• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.363-371
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• 2019

The purpose of this research is to provide data for the relations between lifestyle, stress and hypertension in a group of construction Temporary employee. The methods taken in this study was to survey the general characteristics and stress in the group, and figure out the relations between lifestyle and hypertension. This study targeted at 301 Temporary employee. in Young-dong for six months (2014~2015). Data analysis used errors and percentages, chi-square tests, one-way ANOVA analysis, independent sample t-test, chi-square test and multivariate logistic regression. The study shows that no relations between age and hypertension, but according to job characteristics, aggravate lifestyle just like smoking(P=0.049), eating habit(P=0.012), physical(p=0.022) & psychological(p=0.011) state there is an effect on hypertension. Based on the results of this study, it is found that temporary workers in small and medium-sized construction companies with high work-related disaster rates need to improve their living habits and physical psychological conditions and manage high blood pressure, as well as research and management of chronic diseases such as obesity, diabetes and dyslipidemia.

• Journal of Yeungnam Medical Science
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• v.36 no.1
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• pp.26-35
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• 2019

Background: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure-lowering effects. The effects and mechanism of telmisartan on HGP have not been fully elucidated and, therefore, we investigated these phenomena in hyperglycemic HepG2 cells and high-fat diet (HFD)-fed mice. Methods: Glucose production and glucose uptake were measured in HepG2 cells. Expression levels of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase ${\alpha}$ ($G6Pase-{\alpha}$), and phosphorylation levels of insulin receptor substrate-1 (IRS-1) and protein kinase C ${\zeta}$ ($PKC{\zeta}$) were assessed by western blot analysis. Animal studies were performed using HFD-fed mice. Results: Telmisartan dose-dependently increased HGP, and PEPCK expression was minimally increased at a $40{\mu}M$ concentration without a change in $G6Pase-{\alpha}$ expression. In contrast, telmisartan increased phosphorylation of IRS-1 at Ser302 ($p-IRS-1-Ser^{302}$) and decreased $p-IRS-1-Tyr^{632}$ dose-dependently. Telmisartan dose-dependently increased $p-PKC{\zeta}-Thr^{410}$ which is known to reduce insulin action by inducing IRS-1 serine phosphorylation. Ectopic expression of dominant-negative $PKC{\zeta}$ significantly attenuated telmisartan-induced HGP and $p-IRS-1-Ser^{302}$ and -inhibited $p-IRS-1-Tyr^{632}$. Among ARBs, including losartan and fimasartan, only telmisartan changed IRS-1 phosphorylation and pretreatment with GW9662, a specific and irreversible peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) antagonist, did not alter this effect. Finally, in the livers from HFD-fed mice, telmisartan increased $p-IRS-1-Ser^{302}$ and decreased $p-IRS-1-Tyr^{632}$, which was accompanied by an increase in $p-PKC{\zeta}-Thr^{410}$. Conclusion: These results suggest that telmisartan increases HGP by inducing $p-PKC{\zeta}-Thr^{410}$ that increases $p-IRS-1-Ser^{302}$ and decreases $p-IRS-1-Tyr^{632}$ in a $PPAR{\gamma}$-independent manner

• Journal of The Korean Society of Emergency Medicine
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• v.29 no.5
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• pp.449-454
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• 2018

Objective: The SAFARI score was introduced to assess the risk of convulsive seizure during admission for aneurysmal subarachnoid hemorrhage in 2017. This study was conducted to determine whether the SAFARI score derived from the afore-mentioned study could be applied to patients with aneurysmal subarachnoid hemorrhage in Korea. Methods: We conducted a retrospective study of patients who were diagnosed with aneurysmal subarachnoid hemorrhage from March 2013 to October 2017. Patients' age, sex, blood pressure, pulse rate, body temperature, Glasgow-Coma Scale, Hunt-Hess scale, modified Fisher grade, size of ruptured aneurysm, surgery type, transfusion, and SAFARI score were compared between the seizure and non-seizure groups. The area under the receiver operator characteristic curves was calculated to evaluate the predictive ability for seizure during admission. Logistic regression analysis was used to analyze predictive factors for seizure during admission. Results: A total of 220 patients were included. Ninety-seven (44.1%) were male and 123 (55.9%) were female. The mean age of the patients was 65.8 years old (range, 56-75). The area under the curve of the SAFARI score for predicting seizure was 0.813. The SAFARI score was the only significant predictor of seizure during admission, while other factors were not statistically significant upon logistic regression analysis. Conclusion: The SAFARI score could be used for predicting seizure during admission in patients with aneurysmal subarachnoid hemorrhage.

