• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.321-331
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• 2021

This study sought to analyze factors influencing high-risk drinking in single-person households. For this, data from the 2018 community health survey were used. Subjects were 32,389 adults above the age of 19 in single-person households. For the data analysis, high-risk drinking groups were extracted according to the high-risk drinking rate index of the survey to arrive at influencing factors and differences in health-related and sociodemographic characteristics. The IBM SPSS 25.0 software was used for analysis and a complex sampling design was applied. The results showed that the high-risk drinking rate of Korea's single-person households was 15.0% (male: 25.8%, female: 5.8%) and age, education under high school level, service-industry employees, smokers, people with depression, high blood pressure, and irregular breakfast eaters appeared as common elements for both genders. Stress appeared to only affect males while being diabetic only affected females. High-risk drinking was higher for males in their 30~40s and women in their 20~30s. The younger generation showed the highest numbers in high-risk drinking and factors like stress or depression appeared to be influencing factors for high-risk drinking. Hence, mental health programs along with customized health policies through health forms and lifestyle changes will be required to lower the high-risk drinking rates of single-person households.

• Journal of Digital Convergence
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• v.19 no.1
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• pp.211-216
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• 2021

This study was carried out to evaluate the effects of disinfection using environmental disinfectant after having assessed the extent of contamination through microbial culture testing and the Adenosine Triphosphate Bioluminescence method among the environmental management evaluation methods used for the environment in the hospital ward of patients infected by multidrug-resistant organisms. This study was conducted with the patient wards isolated due to multidrug-resistant organisms as the environmental surface. Specimens were collected from five locations including infusion pumps, IV poles, bedside cabinets, bed railings, keyboards, and blood pressure measurement cuffs. ATP and microbial culture testing were executed prior to, immediately after, and five minutes post-disinfection. According to the result contamination of the infusion pumps was statistically significantly reduced after disinfection. In addition, the bacteria before and after disinfection reduced in IV pole, bed railing, and keyboard. That is, regular environmental surface disinfection can provide safer environments to patients against infection. Therefore, it is necessary to establish guidelines including disinfection methods and intervals for environmental surfaces by evaluating the persistence of disinfectants at various institutions in the future.

• Journal of Digital Convergence
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• v.18 no.12
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• pp.279-284
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• 2020

In January 2020, COVID19 plunged the whole planet into a pandemic. This has caused great economic losses and is causing social confusion. COVID19 has a superior infection rate among people with underlying disease such as heart disease, high blood pressure, diabetes, stroke, depression, and cancer. In addition, it was studied that patients with underlying disease had a higher fatality rate than those without underlying disease. In this study, the presence or absence of underlying disease was classified using EEG data. The data used to classify the presence or absence of underlying disease was EEG data provided by Data Science lab, consisting of 33 features and 69 samples. Z-score was used for data pretreatment. Classification was performed using the neural network NEWFM and ZNN engine. As a result of the classification of the presence or absence of the underlying disease, the experimental results were 77.945 for NEWFM and 76.4% for ZNN. Through this study, it is expected that EEG data can be measured, the presence or absence of an underlying disease is classified, and those with a high infection rate can be prevented from COVID19. Based on this, there is a need for research that can subdivide underlying disease in the future and research on the effects of each underlying disease on infectious disease.

• Journal of Digital Convergence
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• v.20 no.4
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• pp.747-758
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• 2022

This study aimed to identify the factors that influence depression in stressed adults by age. Data were extracted from the 7th Korea National Health and Nutrition Examination Survey, covering 3,333 adults aged 20 to 59 years who were highly aware of stress. Linear regression analysis was performed using the IBM SPSS 25.0 program. The study found that in the case of people in their 20s, education level, health-related quality of life, obesity, weight change, smoking, and subjective body type were significant influencing factors, with an explanatory power of 60.3%. In the case of people in their 30s, gender, household income level, living with spouse, economic activity, health-related quality of life, food intake, obesity, alcohol consumption, smoking, and subjective health were significant influencing factors, with an explanatory power of 30.3%. For people in their 40s, household income level, living with spouse, economic activity, health-related quality of life, smoking, aerobic exercise, and subjective health were significant influencing factors, with an explanatory power of 34.4%. For people in their 50s, gender, education level, income, economic activity, health-related quality of life, protein intake, fat intake, high blood pressure, diabetes, weight control, aerobic exercise, subjective health, and subjective body type were significant influencing factors, with an explanatory power of 42.3%. Therefore, as it was found through this study that the factors affecting depression in stressed adults differ by age, it is necessary to establish an intervention strategy for each age when trying to lower depression in stressed adults.

