• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.720-724
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• 2005

Objective : Skin scale(皮膚甲錯) refers to an excessive dryness of skin which can be found under such conditions as blood deficiency(血虛), blood heat(血熱), damp heat(濕熱), the weakness of stomach(脾胃虛) and blood stasis(瘀血). Method : A sensitive and nervous patient showed symptoms of insomnia and chest discomfort as well as skin scale. He had great anxiety over his illness. He, therefore, was diagnosed as blood stasis caused by outburst of emotions and was prescribed Hyulbuchukeotang(血府逐瘀湯) to remove blood stasis in chest. Result and Conclusion : After taking Hyulbuchukeotang, insomnia, chest discomfort and skin scale eased off. Since not only blood stasis but also other factors may cause skin scale, more research on such cases must be done to determine the efficacy of Hyulbuchukeotang for skin scale.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.4
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• pp.122-134
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• 2009

Purpose: The purpose of this study is to know the blood stasis pattern for the patients who had hysterectomy. Methods: Among the patients who had hysterectomy in the department of obstetrics and gynecology, OO medical center from March 3rd 2009 to October 21st 2009, subjects who met inclusion criteria and submitted appropriate questionnaire. We compared blood stasis score and operational method, age, BMI, past operation history of abdominal and pelvic site, parity, whether adhesiolysis, oriental medicine intervention was done. For statistics, we used independent samples t-test, oneway analysis of variances(ANOVA) and SPSS version 13.0 for windows. Results: Blood stasis score of the subtotal hysterectomy group ($44.43{\pm}15.01$) is higher than that of the total hysterectomy group($39.04{\pm}12.46$). Blood stasis score under the age 40($51.88{\pm}12.68$) is higher than 40-49 age patients($40.34{\pm}14.24$) and over the age 50 patients($41.62{\pm}13.46$). There is no statistically significant difference between laparoscopic and abdominal trial, whether adhesiolysis, oriental medicine intervention was done, BMI, past operation history abdominal and pelvic site, parity, chief complaint before hysterectomy, oriental medicine intervention. Conclusion: Through the results showed, when traditional Korean medical doctors use static blood medication, history of hysterectomy and age should be considered as the history of subtotal hysterectomy and younger age tend to have a higher rate of a blood stasis pattern. We need a further study to develop blood stasis indicators with a validated questionnaire, and more subjects involved at multiple institutions.

• Journal of Korean Medical classics
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• v.29 no.2
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• pp.203-212
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• 2016

Objectives : In order to infer the effect of blood-activating and stasis-dispelling herbs by the analysis of effect terms which have extracted and refined, based on five tastes. Methods : I extracted the effect terms and five tastes of blood-activating and stasis-dispelling herbs written in Herbology. Extracted effect terms was divided into single meaning term and was refined as typical term. After that, I sorted herbs according to the five tastes and find the most highly mentioned effect terms. And I infered each herb's effects based on the relationship between five tastes and most highly mentioned terms. Results & Conclusions : I extracted 5 tastes and 53 effect terms and refined it as 43 effect terms. As the result of analyzing the effect term based the tastes, blood-activating and stasis-dispelling herbs are usually have blood-activating and pain-relieving. The herbs that have the hot taste, have the effect of moving-qi, stasis-breaking and aggregation-dispersing. And I supposed new effects of 5 kinds of herbs among them. The herbs that have the sweet tastes, have the effect of stasis-dispelling. And I supposed new effects of 2 kinds of herbs among them by analyzing the relationship between the tastes and effect terms.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.49-55
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• 2011

