• Title/Summary/Keyword: Blood component

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Indian Buffet Process Inspired Component Analysis for fMRI Data (fMRI 데이터에 적용한 인디언 뷔페 프로세스 닮은 성분 분석법)

  • Kim, Joon-Shik;Kim, Eun-Sol;Lim, Byoung-Kwon;Lee, Chung-Yeon;Zhang, Byoung-Tak
    • Proceedings of the Korean Information Science Society Conference
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    • 2011.06c
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    • pp.191-194
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    • 2011
  • 문서를 이루는 단어들의 빈도수가 지수법칙(power law)를 따른다는 지프의 법칩(Zipf's law)이 있다. 이러한 단어분포를 고려하여 문서의 토픽을 찾아내는 기계학습법이 디리쉴레 프로세스(Dirichlet process) 이다. 이를 발전시켜서 데이터의 잠재 요인(latent factor)들을 베이즈 확률모델에 기반한 샘플링 바탕으로 찾는 방법이 인디언 뷔페 과정(Indian buffet process) 이다. 우리는 25가지의 특징(feature)들에 대한 점수(rating)들이 볼드(blood oxygen dependent level) 신호와 함께 주어지는 PBAIC 2007 데이터에 주성분 분석법(principal component analysis)를 적용했다. PBAIC 2007 데이터는 비디오 게임을 수행하며 기능적뇌영상(functional magnetic resonance imaging, fMRI) 촬영을 하여 얻어진 공개데이터이다. 우리의 연구에서는 주성분 분석법을 이용하여 10개의 독립 성분(independent component)들을 찾았다. 그리고 1.75초 마다 촬영된 BOLD 신호와 10개의 고유벡터(eigenvector)들간의 내적을 취하여 가중치(weight)를 구하였다. 성분들의 가중치를 낮은 순서로 정렬함으로써 각 시간마다 주도적으로 영향을 미치는 성분들을 알아낼 수 있었다.

Design and Implementation of the System for Automatic Classification of Blood Cell By Image Analysis (영상분석을 통한 혈구자동분류 시스템의 설계 및 구현)

  • Kim, Kyung-Su;Kim, Pan-Koo
    • Journal of the Korean Institute of Telematics and Electronics C
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    • v.36C no.12
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    • pp.90-97
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    • 1999
  • Recently, there have been many researches to automate processing and analysing image data in medical field, due to the advance of image processing techniques, the fast communication network and high performance hardware. In this paper, we design and implement the system based on the multi-layer neural network model to be able to analyze, differentiate and count blood cells in the peripheral blood image. To do these, we segment red and white-blood cell in blood image acquired from microscope with CCD(Charge-coupled device) camera and then apply the various feature extraction algorithms to classify. In addition to, we reduce multi-variate feature number using PCA(Principle Component Analysis) to construct more efficient classifier. So, in this paper, we are sure that the proposed system can be applied to a pathological guided system.

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Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs

  • Jeong, Jin Young;Kim, Minji;Park, Seol Hwa;Kim, Byeonghyeon;Oh, Sang-Ik;Kim, Eunju;Jung, Hyunjung
    • Food Science of Animal Resources
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    • v.42 no.4
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    • pp.712-722
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    • 2022
  • In this study, we investigated the residual properties of tebuconazole-treated pigs. Twenty pigs were treated with different concentrations (0.25, 1.25, 2.5, 12.5, and 25 mg/kg bw/d) of tebuconazole for 28 d. Blood biochemistry, histology, and residual levels were analyzed using the VetTest analyzer, Masson's trichrome staining kit, and liquid chromatography-mass spectrometry, respectively. The final body weights were not significantly different between the control and treatment groups. Alkaline phosphatase, blood urea nitrogen, cholesterol, and gamma-glutamyl transpeptidase levels were significantly different from those of the control after exposure for 14 d. However, alanine aminotransferase levels showed changes only after exposure to pesticides for 28 d. The biochemical parameters were separated during the experimental period (14 d versus 28 d) by principal component analysis. Based on variable importance plots, blood urea nitrogen/creatinine ratio, blood urea nitrogen, glucose, and gamma-glutamyl transpeptidase are candidate biomarkers for tebuconazole exposure. The residual levels were observed at T4 (12.5 mg/kg bw/d) and T5 (25 mg/kg bw/d) in the liver and fat tissues, respectively. Fibrosis increased in the liver, kidney, and fat tissues, depending on the tebuconazole concentration. In conclusion, the residue limits of tebuconazole and the physiological changes caused by dietary tebuconazole in pigs provide important information for establishing maximum residue limits of pork and pork products.

