• 동의신경정신과학회지
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• 제9권2호
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• pp.71-85
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• 1998

This study was to investigate the effects of GONGCHENGWHAN(GCW) on the blood and brain tissues of aged rats. For the experiment, the aged rats were divided into three groups : Non treated group (NC), distilled water feeding group(PC), GCW feeding group(GCW).Each group was treated as the procedure for ten days before administration of scopolamine. After this treating, we injected scopolamine to Pc and GCW group their blood cell(WBc, RBC, platelet), blood serum (BUN, creatinine, glucose, uric acid), erythrocyte hemolysis, and the activities of cholinesterase as well as measured the amounts malondialdehysde in the blood serum, catalase, and SOD in the brain tissue.The main results of this investigation are as follows.1. In respect of the number of WBC, GCW group exhibited the administrated incerase in comparison with PC. In respect of the number of RBC· and platelet, however, the changes was not administrated.2. In respect of the number of BUN, creatinine, glucose and uric and the blood, GCW group exhibited the administrated decrease in comparison with PC.3. In respect of erythrocyte hemolysis, GCW group exhibited the administrated repression in comparison with PC.4. In respect of the activity of cholinestease in the blood serum, GCW group exhibited the administrated improvement in comparison with PC.5. In respect of the amounts of malondialdehyde in the blood serum, GCW group exhibited the administrated dexrease in comparison with PC.6. In respect of the activity of catalase in brain tissue, GCW group didn't exhibit the administrated change in comparison with PC7. In respect of the activity of SOD in brain tissue, GCW group exhibited the administrated improvement in comparison with PC.Results of this study indicates that GCW improves the activities of cholinesterase and SOD, but represses the formation of the free radical and the accumulation of the antioxidant materials such as MDA. It implies that GCW has some effects on antiaging.

• Childhood Kidney Diseases
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• 제21권2호
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• pp.61-68
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• 2017

Purpose: To investigate differences in clinical features, blood/urinary findings, and prognosis in different age groups of patients with Henoch-$Sch{\ddot{o}}nlein$ purpura (HSP). Methods: A total of 469 patients with HSP were analyzed retrospectively from June 2003 to February 2016. We classified patients into child or adult groups based on their age. Results: The adult group had more patients with anemia (child vs. adult; 7.5% vs. 16.4%), and higher immunoglobulin A (IgA) (30.0% vs. 50.0%) levels, C-reactive protein (34.2% vs. 54.0%) and uric acid (3.1% vs. 12.1%) levels than the child group. The child group was highly positive for Mycoplasma pneumoniae immunoglobulin M (IgM) (34.4%). More patients in the child group presented with high levels of antistreptolysin O (24.7% vs. 2.9%) and high C4 (11.5% vs. 4.2%). Low C3 (1.1% vs. 10.2%) levels, and renal involvement with gross hematuria (8.6% vs. 21.5 %), nonnephrotic proteinuria (1.1% vs. 11.2%), and nephrotic syndrome (1.1% vs. 6.0%) were common in the adult group. Adults also had poorer renal outcomes [persistent hematuria/proteinuria (10.5% vs. 32.8%), and chronic kidney disease (0% vs. 11.2%)] than the child group. Risk factors for renal involvement such as older age and higher level of uric acid were only found in the child group. The risk factors for poor renal outcome were nephrotic syndrome in the child group and gross hematuria in the adult group. Conclusion: In this study, child and adult groups presented with different clinical manifestations of HSP. We found that risk factors for renal involvement included age and high uric acid level in the child group. Moreover, nephrotic syndrome in the child group and gross hematuria in the adult group increased the risk of poor renal outcome.