• Nutrition Research and Practice
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• v.16 no.1
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• pp.74-93
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• 2022

BACKGROUND/OBJECTIVES: There has been an increased interest in determining calcium magnesium, sodium, and potassium's distinct effects on hypertension over the past decade, yet they simultaneously regulate blood pressure. We aimed at examining the association of dietary calcium, magnesium, sodium, and potassium independently and jointly with hypertension using National Health and Nutrition Examination Survey data from 2007 to 2014. MATERIALS/METHODS: The associations were examined on a large cross-sectional study involving 16684 US adults aged>20 years, using multivariate analyses with logistical models. RESULTS: Sodium and calcium quartiles assessed alone were not associated with hypertension. Potassium was negatively associated with hypertension in the highest quartile, 0.64 (95% confidence interval [CI], 0.48-0.87). When jointly assessed using the high and low cut-off points, low sodium and corresponding high calcium, magnesium, and potassium intake somewhat reduced the odds of hypertension 0.39 (95% CI, 0.20-0.76). The sodium-to-potassium ratio was positively associated with hypertension in the highest quartile1.50 (95% CI, 1.11-2.02). When potassium was adjusted for sodium intake and sodium-to-potassium ratio assessed among women, increased odds of hypertension were reported in the highest quartile as 2.02 (95% CI, 1.18-3.34) and 1.69 (95% CI, 1.12-2.57), respectively. The association of combined minerals on hypertension using dietary goals established that men meeting the reference intakes for calcium and exceeding for magnesium had reduced odds of hypertension 0.51 (95% CI, 0.30-0.89). Women exceeding the recommendations for both calcium and magnesium had the lower reduced odds of 0.30 (95% CI, 0.10-0.69). CONCLUSIONS: Our results suggest that the studied minerals' association on hypertension is stronger when jointly assessed, mostly after gender stratification. As compared to men, women increased their risk of hypertension even with a low sodium intake. Women would also reasonably reduce their risk of developing hypertension by increasing calcium and magnesium intake. In comparison, men would somewhat be protected from developing hypertension with calcium intake meeting the dietary goals and magnesium exceeding the nutritional goals.

• Nutrition Research and Practice
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• v.16 no.1
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• pp.60-73
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• 2022

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized trial included a total of 74 adults, and they were assigned to the placebo group (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS components. Safety was assessed by monitoring adverse events (AEs). RESULTS: After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly decreased in the D. morbifera group compared to that of the placebo group (difference: -0.13 ± 0.20% vs. 0.00 ± 0.28%, P = 0.031; % of change: -2.27 ± 3.63% vs. 0.10 ± 5.10%, P = 0.025). The homeostatic model assessment for insulin resistance level also decreased significantly from its baseline in the D. morbifera group. The systolic BP of D. morbifera group decreased significantly than that of placebo group (difference: -3.9 ± 9.8 mmHg vs. 3.3 ± 11.7 mmHg, P = 0.005; % of change: -2.8 ± 7.7% vs. 3.3 ± 10.2%, P = 0.005). However, the lipid parameters and body composition including body weight did not differ between the groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. morbifera group than it was in the placebo group. No serious AEs occurred in either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 12-week period improved metabolic parameters such as HbA1c and BP and reduced the prevalence of MetS.

• Applied Chemistry for Engineering
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• v.33 no.5
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• pp.545-550
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• 2022

As a result of the rapid entry into an aging society and westernized eating habits, the number of heart disease patients caused by angina pectoris, myocardial infarction, and high blood pressure has increased by more than 100,000 over five years. Heart disease has consistently ranked second in the cause of death in Korea over the past eight years, and medical expenses consumed annually reach 6 trillion won. While various treatments are being proposed for more patients, drug-coated balloon catheters have been developed and gradually commercialized to solve the disadvantages of stent implantation such as restenosis and increased risk of bleeding due to long-term double antiplatelet medication. In Korea, it began to use a drug-coated balloon catheter with the first release of it called "SeQuent Please^Ⓡ (Bibrown Korea)" in 2010. Its demand increased gradually as insurance benefits were applied in 2012. Drug-coated balloon angioplasty is increasing in use not only in Korea but also around the world, especially in the Asia-Pacific region, including Japan. Until now, the demand for domestic products is increasing, and if the efficiency in vivo and clinical trials is proven in the future, it is expected to be an effective procedure compared to high-risk stent implantation.