• Journal of Life Science
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• v.31 no.2
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• pp.192-198
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• 2021

Red yeast rice has been extensively used as food and traditional medicine for thousands of years in East Asian countries. It is produced by the fermentation of a particular yeast (in general, Monascus purpureus) as rice and various cereals (barley, soybean, etc.). Monascus sp. produces many secondary metabolites during its growth, including pigments, monacolins, and γ-aminobutyric acid. Some metabolites―specifically, monacolin K, γ-aminobutyric acid, dimerumic acid, and monascus pigments―have been reported to lower cholesterol and blood pressure while showing anti-obesity effects. In this study, we investigated the anti-obesity effect of ethanol extract from red yeast barley (RYB) fermented with Monascus sp. BHN-MK 2 on 3T3-L1 cells. The anti-obesity effects of RYB extract were examined: its lipid accumulation inhibitory effect was tested by Oil Red O staining, and obesity-related mRNA expression levels were tested by real-time RT-PCR in MDI stimulated 3T3-L1 cells. The intracellular lipid content of MDI-stimulated 3T3-L1 cells decreased significantly to 5.04%, 12.24%, and 23.52% in response to 200, 400, and 800 ㎍/ml RYB, respectively. Moreovers, we evaluated that RYB extract significantly downregulated the expression of C/EBPα, SREBP-1, and PPAR-γ gene in a dose-dependent manner. As a result, red yeast barley ethanol extracts exerted the strongest anti-obesity effects. Also, the results indicate that red yeast barley could be used as a functional anti-obesity food material.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.321-331
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• 2021

This study sought to analyze factors influencing high-risk drinking in single-person households. For this, data from the 2018 community health survey were used. Subjects were 32,389 adults above the age of 19 in single-person households. For the data analysis, high-risk drinking groups were extracted according to the high-risk drinking rate index of the survey to arrive at influencing factors and differences in health-related and sociodemographic characteristics. The IBM SPSS 25.0 software was used for analysis and a complex sampling design was applied. The results showed that the high-risk drinking rate of Korea's single-person households was 15.0% (male: 25.8%, female: 5.8%) and age, education under high school level, service-industry employees, smokers, people with depression, high blood pressure, and irregular breakfast eaters appeared as common elements for both genders. Stress appeared to only affect males while being diabetic only affected females. High-risk drinking was higher for males in their 30~40s and women in their 20~30s. The younger generation showed the highest numbers in high-risk drinking and factors like stress or depression appeared to be influencing factors for high-risk drinking. Hence, mental health programs along with customized health policies through health forms and lifestyle changes will be required to lower the high-risk drinking rates of single-person households.

• Journal of Digital Convergence
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• v.19 no.1
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• pp.211-216
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• 2021

This study was carried out to evaluate the effects of disinfection using environmental disinfectant after having assessed the extent of contamination through microbial culture testing and the Adenosine Triphosphate Bioluminescence method among the environmental management evaluation methods used for the environment in the hospital ward of patients infected by multidrug-resistant organisms. This study was conducted with the patient wards isolated due to multidrug-resistant organisms as the environmental surface. Specimens were collected from five locations including infusion pumps, IV poles, bedside cabinets, bed railings, keyboards, and blood pressure measurement cuffs. ATP and microbial culture testing were executed prior to, immediately after, and five minutes post-disinfection. According to the result contamination of the infusion pumps was statistically significantly reduced after disinfection. In addition, the bacteria before and after disinfection reduced in IV pole, bed railing, and keyboard. That is, regular environmental surface disinfection can provide safer environments to patients against infection. Therefore, it is necessary to establish guidelines including disinfection methods and intervals for environmental surfaces by evaluating the persistence of disinfectants at various institutions in the future.

• Journal of Digital Convergence
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• v.18 no.12
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• pp.279-284
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• 2020

In January 2020, COVID19 plunged the whole planet into a pandemic. This has caused great economic losses and is causing social confusion. COVID19 has a superior infection rate among people with underlying disease such as heart disease, high blood pressure, diabetes, stroke, depression, and cancer. In addition, it was studied that patients with underlying disease had a higher fatality rate than those without underlying disease. In this study, the presence or absence of underlying disease was classified using EEG data. The data used to classify the presence or absence of underlying disease was EEG data provided by Data Science lab, consisting of 33 features and 69 samples. Z-score was used for data pretreatment. Classification was performed using the neural network NEWFM and ZNN engine. As a result of the classification of the presence or absence of the underlying disease, the experimental results were 77.945 for NEWFM and 76.4% for ZNN. Through this study, it is expected that EEG data can be measured, the presence or absence of an underlying disease is classified, and those with a high infection rate can be prevented from COVID19. Based on this, there is a need for research that can subdivide underlying disease in the future and research on the effects of each underlying disease on infectious disease.

