Browse > Article
http://dx.doi.org/10.5223/pghn.2021.24.2.187

Vitamin D Effect on Ultrasonography and Laboratory Indices and Biochemical Indicators in the Blood: an Interventional Study on 12 to 18-Year-Old Children with Fatty Liver  

Namakin, Kokab (Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences (BUMS))
Hosseini, Mahya (Department of Pediatric, Student Research Center Birjand University of Medical Sciences)
Zardast, Mahmoud (Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences (BUMS))
Mohammadifard, Mahyar (Fellowship of Interventional Radiology, Birjand University of Medical Sciences)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.24, no.2, 2021 , pp. 187-196 More about this Journal
Abstract
Purpose: The rising prevalence of childhood obesity in the past decades has caused non-alcoholic fatty liver disease (NAFLD) to become the most common cause of pediatric chronic liver disease worldwide. This study was aimed at determining the effect of vitamin D (Vit D) on ultrasonography and laboratory indices of NAFLD and some blood biochemical indicators in children. Methods: In this interventional study liver ultrasonography was performed in 200 children with overweight and obesity. A 108 had fatty liver among which 101 were randomly divided into two groups of study (n=51) and control (n=50). The study group was treated with Vit D, 50000 U once a week whereas the control group received placebo with the same dose and package, both for 12 weeks. At the end of the intervention lab tests and ultrasound study was performed once again to evaluate the response to treatment. Results: It was found out that Vit D supplementation improved the fatty liver grade in the study group. The mean changes in hemoglobin (Hb), uric acid, highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), insulin, albumin and alanine aminotransferase (ALT) was significantly higher in the study group compared to controls (p<0.05). After the intervention and means adjustment, a significant difference was obtained in HDL-C, insulin, LDL-C and homeostasis model assessment of insulin resistance (HOMA-IR) between the two groups. Conclusion: Vit D supplementation in addition to improving the fatty liver grade in ultrasonography and increasing the blood Vit D level, increases the HDL and Hb level besides decreasing uric acid, LDL, HOMA-IR, insulin and ALT levels.
Keywords
Child; Liver; Enzymes; Non-alcoholic fatty liver disease; Overweight; Obesity; Vitamin D;
Citations & Related Records
연도 인용수 순위
  • Reference
1 de Onis M, Blossner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 2010;92:1257-64.   DOI
2 Yildiz I, Erol OB, Toprak S, Cantez MS, Omer B, Kilic A, et al. Role of vitamin D in children with hepatosteatosis. J Pediatr Gastroenterol Nutr 2014;59:106-11.   DOI
3 Low S, Chin MC, Deurenberg-Yap M. Review on epidemic of obesity. Ann Acad Med Singap 2009;38:57-9.
4 Malespin M, Sleesman B, Lau A, Wong SS, Cotler SJ. Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children. J Clin Gastroenterol 2015;49:345-9.   DOI
5 Burke A, Lucey MR. Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation. Am J Transplant 2004;4:686-93.   DOI
6 Di Sessa A, Umano GR, Cirillo G, Del Prete A, Iacomino R, Marzuillo P, et al. The membrane-bound O-Acyltransferase7 rs641738 variant in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2018;67:69-74.   DOI
7 Khadaee GH, Saeidi M. Increases of obesity and overweight in children: an alarm for parents and policymakers. Int J Pediatr 2016;4:1591-601.
8 Walker RW. Genetic and dietary determinants of nonalcoholic fatty liver disease in Hispanic children [PhD dissertation]. Los Angeles: University of Southern California; 2013.
9 Della Corte C, Carpino G, De Vito R, De Stefanis C, Alisi A, Cianfarani S, et al. Docosahexanoic acid plus vitamin D treatment improves features of NAFLD in children with serum vitamin D deficiency: results from a single centre trial. PLoS One 2016;11:e0168216.   DOI
10 Papandreou D, Karabouta Z, Pantoleon A, Rousso I. Investigation of anthropometric, biochemical and dietary parameters of obese children with and without non-alcoholic fatty liver disease. Appetite 2012;59:939-44.   DOI
11 Trappoliere M, Tuccillo C, Federico A, Di Leva A, Niosi M, D'Alessio C, et al. The treatment of NAFLD. Eur Rev Med Pharmacol Sci 2005;9:299-304.
