• Archives of Pharmacal Research
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• 제27권10호
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• pp.1037-1042
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• 2004

Study of the effects of the methanolic extract of Tagetes patula roots on blood pressure led to the isolation of well known citric (1) and malic acid (7) as hypotensive, and pyridine hydrochloride (4) as hypertensive constituents of the plant along with a new constituent, 2-hydroxy, 5- hydroxymethyl furan (9). Citric acid and malic acid caused 71% and 43% fall in Mean Arterial Blood Pressure (MABP) of rats at the doses of 15 mg/kg and 30mg/kg respectively while pyridine hydrochloride produced 34% rise in the MABP of rats at the dose of 30mg/kg. $LD_{50}\;and\;LD_{100}$ of citric acid in mice have been determined as 545 mg/kg and 1000 mg/kg, respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3645-3651
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• 2012

Conventional pap smear (CPS) examination has been the mainstay for early detection of cervical cancer. However, its widespread use has not been possible due to the inherent limitations, like presence of obscuring blood and inflammation, reducing its sensitivity considerably. Automated methods in use in developed countries may not be affordable in the developing countries due to paucity of resources. On the other hand, manual liquid based cytology (MLBC) is a technique that is cost effective and improves detection of precursor lesions and specimen adequacy. Therefore the aim of the study was to compare the utility of MLBC with that of CPS in cervical cancer screening. A prospective study of 100 cases through MLBC and CPS was conducted from October 2009 to July 2010, in a Medical College in India, by two independent pathologists and correlated with histopathology (22 cases). Morphological features as seen through MLBC and CPS were compared. Subsequently, all the cases were grouped based on cytological diagnosis according to two methods into 10 groups and a subjective comparison was made. In order to compare the validity of MLBC with CPS in case of major diagnoses, sensitivity and specificity of the two methods were estimated considering histological examination as the gold standard. Increased detection rate with MLBC was 150%. The concordance rate by LBC/histopathology v/s CPS/histopathology was also improved (86% vs 77%) The percentage agreement by the two methods was 68%. MLBC was more sensitive in diagnosis of LSIL and more specific in the diagnosis of inflammation. Thus, MLBC was found to be better than CPS in diagnosis of precursor lesions. It provided better morphology with increased detection of abnormalities and preservation of specimen for cell block and ancillary studies like immunocytochemistry and HPV detection. Therefore, it can be used as alternative strategy for cervical cancer prevention in limited resource settings.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.199.2-200
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• 2003

Choline is an important membrane phospholipid constituent and a neurotransmitter precursor that is minimally synthesized in brain. The long-term maintenance of brain choline concentration is dependent on choline transport from plasma, which occurs via saturable transport system at the blood-brain barrier. In the present study, we examined to elucidate the characteristics of transport of cationic amines, especially choline which is one of cationic amines, to BBS using conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) in vitro. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.269.2-270
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• 2002

Atherosclerosis is a main cause of cardiovascular diseases (that is angina. hypertension. cardiac infarction) and stroke. High level of low-density lipoproteins (LDL) in blood has been implicated as an important factor of atherosclerosis progression. Recently researches in endothelial cells unveiled the roles of Iysophosphatidylcholine (LPC). a constituent of oxidized LDL in atherosclerosis. (omitted)

• 생약학회지
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• 제24권3호
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• pp.213-218
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• 1993

The methanol extract of Aralia elata root bark was found to decrease the blood glucose level in normal and alloxan-treated rats. The fractionation process confirmed positive activity in ethylacetate fraction. It is suggested that this fraction may show potent antihyperglyceimic activity through stimulation of insulin secretion.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.191.3-192
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• 2003

Alnus japonica (Betulaceae) has been traditionally used for purifying blood, and curing feces containing blood, enteritis, diarrhea, alcoholism and cut wounds. In the current work, activity guided isolation of the butanol fraction of the Alnus japonica bark led to the isolation of catechin-7-O-${\beta}$-D-apiofuranoside. Anti-inflammatory activity was determined with carrageenan-induced paw edema in mice as an acute inflammation, complete Freund's adjuvant-induced arthritis as a chronic inflammation. Carrageenan- induced paw edema in mice was significantly inhibited at 0.5, 1, 2, and 3 hr after carrageenan injection by administration of the flavonoid glycoside at the dose of 150mg/kg. (omitted)