The Effect of the Goseong-gun Soomchi Complex Marine Healing Program on Improving Lung Health (고성군 숨치 복합 해양치유 프로그램의 폐 건강 개선 효과)

  • Kim, Hyun-Jun;Kim, Seong-Yeol;Park, Jang-Jun;Lee, Si-Woo;Shin, Jae-Suk
    • Journal of The Korean Society of Integrative Medicine
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    • v.10 no.1
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    • pp.109-118
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    • 2022
  • Purpose : The study to verify the effectiveness of the Soomchi combined marine healing program by analyzing the physical composition of the subjects, their blood lipids, and the effects of the program on their lung health-related variables, and heart rate variability variables. Methods : In the experiment, the Soomchi combined marine healing program was conducted for 5 hours a day, 5 days a week. on 15 participants. The results of their body composition, blood lipids, lactic acid, blood pressure, PEF, FEV1 and maximum oxygen intake were analyzed before and after the subjects completed the Soomchi program. For the statistical analysis, the mean and standard deviation (M±SD) of each variable were calculated using SPSS version 20 and an independent t-test was conducted to test for the amount of change in the participants before and after the Soomchi combined marine healing program. All significant levels were set to α=.05. As a result of the experiment Results : First, no statistically significant differences were found in the changes in body composition after the 5-day combined marine healing program was completed. Second, regarding the changes in blood component after the program was conducted, statistically significant differences were found in the lactic acid (p<.05). That is, the experimental group showed a significant decrease in lactic acid after the program whereas the control group showed a significant increase. Third, systolic blood pressure decreased significantly and while in PEF and FEV1 increased significantly in the experimental group after the program. Fourth, the LF of the control group significantly decreased after 5 days. Conclusion : After the Soomchi Lung Health Ocean Healing Program, positive physical changes were observed in the lung health variables and heart rate variability of the participants.

Metabolism of Poncirin by Intestinal Bacteria (장내 세균에 의한 폰시린의 대사)

  • 윤황금;현성혜;김동현;김남재;홍남두
    • YAKHAK HOEJI
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    • v.37 no.3
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    • pp.262-269
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    • 1993
  • Poncirin which is one of the flavanone rhamnoglucosides showed anti-inflammatory activity as the major component of fruit of Poncirus trifoliata. Poncirin did not show antiinflammatory effect when it was intraperitoneally administered, but it was very effective when orally administered. Poncirin was not metabolized by blood and liver enzymes but by intestinal bacteria of human and rats. Among the human intestinal bacteria, Streptococcus Y-25 converted poncirin to ponciretin through the poncirenin and Staphylococcus Y-88 converted to ponciretin directly.

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Effects of feeding system on growth performance, plasma biochemical components and hormones, and carcass characteristics in Hanwoo steers

  • Chung, Chan Sung;Cho, Woong Ki;Jang, In Seok;Lee, Sung Sill;Moon, Yea Hwang
    • Asian-Australasian Journal of Animal Sciences
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    • v.30 no.8
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    • pp.1117-1123
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    • 2017
  • Objective: This study was conducted to compare growth performance, blood components and carcass traits by two feeding systems (concentrate with roughage separately [CON] vs total mixed ration [TMR]) in Hanwoo steers, and to learn the relationship between blood components during fattening or finishing phases and carcass traits in Hanwoo steers. Methods: Sixty steers aged 8 months were allotted to two feeding systems and fed similar amounts of average dry matter and total digestible nutrient throughout whole experimental period according to each feeding program. Steers were weighed monthly, taken blood at the end of growing, fattening and finishing periods, and slaughtered at 30 month of age. Results: Growing performance was higher (p<0.05) in the CON group compared to the TMR group during fattening and finishing periods. The CON group was lower (p<0.05) in blood aspartic acid transaminase, blood urea nitrogen and retinol levels during growing period, but higher in triglyceride and cholesterol levels during fattening and finishing periods compared to the TMR group. The CON group was greater (p<0.05) in rib-eye area, and lighter (p<0.05) red in meat color compared to the TMR group. In the correlation coefficients between blood components of steers and carcass traits, retinol had a negative (p<0.05) correlation with marbling score and rib-eye area. Leptin had a positive (p<0.05) correlation with back fat thickness. Blood cholesterol and triglyceride were positively (p<0.05) correlated with carcass weight and rib-eye area. Conclusion: Growth performance, carcass ribeye area and meat color showed a more desirable result in the CON compared to the TMR in Hanwoo steers. Assessing the accumulated data of carcass traits with blood components including hormones-particularly retinol, cholesterol, triglyceride, and leptin-during the fattening or finishing phases, it may be possible to find a biomarker for determining beef quality in living animals.

