• 융합신호처리학회논문지
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• 제22권2호
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• pp.51-56
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• 2021

상완 수축기 혈압과 맥압은 50세 이상의 개인에서 심혈관 질환의 예측 인자이다. 강성이 증가함에 따라 수축기 후기의 반사 진폭과 압력이 증가하여 좌심실 부하와 심근 산소 요구량이 증가한다. 따라서 강성이 혈압에 미치는 영향을 연구 할 필요가 있다. 본 연구에서는 약물 복용 전후에 혈압 맥파를 측정하고, 심부전 환자에서 심근 심장 이식 전후에 혈압 맥파를 측정하였다. Windkessel 모델의 R, L 및 C 구성 요소 간의 상관관계는 혈압을 높임으로써 추정되었다. 커브 피팅 방법을 사용하여 Windkessel 모델의 매개 변수를 모델링 한 결과 혈압의 증가와 수축기 상승 시간의 감소는 RLC Windkessel 모델의 L 성분이 증가했기 때문이다. 혈관의 다양한 기계적 특성 중에 높은 BP 파형에 영향을 미치는 가장 중요한 매개 변수는 실험결과로 이너턴스인 것을 증명하였다.

• 대한한의학원전학회지
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• 제29권1호
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• pp.17-41
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• 2016

Subjects : A literature research on the constitution and medicinal effect & adaptation diseases of "Bullsusan". "Bullsusan" is a herbal prescription composed of Angelicae Gigantis Radix(當歸) and Cnidii Rhizoma(川芎). Objectives : Through the researching on the records of "Bullsusan" in Korean Traditional Medical Books, gain the literature evidence for adaptation to these days child labor as a pre-labor keeping herbal medicine. And have detailed consideration on the constitution of prescription and medicinal effect & adaptation diseases of "Bullsusan". Methods : First, researched the records of "Bullsusan" in Korean Traditional Medical Books which were included at A Series of Korean Medicine(韓國醫學大系) and analysed component ratio, nickname, herbal manufacture and drug processing method, medicinal effect and adaptation diseases. Second, referred related Korean and Chinese researches that examined the medicinal effect and adaptation diseases of "Bullsusan" by scientific experimentation. Conclusions : We found total 46 records of "Bullsusan" from 20 kinds of Korean Traditional Medical Books included at A Series of Korean Medicine. Prescription component ratio of Angelicae Gigantis Radix and Cnidii Rhizoma were 3:2, 1:1, 2:1, 1:1. 3:2 had most 20 records and 1:1 had second 14 records. Especially 1:1 had a tendency of having nickname "Goonguitang", but not must had. First herbal manufacture was powder, it had 8 records. First drug processing method was decocting with water and alcohol, had 19 records. Medical Effects of "Bullsusan" can be induced to next 8, that were "remove get bad blood, give birth new blood", "easy labor by reducing fetal volume", "acceleration of labor", "test of fetal survival, elimination of dead embryo", "elimination of placenta", "revive", "allaying pain", "nourish the blood". From these medical effects, 9 adaptation diseases can be induced. That were "threatened abortion", "womb ache and vaginal bleeding by spontaneous abortion", "pre-labor keeping(prevention of hard labor)", "acceleration of labor", "hard labor", "missed abortion", "postnatal vaginal bleeding, dizziness, asthma, headache, womb ache", "postnatal mastoptosis and mastodynia", "first aid symptom like as dizziness, unconsciousness, stroke caused by excessive bleeding". The medical effect of "acceleration of labor" and "elimination of placenta" have been examined by modern clinical research. The effect of "remove get bad blood, give birth new blood", "allaying pain" and "nourish the blood" have been examined by modern experimental study. But overdosing on "Bullsusan" to pregnant mouse can cause natural abortion, so the proper dose of "Bullsusan" in pregnant period is very important.

• 디지털융복합연구
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• 제11권6호
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• pp.235-244
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• 2013