• 보건교육건강증진학회지
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• 제13권1호
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• pp.117-127
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• 1996

The purpose of this study was to investigate the variation in constituent element of blood between the massage group and non-massage group for period of convalescence after giving intense physical exercise of 180beat/min. for 10 men studying physical exercises. Education in K university served as the subjects for this study. The following are the results of the study. 1. The variation in white blood corpuscles showed a tendency of equal ascension in both groups just after finishing physical exercise, but the subjects in the massage group showed quicker recuperation than the subjects in the non-massage. The subjects in the massage group showed a lower tendency than the subjects in the non-massage group for 30minutes after finishing physical exercise. 2. In the variation of red blood corpuscles, it was increased in the massage and non-massage group after physical exercise, but it showed a tendency to drastically decrease in the massage group after 30 minutes. 3. Hemoglobin showed a variation increasing in the massage group and non-massage group after physical exercise, but it showed a tendency of rapid decrease in the massage group after 30 minutes. 4. In the variation of hematocrit, it showed a tendency of similar increase after physical exercise in the massage and non-massage group, but the subjects in the massage group showed a higher decrease than ones in the non-massage after 30 minutes. 5. Blood platelet was increased in the subjects of the massage group after physical exercise, but it was decreased drastically after 30 minutes. 6. In the variation of blood glucose, it was increased in the subjects in the massage group and decreased in the non-massage group after physical exercise, but it showed a tendency of rapid decrease in the non-massage group after 30 minutes.

• 혜화의학회지
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• 제22권1호
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• pp.1-10
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• 2013

Through a consideration of the contralateral collateral needling(繆刺) from "Neijing", the conclusions are as follows. The contralateral collateral needing is defined as a disordered state, and also as the pricking bloodletting method. Unlike the seasonal deficiency pathogen(虛邪), which are affected by the four seasons, the subject of the contralateral collateral needling is the extra pathogen(奇邪), which is the cause of the extra disease(奇病), therefore the treatment should be different from the general. The contralateral collateral needling is generally used when a pain is generated from the veins(絡) by an external pathogen(邪). However, it can be used as the treatment for an emotional disorder, such as flight or sorrow, or a body constituent(身形) disorder caused by internal parts of the five viscera. Although the contralateral collateral needling(繆刺) and the contralateral meridian needling(巨刺) share the left and right cross treatment(右取左, 左取右) in common, but they are different in every aspect, as the causes, transmutation, location, and feature of disease, relation of qi and blood, and location and method of needling(刺鍼). The medical procedure of the contralateral collateral needling is collateral needling(刺絡) the parts of blood collaterals(血絡) or bruising(痏) well points(井穴) of the end of the both sides of limbs, and using the left and right cross treatment when the former methods are not making any progress. The symptoms of contralateral collateral needling are head, chest, and abdomen pains, and they are treated at the end of the limbs. The bloodletting method(刺絡法), extracting a little amount of blood at well points or blood collaterals, or the collateral vessel pricking therapy(瀉血法), extracting a lot of blood by using cupping(附缸), for example, are contemporary successions of the collateral needling(絡刺), the leopard-spot needling(豹文刺), and the contralateral collateral needling.

• 대한임상검사과학회지
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• 제36권2호
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• pp.252-257
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• 2004

The purpose of this study was to investigate the variation in constituent element of blood between the massage group and non-massage group in the period of convalescence after giving intense physical exercise for ten T'ae-Kwondo martial artists. In the variations of red blood cells, white blood cells, hematocrit, hemoglobin and blood platelet, levels decreased during the rest time after physical exercise, but the subjects in the massage group showed lower tendency than the subjects in the non-massage group after physical exercise. The variation of calcium showed an ascension tendency in the massage group after physical exercise. Creatine phosphokinase was increased after physical exercise, but it showed a tendency of rapid decrease in the massage group. Lactic acid showed a variation increase after physical exercise. It showed a tendency of decrease during the rest time in the non-massage group, but it was increased after sports massage. The variation of blood glucose was increased after physical exercise. It was maintained in the massage group after physical exercise in contrast to the non-massage group whose levels decreased during the rest time.

• 대한지역사회영양학회지
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• 제13권1호
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• pp.91-99
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• 2008

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged $\geq$ 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.