• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.5
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• pp.1374-1385
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• 2008

This study aims at finding blood glucose levels in rural residents and factors influencing their glucose levels. For these purposes, the researcher surveyed 1,857 residents in a rural area, Geumsan-gun, Chungcheongnam-do between January and February 2006. Consequently, as major factors influencing fasting glucose and 2-h plasma glucose, it was indicated that insulin, C-reative protein, gamma-glutamy transferase, blood pressure levels, and age were important variables, and thus in light of this result, in order to prevent diabetes, it is very important to control obesity and blood pressure and also it is needed to establish national health management plans fur preventing and controling diabetes and its complications fur the aging society

• Applied Microscopy
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• v.46 no.3
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• pp.140-149
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• 2016

This study intended to compare the effects of the sugar-Omija extract tea (SO) and LuoHanGuo-Omija extract tea (LO) to blood glucose levels and metabolism among streptozotocin (STZ)-induced diabetic mice and to prove the positive effects of LuoHanGuo extract as a sugar substitute. According to the results, the rate of blood glucose increase and the blood glucose level was reduced, and the weight was increased. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride, low density lipoprotein cholesterol, and total cholesterol was decreased, and albumin, total protein, and high density lipoprotein cholesterol (HDL-C) was increased in the STZ/LO group as compared to the STZ group. Compared to the STZ/SO group, the rate of blood glucose increase and glucose tolerance was decreased. AST, ALT, and total cholesterol was decreased, and HDL-C level was high. In conclusion, the LO displayed hypoglycemic effect, prevented weight loss caused by diabetes, recovered liver function, and improved lipid metabolism. In addition, such positive effects were obviously shown during comparison with the experimental group treated with the SO. Therefore, the LO were considered as favorable food supplements that can be safely taken by persons with diabetes, obesity, hypertension, and heart disease; they have to control their sugar intake as well as their diet.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.27-37
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• 1998

In order to investigate the effect of lowering blood glucose level, 27 medications of Sagal part in Donguibogam and the contraindicated medications to Sogal including Ijintang, Dodamtang, Chukdamtang and other six medications which were used to treat Diabetes in the 6th I.M of Kyung Hee Oriental Medical Center were given to the Alloxan induced diabetic mouse and blood glucose level were observed in the 2nd and 4th day. The result of this stqdy are as follows: 1. The 17 medicatlons(63% of 27 medicine) of Sogal part decreased' the glucose level significantly.(Singihwan, Baekhotang, Jowiseunggitang, Yukamijihwangwon, Palmihwan, Kamijeonssibaekchultang, Insamsukgotang, Sacngjinyanghyultang, Insambokryungsan, Hwalhyulyunjosaengjineum, Chungsinbogitang, Hwanggitang, Hwangryunjihwangtang, Ojeupokchunhwan, Yongbongwon, Joosahwangryunwon, Kagambaekchulsan) 2. Dry herbs like Banha, Namsung are the contraindicated herbs in the Sogal part of Donguibogam but Ijintang and Dodamtang which include those herbs also decreased the blood glucose level significantly. 3. The three medications-Bangpungtongsungsan, Bohyulansintang, Bogantang from the six me dications which were used to treat Diabetes in the 6th I.M. of Kyung Hee Oriental Hospital also decreased the blood glucose level significantly.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.17 no.2
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• pp.104-111
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• 2010

Purpose: To evaluate the effects of continuous self monitoring of blood glucose (SMBG) on glycemic control in diabetic patients. Methods: Among the diabetic patients who visited the department of internal medicine in H hospital from April 1 to October 27 2008, 76 patients were divided into the experimental group (n=39) and control group (n=36). The experimental group was required to measure blood glucose levels at least twice every other day using SMBG; their compliance was aided by weekly telephone reminders for 3 months after discharge. Glycated hemoglobin, fasting blood sugar and postprandial 2 hours glucose level, triglyceride and high density lipoprotein were measured before and after the study. Results: Baseline characteristics were not different between the experimental and control groups. Three months later, there was a significant difference in postprandial glucose between the two groups (t=-2.042, p=.045). Conclusion: There was significant improvement of glycemic control after the use of continuous SMBG, suggesting its value in strict glycemic control and the merit of an aggressive education program.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.05a
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• pp.19-29
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• 1998

Blood glucose level은, 간에 있어서의 glucose 생산과, 말초조직(뇌, 근육, 지방등)에 있어서의 glucose의 흡수 사이의 balancing에 의해 결정된다. 정상적으로는, 췌장에서 분비되는 인슐린(insulin)의 작용으로 이 균형 상태가 매우 안정적(80-85mg/㎗)으로 유지되게 된다. 즉 음식물 섭취후의 blood glucose level이 급격한 증가를 보이게 되면, insulin은 말초 조직에서의 glucose의 흡수를 촉진시켜 결과적으로 glycogen 합성을 증가시키는 한편, 간에서의 glycogenolysis와 gluconeogenesis를 저해하므로써, 이들 상승된 혈당치를 낮추게 하는 것이다. 이러한 작용은 안정된 혈당 농도를 회복시키는 이른바 glucose homeostasis를 유지하게 해 준다.

• Membrane Journal
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• v.8 no.1
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• pp.22-28
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• 1998

Multi-layered gelatin films were used for the preparation of diagnostic membranes to measure blood glucose concentration. Diffusion rates of glucose through multi-layer gelatin films were monitored to obtain blood-glucose level by using glucose dehydrogenase and diaphorase. The effects of coating edge distance, enzyme quantities, film thickness, and outside temperature on the maximum diffusion rates of glucose were examined.