본 연구는 수중운동 참여가 정신지체장애인의 혈액성분 및 혈관탄성에 미치는 영향을 규명하기 위하여 수행되었다. 연구의 대상자는 교육 가능한 정신지체장애인 24명이었으며, 수중운동집단 12명, 통제집단 12명으로 무선배정하고 수중운동집단은 9주간 주 5회 1일 60분 실시하였다. 자료처리는 집단별 운동프로그램 참여 전, 후에 대한 평균치의 차이검증은 대응표본 t-test를 실시하였으며, 통계적 유의수준은 p<.05로 설정하여 다음과 같은 결론을 얻었다. 첫째, 수중운동 참여집단에서 체중 및 체지방률은 사후 유의한 감소를 나타냈다(p<.05). 둘째, 수중운동 참여집단에서 사후, Total-Cholesterol, Triglyceride, HDL-C, LDL-C은 유의한 감소와 증가를 나타냈다(p<.05). 셋째, 수중운동집단에서 혈관탄성은 사후, 상지 우, 좌, 하지 우, 좌는 사전과 비교하여 유의한 증가를 나타냈다(p<.05). 이상의 결과를 종합해 볼 때, 정신지체장애인을 대상으로 수중운동참여는 신체조성 및 혈액성분, 혈관탄성에 긍정적인 영향을 미치는 것으로 나타나 심혈관계질환 및 각종 합병증 발병률이 높은 정신지체장애인에게 바람직한 운동프로그램이 될 것으로 사료되며, 후속 연구에서는 정신지체장애인의 신체적 특성 및 개인의 체력수준에 알맞은 과학적이고 체계적인 운동프로그램을 모색하고 제시되어야 할 것으로 사료된다.

• The Korean Journal of Physiology
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• 제9권1호
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• pp.33-37
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• 1975

Adult rabbits were anesthetized with nembutal, 30 mg/kg. Carotid artery and jugular vein were exposed surgically and cannulated with polyethylene tubing. Arterial blood pressure was recorded via pressure transducer on the physiograph and $100{\mu}g/ml$ of histamine solution was infused through the jugular vein by using the constant infusion pump with a rate of 0.92 ml/min or 1.40 ml/min. Mean arterial blood pressure was maintained at $40{\sim}70 mmHg$ and hypotension was kept for 2 hours. After the termination of this period, blood was taken and osmotic fragility was mea sured immediately. Also, every sample of normal blood and shocked blood was incubated for 1 hour or 2 hours at $37^{\circ}C$ in order to see whether or not there was some influence of incubation. Furthermore to clarify which component was responsible for the change on the fragility, the mixtures of normal blood cells with shocked plasma and shocked blood cells with normal plasma were also incubated at $37^{\circ}C$ for one or two hours and fragility in such cases was measured. The data obtained were analysed by probit-plot method and the concentration of saline solution at which the hemolysis started to occur, 50% of blood cells were hemolysed and that at which the red blood cells hemolysed completely were determined. The values for the blood of hypotension stage were compared with those of the control blood. The results obtained were as fellows: 1. Osmotic fragility of red blood cell was increased in hypotensive state induced by histamine. 2. The differences of osmotic fragility after two hours of incubation were negligible both in normal blood and in that of hypotensive state. 3. Osmotic resistance of normal red blood cell incubated in shock plasma was less than that of shock red blood cell incubated in normal plasma. It was suggested that plasma in hypotensive state caused by histamine might be primarily responsible for the alteration of red blood cell fragility.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.101-106
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• 2004

In this paper, a blood vessel in an angiographic image, which plays an importance role in the diagnose diseases including in the eyes, brain and heart, is enhanced by using a directed diffusion technique. A fundamental component of the angiographic analysis is vessel segmentation that the proposed method provides a preprocessing of the image into a form suitable for human analysis, or more importantly, for machine analysis such the segmentation. Vessel enhancement is a challenging problem due to the complex nature of vascular trees and to imaging imperfections. Some parts of the inherent imperfections in angiography are the intensity inhomogeneity between the larger and smaller vessels, and another imperfection is the leakage of contrast agent into the background tissue that provides to low contrast between vessels and tissue. In the proposed scheme, the directed diffusion solves the problem by formulating a local geometric structure, which consists of direction and scale of the blood vessels. The diffusion process uses the local structure to enhance by a diffusivity tensor. The proposed algorithm can be applied to maintain sharpness and coherence-smooth the intra-regions into homogeneity better than traditional diffusion methods, which are Gaussian regulation and coherence enhancing diffusion.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2010년도 춘계학술발표대회
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• pp.45.1-45.1
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• 2010

In this experiment, artificial blood vessel was fabricated from electro-spun PU/PCL. To assist with endothelial growth, PU/PCL surface was coated with the RGD peptide. To prevent a clot of blood, anti-thrombus agent was loaded to the fibrous mat and values were reflected through FT-IR data. In vitro study, SEM and MTT data showed that the component was of excellent biocompatibility and cell proliferation. In in vivo study, the artificial blood vessel was implanted in a dog's artery. The results of the CT scan, ultrasound and H&E staining showed that artificial blood vessel was excellent for artery replacement applications.

