• Advances in nano research
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• v.14 no.3
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• pp.247-259
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• 2023

Muscle strength and hypertrophy are equivalent when low-intensity resistance exercise is paired with blood flow restriction. This paper deals with the impact of physical exercise in the form of body activities on drug delivery using nanodevices. The body's actions impact the blood flow since the nano drug delivery devices are released into the bloodstream, and physical exercise and all the activities that change the blood flow influence the stability of these nanodevices. The nanodevice for the drug delivery purpose is modeled via nonuniform tube structures based on the high-order beam theory along with the nonlocal strain gradient theory. The nanodevice is made by a central nanomotor as well as two nanoblade in the form of truncated conical nanotubes carrying the nanomedicine. The mathematical simulation of rotating nanodevices is numerically solved, and the effect of various parameters on the stability of nanodevices has been studied in detail after the validation study.

• Korean Journal of Exercise Nutrition
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• v.24 no.2
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• pp.30-37
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• 2020

[Purpose] The present study investigated the effect of endurance exercise with blood flow restriction (BFR) performed at either 25% maximal oxygen uptake (${\dot{V}}O_2$ max) or 40% ${\dot{V}}O_2$ max) on muscle oxygenation, energy metabolism, and endocrine responses. [Methods] Ten males were recruited in the present study. The subjects performed three trials: (1) endurance exercise at 40% ${\dot{V}}O_2$ max without BFR (NBFR40), (2) endurance exercise at 25% ${\dot{V}}O_2$ max with BFR (BFR25), and (3) endurance exercise at 40% ${\dot{V}}O_2$ max with BFR (BFR40). The exercises were performed for 15 min during which the pedaling frequency was set at 70 rpm. In BFR25 and BFR40, 2 min of pressure phase (equivalent to 160 mmHg) followed by 1 min of release phase were repeated five times (5 × 3 min) throughout 15 minutes of exercise. During exercise, muscle oxygenation and concentration of respiratory gases were measured. The blood samples were collected before exercise, immediately after 15 min of exercise, and at 15, 30, and 60 minutes after completion of exercise. [Results] Deoxygenated hemoglobin (deoxy-Hb) level during exercise was significantly higher with BFR25 and BFR40 than that with NBFR40. BFR40 showed significantly higher total-hemoglobin (total-Hb) than NBFR40 during 2 min of pressure phase. Moreover, exercise-induced lactate elevation and pH reduction were significantly augmented in BFR40, with concomitant increase in serum cortisol concentration after exercise. Carbohydrate (CHO) oxidation was significantly higher with BFR40 than that with NBFR40 and BFR25, whereas fat oxidation was lower with BFR40. [Conclusion] Deoxy-Hb and total Hb levels were significantly increased during 15 min of pedaling exercise in BFR25 and BFR40, indicating augmented local hypoxia and blood volume (blood perfusion) in the muscle. Moreover, low-and moderate-intensity exercise with BFR facilitated CHO oxidation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.183-190
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• 2017

Blood flow restriction(BFR) exercise is defined as low and short lengthexercise with pneumatic pressure belts at the top of the limbs. This study was conducted to investigate the effects of walking exercise with BFR on body composition, growth hormone, and muscle damage markers in obese women. Eleven obese women(> BMI 25kg/m2&> body fat 30%) wore pneumatic pressure belts at both femurs and performed walking exercise twice per day, 3days/wk for 4 week (walking 2min; resting 1min). Body weight, BMI and body fat significantly decreased after exercise(p<0.05), while% body fat was slightly decreased after exercise, although this difference was not significant. Growth hormones increased slightly after exercise, although not significantly. Muscle damage markers (CK(p<0.05), LDH(p<0.05) and K+(p<0.01 increased significantly after exercise, but Mb was did not change significantly. These results suggest that 4-weeks ofblood flow restriction exercisecould be used to prevent and treat obesity and related chronic diseases, as well as metabolic syndrome. Moreover, the effects were similar to those observed in response to high intensity resistance programs, despite the short period for which BFR were conducted.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.363-371
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• 2021

The goal of this study was to investigate the influence of exercise training with or without blood flow restriction (BFR) on physical performance and balance in elderly females. Participants (N = 43) were randomly divided into combined exercise with BFR group (n = 14, EX-BFR), only combine exercise group (n =14, EX) or a non-exercise control group (n = 15, CON). Both EX-BFR and EX groups had completed exercise training for 12 weeks. During the training period, the CON group maintained their normal lives. After baseline tests, two-way repeated measures ANOVA with contrast testing was conducted using SPSS 22.0. Study results found that physical performance and balance in both EX-BFR and EX groups were significantly improved, and fall index in both EX-BFR and EX groups were significantly decreased. There were no changes in the CON group. In addition, the % change and effect size of all variables in the EX-BFR group were larger than the EX group. So, the results showed that the EX-BFR group had performed more intense exercise caused by restricted blood flow during the training period compared to the EX group. Thus, exercise with BFR training may additionally influence physical performance and balance in elderly females.