• YAKHAK HOEJI
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• v.39 no.4
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• pp.367-372
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• 1995

Mori Folium(MF) methanol extract and its water soluble fraction showed significant blood glucose lowering effects alloxan-induced hyperglycemic mice. Their hypoglycemic activities seemed to nothing to do with the stimulation of insulin release or insulin-like action, according to our experiments. On the other hand, MF prevents the hyperglycemic responses from an oral load of starch and glucose in vivo. Since complex carbohydrates present in a diet must be degraded to monosaccharides by $\alpha$-glucohydrolase before being absorbed in the gastrointestinal tract, it is thought that blood glucose lowering effects of MF may be related to the inhibition of $\alpha$-glucohydrolase catalyzed enzymatic reaction. In addition, experiments that examined an effect of MF water soluble fraction on gastrointestinal movement showed no significant GI movement inhibitory effect. In conclusion, MF water soluble fraction may possess active component which is a potential candidate as an orally active agent for the treatment of diabetes mellitus.

• Nutrition Research and Practice
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• v.2 no.3
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• pp.152-157
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• 2008

The purpose of this study was to investigate the effect of soybean on blood glucose and lipid concentrations, and antioxidant enzyme activity in type 2 diabetes mellitus(DM) patients. We divided patients into two groups and fed them, respectively, a basal diet(control group) and a basal diet with 69 g/d of soybean(soybean group) for 4 weeks. Pills with roasted soybean powder were provided to the soybean supplementation group three times a day. Macronutrients intake except dietary fiber was similar between the two groups. No significant differences were observed in dietary intakes or body weight before and after the supplementation. Energy composition ratio of C:F:P was 65:19:16 in the control group, 64:20:16 in the soybean group. The blood parameters of subjects before supplementation, such as fasting blood glucose, postprandial glucose level, total cholesterol, triglyceride, LDL-cholesterol and $HbA_1C$ were not different between the two groups. After supplementation, fasting blood glucose(p<0.001), postprandial glucose level(p<0.001) and serum triglyceride level(p<0.05) were significantly reduced in the soybean group in comparison with the control group. The total cholesterol level was not significantly different between the control and the supplemented group after 4 weeks of treatment. TBARS levels of the soybean group were not significantly different from those of the control group. The activities of catalase(p<0.01) and glutathione peroxidase(p<0.05) were significantly higher in the soybean group compared to the control group. The results of this study suggest that soybean supplementation would be helpful to control blood glucose and serum lipid in diabetic patients. Also, soybean showed an antioxidant activity that may contribute to enhance the effect of antioxidant defense. This activity contributes to protection against oxidative damage in type 2 DM patients. Soybean may have potential use in the disease management of patients with DM.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.215-221
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• 2004

To determine the effects of caloric restriction on obese type 2 diabetes we measured body blood glucose and serum lipid level in dietary restricted Otsuka Long Evans Tokushima Fatty (OLETF) rats. OLETF rats (obese diabetic rats) and Long Evans Tokushima Otsuka (LETO) rats (control rats) were grouped into 2 groups; control (free feed) group and 30% caloric restricted (30% CR) group. At 24 weeks of age the 30% CR animals were provided a diet at a level of 30% less food (by weight) than control rats consumed during the previous week. Blood glucose levels and serum triglyceride, total cholesterol, and high density lipoprotein (HDL)-cholesterol levels of CR rats were determined every 2 weeks for 8 weeks total. Blood glucose, triglyceride and total cholesterol levels of OLETF rats were significantly higher compared to LETO rats. In OLETF rats, the blood glucose levels were decreased to 61% by 8 weeks in the 30% CR compared to the non-CR control group, but changes of blood glucose levels were not observed in LETO rats during the 8weeks in the 30% CR. The serum triglyceride levels of OLETF rats were decreased significantly in the 30% CR but no change in the serum of LETO rats was found. The total cholesterol level was not changed by dietary restriction in LETO rats, but significant changes were observed in OLETF rats by 30% dietary restriction. HDL-cholesterol levels were also increased by dietary restriction in both LETO and OLETF rats. These results suggested that elevated blood glucose, triglyceride and total cholesterol levels in diabetes II patients may be reduced by caloric restriction.

• Journal of Biomedical Engineering Research
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• v.44 no.1
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• pp.33-40
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• 2023

Transcutaneous auricular vagus nerve stimulation (taVNS) is known to be effective in improving symptoms of numerous diseases such as depression and epilepsy by increasing vagus nerve activity through electrical stimulation. The purpose of this study is to investigate the effect of vagus nerve stimulation on the activity of autonomic nervous system and the changes in postprandial blood glucose levels. Seven healthy adults participated in a non-invasive transcutaneous auricular vagus nerve stimulation experiment. taVNS (25 Hz, 200 ㎲, biphasic pulse) was applied to the cymba concha (taVNS group) or the earlobe (Sham-taVNS group) of the left ear. As autonomic nervous system signals, skin conductance level, skin temperature, and heart rate were recorded during the application of taVNS. Postprandial blood glucose changes due to food intake were recorded at 5 min intervals for 25 minutes after taVNS or sham-taVNS. The taVNS showed a significantly lower skin conductance level than the shamtaVNS (p < 0.05). The increase rate of postprandial blood glucose was significantly lower in the taVNS than in the sham-taVNS (p < 0.05). These results showed that taVNS reduced the activity of the sympathetic nerve system and alleviated early rise in postprandial blood glucose. Although further studies in diabetic patients are needed, this study suggest that taVNS has a potential for clinical use to improve postprandial blood glucose.