proposed model and non-hemispherical model produced a c;ame mean value of $45\;cm^3/sec$, moreover, both flow models produced a similar pulsatile flow rate.

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The Effect of Pulsatile Flow on Ultrafiltration In-Vitro Study and Comparison with Roller Pump

  • Lee K.;Jeong J. H.;Mun C. H.;Lee J. C.;Min B. G.
    • Journal of Biomedical Engineering Research
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    • v.26 no.5
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    • pp.337-341
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    • 2005
  • Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.

A Study on the Significance of the Colloidal Radiogold Disappearance Rate as a Simple Clinical Liver Function Test (임상간기능검사법(臨床肝機能檢査法)으로서의 교질형방사성금(膠質形放射性金)의 혈중소실율(血中消失率)의 의의(意義)에 관(關)한 연구(硏究))

  • Hong, Chang-Gi
    • The Korean Journal of Nuclear Medicine
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    • v.3 no.1
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    • pp.1-12
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    • 1969
  • Liver functions in diffuse parenchymal liver disease such as cirrhosis of the liver depend largely on the effective hepatic blood flow rather than on the individual cell functions. Clinical methods of measuring the hepatic blood flow were developed recently by the application of colloidal disappearance rate. In order to correlate the radiogold disappearance rate to conventional biochemical liver function tests, 21 normal subjects and 80 cases of cirrhosis of the liver were studied with both methods. The results are summarized as following: 1. The validity of external counting method to measure the blood disappearance rate of colloidal radiogold was confirmed by in vitro counting of the serial blood samples. 2. The blood disappearance rate of collidal radiogold was essentially the same. as the liver uptake rate of colloidal radiogold in normal and cirrhotic subjects with various degrees of functional disturbance. And it seemed there was no serious extrahepatic removal of the colloidal radiogold. 3. The disappearance rate of colloidal radiogold was not significantly changed by the posture change, but was enhanced by ingestion of 500 ml of water. 4. The disappearance rate of colloidal radiogold was not influenced by single dose of Telepaque, while BSP retention was increased after Telepaque. 5. The mean disappearance half time of colloidal radiogold in normal subjects was $2.49{\pm}0.391$(S.D.) minutes. The mean normal disappearance rate constant (K value) was $0.285{\pm}0.0428$(S.D.)/minute. 6. The colloidal radiogold disappearance half time was abnormally prolonged (over 3.2 min.) in $87.7{\pm}3.68$(S.D.) % of cirrhotic subjects. 7. In patients of liver cirrhosis the blood disappearance rate of colloidal radiogold correlated well to serum albumin and globulin levels and BSP retention which were considered to reflect functions of hepatic parenchymal cells. There was, however, no correlation between colloidal disappearance rate and thymol turbidity test, serum glutamic pyruvic transaminase, and serm alkaline phosphatase activities. The latters were considered to be associated with the activity of liver disease.

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Effect of Mori Folium Extract on Improvement of Blood Flow in Ferric Chloride-Induced Carotid Artery Damage Rat Model (염화제2철이 유도하는 경동맥 손상 렛트 모델에서 상엽 추출물의 혈행개선 효과)

  • Kang, Hyun Ju;Jeon, In Hwa;Kwon, Tae Oh;Choi, Jiwon;Kim, Sung Zoo;Jang, Seon Il
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.28 no.6
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    • pp.607-613
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    • 2014
  • In a previous study, we have shown that mulberry leaves (Mori Folium) extract MFE) and its compounds have the antioxidant effect in human red blood cells. However, the possible effect of MFE and its compounds on improvement of blood flow were not reported. Therefore, the aim of this study is to investigate the effects of MFE and its compounds on improvement of blood flow in a rat model of topical ferric chloride ($FeCl_3$)-induced carotid artery damage. The $FeCl_3$ treatment seriously damaged the carotid artery: the walls of the artery, blood flow rate, blood vessel diameter, blood vessel area and blood flow amount. However, administration of MFE or its compound has ameliorated the blood flow and suppressed thrombus in blood vessels. Moreover, the concentrations of serum total cholesterol, triglycerides, and LDL cholesterol in the MET and its compound groups were remarkably reduced in comparison to the control group, and HDL cholesterol concentration was higher in the MET and its compound groups than in the control group. These results suggest that MFE and its compounds ameliorate the thrombosis against blood vessel damage.