• Journal of Dairy Science and Biotechnology
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• v.40 no.3
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• pp.93-102
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• 2022

This study was conducted using response surface methodology (RSM) to elucidate fermentation conditions that will optimize ACE inhibitory activity using Lactiplantibacillus plantarum K79. Four independent variables [skim milk (with 1% added glucose) concentration (6%-14%), incubation temperature (32℃-42℃), incubation time (8-24 h), and amount of added starter (0.02%-0.2%)] were evaluated using five-level central composite design and response surface methodology to determine the optimum fermentation condition. The dependent variables were angiotensin converting enzyme (ACE) inhibitory activity (the value obtained from 102 diluted supernatant), and pH. The respective coefficients of determinations (R²) were 0.791 and 0.905 for ACE inhibitory activity and pH. The maximum ACE inhibitory activity was 90% under the following conditions: 10% skim milk (with 1% added glucose) concentration, 37℃ incubation temperature, 17.8 h incubation time, and 0.2% added starter. Based on the RSM, using predicted best ACE conditions for fermentation of 13.49% skim milk (with 1% added glucose) with 0.0578% starter at 33.4℃ for 21.5 h, the predicted ACE inhibitory activity and pH values were 86.69% and 4.6, respectively. Actual ACE inhibitory activity and pH values were 85.5% and 4.58, respectively

• Journal of Korea Entertainment Industry Association
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• v.14 no.5
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• pp.217-227
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• 2020

The purpose of the study is to analyze the changes of the heart rate, hand function, and health related quality of life of the people with intellectual disability through the increase of the auditory stimulation. The subjects were 16 people with intellectual disability. The increase of the auditory stimulation was modulated through the music sound and the intensity was consisted of 60dB, 65dB and 70dB. The wist heart rate and blood pressure monitor was used to measure the heart rate during the application of the auditory stimulation increase. The hand function of right and left hand was measured by the Purdue pegboard. Health related of quality of life was measured by the short form-8 health survey. As the results, the increase of the heart rate was showed by the increase of the auditory stimulation and the decrease of the hand function and health related quality of life was showed. For these, the increase of the auditory stimulation acts as a psychological distress, thereby the increase of the heart rate and the reduction of the hand function and health relate quality of life showed. Thus, to decrease of the heart rate and increase the hand function and the health related quality of life of the people with intellectual disability, the intensity of the auditory stimulation should be considered in the environmental stimulation.

• The Korea Journal of Herbology
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• v.27 no.6
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• pp.107-114
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• 2012

Objectives : In this study, we investigated the anti-diabetic and anti-inflammatory effects of water extract from leaves of Ligustrum japonicum (WLJ) in db/db mouse. Methods : The db/db mice were treated orally with WLJ (300 mg/kg/day) for 10 weeks to examine the long-term effects on hyperglycemia and glomerular tissue as well as biochemical and functional abnormalities in the kidney. Results : WLJ treatment markedly reduced plasma levels of glucose, triglyceride, creatinine, and systolic blood pressure in diabetic db/db mouse. Treatment of WLJ significantly increased plasma level of high density lipoprotein (HDL)-cholesterol. We also found that overexpressions of vascular cellular adhesion molecule (VCAM)-1 and endothelin (ET)-1 were observed in aortic tissue of db/db mouse, whereas, WLJ suppressed both expression of VCAM-1 and ET-1 in aorta. In renal tissue, overexpressions of ICAM-1 and TGF-${\beta}1$ were found in untreated db/db mouse, however, significantly decreased those levels by WLJ treatment. The insulin immunoreactivity of the pancreatic islets remarkably increased in WLJ treated db/db mouse compared with untreated db/db mouse. Taken together, WLJ treatment ameliorated hyperglycemia and hyperlipidemia via improvement of insulin secretion and lipid metabolism, respectively. Furthermore, WLJ treatment also ameliorated hypertension via inhibition of inflammatory process in vascular and renal tissues. Conclusions : Ligustrum japonicum has an anti-diabetic and anti-inflammatory effects in db/db mouse. Thus, these results suggested a beneficial effect of Ligustrum japonicum in treatment with diabetes and diabetic vasculopathy.