12 Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006;43(2 Suppl 1):S99-112.   DOI
13 Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab 2008;10:185-97.   DOI
14 Maki KC, Rubin MR, Wong LG, McManus JF, Jensen CD, Marshall JW, et al. Serum 25-hydroxyvitamin D is independently associated with high-density lipoprotein cholesterol and the metabolic syndrome in men and women. J Clin Lipidol 2009;3:289-96.   DOI
15 James WP. 22 Marabou symposium: the changing faces of vitamin D. Nutr Rev 2008;66(10 Suppl 2):S213-7.   DOI
16 Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 2008;168:1629-37.   DOI
17 Foroughi M, Maghsoudi Z, Askari G. The effect of vitamin D supplementation on blood sugar and different indices of insulin resistance in patients with non-alcoholic fatty liver disease (NAFLD). Iran J Nurs Midwifery Res 2016;21:100-4.   DOI
18 Shiasi-Arani K, Ghasemi SE, Moravveji SA, Shahpouri-Arani A. Frequency of metabolic syndrome and type 2 diabetes among the obese children and adolescents in Kashan during 2009-11. Feyz J Kashan Univ Med Sci 2012;16:240-7.
19 Nobili V, Giorgio V, Liccardo D, Bedogni G, Morino G, Alisi A, et al. Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease. Eur J Endocrinol 2014;170:547-53.   DOI
20 Baziar N, DJafarian K, Shadman Z, Qorbani M, Khoshniat Nikoo M, Razi F. Effect of vitamin D supplementation on improving vitamin D levels and insulin resistance in vitamin D insufficient or defficient type2 diabetics. IJDLD 2014;13:425-33.
21 Han SS, Kim M, Kim H, Lee SM, Oh YJ, Lee JP, et al. Non-linear relationship between serum 25-hydroxyvitamin D and hemoglobin in Korean females: the Korean National Health and Nutrition Examination Survey 2010-2011. PLoS One 2013;8:e72605.   DOI
22 Sharma S, Jain R, Dabla PK. The role of 25-hydroxy vitamin D deficiency in iron deficient children of North India. Indian J Clin Biochem 2015;30:313-7.   DOI
23 Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 2012;97:1953-61.   DOI
24 Takir M, Solak Y, Erek A, Kostek O, Oral A, Elcioglu OC, et al. Association between elevated serum uric acid and vitamin D insufficiency among the middle-aged and elderly population. Turk Nephrol Dial Transplant J 2016;25:182-6.   DOI
25 Peng H, Li H, Li C, Chao X, Zhang Q, Zhang Y. Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women. PLoS One 2013;8:e61159.   DOI
26 Mohamed GA, Al-Harizi WM, Bedewi MA, Gafar HH. Vitamin D deficiency in knee osteoarthritis and its relationship with obesity in Saudi Arabia. Life Sci J 2015;12:104-11.
27 Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial. J Pediatr (Rio J) 2014;90:28-34.   DOI
28 Ashraf AP, Alvarez JA, Gower BA, Saenz KH, McCormick KL. Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females. Obesity (Silver Spring) 2011;19:2214-21.   DOI
29 Rhee EJ, Kim MK, Park SE, Park CY, Baek KH, Lee WY, et al. High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome. Endocr J 2013;60:743-52.   DOI
30 Katz K, Brar PC, Parekh N, Liu YH, Weitzman M. Suspected nonalcoholic fatty liver disease is not associated with vitamin d status in adolescents after adjustment for obesity. J Obes 2010;2010:496829.   DOI
31 Amer M, Qayyum R. Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006). Am J Cardiol 2012;109:226-30.   DOI
32 Tavakoli F, Namakin K, Zardast M. Vitamin D supplementation and high-density lipoprotein cholesterol: a study in healthy school children. Iran J Pediatr 2016;26:e3311.   DOI
33 Ock SY, Ha KH, Kim BK, Kim HC, Shim JS, Lee MH, et al. Serum 25-hydroxyvitamin D concentration is independently inversely associated with insulin resistance in the healthy, non-obese Korean population. Diabetes Metab J 2016;40:367-75.   DOI
34 Song BM, Kim HC, Choi DP, Oh SM, Suh I. Association between serum 25-hydroxyvitamin D level and insulin resistance in a rural population. Yonsei Med J 2014;55:1036-41.   DOI
35 Choi DP, Oh SM, Lee JM, Cho HM, Lee WJ, Song BM, et al. Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents. PLoS One 2014;9:e103108.   DOI
36 Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017-29.   DOI