Effects of Uwhangchungsimwon(牛黃淸心元) on Cerebral Blood Flow and Systemic Blood Pressure in Humans (우황청심원이 정상인의 뇌혈류 및 혈압에 미치는 영향)

  • Kim, Young-Suk
    • The Journal of Internal Korean Medicine
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    • v.20 no.1
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    • pp.222-231
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    • 1999
  • Uwhangchungsimwon(UC) has been used in the treatment of a wide variety of conditions including stroke, hypertension, arteriosclerosis, autonomic imbalance, mental instablity, etc in Korean traditional hospitals, In particular it is often initialy chosen for emergency care of acute stroke. The aim of this study was to evaluate the effect of UC on cerebral hemodynamics. Using transcranial Doppler ultrasound, we studied changes of mean flow velocity and pulsatility index(PI) of middle cerebral arteries (MCAs) from 11 health young volunteers who were administrated with 1 pill UC and 11 health controls who were not. We obtained hypercapnia with breath-holding and evaluated cerebrovascular reactivity with breath-holding index(BHI). Systolic blood pressure, diastolic blood pressure, and heart rate were measured using ambulatory blood pressure monitoring(ABPM). In UC administration group, the evaluation was performed during basal condition. and repeated at 20, 40, and 60 min after administration. In controls, the evaluation was performed at corresponding time intervals. Mean flow velocity in middle cerebral artery, systolic blood pressure, diastolic blood pressure, and heart rate did not change during the observation period and were not different between these two groups. However, administration of UC was associated with decreases in PI by $3.6{\sim}12.4%$ in BHI by $17.9{\sim}24.8%$ compared with pre-administration period. Decreases in PI and BHI with UC were significantly different compared with control group (p<0.05). These results indicate that UC decreases PI and BHI in cerebral artery, which is due to a dilation of cerebral resistance vessels.

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Experimental Study of CheonghunHwadam-tang on the Cerebral Blood Flow in Rats (청훈화담탕이 국소뇌혈류량에 미치는 실험적 연구)

  • Kim Cheon Joong;Cho Su In;Jeong Hyun Woo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.16 no.2
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    • pp.316-321
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    • 2002
  • CheonghunHwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CheonghunHwadam-tangGamypang(CHTG) was CHT adding Aurantii Fructus(AF), Gastrodae Rhizoma(GR). The effects of CHT on the cerebral blood flow and cardiacvascular system is not known. The purpose of this Study was to investigate effects of CHT and CHTG on the regional cerebral blood flow(rCBF), mean arterial blood pressure(BP), cardiac muscle contractile force(CMF), heart rate(HR). The changes of cerebral blood flow and movement of cardiacvascular system(BP, CMF, HR) was determinated by Laser-Doppler Rowmetry(LDF). The results were as follows; 1. CHT extract increased rCBF, but decreased BP, HR in a dose-dependent manner. 2. AF extract accelerated rCBF and movement of cardiacvascular system in a dose-dependent manner. 3. GR extract increased significantly rCBF(10.0mg/kg, p<0.05) as well as accelerated BP and rCBF in a dose-dependent manner. 4. CHTG extract increased significantly rCBF(10.0mg/kg, p<0.01) in a dose-dependent, but was not changed movement of cardiacvascular system. This results suggest that CHTG is significantly treated more than CHT in vertigo by wind, fire and phlegm.

A Study on Cerebral Blood Flow Enhancement Device Using Blood Oxygen Level Sensor (Blood Oxygen Level Sensor를 이용한 대뇌혈류증가 장치에 관한 연구)

  • Lim, Jung-Hyun;Joh, In-Hee;Kim, Young-kil
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2018.05a
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    • pp.188-192
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    • 2018
  • Surgery to increase cerebral blood flow is one of the treatment methods of cerebral infarction. However, invasive methods, such as surgery, may result in postoperative complications or side effects. In order to supplement this invasive method, non-invasive devices have been introduced that use human blood pressure to pressurize the extremities to increase cerebral blood flow. However, the problem of poor speed and accuracy was raised. In this paper, the perfusion index of each arm was measured by applying pressure to both arms using Blood Oxygen Level Sensor to improve the accuracy of measurement and measurement time. The pressure applied to the arm by 75% of the moment when it falls to the leg and the pressure calculated by using the pressure value obtained from the arm. Like the existing blood pressure measuring cerebral blood flow increasing device, the blood flow can be increased by more than 20% and the measurement time can be shortened, so that it can be selectively used for the patient with cerebral infarction.