• 한국임상수의학회지
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• 제36권4호
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• pp.219-224
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• 2019

The aim of this study was to evaluate the safety and effects of a soy lecithin-based supplement on the general health, skin condition, and blood lipid levels of dogs. Twenty-five, healthy, privately-owned dogs were enrolled in the study. Oral supplementation was administered for 8 weeks in the treatment group. Evaluation items included a thorough physical examination, owner responses to a questionnaire, blood analysis (CBC, CRP, serum chemistry, lipid profile). The results showed a significant improvement in amount of exercise, water intake, skin exfoliation in the treatment group (P < 0.05) but no significant changes in the other evaluation items, including no significant changes in blood component results following administration of the supplement. Most dogs well tolerated the treatment, and there were no serious adverse events. We suggest that soy lecithin has potential as a nutraceutical for the positive effect of general health condition such as activity and skin condition. Further studies are needed to establish the appropriate dose level and administration frequency of soy lecithin in dogs.

• Food Science and Biotechnology
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• 제16권2호
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• pp.249-254
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• 2007

The effects of chronic chitosan salt supplementation on the systolic (SBP) and diastolic blood pressure (DBP), and physiological parameters were investigated in healthy male and female adult. Chitosan salt was conducted by measuring various health-related factors such as body composition, plasma $Na^+$, $Cl^-$, lipid, and lipoproteins profiles, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) activity. Chitosan salt supplementation no significant differences before and after supplement in body composition variables and in SBP and DBP in either male or female. Plasma sodium and chlorine concentration no significant changes during chitosan salt supplementation, and no significant difference between two genders. Plasma GOT and GPT activity no different before and after supplement in either male or female. GOT activity significantly higher for male before supplement (p<0.05), and 2 weeks after supplement (p<0.01). The lipid and lipoproteins profiles of plasma no significant changes during chitosan salt supplementation in either male or female subjects. In summary, the chronic intake of chitosan salt did not affect the SBP or DBP, and posed no health risks.

• 대한수의학회지
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• 제30권3호
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• pp.271-275
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• 1990

The tests related to red cell fragility were performed. Samples of blood anticoagulated with heparin were obtained from Korean native cattle in Chonbuk region abattoir, and classified by the district(Kun) with reference to breeding location. Hemolysis test for red cell fragility was performed with whole blood and glutathione peroxidase activity was measured spectrophotometrically. Blood concentration of selenium, inorganic component of glutathione peroxidase, was also determined fluorophotometrically. The results obtained were summerized as follows; 1. Percent hemolysis of erythrocytes ranged from 13.53 to 20.74%, and its mean Palue was low as $17.11{\pm}9.91%$. Means in all were not district(Kun) in Chonbuk region significantly different. 2. Glutathione peroxidase activity ranged from 2,881 to 4,000mU/ml, and high mean values, $3,352{\pm}1,872mU/ml$, reflected low percent hemolysis. 3. There was a highly negative correlation between the red cell fragility(Y) and blood glutathione peroxidase activity(X). The linear regression equation for these data was: Y=29.86-3.75X with a correlation coefficient of r=-.6886 (p<0.01) 4. Blood selenium concentration ranged from 0.16 to $0.24{\mu}g/ml$, and mean values was normal level as $0.2{\pm}0.11{\mu}g/ml$. 5. There was a highly positive correlation between blood selenium concentration(X), and blood glutathione peroxidase activity(Y). The linear regression for these data was: Y=230+15,790X, with a correlation coefficient officient of r=0. 8635.

• 디지털융복합연구
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• 제11권10호
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• pp.493-505
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• 2013

홍삼추출물이 혈액생화학성분, 대퇴골의 골밀도 및 골무기질 등에 미치는 영향을 알아보기 위하여 난소절제(OVX) 흰쥐에 홍삼추출물을 투여하였으며, 실험결과는 일원변량분산분석과 Scheffe의 사후검정을 통하여 분석하였다. 그 결과 홍삼추출물은 OVX군에 비하여 혈중 알부민, HDL Ca, P, Mg 및 estradiol, 골밀도, 대퇴골의 회분, Ca 및 P을 유의하게 증가시키고, 혈중 ALP, AST, ALT, 혈당, 총콜레스테롤, 중성지질, LDL, creatinine, osteocalcin 및 N-terminal telopeptide를 유의하게 감소시켰다(p < 0.01). 이상의 결과로부터 홍삼추출물은 난소절제로 저하된 간과 신장의 기능, 혈중 당, 지질 및 무기질, 골밀도, 골무기질 함량 및 골다공증관련 대사지표들을 정상수준으로 회복시켜 준다는 것을 알 수 있었다.