• Journal of the Korean Society of Food Science and Nutrition
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• v.20 no.2
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• pp.187-196
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• 1991

Aging is the progressive accumulation of changes with time associated with responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age. Lipid peroxides easily produced in the membrane system by the chain reaction of free radicals which occurred from various environmental factors. The amount of lipid peroxides produced in biological system increased with aging process, and lipid peroxidation damages involved in aging process and pathological disorders. Although lipid peroxides have such deleterious effects on the organisms, there are numerous substances and mechanisms which prevent the reaction of peroxide formation and protect the subject from its toxicity. This review provides an overview of how does lipid peroxidation of unsaturated lipids take place by free radical, and what is the intervention of lipid peroxides in pathogenesis of some human diseases, and also how does food restriction influences the aging process and various pathological disorders. The major focus of this paper is to review the evidence indicating that food restriction retards the aging process, and possible mechanisms of its actions. Therefore, it discussed the effects of age and food restriction on life-span, membrane yield, lipid peroxidation, fatty acid composition and peroxidizability, cholesterol and triglyceride levels, prostaglasndin and thromboxane synthesis, which may be concerned with blood flow, membrane fluidity, homeostasis and glomerular filtration rate in living body.

• PNF and Movement
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• v.18 no.3
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• pp.393-401
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• 2020

Purpose: In recent years, there has been increasing interest in using blood flow-restricted exercise (BFRE) or KAATSU training. The KAATSU training method, which partially restricts arterial inflow and fully restricts venous outflow in the working musculature during exercise at reduced exercise intensities, has been proven to result in substantial increases in both muscle hypertrophy and strength. The purpose of this study was to investigate the proper level of pressure for KAATSU training using compound muscle action potential (CMAP) analysis. Methods: Twenty-two healthy adults voluntarily participated in this study. CMAP was conducted by measuring the terminal latency and amplitude using a motor nerve conduction velocity test. For reference-line, supramaximal electrical stimulation was applied to the median nerves of the participants to obtain CMAP for the abductor pollicis brevis. For baseline, the intensity of the electrical stimulation was decreased to a level at which the CMAP amplitude was about a third of the CMAP amplitude obtained by the supramaximal electrical stimulation. The pressure levels for the KAATSU were set as a systolic blood pressure (strong pressure), the median values of systolic and diastolic blood pressure (intermediate pressure), and diastolic blood pressure (weak pressure). In the KAATSU condition, CMAP was performed under the same conditions as baseline after low-intensity thumb abduction exercises were performed at the subjects' own pace for one minute. Results: As the pressure increased, the CMAP amplitude was significantly increased, signifying that more muscle fibers were recruited. Conclusion: This study found that KAATSU training recruited more muscle fibers than low-intensity exercise without the restriction of blood flow.

• Journal of Korea Entertainment Industry Association
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• v.14 no.8
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• pp.447-454
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• 2020

The purpose of this study was to determine the clinical effects of blood flow regulation exercise for improving patients' health care and its usefulness as a rehabilitation model for various diseases by analyzing and examining the existing literature. A literature review of Korean academic journals published over a 10-year period, from 2010 to 2019, was conducted using words such as "blood flow regulation," "blood flow restriction," "low-intensity exercise," and "Kaatsu." Kaatsu is a blood flow regulation exercise developed in 1966 by Dr. Yoshiaki Sato of Japan. It is an efficient and effective exercise method that uses blood flow regulation bands that increase the secretion of growth hormones to develop muscles within a short time, improves blood circulation and metabolism to prevent and improve adult diseases, shortens the rehabilitation period, and improves cardiovascular function. The study participants consisted of 10 patients, of whom four were elderly, four had obesity, one was a stroke patient, and one was a trauma patient. The results of this study show that the blood flow regulation exercise, which is a low-intensity exercise, has the same effect as high-intensity exercise, which supports the evidence that it is a highly efficient exercise method for muscle development and rehabilitation of the elderly, adolescents, and patients with injuries who have difficulty in general exercising. For future studies, further reviews are necessary to verify the effectiveness of the exercise method according to blood flow regulation site and type of disease.

