Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Effects of GONGCHENGWHAN on the Blood Cell, Serum and Antioxidant Effects on Serum, Brain Tissue of Mouse

공청환(拱淸丸)이 노화(老化) 백서(白鼠)의 혈액변화(血液變化) 및 혈청(血淸)과 뇌조직(腦組織)의 항산화물활성(抗酸化物活性)에 미치는 영향(影響)

  • Chae Jong-Gul (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Tae Jeon University) ;
  • Lee Sang-Ryong (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Tae Jeon University)
  • 채종걸 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상용 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 1998.12.30
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Abstract

This study was to investigate the effects of GONGCHENGWHAN(GCW) on the blood and brain tissues of aged rats. For the experiment, the aged rats were divided into three groups : Non treated group (NC), distilled water feeding group(PC), GCW feeding group(GCW).Each group was treated as the procedure for ten days before administration of scopolamine. After this treating, we injected scopolamine to Pc and GCW group their blood cell(WBc, RBC, platelet), blood serum (BUN, creatinine, glucose, uric acid), erythrocyte hemolysis, and the activities of cholinesterase as well as measured the amounts malondialdehysde in the blood serum, catalase, and SOD in the brain tissue.The main results of this investigation are as follows.1. In respect of the number of WBC, GCW group exhibited the administrated incerase in comparison with PC. In respect of the number of RBC· and platelet, however, the changes was not administrated.2. In respect of the number of BUN, creatinine, glucose and uric and the blood, GCW group exhibited the administrated decrease in comparison with PC.3. In respect of erythrocyte hemolysis, GCW group exhibited the administrated repression in comparison with PC.4. In respect of the activity of cholinestease in the blood serum, GCW group exhibited the administrated improvement in comparison with PC.5. In respect of the amounts of malondialdehyde in the blood serum, GCW group exhibited the administrated dexrease in comparison with PC.6. In respect of the activity of catalase in brain tissue, GCW group didn't exhibit the administrated change in comparison with PC7. In respect of the activity of SOD in brain tissue, GCW group exhibited the administrated improvement in comparison with PC.Results of this study indicates that GCW improves the activities of cholinesterase and SOD, but represses the formation of the free radical and the accumulation of the antioxidant materials such as MDA. It implies that GCW has some effects on antiaging.

Keywords

References

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