• Journal of Digital Convergence
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• v.20 no.4
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• pp.747-758
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• 2022

This study aimed to identify the factors that influence depression in stressed adults by age. Data were extracted from the 7th Korea National Health and Nutrition Examination Survey, covering 3,333 adults aged 20 to 59 years who were highly aware of stress. Linear regression analysis was performed using the IBM SPSS 25.0 program. The study found that in the case of people in their 20s, education level, health-related quality of life, obesity, weight change, smoking, and subjective body type were significant influencing factors, with an explanatory power of 60.3%. In the case of people in their 30s, gender, household income level, living with spouse, economic activity, health-related quality of life, food intake, obesity, alcohol consumption, smoking, and subjective health were significant influencing factors, with an explanatory power of 30.3%. For people in their 40s, household income level, living with spouse, economic activity, health-related quality of life, smoking, aerobic exercise, and subjective health were significant influencing factors, with an explanatory power of 34.4%. For people in their 50s, gender, education level, income, economic activity, health-related quality of life, protein intake, fat intake, high blood pressure, diabetes, weight control, aerobic exercise, subjective health, and subjective body type were significant influencing factors, with an explanatory power of 42.3%. Therefore, as it was found through this study that the factors affecting depression in stressed adults differ by age, it is necessary to establish an intervention strategy for each age when trying to lower depression in stressed adults.

• Nutrition Research and Practice
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• v.16 no.1
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• pp.74-93
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• 2022

BACKGROUND/OBJECTIVES: There has been an increased interest in determining calcium magnesium, sodium, and potassium's distinct effects on hypertension over the past decade, yet they simultaneously regulate blood pressure. We aimed at examining the association of dietary calcium, magnesium, sodium, and potassium independently and jointly with hypertension using National Health and Nutrition Examination Survey data from 2007 to 2014. MATERIALS/METHODS: The associations were examined on a large cross-sectional study involving 16684 US adults aged>20 years, using multivariate analyses with logistical models. RESULTS: Sodium and calcium quartiles assessed alone were not associated with hypertension. Potassium was negatively associated with hypertension in the highest quartile, 0.64 (95% confidence interval [CI], 0.48-0.87). When jointly assessed using the high and low cut-off points, low sodium and corresponding high calcium, magnesium, and potassium intake somewhat reduced the odds of hypertension 0.39 (95% CI, 0.20-0.76). The sodium-to-potassium ratio was positively associated with hypertension in the highest quartile1.50 (95% CI, 1.11-2.02). When potassium was adjusted for sodium intake and sodium-to-potassium ratio assessed among women, increased odds of hypertension were reported in the highest quartile as 2.02 (95% CI, 1.18-3.34) and 1.69 (95% CI, 1.12-2.57), respectively. The association of combined minerals on hypertension using dietary goals established that men meeting the reference intakes for calcium and exceeding for magnesium had reduced odds of hypertension 0.51 (95% CI, 0.30-0.89). Women exceeding the recommendations for both calcium and magnesium had the lower reduced odds of 0.30 (95% CI, 0.10-0.69). CONCLUSIONS: Our results suggest that the studied minerals' association on hypertension is stronger when jointly assessed, mostly after gender stratification. As compared to men, women increased their risk of hypertension even with a low sodium intake. Women would also reasonably reduce their risk of developing hypertension by increasing calcium and magnesium intake. In comparison, men would somewhat be protected from developing hypertension with calcium intake meeting the dietary goals and magnesium exceeding the nutritional goals.

• Nutrition Research and Practice
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• v.16 no.1
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• pp.60-73
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• 2022

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized trial included a total of 74 adults, and they were assigned to the placebo group (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS components. Safety was assessed by monitoring adverse events (AEs). RESULTS: After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly decreased in the D. morbifera group compared to that of the placebo group (difference: -0.13 ± 0.20% vs. 0.00 ± 0.28%, P = 0.031; % of change: -2.27 ± 3.63% vs. 0.10 ± 5.10%, P = 0.025). The homeostatic model assessment for insulin resistance level also decreased significantly from its baseline in the D. morbifera group. The systolic BP of D. morbifera group decreased significantly than that of placebo group (difference: -3.9 ± 9.8 mmHg vs. 3.3 ± 11.7 mmHg, P = 0.005; % of change: -2.8 ± 7.7% vs. 3.3 ± 10.2%, P = 0.005). However, the lipid parameters and body composition including body weight did not differ between the groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. morbifera group than it was in the placebo group. No serious AEs occurred in either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 12-week period improved metabolic parameters such as HbA1c and BP and reduced the prevalence of MetS.