Isolation of Flavone Glycoside from Circium japonicum var ussuriense and Biological Activity on the Cardiovascular System (엉겅퀴 지상부의 심혈관 작용활성 및 후라본 배당체의 분리)

  • Lim, Sang-Sun;Lee, Jong-Ho;Park, Jong-Cheol
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.26 no.2
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    • pp.242-247
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    • 1997
  • A flavone glycoside was separated from the aerial part of Circium japonicum var ussuriense Kitamura and the effect on cardiovascular system was investigated. The cadiovascular contractility of this compound was observed in the artria and aortae from normal rats. It increased the spontancous beat in right atria and the contractile force in left atria, and caused the contraction of thoracic aortae. For the blood pressure, it had ascending effect. The effective component, which acted on stimulation and contraction in the artria and aortae of rats was fractionated with n-BuOH, separated and identified by column chromatography, UV, IR, $^1H-NMR$ and $^{13}C-NMR$. The chemical structure for this component was determined to be $hispidulin-7-{\alpha}-rhamnopyranosyl(1{\rightarrow}2)-{\beta}-D-glucopyranoside$.

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Literature research on the use of succium and pumpkin in postpartum edema (산후부종(産後浮腫)의 호박(琥珀)과 남과(南瓜)의 오용에 대한 문헌고찰)

  • Ahn, Sang-Young;Han, Chang-Hyun;Kwon, Oh-Min;Park, Sang-Young;Ahn, Sang-Woo
    • Herbal Formula Science
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    • v.17 no.2
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    • pp.39-51
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    • 2009
  • Objectives : In Korea the practice of folk remedies is widely spread. One of the main uses is the utilization of pumpkin in postpartum edema. While this practice is widely propagated no one could exactly define the evidence of its uses. Therefore we aimed to provide literature evidence of correct prescription in postpartum edema. Methods : As the use of pumpkin in postpartum edema is particular to korea, we revised all the medical book published from the 17th century, the time supposed to have been introduced pumpkin in Korean peninsula. We also researched the prescription mainly used in postpartum edema, and the common main herbal component, succium. As pumpkin and succium is homophony to 'Ho bak' in korean it had the possibility of being misinterpreted. Results : On our literature research we found the precautions of pumpkin to provoke gi-stagnatio and dampness obstruction and that it was restricted while the recovery of all kind of diseases as well as in puerperium. The main reason of postpartum edema is caused by blood stasis which when the blood gains its normal circulation, edema is dispersed by itself. For this propose main prescription was Jogyeongsan調經散 type with its main component succium which medical properties are cited in all medical classics consistently. From the literature of "Juchonsinbang" and "Uibanghapbu" we found three different prescriptions, Hobakgo琥珀膏, Hobakgo胡朴膏, and Namgwago南瓜膏 which contents and their medical proposes were equal. Conclusions : By these finding we could refer that the use of pumpkin in postpartum edema was caused by homophonic reasonal misinterpretation of succinum in korean. This research provides the literature evidence to correct pumpkin's misuse and also the necessity of restriction of the use of even most common products for medical proposes and/or at least the importance of being guided by the experts.

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Applications of prescriptions including Paeoniae Radix as a main component in Dongeuibogam (동의보감(東醫寶鑑) 중(中) 백작약(白芍藥)이 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察))

  • Lee, Chi-Woong;Kook, Yoon-Bum
    • Herbal Formula Science
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    • v.18 no.2
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    • pp.53-76
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    • 2010
  • This report describes 173 formulas related to which are mainly used Paeoniae Radix in Dongeuibogam. The following conclusions were induced through investigations on the formulas that are used Paeoniae Radix as a main component. 1. We found the formulas in Dongeuibogam that Paeoniae Radix is used as a main ingredient in each prescriptions. 22 times(12.4%) of them are recorded in women's disease chapter, 20 times(11.3%) are in feces chapter, 14 times(7.9%) are in uterus, 12 times(6.8%) are in wind chapter, 10 times(5.6%) are in fatigue chapter, 9 times(5.1%) are in blood chapter, which are arranged in order of frequency. 2. Formulas that utilize Paeoniae Radix as the main ingredient are used in the treatment of women's disease, diarrhea, paralysis, yin and yang-deficiency syndrome. They are also used for treating 117 different types of diseases. 3. The dosage of Paeoniae Radix in formulas is from 1 don(nearly 3.75g) to 1 nyang 5 don (nearly 56.25g), however 1 don has been taken the most for clinical application. 4. Paeoniae Radix can make various effects with other ingredient, like fulfilling yin and blood, relaxing muscles and allaying pain. And this can be found in the formulas such as Samultang(四物湯), Jakyackgamchotang(芍藥甘草湯), Sambaektang(三白湯).