Objectives : The purpose of this study was 1) to investigate the possibility of taking blood stasis pattern as a clinical parameter of frozen shoulder, using blood stasis pattern questionnaire (BSPQ) to frozen shoulder group comparing with normal group, and 2) to find out the relationship of the severity of main frozen shoulder symptoms (pain and limited range of motion of shoulder) and the level of blood stasis pattern through BSPQ analysis. Methods : During the period of January 2010 to July 2010, fifty five frozen shoulder patients who visited outpatient clinic of department of acupuncture and moxibustion in East-West Neo Medical Center, Kyung Hee University and fifty five normal people without shoulder pain nor limited ROM in shoulder joint were evaluated through BSPQ, and to the frozen shoulder group, also evaluated three different visual analogue scales (VAS) of pain (pain on average, pain at night, and pain on motion) and active / passive range of motion (ROM) of shoulder joint. Results : Mean blood stasis pattern score of frozen shoulder patients group was significantly higher than the score of normal group (patients vs normal group : $4.85{\pm}1.68$ vs $3.49{\pm}1.54$). Three different types of pain VAS (on average, at night and on motion) showed low to very low positive correlation with BSPQ scores when analyzed with Pearson's correlation coefficient. ROM levels in shoulder joint were not significantly related to BSPQ scores, though active external rotation range showed low positive correlation with BSPQ scores. Conclusions : Patients with frozen shoulder showed higher blood stasis pattern score in BSPQ but the level of blood stasis pattern is not significantly related to the severity of pain or limitation of ROM in shoulder joint.

• The Journal of Dong Guk Oriental Medicine
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• v.2 no.1
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• pp.155-166
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• 1993

Geukhachukeutang is used to cure blood stasis in Oriental Medicine. In order to investigate medical value on intravascula coagulation and contusion blood stasis, the effect of Platelet number, Fibrinogen quantity, Prothrombin time, FOP density, Paw edema increasing rate after prescribing Geukhachukeutang concentration liquid orally were observed. The obtained results are summerized as follows ; 1. Platelet number and Fibrinogen quantity are significantly increased, and Prothrombin time and FOP density are significantly decreased by Geukhachukeutang after inducing intravascula coagulation. 2. Platelet number and Fibrinogen quantity are not significantly increased, and Prothrombin time is not significantly decreased either, by Geukhachukeutang after inducing contusion blood stasis but Paw edema increasing rate is remarkablely decreased in three or four hours of the groups of prescribing. According to the above results, Geukhachukeutang will be used for contusion blood stasis and Intravascula coagulation effectively owing to being accepted as a favorable operation on Platelet number, Fibrinogen quantity, Prothrombin time, FDP density and Paw edema increasing rate.

• Journal of Society of Preventive Korean Medicine
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• v.22 no.3
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• pp.83-89
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• 2018

Objectives : The aim of this study was to investigate expert opinions on the questions contained in a questionnaire for diagnosing blood stasis accompanying metabolic disorders. Methods : Two rounds of Delphi survey were conducted online targeting on one hundred Korean medicine doctors. Respondents rated the appropriateness of the 30 questions in diagnosing metabolic disorder on a five-point scale, anchored at '5 = very appropriate', '4 = appropriate', '3 = somewhat appropriate', '2 = inappropriate', and '1 = very inappropriate'. Results : The mean score on 30 questions of first and second Delphi survey was 3.26 points and 3.31 points, respectively. The ranking of the top 10 questions that were rated as appropriate for diagnosing blood stasis accompanying metabolic disorder were 'sublingual varices', 'reddish black tongue', 'reddish black gum', 'reddish black lips', ''dark purple palatal mucosa and venous edema', 'night pain, 'ecchymosis of the tongue', 'piercing pain', 'ecchymosis of the skin' and 'prolonged numbness'. Conclusions : The experts agreed that three of the most typical symptoms of blood stasis and the conditions of capillary vessels in the tongue or the oral cavity were highly associated with metabolic disorder, whereas the questions related to abdominal pain lacked an association with metabolic disorders.

• The Journal of Internal Korean Medicine
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• v.23 no.2
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• pp.313-320
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• 2002

Insomnia is defined as an experience of inadequate or poor-quality sleeping habit, coupled with more than one of the following symptoms : having difficulty sleeping, waking up too early in the morning or not having sound sleep. Insomnia is one of the most common complications that stroke patients experience, which interfere the patients' recovery. The authors observed two improved cases of insomnia in stroke patients by administrating traditional Korean medicine. The patients suffered from insomnia with nocturnal irritation, constipation, petechia of the tongue, thready or weak pulse. These symptoms, were diagnosed as blood stasis and we administered Hyulboochucke-tang three times a day, to improve blood circulation to remove blood stasis. After the administration, nocturnal irritation disappeared and the insomnia improved. Based on this experience, it is considered that enhancing blood circulation to remove blood stasis can be applied to the treatment of insomnia that stroke patients suffer.