• Journal of Korea Entertainment Industry Association
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• v.15 no.7
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• pp.225-233
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• 2021

This study quantitatively compares and analyzes lower extremity muscle activity and motor neurons by performing blood flow-restricting aerobic training in the lower extremities, which is closely related to aerobic capacity for health, in normal people, and provides basic data to suggest the effectiveness of an effective blood-restricting exercise program. would like to provide A group of 10 people who applied aerobic exercise on a treadmill by restricting blood flow to 140 mmHg of pressure was set as Experimental Group I. And 11 people who applied only aerobic exercise on a treadmill were randomly assigned as a control group. The intervention program was implemented on a treadmill for 4 weeks, 3 times a week, once a day, for 30 minutes once. In addition, muscle activity and motor neurons were measured and analyzed using surface electromyography before intervention. As a result of the study, the muscle activity of the rectus femoris, biceps femoris, tibialis anterior and gastrocnemius was significantly increased (p<.001) in the pre-and-poster comparison within the group of experimental group I (p<.001). In the pre-and-poster comparison of the control group, the muscle activity of the rectus femoris, biceps femoris, tibialis anterior and gastrocnemius was significantly increased (p<.001). In comparison of changes between groups, there was a significant difference in the activity of the rectus femoris muscle (p<.05). Combining aerobic exercise in parallel with lower extremity blood flow restriction can be developed into an injury prevention exercise program that can restore functional activity in rehabilitation training for elite athletes and elderly people with weak joints. In addition, based on these results in future research, it is considered that it is necessary to expand the scope of non-normal subjects and conduct various studies according to the pressure intensity.

• Journal of the Korean Society of Clothing and Textiles
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• v.18 no.3
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• pp.387-394
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• 1994

Journal of the Korean Society of Clothing and Textiles Vol. 18, No. 3 (1994) p. 387∼394 In this study, the restriction of slacks (blue jean) versus box pleats skirt was investigated, from the view point of peripheral blood flow at the toe according to motion variation and E.M.G. analysis of leg muscles after walking on the flat or going up and down stairways. Besides, the pressure of slacks on the lower extrimity was measured statically and dynamically. The main results were summerized as follows; 1. The clothing pressure applied by slacks was; each one of thigh and lower leg was 18.2 g/ cm2 and 22.1 g/cm2 in upright, 63.4 g/cm2 and 26.6 g/cm2 in sitting on the chair, on both sides of thigh and lower leg 272.0 g/cm2 over in squatting. 2. When the motion starts from upright, the dynamic clothing pressure reach their peak before the motions end. When the motion ends and the body comes to a still condition, the clothing pressure grow lower and indicate a constant value. but when the body starts moving again to return to upright, the pressures once grow higher and go to zero value after reaching the peak. The pressure on the knee show much greater than those on the hip. This can be because these pressures depend on the degree of skin stretching motion and of its curvature. 3. The surface E.M.G. in leg muscles M. rectus femoris and M. gastrocnemius were recoreded. In the case of wearing slacks, two muscles were activated much more than wearing skirt. 4. The peripheral blood flow at the toe by wearing slacks was lower than wearing skirt. Also the case when squatting, the peripheral blood flow at the toe was low.

• Proceedings of the Korea Contents Association Conference
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• 2019.05a
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• pp.385-386
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• 2019

본 연구의 목적은 균형에 이상이 있는 20대 정상 성인에게 혈류제한성 탄력밴드 훈련 적용 시 균형능력 회복에 미치는 효과를 알아보고자 하였다. 12명의 남성을 대상으로 대조군(n=6), 실험군(n=6)으로 무작위할당하였다. 두 군은 고강도 축구경기를 통한 균형능력 손상 유발 후 실험군은 1주일 3회 1시간씩 4주 동안 혈류제한성 탄력밴드 훈련을 실시하였고, 대조군은 아무런 훈련을 실시하지 않았다. 모든 대상자는 경기 전, 경기 후, 경기 4주 후에 정적 및 동적 균형을 측정하였다. 연구 결과, 정적균형에서 대조군은 경기 전으로 유의한 회복을 나타내지 않았으나, 실험군은 유의한 회복을 나타냈다. 동적균형에서는 대조군과 실험군 모두에서 유의한 회복을 나타냈다. 혈류제한성 탄력밴드 운동은 단기간에 효율적으로 근력을 향상시킴으로써 균형능력 회복에 긍정적 영향을 줄 수 있다고 판단된다.