• 한국환경과학회지
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• 제23권6호
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• pp.1029-1035
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• 2014

This study was investigate the influences of wild haw (Crataegus pinnatifida $B_{UNGE}$) on lowering blood urea nitrogen (BUN) and creatinine concentrations in dyslipidemic rats. Four groups of rats were fed different diets for 5 weeks: basal diet (BD group), nondyslipidemic diet+feral haw extract (NDF group), dyslipidemic diet (DLD group), dyslipidemic diet+feral haw extract (DFH group). BUN, creatinine and uric acid concentrations were significantly higher in the DLD group than in the BD group. However, DFH group significantly lowered BUN, creatinine and uric acid concentrations compared to the DLD group. Amylase activity was significantly lower in the DLD group than in the BD group, while DFH group significantly higher compared to the DLD group. Lipase activity was also also significantly lower in the DLD group than the other group. Accordingly, these results suggest that haw extract could be effective for improving kidney function in dyslipidemic rats.

• 대한수의학회지
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• 제39권6호
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• pp.1141-1150
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• 1999

Renal failure is one of the main causes of economic impacts in the poultry industry and complex syndrome with different severity of clinical signs caused by multiple nephropathogenic factors such as infectious bronchitis viral infection and excess salt and calcium in diet. To evaluate the correlation between severity of renal failure and the causative nephropathogenic factors, one-day-old specific pathogen free chickens were treated with either single causative factor or multiple causative factors described as above. Each group was designed as control for non-treated control, IB for infectious bronchitis virus (IB virus) infection, IBHNa for IB virus infection with high diet salt, IBHCa for IB virus infection with high diet calcium, IBHNC for IB virus infection with high diet salt and calcium, HNa for high diet salt, HCa for high diet calcium and HNC for high diet salt and calcium. Chickens were inoculated with IB virus at 1-day-old and remained on their respective diets until 21 day of age. Plasma $Na^+$, $Cl^-$, BUN, creatinine, calcium and uric acid values were examined. The results obtained were as follows ; IB virus and high dietary calcium combined treatment showed elevated plasma uric acid. BUN and creatinine values were not characteristic on chicken renal failure. But plasma uric acid values were increased according to renal lesion. Hypercalcemia and hyperuricemia did not induce urate deposition and mineralization in the kidney.

• 동의생리병리학회지
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• 제20권6호
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• pp.1485-1496
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• 2006

Various kinds of related parameters on hypertension such as anti-oxygen effect, ACE, weight of body, hwart and kidney, blood pressure, heartbeat rates, contents of aldosterone, catecholamine, change rates, of plasma constituents, uric acid, BUN, creatinine were determined to verify the effects on hypertension by Kamisamul-tang (KSMT). And the results are concluded as follows. KSMT did not show any cytotoxicity at the range of concentration (1-250 ${\mu}g/m{\ell}$) on the human fibroblast cell (hFCs). KSMT decreased the production of reactive oxygen species (ROS) and DPPH generation depending on the concentration. KSMT significantly inhibited angiotensin converting enzyme(ACE) activity depending on the concentration compared with control. KSMT maintained body weight of body, heat and kidney nearly normal group in hypertensive rat induced by DOCA-salt. KSMT significantly blood pressure and heart beat rate compared with control in hypertensive rat induced by DOCA-salt. KSMT significantly decreased aldosterone, dopamine, norepineph- rine, epinephrine compared with control in hypertensive rat induced by DOCA-salt. KSMT significantly decreased the level of potassium and cloride compared with control wheareas increased that of calcium significantly in hypertensive rat induced by DOCA-salt. KSMT significantly decreased the level of uric acid and BUN compared with control in hypertensive rat induced by DOCA-salt. It is verified experimentally tat Kamisamultang(KMST) which has been used broadly as a clinical therapeutics in oriental medicine is effective for anti-hypertension mechanism. And it could be applied to develope the reliable prescriptions for anti-hypertension in the future.