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The effect of posture on the human thermoregulatory response (인체의 자세가 체온조절에 미치는 영향)

  • Shim, Hyun Sup;Choi, Jeong Wha
    • Journal of the Korean Society of Clothing and Textiles
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    • v.17 no.3
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    • pp.415-427
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    • 1993
  • The purpose of this study was to evaluate the thermoregulatory responses to postures under different environmental conditions and to obtain the basal information for standard clothing weight, indoor climates, and working condition. Two adult female (22.5yrs, 46kg) were participated in this study. The experimental conditions were divided into three groups ; 1) comfort($27{\pm}1^{\circ}C$, $60{\pm}10%$), 2) hot($34{\pm}1^{\circ}C$, $60{\pm}10%$), and 3) cold($21{\pm}1^{\circ}C$, $50{\pm}10%$) condition. The postures performed were as follows; standing, sitting on the chair, sitting on the floor, and supine on the floor. At each condition, subjective sensations, 12 points skin temperature, rectal temperature, total and local sweat rate, pulse rates, blood pressure, skin blood flow rate were measured. The results were as follows : 1. Rectal temperature was high significant among groups in order of supine, sitting on the floor, sitting on the chair, standing posture(p<0.01). 2. Skin temperature was high in part of contact with the surface of the floor or wall and the effect of posture was greater in peripheral temperature than torso temperature. Sitting on the chair and sitting on the floor posture showed higher peripheral temperature than standing and supine posture. And peripheral temperature was lower in supine posture than any other postures. 3. Total and local sweat rate were decreased in order of standing, sitting on the chair, sitting on the floor, supine posture. 4. Pulse rate and disastolic blood pressure were higher in standing posture than supine posture, and there was significant difference between two postures(p<0.001). 5. Blood flow rate of thigh was high in sitting on the chair and sitting on the floor posture and low in standing posture. Blood flow rate of leg was low in standing posture significantly(p<0.01). 6. In comfort and hot condition, temperature sensation and comfort sensation were higher in standing posture and lower in supine posture than any other postures. In cold condition, temperature sensation was lower and comfort sensation was higher in standing and supine posture than any other postures. And supine posture was appeared positive in hot condition and negative in cold condition. From this study, we confirmed the effects of posture on human thermoregulatory responses. Results indicate that even under same conditions and clothing weight, the insulation of clothing will be different to postures.

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Cerebral blood flow enhancement device using Blood Oxygen Level Sensor (Blood Oxygen Level Sensor를 이용한 대뇌혈류증가 장치)

  • Lim, Jung-hyun;Joh, In-Hee;Kim, Young-kil
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.8
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    • pp.1083-1089
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    • 2018
  • Surgery to increase cerebral blood flow is one of the treatment methods of cerebral infarction. In order to supplement this invasive method, non-invasive devices have been introduced that use human blood pressure to pressurize the extremities to increase cerebral blood flow. However, the problem of poor speed and accuracy was raised. In this paper, the perfusion index of each arm is measured by applying pressure to both arms using Blood Oxygen Level Sensor to improve the accuracy of measurement and measurement time. The pressure applied to the arm is calculated by using the pressure value obtained from the arm. Like the existing blood pressure measuring cerebral blood flow increasing device, the blood flow can be increased by more than 20% and the measurement time can be shortened, so that it can be selectively used for the patient with cerebral infarction.

The Effects of Regular Resistive Exercise on Cardiopulmonary Ability and Cerebral Blood Flow Velocity (규칙적인 저항 운동이 심폐 능력과 뇌혈류 속도에 미치는 영향)

  • Yu, Jae-Ho;Lee, Suk-Min
    • Journal of the Korean Society of Physical Medicine
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    • v.5 no.2
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    • pp.255-264
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    • 2010
  • Purpose : The purpose of this study is to analysis effects of resistive exercise on cardiopulmonary fitness and cerebral artery blood flow velocity. Methods : Ten healthy university students had done resistive exercise without aerobic exercise over one year participated resistive exercise group and ten general university students, then were calculated oxygen consumption ($VO_2$) and respiratory exchange rate($VO_2/VCO_2$). After a week, they were measured Transcranial Doppler Ultrasonography(TCD) at moderate exercise(HRmax 50%), maximal exercise (HRmax 100%) for taking cerebral blood flow velocity. Results : In the comparison between groups, resistive exercise group showed significant higher oxygen consumption and lower respiratory exchange than controls(p<0.05). In resistive exercise group, oxygen consumption was significant negative correlation with cerebral artery pulsatory index(p<0.05). but, oxygen consumption was significant positive correlation with systolic blood flow velocity in controls(p<0.05). Conclusions : After considering all the factors, important value in resistive exercise is regular participation and help us increasing contingency response ability.