• Journal of Haehwa Medicine
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• v.9 no.2
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• pp.241-250
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• 2001

A study on relation of angiogenesis and blood stagnation in cancer was done, and the results were as follows. 1. Angiogenesis is a sequence of vascular proliferation and accomplished by regulation of anti-angiogenesis factor and indicating factor. These factors are secreted in the course of blood coagulation, inflammation, and regeneration. 2. Angiogenesis in cancer is a important action in growth of tumor and metastasis because it supply oxygen and nutrition. 3. The complicated processes, for example, platelet coagulation, action of coagulator factor & dissolution factor and interaction of variety factors are related to blood stasis and promoting blood circulation to remove blood stasis in oriental medicine. 4. Promoting blood circulation to remove blood stasis is expected to suppress angiogenesis, and we expect advanced study will be accomplished in future.

• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.615-619
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• 2000

Objective : The prostatic disease is characterized as relatively incurable, chronic and recurrent illness. Because of this property, we have the difficulty in treating this illness. Besides, the drug selectivity is restricted to the specific prostatic membrane, the barrier of prostate. This study was to evaluate the efficency of the activating blood flow and removing blood stasis Method to Prostatic disease. Methods : We investigated 51 prostatic patiens with NIH chronic prostatitis symptom index, digital rectal examination(DRE), expressed prostatic secretion(EPS). After investigation we treated the patients with herb which was aimed to activate the blood flow and remove the blood stasis method to prostatic disease. Results : After the treatment, symptom index score of the prostatic patients was reduced from 11.7 to 7.4. The cure rate of 51 prostatic patients was 76.5%. Also the cure rate of the patients who was treated over 4 weeks was higher than the patients treated below 4 weeks, 87.5% to 66.7% respectively. conclusions : These results indicate that oriental medical theraphy is useful enough to treat the prostatic patients. Therefore, the more research about the herb which has activating blood flow and removing blood stasis effect is necessary.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.4
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• pp.17-32
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• 2006

Purpose : The aim of this study is to investigate the antibiotic effects of 14 herbs among blood-activating stasis-dispelling medicinals on vaginal microorganisms. Methods : Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Candida albicans, and Gardnerella vaginalis were used for vaginal pathogenic microorganisms. Lactobacillus gasseri, Streptococcus spp. and Escherichia coli HB101 were used for vaginal normal flora. The blood-activating stasis-dispelling medicinals, Mucunae Caulis, Salviae Radix, Persicae Semen, Myrrha, Zedoariae Rhizoma, Achuranthis Radix, Leonuri Herba, Melandrii Herba, Gleditsiae Spina, Lycopi Herba, Scirpi Rhizoma, Caesalpiniae Lignum, Corydlais Tuber and Polygoni Cuspidati Radix were used in this study. In vitro antibiotic activities were observed by optical density and colony test. Results : The optical density and colony test showed that Gleditsiae Spina, Scirpi Rhizoma, Corydlais Tuber, Polygoni Cuspidati Radix and Melandrii Herba of herbs among blood-activating stasis-dispelling medicinals had antimicrobial effect. Gleditsiae Spina had antimicrobial susceptibility and selective toxicity in Gardnerella vaginalis and MRSA. Scirpi Rhizoma had antimicrobial susceptibility and selective toxicity in Staphylococcus aureus and MRSA. Corydlais Tuber had antimicrobial susceptibility and selective toxicity in MRSA. Polygoni Cuspidati Radix had antimicrobial susceptibility and selective toxicity in Gardnerella vaginalis, Staphylococcus aureus and MRSA. Melandrii Herba had antimicrobial susceptibility and selective toxicity in Gardnerella vaginalis. Conclusion : According to the above results, we could suggest that Gleditsiae Spina, Scirpi Rhizoma, Corydlais Tuber, Polygoni Cuspidati Radix and Melandrii Herba of herbs among blood-activating stasis-dispelling medicinals be available to antimicrobial agent of vaginal pathogenic microbial species in vitro.