• 대한의생명과학회지
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• 제24권4호
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• pp.411-417
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• 2018

The aim of this study was to investigate the impact of participation in the 622 km hyper-ultra-marathon on hepatic metabolism and renal function in middle-aged men. Healthy middle-aged male amateur ultra-marathoners between the ages of 40 and 60. Blood was collected at the pre-race, immediately after 300 km, 622 km hyper-ultra marathon race, 72 hours (3 day) and 144 hours (6 day) after the race, AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), ${\gamma}$-GTP (gamma glutamyl transferase), T-Bil (total bilirubin), D-Bil (direct bilirubin), T-protein (total protein), albumin, uric acid, BUN (blood urea nitrogen), creatinne were analyzed. ALP was significantly increased at 300 km, 622 km, day 3 and day 6 than the pre-race. ${\gamma}$-GTP, T-protein, albumin, uric acid, BUN and creatinine were not significantly different between the distances and the recovery period respectively. AST and ALT were significantly increased at 300 km, 622 km, day 3 and day 6 than the pre-race, respectively (P<0.05) at day 3 and day 6 they showed significant decrease from 300 km and 622 km, respectively (P<0.05). T-Bil and D-Bil increased significantly at 300 km and 622 km, respectively (P<.05) and significantly decreased at day 3 (P<0.05) compared to the pre-race, at day 3 and day 6 they were decreased significantly than 300 km and 622 km, respectively (P<0.05). In conclusion, no disturbance of renal function was observed according to the distances and between the recovery period of 622 km hyper-ultra marathon race, but reversible hepatocyte function could be degraded and some hemolysis of blood vessels was induced.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권2호
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• pp.187-196
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• 2021

Purpose: The rising prevalence of childhood obesity in the past decades has caused non-alcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children. Methods: In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. A 108 had fatty liver among which 101 were randomly divided into two groups of study (n=51) and control (n=50). The study group was treated with Vit D, 50000 U once a week whereas the control group received placebo with the same dose and package, both for 12 weeks. At the end of the intervention lab tests and ultrasound study was performed once again to evaluate the response to treatment. Results: It was found out that Vit D supplementation improved the fatty liver grade in the study group. The mean changes in hemoglobin (Hb), uric acid, highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), insulin, albumin and alanine aminotransferase (ALT) was significantly higher in the study group compared to controls (p<0.05). After the intervention and means adjustment, a significant difference was obtained in HDL-C, insulin, LDL-C and homeostasis model assessment of insulin resistance (HOMA-IR) between the two groups. Conclusion: Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels.

• Clinical and Experimental Pediatrics
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• 제50권9호
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• pp.882-890
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• 2007

목 적 : 제대혈액 내 줄기세포 자가 이식이 극소저출생 미숙아의 신경학적 손상을 방지할 수 있는지 알아보고자 하였다. 방 법 : 출생체중 1,500 g 미만, 제태연령 32주 이하인 미숙아 26명을 대상으로 하였다. 환자의 제대혈에서 단핵구만 분리한 후 생후 24-48시간 사이에 단핵구로서 평균 $5.87{\times}10^7/kg$개를 정맥주사 하였다. 평가 변수들로서는 저산소성-허혈성 뇌증의 예측 지표로 사용되는 유핵 적혈구수, 소변내의 uric acid/creatinine 비와 NSE, IL-6, $IL-1{\beta}$ 등과 신경세포 보호 작용이 있는 것으로 알려진 GDNF의 농도를 혈청 및 뇌척수액에서 측정하였다. 임상적으로는 생후 1개월의 두위 증가 정도와 함께 뇌 병변, 기관지폐이형성증, 미숙아 망막증, 괴사성 장염 등의 발생 정도를 평가하였다. 결 과 : 1) 소변내 uric acid/ceartinine 비는 줄기세포 자가 이식군과 대조군 사이에 차이가 없었으나 유핵 적혈구수의 감소는 줄기세포 이식군에서 빠르게 감소하는 경향을 보였다. 2) 제대혈 자가 줄기 이식 전후에 시행한 혈청 NSE와 IL-6는 생후 제 7일에 의미 있게 감소하였으나 뇌척수액에서는 통계학적인 의미를 보이지 않았다. 혈청 $IL-1{\beta}$는 생후 제 7일에 감소하고, 혈청 GDNF 농도는 줄기세포 이식 후 증가하는 경향을 보였으나 모두 통계학적인 의미는 없었고 뇌척수액에서도 차이를 보이지 않았다. 3) 생후 1개월에서의 두위 성장(2 cm 이상)은 줄기세포 이식군에서 11명(46%), 대조군은 3명(27%)이었다. 4) 생후 1개월에서의 뇌병변은 줄기세포 이식군 24명 중 3명에서 뇌실주위 연화증이 발생하였고 그 중 1명은 뇌실확장증을 동반하였으며 대조군에서는 11명 중 2명에서 뇌실주위 백질연화증과 뇌실확장증이 발생하였다. 5) 줄기세포 이식군에서 기관지폐이형성증 및 괴사성 장염이 각각 1명씩 발생하였고 대조군에서는 미숙아 망막증이 2명에서 발생하였다. 6) 줄기세포 이식군에서 신생아호흡곤란 증후군과 연관된 패혈증으로 2명이 사망하였으며 제대혈 줄기세포 자가 이식과는 연관관계가 없었다. 결 론 : 극소 저출생체중 미숙아에서 제대혈 자가이식술은 윤리적인 문제없이 쉽게 시행할 수 있는 안전하고 실용적인 신경손상 예방 및 치료법으로 기대된다. 향후 장기적인 신경학적 추적 검사 및 비침습적이며 정교한 평가 변수 확립이 필요하다.

• 약학회지
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• 제31권4호
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• pp.197-203
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• 1987

When pyrazinamide is used in the treatment of tuberculosis, the measurement of pyrazinoic acid which is an intermediate metabolite of pyrazinamide in body is required in order to prevent its associated side-effects, especially that of hyperuricemia. Effects of vitamin B$_6$ on pyrazinoic acid metabolism were studied in this experiment. The activity of hepatic pyrazinoic acid oxidizing enzyme in the presence of pyridoxal was powerfully inhibited, and the pattern was competitive inhibition type. Whereas, its enzyme activity was significantly increased by the treatment of pyridoxal, and the characteristics of the increase may include induction of enzyme proteins. As mice received pyrazinoic acid(300mg/kg) after pyridoxal-pretreatment(40mg/kg) once daily for 4 days, the blood level of pyrazinoic acid and uric acid was decreased significantly.

• 대한영양사협회학술지
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• 제4권1호
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• pp.20-29
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• 1998

The purpose of this study was to investigate the effect of food habits on blood components level(blood glucose, uric acid, hemoglobin, some lipids levels) and health condition in Taejon. The study was conducted with 250 subjects (male 130, female120) who visited in a general hospital from May to June in 1997. Questionaires were used for food habits. The data were analyzed by using $x^2$-test, t-test, ANOVA and multiple range test. Results were summerized s follow : mean of Broca Index were 110.0 $\pm$13.7% in male, 110.6$\pm$16.6% in female. Mean values of systolic blood pressure and diastolic blood pressure were 130.9$\pm$17.6mmHg, 76.2$\pm$12.6mmHg, respectively. The systolic blood pressure was significantly higher in man than woman, Mean serum total cholesterol, LDL-cholesterol, and HDL-cholesterol and triglyceride levels were 202.8$\pm$40.2, 121.1$\pm$35.5, 50.3$\pm$12.9, 157.1$\pm$112.6mg/dl, respectively. Triglyceride level was significantly higher in man than woman. But HDL-cholesterol was significantly lower in man than woman. And also, the value of LPH and AI were higher in man. So Man has more risk of atherogenesis than woman. Mean values of blood sugar, uric acid and hemoglobin was 102.7$\pm$1.36mg/dl and 14.1$\pm$1.56g/dl were higher in man than woman except blood sugar. Food habit of woman were better than it of man. The levels of education and income did not affect to food habit score. The most problem of habits were intake of salty food and lack of exercise. The intake of nutrients were higher as food habit score was higher. Intakes of energy, Ca, vitamin A and vitamin $B^1$ were lower than RDA's of nutrients in bad food habit group. This result did not show that blood components level and health condition were significantly different by food habits. But Broca Index and triglyceride levels were higher in bad food habit group than other groups, but not statistically significant. By this result, it is more needed food habit education to man and young people. The education of food habits will include the real methods of weight control, low intake of salt and exercise to bad food habit group.